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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for ZNF711_TFAP2A_TFAP2D
Z-value: 1.25
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Transcription factors associated with ZNF711_TFAP2A_TFAP2D
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TFAP2A | hg38_v1_chr6_-_10414985_10415041 | 0.43 | 3.4e-02 | Click! |
| TFAP2D | hg38_v1_chr6_+_50713526_50713526 | -0.37 | 6.7e-02 | Click! |
| ZNF711 | hg38_v1_chrX_+_85244075_85244121 | 0.20 | 3.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF711_TFAP2A_TFAP2D
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_94541636 Show fit | 6.27 |
ENST00000370207.4
|
coagulation factor III, tissue factor |
|
| chr1_-_94541746 Show fit | 5.32 |
ENST00000334047.12
|
coagulation factor III, tissue factor |
|
| chr8_-_47738153 Show fit | 3.57 |
ENST00000408965.4
|
CCAAT enhancer binding protein delta |
|
| chr4_+_155667654 Show fit | 3.48 |
ENST00000513574.1
|
guanylate cyclase 1 soluble subunit alpha 1 |
|
| chr6_-_142945160 Show fit | 3.12 |
ENST00000367603.8
|
HIVEP zinc finger 2 |
|
| chr6_-_142945028 Show fit | 3.05 |
ENST00000012134.7
|
HIVEP zinc finger 2 |
|
| chr18_+_62325269 Show fit | 2.97 |
ENST00000639222.1
ENST00000269485.11 ENST00000616710.4 ENST00000617039.4 |
TNF receptor superfamily member 11a |
|
| chr4_+_139015751 Show fit | 2.80 |
ENST00000280614.4
|
nocturnin |
|
| chr10_+_28677487 Show fit | 2.80 |
ENST00000375533.6
|
BMP and activin membrane bound inhibitor |
|
| chr18_+_62325294 Show fit | 2.48 |
ENST00000586569.3
|
TNF receptor superfamily member 11a |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 11.6 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
| 0.1 | 8.0 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.1 | 6.1 | GO:0033173 | calcineurin-NFAT signaling cascade(GO:0033173) |
| 0.1 | 5.9 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 1.8 | 5.4 | GO:0060086 | circadian temperature homeostasis(GO:0060086) |
| 0.2 | 4.9 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 0.2 | 4.8 | GO:0060347 | heart trabecula formation(GO:0060347) |
| 0.2 | 4.1 | GO:1901725 | regulation of histone deacetylase activity(GO:1901725) |
| 0.0 | 4.1 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle(GO:2000134) |
| 0.1 | 4.0 | GO:0035767 | endothelial cell chemotaxis(GO:0035767) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.0 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 13.9 | GO:0005924 | cell-substrate adherens junction(GO:0005924) |
| 0.3 | 11.5 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.1 | 10.4 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 8.9 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 7.5 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 7.2 | GO:0005813 | centrosome(GO:0005813) |
| 0.5 | 7.1 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.1 | 6.4 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.2 | 6.3 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 22.8 | GO:0002020 | protease binding(GO:0002020) |
| 0.0 | 10.8 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.3 | 7.8 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.4 | 6.5 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 6.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 6.2 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.9 | 6.0 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
| 0.1 | 5.7 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.1 | 5.5 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.4 | 5.4 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.4 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.2 | 13.3 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.2 | 8.2 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 8.0 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 7.8 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.2 | 6.4 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 6.3 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 5.1 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 5.0 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.1 | 4.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 13.1 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.2 | 9.8 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.2 | 7.9 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.1 | 6.8 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.1 | 6.5 | REACTOME TRANS GOLGI NETWORK VESICLE BUDDING | Genes involved in trans-Golgi Network Vesicle Budding |
| 0.1 | 6.3 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 5.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 5.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 5.3 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 5.1 | REACTOME CA DEPENDENT EVENTS | Genes involved in Ca-dependent events |