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Illumina Body Map 2 (GSE30611)
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Results for AHR_ARNT2
Z-value: 2.04
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Transcription factors associated with AHR_ARNT2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ARNT2 | hg38_v1_chr15_+_80441229_80441313 | 0.72 | 4.2e-06 | Click! |
| AHR | hg38_v1_chr7_+_17298642_17298658 | -0.07 | 7.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of AHR_ARNT2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 28.9 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.6 | 23.2 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 0.9 | 18.8 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 5.8 | 17.4 | GO:1990709 | presynaptic active zone organization(GO:1990709) |
| 0.3 | 13.2 | GO:0007616 | long-term memory(GO:0007616) |
| 0.3 | 12.6 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.1 | 12.6 | GO:0007269 | neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643) |
| 0.2 | 11.0 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.7 | 10.8 | GO:0070777 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 3.5 | 10.4 | GO:0008355 | olfactory learning(GO:0008355) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 53.9 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.6 | 26.2 | GO:1902711 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
| 0.2 | 23.4 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.2 | 19.4 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 2.1 | 18.9 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.1 | 17.3 | GO:0098793 | presynapse(GO:0098793) |
| 0.1 | 16.9 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 16.7 | GO:0045202 | synapse(GO:0045202) |
| 0.1 | 15.3 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 15.2 | GO:0030424 | axon(GO:0030424) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 19.1 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.6 | 18.9 | GO:0031489 | myosin V binding(GO:0031489) |
| 1.0 | 18.7 | GO:0008503 | benzodiazepine receptor activity(GO:0008503) |
| 0.3 | 17.4 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.0 | 14.3 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.4 | 14.0 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.0 | 13.5 | GO:0015631 | tubulin binding(GO:0015631) |
| 1.5 | 13.2 | GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 0.1 | 12.9 | GO:0019208 | phosphatase regulator activity(GO:0019208) |
| 0.2 | 12.6 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 18.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.3 | 15.3 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.2 | 12.2 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.4 | 11.5 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 11.0 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 10.9 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 9.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 8.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 6.8 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 6.4 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 39.0 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.5 | 22.5 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.7 | 21.2 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.2 | 17.6 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.2 | 14.9 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 0.4 | 13.8 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.4 | 10.4 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.6 | 10.0 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.1 | 9.6 | REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES | Genes involved in Transmission across Chemical Synapses |
| 0.3 | 9.3 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |