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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for ZNF652
Z-value: 1.38
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Transcription factors associated with ZNF652
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF652 | hg38_v1_chr17_-_49362206_49362279 | 0.40 | 5.0e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF652
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_89836213 Show fit | 9.35 |
ENST00000618500.4
ENST00000508895.5 |
synuclein alpha |
|
| chr3_-_149333407 Show fit | 7.26 |
ENST00000470080.5
|
transmembrane 4 L six family member 18 |
|
| chr3_-_149333619 Show fit | 7.15 |
ENST00000296059.7
|
transmembrane 4 L six family member 18 |
|
| chr4_-_89835617 Show fit | 5.54 |
ENST00000611107.1
ENST00000345009.8 ENST00000505199.5 ENST00000502987.5 |
synuclein alpha |
|
| chr14_+_24398986 Show fit | 4.67 |
ENST00000382554.4
|
NYN domain and retroviral integrase containing |
|
| chr1_+_61082398 Show fit | 4.02 |
ENST00000664149.1
|
nuclear factor I A |
|
| chr18_+_44697118 Show fit | 3.94 |
ENST00000677077.1
|
SET binding protein 1 |
|
| chr17_+_50095331 Show fit | 3.66 |
ENST00000503176.6
|
pyruvate dehydrogenase kinase 2 |
|
| chr1_+_61082553 Show fit | 3.43 |
ENST00000403491.8
ENST00000371187.7 |
nuclear factor I A |
|
| chr4_-_185810894 Show fit | 3.43 |
ENST00000448662.6
ENST00000439049.5 ENST00000420158.5 ENST00000319471.13 |
sorbin and SH3 domain containing 2 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 14.9 | GO:1903284 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
| 0.3 | 10.6 | GO:0072189 | ureter development(GO:0072189) |
| 0.3 | 9.1 | GO:0050667 | homocysteine metabolic process(GO:0050667) |
| 0.1 | 6.0 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
| 0.8 | 5.5 | GO:1905123 | regulation of glucosylceramidase activity(GO:1905123) |
| 0.3 | 5.4 | GO:0050812 | regulation of acyl-CoA biosynthetic process(GO:0050812) |
| 0.1 | 5.0 | GO:0048208 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 0.3 | 4.7 | GO:0015074 | DNA integration(GO:0015074) |
| 0.4 | 3.9 | GO:0070543 | response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 0.2 | 3.8 | GO:0070208 | protein heterotrimerization(GO:0070208) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 18.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 10.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.5 | 9.1 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.0 | 6.9 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.9 | 5.4 | GO:0005967 | mitochondrial pyruvate dehydrogenase complex(GO:0005967) |
| 0.0 | 4.1 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 3.7 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.5 | 2.9 | GO:0042272 | nuclear RNA export factor complex(GO:0042272) |
| 0.1 | 2.8 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 2.4 | GO:0000123 | histone acetyltransferase complex(GO:0000123) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 14.9 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.9 | 9.1 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.0 | 8.3 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.9 | 5.4 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 1.1 | 4.5 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 0.3 | 4.4 | GO:0004791 | thioredoxin-disulfide reductase activity(GO:0004791) |
| 0.1 | 4.4 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.5 | 3.9 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.5 | 3.5 | GO:0004797 | deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797) |
| 0.0 | 3.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.0 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 9.6 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.1 | 8.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 4.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 4.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.7 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.0 | 2.0 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.9 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.8 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 1.6 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 12.2 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.3 | 5.4 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 4.8 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.2 | 3.8 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.1 | 3.5 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.1 | 3.5 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.0 | 3.0 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.1 | 2.1 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 2.0 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 2.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |