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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for ZKSCAN3

Z-value: 0.35

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Transcription factors associated with ZKSCAN3

Gene Symbol Gene ID Gene Info
ZKSCAN3
ENSG00000189298.14 ZKSCAN3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZKSCAN3hg38_v1_chr6_+_28349907_28349983-0.096.9e-01Click!

Activity profile of ZKSCAN3 motif

Sorted Z-values of ZKSCAN3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZKSCAN3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr7_+_1044542 0.98 ENST00000444847.2
GPR146
G protein-coupled receptor 146
chr19_+_39296399 0.82 ENST00000333625.3
IFNL1
interferon lambda 1
chr2_+_190880809 0.80 ENST00000320717.8
GLS
glutaminase
chr7_+_155298561 0.77 ENST00000476756.1
INSIG1
insulin induced gene 1
chr17_+_34270213 0.75 ENST00000378569.2
ENST00000394627.5
ENST00000394630.3
CCL7
C-C motif chemokine ligand 7
chr19_-_39245006 0.51 ENST00000413851.3
ENST00000613087.4
IFNL3
interferon lambda 3
chr1_+_65792889 0.50 ENST00000341517.9
PDE4B
phosphodiesterase 4B
chr3_-_122793772 0.47 ENST00000306103.3
HSPBAP1
HSPB1 associated protein 1
chr6_+_158560057 0.42 ENST00000684151.1
TMEM181
transmembrane protein 181
chr12_+_109098118 0.41 ENST00000336865.6
UNG
uracil DNA glycosylase
chr1_+_93448108 0.41 ENST00000271234.13
ENST00000260506.12
FNBP1L
formin binding protein 1 like
chr1_+_3682306 0.40 ENST00000603362.5
ENST00000604479.5
TP73
tumor protein p73
chr1_+_93448155 0.33 ENST00000370253.6
FNBP1L
formin binding protein 1 like
chrX_+_151694967 0.32 ENST00000448726.5
ENST00000538575.5
PRRG3
proline rich and Gla domain 3
chr16_-_28495519 0.31 ENST00000569430.7
CLN3
CLN3 lysosomal/endosomal transmembrane protein, battenin
chr10_+_75431605 0.30 ENST00000611255.5
LRMDA
leucine rich melanocyte differentiation associated
chr5_+_176810552 0.25 ENST00000329542.9
UNC5A
unc-5 netrin receptor A
chr21_+_46001300 0.24 ENST00000612273.2
ENST00000682634.1
COL6A1
collagen type VI alpha 1 chain
chr5_+_176810498 0.24 ENST00000509580.2
UNC5A
unc-5 netrin receptor A
chr6_+_42929430 0.18 ENST00000372836.5
CNPY3
canopy FGF signaling regulator 3
chr6_+_32968557 0.16 ENST00000374825.9
BRD2
bromodomain containing 2
chr17_-_18644418 0.15 ENST00000575220.5
ENST00000405044.6
ENST00000573652.1
TBC1D28
TBC1 domain family member 28
chr2_+_190880834 0.13 ENST00000338435.8
GLS
glutaminase
chr2_-_166375901 0.12 ENST00000303354.11
ENST00000645907.1
ENST00000642356.2
ENST00000452182.2
SCN9A
sodium voltage-gated channel alpha subunit 9
chr11_-_119346695 0.11 ENST00000619721.6
MFRP
membrane frizzled-related protein
chrX_+_86148441 0.10 ENST00000373125.9
ENST00000373131.5
DACH2
dachshund family transcription factor 2
chr2_-_166375969 0.09 ENST00000454569.6
ENST00000409672.5
SCN9A
sodium voltage-gated channel alpha subunit 9
chr1_+_226062704 0.09 ENST00000366814.3
ENST00000366815.10
ENST00000655399.1
ENST00000667897.1
H3-3A
H3.3 histone A
chr7_-_151210488 0.08 ENST00000644661.2
H2BE1
H2B.E variant histone 1
chr1_-_19484635 0.07 ENST00000433834.5
CAPZB
capping actin protein of muscle Z-line subunit beta
chr1_-_86156737 0.07 ENST00000370571.7
COL24A1
collagen type XXIV alpha 1 chain
chr14_-_106389858 0.06 ENST00000390617.2
IGHV3-35
immunoglobulin heavy variable 3-35 (non-functional)
chr20_-_59042748 0.06 ENST00000355937.9
ENST00000371033.9
PRELID3B
PRELI domain containing 3B
chr22_+_49918626 0.05 ENST00000328268.9
ENST00000404488.7
CRELD2
cysteine rich with EGF like domains 2
chr22_-_49918404 0.05 ENST00000330817.11
ALG12
ALG12 alpha-1,6-mannosyltransferase
chr15_-_41332487 0.03 ENST00000560640.1
ENST00000220514.8
OIP5
Opa interacting protein 5
chr22_+_49918733 0.03 ENST00000407217.7
ENST00000403427.3
CRELD2
cysteine rich with EGF like domains 2
chr6_-_31540536 0.02 ENST00000376177.6
DDX39B
DExD-box helicase 39B
chr19_-_4182527 0.01 ENST00000601571.1
ENST00000601488.5
ENST00000305232.10
ENST00000337491.7
SIRT6
sirtuin 6

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.2 0.9 GO:0006543 glutamine catabolic process(GO:0006543)
0.1 0.8 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.1 0.4 GO:0009405 pathogenesis(GO:0009405)
0.1 0.8 GO:0032696 negative regulation of interleukin-13 production(GO:0032696)
0.1 0.3 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.1 0.5 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.1 0.7 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.5 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.4 GO:0045008 depyrimidination(GO:0045008)
0.0 0.4 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0032002 interleukin-28 receptor complex(GO:0032002)
0.2 0.8 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.2 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.5 GO:0000930 gamma-tubulin complex(GO:0000930)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0004359 glutaminase activity(GO:0004359)
0.2 0.8 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.0 0.4 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0 0.4 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.4 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.5 GO:0043015 gamma-tubulin binding(GO:0043015)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.5 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.2 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines