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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for ZNF35

Z-value: 0.33

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Transcription factors associated with ZNF35

Gene Symbol Gene ID Gene Info
ENSG00000169981.11 ZNF35

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF35hg38_v1_chr3_+_44648719_44648776-0.395.3e-02Click!

Activity profile of ZNF35 motif

Sorted Z-values of ZNF35 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF35

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr1_+_61404076 1.24 ENST00000357977.5
nuclear factor I A
chr7_-_28958321 0.95 ENST00000539664.3
TLR4 interactor with leucine rich repeats
chr12_-_42483604 0.89 ENST00000640132.1
prickle planar cell polarity protein 1
chr2_-_189580773 0.83 ENST00000261024.7
solute carrier family 40 member 1
chr1_+_84164962 0.75 ENST00000614872.4
ENST00000394839.6
protein kinase cAMP-activated catalytic subunit beta
chr2_+_66435558 0.60 ENST00000488550.5
Meis homeobox 1
chr12_-_46372763 0.37 ENST00000256689.10
solute carrier family 38 member 2
chr9_+_128091436 0.36 ENST00000682371.1
ENST00000373066.9
ENST00000432073.6
solute carrier family 25 member 25
chr2_+_147845020 0.31 ENST00000241416.12
activin A receptor type 2A
chr3_-_58537283 0.30 ENST00000459701.6
acyl-CoA oxidase 2
chr3_-_58537181 0.29 ENST00000302819.10
acyl-CoA oxidase 2
chr6_+_156776020 0.27 ENST00000346085.10
AT-rich interaction domain 1B
chr15_-_101252040 0.27 ENST00000254190.4
chondroitin sulfate synthase 1
chr7_+_27242796 0.27 ENST00000496902.7
even-skipped homeobox 1
chr3_-_132684685 0.23 ENST00000512094.5
ENST00000632629.1
nephrocystin 3
NPHP3-ACAD11 readthrough (NMD candidate)
chr4_+_173370908 0.22 ENST00000296504.4
Sin3A associated protein 30
chr8_-_94262308 0.22 ENST00000297596.3
ENST00000396194.6
GTP binding protein overexpressed in skeletal muscle
chr17_-_65561640 0.22 ENST00000618960.4
ENST00000307078.10
axin 2
chr4_-_145938775 0.21 ENST00000508784.6
zinc finger protein 827
chr18_+_41955186 0.21 ENST00000639914.1
ENST00000262039.9
ENST00000398870.7
ENST00000586545.5
ENST00000585528.5
phosphatidylinositol 3-kinase catalytic subunit type 3
chr17_-_445939 0.19 ENST00000329099.4
refilin B
chr4_-_83010709 0.18 ENST00000506560.5
ENST00000442461.6
ENST00000340417.8
ENST00000446851.6
lin-54 DREAM MuvB core complex component
chr6_+_96563117 0.18 ENST00000450218.6
four and a half LIM domains 5
chr7_+_74657695 0.18 ENST00000573035.6
general transcription factor IIi
chr6_-_132763424 0.18 ENST00000532012.1
ENST00000525270.5
ENST00000530536.5
ENST00000524919.5
vanin 2
chr14_-_91732059 0.16 ENST00000553329.5
ENST00000256343.8
cation channel sperm associated auxiliary subunit beta
chr19_+_926001 0.16 ENST00000263620.8
AT-rich interaction domain 3A
chr12_-_10939263 0.15 ENST00000537503.2
taste 2 receptor member 14
chr19_+_49591170 0.15 ENST00000418929.7
proline rich 12
chr8_-_144529048 0.14 ENST00000527462.1
ENST00000313465.5
ENST00000524821.6
chromosome 8 open reading frame 82
chr10_+_61901678 0.14 ENST00000644638.1
ENST00000681100.1
ENST00000279873.12
AT-rich interaction domain 5B
chr7_+_27242700 0.14 ENST00000222761.7
even-skipped homeobox 1
chr20_+_58907981 0.13 ENST00000656419.1
GNAS complex locus
chr7_+_80602150 0.12 ENST00000309881.11
CD36 molecule
chr22_-_36703723 0.11 ENST00000300105.7
calcium voltage-gated channel auxiliary subunit gamma 2
chr13_-_35855627 0.11 ENST00000379893.5
doublecortin like kinase 1
chr16_+_14833713 0.10 ENST00000287667.12
ENST00000620755.4
ENST00000610363.4
NODAL modulator 1
chr19_-_14090695 0.10 ENST00000533683.7
sterile alpha motif domain containing 1
chr14_-_31420531 0.09 ENST00000382464.6
ENST00000543095.7
HEAT repeat containing 5A
chr4_+_74308463 0.09 ENST00000413830.6
epithelial mitogen
chr12_+_93467506 0.09 ENST00000549982.6
ENST00000552217.6
ENST00000393128.8
ENST00000547098.5
mitochondrial ribosomal protein L42
chr17_-_59151794 0.08 ENST00000584089.1
spindle and kinetochore associated complex subunit 2
chr4_-_88823214 0.08 ENST00000513837.5
ENST00000503556.5
family with sequence similarity 13 member A
chr7_-_78771265 0.08 ENST00000630991.2
ENST00000629359.2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr7_+_123848070 0.07 ENST00000476325.5
hyaluronidase 4
chr12_-_102478539 0.06 ENST00000424202.6
insulin like growth factor 1
chr3_+_10115667 0.06 ENST00000530758.2
BRICK1 subunit of SCAR/WAVE actin nucleating complex
chr5_-_39202991 0.05 ENST00000515010.5
FYN binding protein 1
chr16_+_76277568 0.05 ENST00000622250.4
contactin associated protein family member 4
chr13_-_35855758 0.05 ENST00000615680.4
doublecortin like kinase 1
chr14_-_73558945 0.03 ENST00000563329.1
ENST00000553558.6
ENST00000334988.2
HEAT repeat containing 4
chr4_+_94455245 0.03 ENST00000508216.5
ENST00000514743.5
PDZ and LIM domain 5
chr3_+_69936583 0.03 ENST00000314557.10
ENST00000394351.9
melanocyte inducing transcription factor
chrM_+_4467 0.02 ENST00000361453.3
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2
chr4_+_87832917 0.02 ENST00000395102.8
ENST00000497649.6
ENST00000540395.1
ENST00000560249.5
ENST00000511670.5
ENST00000361056.3
matrix extracellular phosphoglycoprotein
chr4_-_98929092 0.02 ENST00000280892.10
ENST00000511644.5
ENST00000504432.5
ENST00000450253.7
ENST00000505992.1
eukaryotic translation initiation factor 4E
chr13_+_77535681 0.01 ENST00000349847.4
sciellin
chr13_+_77535669 0.01 ENST00000535157.5
sciellin
chr3_-_64019334 0.01 ENST00000480205.5
proteasome 26S subunit, non-ATPase 6
chr14_-_55191534 0.00 ENST00000395425.6
ENST00000247191.7
DLG associated protein 5

