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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for ZNF282

Z-value: 0.47

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Transcription factors associated with ZNF282

Gene Symbol Gene ID Gene Info
ENSG00000170265.12 ZNF282

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF282hg38_v1_chr7_+_149195537_1491955590.223.0e-01Click!

Activity profile of ZNF282 motif

Sorted Z-values of ZNF282 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF282

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr1_+_145927105 2.31 ENST00000437797.5
ENST00000601726.3
ENST00000599626.5
ENST00000599147.5
ENST00000595494.5
ENST00000595518.5
ENST00000597144.5
ENST00000599469.5
ENST00000598354.5
ENST00000598103.5
ENST00000600340.5
ENST00000630257.2
ENST00000625258.1
LIX1L antisense RNA 1
novel protein, lncRNA-POLR3GL readthrough
chr2_-_156332694 1.57 ENST00000424077.1
ENST00000426264.5
ENST00000421709.1
ENST00000339562.9
nuclear receptor subfamily 4 group A member 2
chr4_-_74038681 1.10 ENST00000296026.4
C-X-C motif chemokine ligand 3
chrX_+_102712438 0.58 ENST00000486814.2
ENST00000535209.6
ENST00000543253.6
ENST00000332262.10
ENST00000483720.6
G protein-coupled receptor associated sorting protein 2
chr5_+_175872741 0.50 ENST00000502265.5
complexin 2
chr12_+_93570969 0.50 ENST00000536696.6
suppressor of cytokine signaling 2
chr17_+_68512878 0.49 ENST00000585981.5
ENST00000589480.5
ENST00000585815.5
protein kinase cAMP-dependent type I regulatory subunit alpha
chr22_+_26621952 0.46 ENST00000354760.4
crystallin beta A4
chrX_+_102712471 0.45 ENST00000652409.1
ARMCX5-GPRASP2 readthrough
chr16_-_66552460 0.44 ENST00000678015.1
ENST00000569718.6
ENST00000678314.1
ENST00000562484.2
thymidine kinase 2
chr8_+_10525529 0.43 ENST00000328655.8
ENST00000522210.1
serine protease 55
chr18_+_56651335 0.41 ENST00000589935.1
ENST00000254442.8
ENST00000357574.7
WD repeat domain 7
chr22_+_31082860 0.38 ENST00000619644.4
smoothelin
chr16_+_67170497 0.38 ENST00000563439.5
ENST00000268605.11
ENST00000564992.1
ENST00000564053.5
nucleolar protein 3
chr7_+_139341311 0.35 ENST00000297534.7
ENST00000541515.3
formation of mitochondrial complex V assembly factor 1 homolog
FMC1-LUC7L2 readthrough
chr18_+_56651385 0.34 ENST00000615645.4
WD repeat domain 7
chr1_+_2073462 0.33 ENST00000400921.6
protein kinase C zeta
chr16_+_66552558 0.31 ENST00000345436.8
ENST00000351137.8
ENST00000362093.4
ENST00000264001.9
ENST00000417030.2
ENST00000527729.5
ENST00000532838.1
ENST00000615332.5
ENST00000616804.5
chemokine like factor
CKLF-CMTM1 readthrough
chr7_+_2242207 0.31 ENST00000356714.6
nudix hydrolase 1
chr8_-_27772585 0.29 ENST00000522915.5
ENST00000356537.9
coiled-coil domain containing 25
chr16_+_29790715 0.29 ENST00000561482.5
ENST00000569636.6
ENST00000160827.9
kinesin family member 22
chr19_-_6110463 0.28 ENST00000587181.1
ENST00000587321.1
ENST00000586806.1
ENST00000303657.10
ENST00000589742.5
ENST00000592546.5
regulatory factor X2
chr1_+_2073986 0.26 ENST00000461106.6
protein kinase C zeta
chr7_+_2242256 0.26 ENST00000397046.5
ENST00000397048.5
ENST00000454650.1
nudix hydrolase 1
chr17_-_63896621 0.25 ENST00000453363.7
chorionic somatomammotropin hormone 1
chr4_+_87422800 0.25 ENST00000440591.6
nudix hydrolase 9
chr1_+_16921923 0.24 ENST00000375541.10
ciliary rootlet coiled-coil, rootletin
chr2_-_187513641 0.24 ENST00000392365.5
ENST00000435414.5
tissue factor pathway inhibitor
chr3_-_180989678 0.24 ENST00000491873.5
ENST00000382564.8
ENST00000486355.1
DnaJ heat shock protein family (Hsp40) member C19
chr3_+_45886537 0.23 ENST00000357632.7
ENST00000422395.1
C-C motif chemokine receptor 9
chr3_+_45886501 0.23 ENST00000395963.2
C-C motif chemokine receptor 9
chr8_-_109644766 0.23 ENST00000533065.5
ENST00000276646.14
syntabulin
chr3_-_49869886 0.23 ENST00000296471.11
ENST00000488336.5
ENST00000477224.6
ENST00000467248.5
ENST00000466940.5
ENST00000463537.5
ENST00000480398.2
CaM kinase like vesicle associated
chr11_+_112086853 0.23 ENST00000528182.5
ENST00000528048.5
ENST00000375549.8
ENST00000528021.6
ENST00000526592.5
ENST00000525291.5
succinate dehydrogenase complex subunit D
chr19_-_38899800 0.22 ENST00000414941.5
ENST00000358931.9
ENST00000392081.6
sirtuin 2
chr4_+_39459039 0.22 ENST00000509519.5
ENST00000640888.2
ENST00000424936.6
ENST00000381846.2
ENST00000513731.6
lipoic acid synthetase
chr17_-_63896568 0.22 ENST00000610991.1
ENST00000316193.13
ENST00000329882.8
chorionic somatomammotropin hormone 1
chr15_+_50908674 0.21 ENST00000261842.10
ENST00000560508.1
adaptor related protein complex 4 subunit epsilon 1
chr6_-_79234619 0.21 ENST00000344726.9
ENST00000275036.11
high mobility group nucleosomal binding domain 3
chr11_-_124313949 0.21 ENST00000641015.1
olfactory receptor family 8 subfamily D member 1
chr19_-_38899529 0.21 ENST00000249396.12
ENST00000437828.5
sirtuin 2
chr6_-_32184227 0.20 ENST00000450110.5
ENST00000375067.7
ENST00000375056.6
advanced glycosylation end-product specific receptor
chr4_+_39459069 0.19 ENST00000261434.8
ENST00000340169.7
ENST00000638451.1
ENST00000640349.1
lipoic acid synthetase
chr9_+_136327424 0.19 ENST00000616132.4
G protein signaling modulator 1
chr21_+_7744971 0.19 ENST00000622934.3
ENST00000619874.4
ENST00000612624.4
ENST00000624304.3
ENST00000624758.3
small integral membrane protein 11B
chr16_+_67893244 0.19 ENST00000291041.6
ENST00000570631.5
protein serine kinase H1
chr13_+_30735523 0.18 ENST00000380490.5
arachidonate 5-lipoxygenase activating protein
chr9_-_137028878 0.18 ENST00000625103.1
ENST00000614293.4
ATP binding cassette subfamily A member 2
chr6_-_32184287 0.18 ENST00000375069.7
ENST00000375070.7
ENST00000438221.6
ENST00000620802.4
ENST00000538695.2
advanced glycosylation end-product specific receptor
chr1_-_23825402 0.17 ENST00000235958.4
ENST00000436439.6
ENST00000374490.8
3-hydroxy-3-methylglutaryl-CoA lyase
chr6_-_32184243 0.17 ENST00000375055.6
ENST00000375076.9
advanced glycosylation end-product specific receptor
chr1_+_34782259 0.17 ENST00000373362.3
gap junction protein beta 3
chr17_+_57105899 0.17 ENST00000576295.5
A-kinase anchoring protein 1
chr2_+_48617798 0.17 ENST00000448460.5
ENST00000437125.5
ENST00000430487.6
general transcription factor IIA subunit 1 like
chr22_-_50532489 0.15 ENST00000329363.9
ENST00000437588.2
outer dense fiber of sperm tails 3B
chr8_-_74321532 0.15 ENST00000342232.5
junctophilin 1
chr2_-_196799642 0.15 ENST00000409364.3
ENST00000263956.8
general transcription factor IIIC subunit 3
chr17_+_43171187 0.15 ENST00000542611.5
ENST00000590996.6
ENST00000589872.1
NBR1 autophagy cargo receptor
chr17_-_75941035 0.15 ENST00000586717.5
Fas binding factor 1
chr2_+_241776816 0.15 ENST00000192314.7
galactose-3-O-sulfotransferase 2
chr3_-_180989518 0.15 ENST00000479269.5
ENST00000646965.1
DnaJ heat shock protein family (Hsp40) member C19
chr11_+_66510626 0.13 ENST00000526815.5
ENST00000318312.12
ENST00000525809.5
ENST00000455748.6
ENST00000393994.4
ENST00000630659.2
Bardet-Biedl syndrome 1
chr1_-_53838276 0.13 ENST00000371429.4
NDC1 transmembrane nucleoporin
chr18_-_49491586 0.12 ENST00000584895.5
ENST00000580210.5
ENST00000579408.5
RPL17-C18orf32 readthrough
ribosomal protein L17
chr1_+_160343375 0.12 ENST00000294785.10
ENST00000421914.5
ENST00000438008.5
nicastrin
chr21_+_34375500 0.12 ENST00000399299.5
ENST00000399292.8
ENST00000474455.1
ENST00000399295.2
small integral membrane protein 11A
chr17_-_78903193 0.12 ENST00000322630.3
ENST00000586713.5
CEP295 N-terminal like
chr17_-_39688016 0.11 ENST00000579146.5
ENST00000300658.9
ENST00000378011.8
ENST00000429199.6
post-GPI attachment to proteins phospholipase 3
chr6_+_44219527 0.11 ENST00000651428.1
solute carrier family 29 member 1 (Augustine blood group)
chr7_-_158704740 0.10 ENST00000409339.3
ENST00000356309.8
ENST00000409423.5
non-SMC condensin II complex subunit G2
chr10_-_124791812 0.10 ENST00000652548.1
ENST00000368836.7
EEF1A lysine methyltransferase 2
chr15_-_44663644 0.10 ENST00000559511.6
ENST00000427534.6
ENST00000559193.5
ENST00000261866.12
ENST00000535302.6
ENST00000684235.1
ENST00000682065.1
ENST00000682669.1
ENST00000558319.5
SPG11 vesicle trafficking associated, spatacsin
chr17_-_63873676 0.10 ENST00000613718.3
ENST00000392886.7
ENST00000345366.8
ENST00000336844.9
ENST00000560142.5
chorionic somatomammotropin hormone 2
chr8_-_22131003 0.09 ENST00000381418.9
HR lysine demethylase and nuclear receptor corepressor
chr8_-_22131043 0.09 ENST00000312841.9
HR lysine demethylase and nuclear receptor corepressor
chr1_+_45326869 0.08 ENST00000334815.6
4-hydroxyphenylpyruvate dioxygenase like
chr18_-_49492305 0.08 ENST00000615479.4
ENST00000583637.5
ENST00000618613.5
ENST00000615760.4
ENST00000578528.1
ENST00000578532.5
ENST00000580387.5
ENST00000579248.5
ENST00000580261.6
ENST00000581373.5
ENST00000618619.4
ENST00000617346.4
ENST00000583036.5
ENST00000332968.11
ribosomal protein L17
RPL17-C18orf32 readthrough
chr17_-_63881842 0.07 ENST00000449787.6
ENST00000456543.6
ENST00000622506.4
ENST00000332800.7
ENST00000423893.7
growth hormone 2
chrX_+_154429092 0.07 ENST00000619046.5
ATPase H+ transporting accessory protein 1
chr19_-_48617797 0.06 ENST00000546623.5
ENST00000084795.9
ribosomal protein L18
chr11_-_130428605 0.06 ENST00000257359.7
ADAM metallopeptidase with thrombospondin type 1 motif 8
chr11_+_63536801 0.06 ENST00000255688.8
ENST00000439013.6
phospholipase A and acyltransferase 4
chr2_+_231395702 0.06 ENST00000287590.6
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
chr17_+_39688079 0.06 ENST00000578199.5
erb-b2 receptor tyrosine kinase 2
chr6_+_128883114 0.05 ENST00000421865.3
ENST00000618192.4
ENST00000617695.4
laminin subunit alpha 2
chr1_-_9069608 0.05 ENST00000377424.9
solute carrier family 2 member 5
chr2_+_241350087 0.05 ENST00000451310.1
septin 2
chr15_-_83067199 0.05 ENST00000261721.9
BTB domain containing 1
chr10_+_112447198 0.04 ENST00000393077.3
ENST00000432306.5
vesicle transport through interaction with t-SNAREs 1A
chr12_-_113403873 0.04 ENST00000552280.5
ENST00000257549.9
serine dehydratase
chr1_-_108192818 0.04 ENST00000370041.4
solute carrier family 25 member 24
chr1_-_145927447 0.04 ENST00000632555.1
ENST00000369307.4
ENST00000583313.7
RNA binding motif protein 8A
chr17_-_58527980 0.04 ENST00000583114.5
septin 4
chr2_-_240557957 0.04 ENST00000373318.6
ENST00000406958.5
ENST00000272972.7
ENST00000401804.5
ENST00000361678.8
ENST00000391987.5
ENST00000405523.7
ankyrin repeat and MYND domain containing 1
chr14_-_36520222 0.04 ENST00000354822.7
NK2 homeobox 1
chr1_-_235128819 0.04 ENST00000366607.5
translocase of outer mitochondrial membrane 20
chr17_-_81947233 0.04 ENST00000409745.2
myeloid associated differentiation marker like 2
chrM_+_9207 0.03 ENST00000362079.2
mitochondrially encoded cytochrome c oxidase III
chr11_-_112086727 0.03 ENST00000504148.3
ENST00000541231.1
translocase of inner mitochondrial membrane 8 homolog B
chr6_+_138796111 0.03 ENST00000367682.6
epithelial cell transforming 2 like
chr17_-_28854972 0.03 ENST00000583953.6
family with sequence similarity 222 member B
chr20_-_44521989 0.02 ENST00000342374.5
ENST00000255175.5
serine incorporator 3
chr11_-_6612141 0.02 ENST00000527248.2
ENST00000299424.9
TATA-box binding protein associated factor 10
chr6_+_10747765 0.02 ENST00000461342.5
ENST00000475942.5
ENST00000379542.10
ENST00000379530.7
ENST00000473276.5
ENST00000481240.5
ENST00000467317.5
transmembrane protein 14B
chr19_-_42877988 0.01 ENST00000597058.1
pregnancy specific beta-1-glycoprotein 1
chr16_-_62036412 0.01 ENST00000577390.6
cadherin 8
chr12_+_4649097 0.01 ENST00000648836.1
ENST00000266544.10
novel protein
NADH:ubiquinone oxidoreductase subunit A9
chr9_-_39874562 0.01 ENST00000622735.2

chr6_+_139028680 0.00 ENST00000367660.4
ABRA C-terminal like
chr5_+_79069754 0.00 ENST00000518666.5
ENST00000521567.1
ENST00000255192.8
betaine--homocysteine S-methyltransferase 2
chr19_-_39846329 0.00 ENST00000599134.1
ENST00000597634.5
ENST00000598417.5
ENST00000601274.5
ENST00000594309.5
ENST00000221801.8
fibrillarin
chr18_-_56651122 0.00 ENST00000590954.5
thioredoxin like 1
chr6_+_39793008 0.00 ENST00000398904.6
dishevelled associated activator of morphogenesis 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.2 0.5 GO:1904597 regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904596) negative regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904597) regulation of advanced glycation end-product receptor activity(GO:1904603) negative regulation of advanced glycation end-product receptor activity(GO:1904604) negative regulation of connective tissue replacement(GO:1905204)
0.2 0.5 GO:0002304 gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305)
0.1 0.4 GO:2000777 positive regulation of oocyte maturation(GO:1900195) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
0.1 0.4 GO:0009106 lipoate metabolic process(GO:0009106)
0.1 0.4 GO:0014876 response to injury involved in regulation of muscle adaptation(GO:0014876)
0.1 0.6 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.1 0.2 GO:0046707 IDP metabolic process(GO:0046707) IDP catabolic process(GO:0046709)
0.1 0.4 GO:0046092 deoxycytidine metabolic process(GO:0046092)
0.1 0.6 GO:0046061 dGTP catabolic process(GO:0006203) dATP catabolic process(GO:0046061)
0.1 0.2 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.0 0.2 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.5 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 1.1 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.0 0.4 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.0 0.2 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.2 GO:0032377 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0 0.5 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.1 GO:0015862 uridine transport(GO:0015862)
0.0 0.5 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.5 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 0.2 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.3 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.2 GO:2001300 lipoxin metabolic process(GO:2001300)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.6 GO:0043203 axon hillock(GO:0043203)
0.0 0.4 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.2 GO:0045281 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952) nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.2 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.2 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.1 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.2 GO:0097433 dense body(GO:0097433)
0.0 0.2 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.1 GO:0005816 spindle pole body(GO:0005816)
0.0 0.2 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.1 GO:0000796 condensin complex(GO:0000796)
0.0 0.7 GO:0031904 endosome lumen(GO:0031904)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0047693 GTP diphosphatase activity(GO:0036219) 2-hydroxy-adenosine triphosphate pyrophosphatase activity(GO:0044713) 2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity(GO:0044714) ATP diphosphatase activity(GO:0047693)
0.2 0.5 GO:1904599 advanced glycation end-product binding(GO:1904599)
0.1 0.4 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.1 0.4 GO:0016979 lipoate-protein ligase activity(GO:0016979)
0.1 1.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 0.4 GO:0004137 deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
0.1 0.5 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 0.2 GO:0019144 ADP-sugar diphosphatase activity(GO:0019144)
0.1 1.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.2 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.0 0.2 GO:0004419 hydroxymethylglutaryl-CoA lyase activity(GO:0004419)
0.0 0.4 GO:0089720 death effector domain binding(GO:0035877) caspase binding(GO:0089720)
0.0 0.2 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.0 0.1 GO:0005119 smoothened binding(GO:0005119)
0.0 0.5 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.1 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.0 0.6 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.5 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.1 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.0 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 0.4 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.0 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.5 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 1.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.5 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.4 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription