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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for ZNF232

Z-value: 0.34

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Transcription factors associated with ZNF232

Gene Symbol Gene ID Gene Info
ZNF232
ENSG00000167840.13 ZNF232

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF232hg38_v1_chr17_-_5123102_5123128,
hg38_v1_chr17_-_5111836_5111845		-0.491.3e-02Click!

Activity profile of ZNF232 motif

Sorted Z-values of ZNF232 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF232

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_-_224947030 2.01 ENST00000409592.7
DOCK10
dedicator of cytokinesis 10
chr19_-_10380558 0.60 ENST00000524462.5
ENST00000525621.6
ENST00000531836.5
TYK2
tyrosine kinase 2
chr2_-_112764600 0.56 ENST00000302450.11
CKAP2L
cytoskeleton associated protein 2 like
chr18_+_63970029 0.46 ENST00000353706.6
ENST00000542677.5
ENST00000397985.7
ENST00000636430.1
ENST00000397988.7
ENST00000448851.5
SERPINB8
serpin family B member 8
chr11_+_35189964 0.44 ENST00000524922.1
CD44
CD44 molecule (Indian blood group)
chr18_+_58149314 0.42 ENST00000435432.6
ENST00000357895.9
ENST00000586263.5
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr2_+_74198605 0.41 ENST00000409804.5
ENST00000678340.1
ENST00000679055.1
ENST00000394053.7
ENST00000409601.1
MTHFD2
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
chr10_+_89283685 0.34 ENST00000638108.1
IFIT2
interferon induced protein with tetratricopeptide repeats 2
chr3_-_185498964 0.33 ENST00000296254.3
TMEM41A
transmembrane protein 41A
chr3_-_185499022 0.32 ENST00000421852.6
TMEM41A
transmembrane protein 41A
chr12_+_75481204 0.27 ENST00000550491.1
GLIPR1
GLI pathogenesis related 1
chr10_+_49609095 0.26 ENST00000339797.5
CHAT
choline O-acetyltransferase
chr5_+_147878703 0.26 ENST00000296694.5
SCGB3A2
secretoglobin family 3A member 2
chr1_-_13285154 0.23 ENST00000357367.6
ENST00000614831.1
PRAMEF8
PRAME family member 8
chr14_-_106675544 0.22 ENST00000390632.2
IGHV3-66
immunoglobulin heavy variable 3-66
chr16_+_50025217 0.20 ENST00000427478.7
CNEP1R1
CTD nuclear envelope phosphatase 1 regulatory subunit 1
chr1_-_204685700 0.20 ENST00000367177.4
LRRN2
leucine rich repeat neuronal 2
chr22_-_42614911 0.19 ENST00000617178.4
ENST00000348657.6
ENST00000451060.6
POLDIP3
DNA polymerase delta interacting protein 3
chr10_-_60141004 0.19 ENST00000355288.6
ANK3
ankyrin 3
chr16_+_30650728 0.18 ENST00000568754.5
PRR14
proline rich 14
chr16_+_30651039 0.17 ENST00000542965.2
PRR14
proline rich 14
chr20_+_4148779 0.17 ENST00000621355.4
ENST00000339123.10
ENST00000278795.7
ENST00000305958.9
ENST00000346595.6
SMOX
spermine oxidase
chr16_+_30650932 0.16 ENST00000300835.9
PRR14
proline rich 14
chr14_-_106269133 0.16 ENST00000390609.3
IGHV3-23
immunoglobulin heavy variable 3-23
chr1_-_35641498 0.15 ENST00000373237.4
PSMB2
proteasome 20S subunit beta 2
chrY_+_12904102 0.15 ENST00000360160.8
ENST00000454054.5
DDX3Y
DEAD-box helicase 3 Y-linked
chr11_-_117929380 0.15 ENST00000528626.5
ENST00000445164.6
ENST00000430170.6
ENST00000524993.6
ENST00000526090.1
TMPRSS13
transmembrane serine protease 13
chr12_+_55549602 0.15 ENST00000641569.1
ENST00000641851.1
OR6C4
olfactory receptor family 6 subfamily C member 4
chr2_-_166149120 0.15 ENST00000641575.1
ENST00000641603.1
SCN1A
sodium voltage-gated channel alpha subunit 1
chr6_+_109095110 0.15 ENST00000521277.5
ENST00000407272.5
ENST00000519286.5
CEP57L1
centrosomal protein 57 like 1
chrX_-_131289412 0.15 ENST00000652189.1
ENST00000651556.1
IGSF1
immunoglobulin superfamily member 1
chr2_-_166149204 0.15 ENST00000635750.1
SCN1A
sodium voltage-gated channel alpha subunit 1
chr19_+_17933001 0.14 ENST00000445755.7
CCDC124
coiled-coil domain containing 124
chr14_+_22547495 0.12 ENST00000611116.2
TRAC
T cell receptor alpha constant
chr12_-_9733292 0.12 ENST00000621400.4
ENST00000327839.3
CLECL1
C-type lectin like 1
chr3_+_127915226 0.11 ENST00000405109.5
KBTBD12
kelch repeat and BTB domain containing 12
chr15_-_79090760 0.11 ENST00000419573.7
ENST00000558480.7
RASGRF1
Ras protein specific guanine nucleotide releasing factor 1
chr1_+_237042176 0.11 ENST00000366574.7
RYR2
ryanodine receptor 2
chr6_-_49713521 0.11 ENST00000339139.5
CRISP2
cysteine rich secretory protein 2
chrX_+_50067576 0.11 ENST00000376108.7
CLCN5
chloride voltage-gated channel 5
chr6_-_49713564 0.11 ENST00000616725.4
ENST00000618917.4
CRISP2
cysteine rich secretory protein 2
chr2_-_31414694 0.10 ENST00000379416.4
XDH
xanthine dehydrogenase
chr1_-_160579439 0.10 ENST00000368054.8
ENST00000368048.7
ENST00000311224.8
ENST00000368051.3
ENST00000534968.5
CD84
CD84 molecule
chr1_-_193105373 0.10 ENST00000367439.8
GLRX2
glutaredoxin 2
chr3_+_51829417 0.10 ENST00000440739.3
ENST00000444293.5
IQCF3
IQ motif containing F3
chr10_-_114144599 0.09 ENST00000428953.1
CCDC186
coiled-coil domain containing 186
chr1_+_84479239 0.08 ENST00000370656.5
ENST00000370654.6
RPF1
ribosome production factor 1 homolog
chr19_-_49877279 0.08 ENST00000391832.7
ENST00000344175.10
AKT1S1
AKT1 substrate 1
chr6_+_131637296 0.07 ENST00000358229.6
ENST00000357639.8
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr14_-_24242600 0.07 ENST00000646753.1
ENST00000558566.1
ENST00000267415.12
ENST00000559019.1
ENST00000399423.8
ENST00000626689.2
TINF2
TERF1 interacting nuclear factor 2
chr6_-_109094819 0.07 ENST00000436639.6
SESN1
sestrin 1
chr21_+_37420299 0.06 ENST00000455097.6
ENST00000643854.1
ENST00000645424.1
ENST00000642309.1
ENST00000645774.1
ENST00000398956.2
DYRK1A
dual specificity tyrosine phosphorylation regulated kinase 1A
chr2_-_74392025 0.06 ENST00000440727.1
ENST00000409240.5
DCTN1
dynactin subunit 1
chr5_+_95646854 0.06 ENST00000311364.8
ENST00000458310.1
RFESD
Rieske Fe-S domain containing
chr17_+_28473635 0.05 ENST00000314669.10
ENST00000545060.2
SLC13A2
solute carrier family 13 member 2
chrY_+_12904860 0.05 ENST00000336079.8
DDX3Y
DEAD-box helicase 3 Y-linked
chr17_-_19377876 0.05 ENST00000674596.1
ENST00000642870.2
B9D1
B9 domain containing 1
chr5_+_95646730 0.04 ENST00000511684.5
ENST00000380005.9
RFESD
Rieske Fe-S domain containing
chr6_+_109095481 0.04 ENST00000521522.5
ENST00000524064.5
ENST00000522608.5
ENST00000517392.6
ENST00000521503.5
ENST00000519407.5
ENST00000519095.5
ENST00000368968.6
ENST00000522490.5
ENST00000523209.5
ENST00000368970.6
ENST00000520883.5
ENST00000523787.5
CEP57L1
centrosomal protein 57 like 1
chr17_+_28473278 0.03 ENST00000444914.7
SLC13A2
solute carrier family 13 member 2
chr1_-_152115443 0.03 ENST00000614923.1
TCHH
trichohyalin
chr11_+_18172837 0.03 ENST00000314254.3
MRGPRX4
MAS related GPR family member X4
chr1_+_203795614 0.02 ENST00000367210.3
ENST00000432282.5
ENST00000453771.5
ENST00000367214.5
ENST00000639812.1
ENST00000367212.7
ENST00000332127.8
ENST00000550078.2
ZC3H11A
ZBED6
zinc finger CCCH-type containing 11A
zinc finger BED-type containing 6
chr3_+_184300564 0.02 ENST00000435761.5
ENST00000439383.5
PSMD2
proteasome 26S subunit, non-ATPase 2
chr19_-_15125751 0.02 ENST00000263383.8
ILVBL
ilvB acetolactate synthase like
chr7_-_1569955 0.01 ENST00000288607.3
ENST00000404674.7
PSMG3
proteasome assembly chaperone 3
chr9_+_114323098 0.01 ENST00000259396.9
ORM1
orosomucoid 1
chr4_-_87529460 0.01 ENST00000418378.5
SPARCL1
SPARC like 1
chr13_+_27251569 0.01 ENST00000272274.8
ENST00000319826.8
ENST00000326092.8
RPL21
ribosomal protein L21
chr4_+_39406917 0.00 ENST00000257408.5
KLB
klotho beta

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.2 GO:1900827 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.4 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.4 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 0.1 GO:0046110 xanthine metabolic process(GO:0046110)
0.0 0.2 GO:0046208 spermine catabolic process(GO:0046208)
0.0 0.1 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.5 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.3 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.0 0.1 GO:0098904 regulation of AV node cell action potential(GO:0098904)
0.0 0.1 GO:0032661 regulation of interleukin-18 production(GO:0032661)
0.0 0.3 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.1 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.0 0.4 GO:0046653 tetrahydrofolate metabolic process(GO:0046653)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.2 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.0 0.1 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.0 0.5 GO:0043194 axon initial segment(GO:0043194)
0.0 0.2 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.1 0.3 GO:0004102 choline O-acetyltransferase activity(GO:0004102)
0.0 0.2 GO:0052901 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.0 0.1 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.0 0.1 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.0 0.4 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.1 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.0 0.1 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.0 0.2 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.1 GO:0034711 inhibin binding(GO:0034711)
0.0 0.1 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.0 0.1 GO:0030614 oxidoreductase activity, acting on phosphorus or arsenic in donors(GO:0030613) oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor(GO:0030614)
0.0 0.4 GO:0005540 hyaluronic acid binding(GO:0005540)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.0 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.2 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.3 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 2.0 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production