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.2 0.9 GO:2000691 negative regulation of cardioblast differentiation(GO:0051892) regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691)
0.1 0.4 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.1 0.7 GO:0097338 response to clozapine(GO:0097338)
0.1 0.2 GO:0061182 negative regulation of chondrocyte development(GO:0061182)
0.1 0.2 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 0.2 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 0.3 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.0 1.2 GO:0072189 ureter development(GO:0072189)
0.0 0.4 GO:0032328 alanine transport(GO:0032328)
0.0 0.2 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.3 GO:0097026 dendritic cell dendrite assembly(GO:0097026)
0.0 0.6 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.6 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.0 0.4 GO:0015866 ADP transport(GO:0015866)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.0 0.0 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.0 0.9 GO:0034142 toll-like receptor 4 signaling pathway(GO:0034142)
0.0 0.1 GO:2000334 response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 0.2 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.1 GO:1904075 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.2 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 0.2 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.1 0.3 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.2 GO:0036128 CatSper complex(GO:0036128)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.1 0.8 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.1 0.3 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0 0.7 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.2 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.3 GO:0098821 BMP receptor activity(GO:0098821)
0.0 0.4 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.9 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.1 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID IL3 PATHWAY IL3-mediated signaling events
0.0 1.1 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0 0.8 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.7 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.4 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle