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Illumina Body Map 2 (GSE30611)

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Results for AIRE

Z-value: 0.80

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Transcription factors associated with AIRE

Gene Symbol Gene ID Gene Info
AIRE
ENSG00000160224.17 autoimmune regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
AIREhg38_v1_chr21_+_44285869_442858840.105.9e-01Click!

Activity profile of AIRE motif

Sorted Z-values of AIRE motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_24956604 4.42 ENST00000610854.2
NEFL
neurofilament light
chr12_+_75480800 3.31 ENST00000456650.7
GLIPR1
GLI pathogenesis related 1
chrX_-_140784366 2.98 ENST00000674533.1
CDR1
cerebellar degeneration related protein 1
chr6_-_31546552 2.73 ENST00000303892.10
ENST00000376151.4
ATP6V1G2
ATPase H+ transporting V1 subunit G2
chr2_-_240820945 2.56 ENST00000428768.2
ENST00000650053.1
ENST00000650130.1
KIF1A
kinesin family member 1A
chr12_+_75480745 2.20 ENST00000266659.8
GLIPR1
GLI pathogenesis related 1
chr15_+_51751587 2.16 ENST00000539962.6
ENST00000249700.9
TMOD2
tropomodulin 2
chr12_-_62192762 2.15 ENST00000416284.8
TAFA2
TAFA chemokine like family member 2
chr12_+_75481204 2.15 ENST00000550491.1
GLIPR1
GLI pathogenesis related 1
chr6_-_31546716 1.99 ENST00000483251.1
ATP6V1G2
ATPase H+ transporting V1 subunit G2
chr17_-_40565459 1.92 ENST00000578085.1
ENST00000246657.2
CCR7
C-C motif chemokine receptor 7
chr3_+_46370854 1.90 ENST00000292303.4
CCR5
C-C motif chemokine receptor 5
chr10_-_96359273 1.85 ENST00000393871.5
ENST00000419479.5
ENST00000393870.3
OPALIN
oligodendrocytic myelin paranodal and inner loop protein
chr1_+_40374648 1.74 ENST00000372708.5
SMAP2
small ArfGAP2
chr7_-_36724457 1.73 ENST00000617537.5
ENST00000435386.1
AOAH
acyloxyacyl hydrolase
chr7_-_36724380 1.64 ENST00000617267.4
AOAH
acyloxyacyl hydrolase
chr2_-_224947030 1.63 ENST00000409592.7
DOCK10
dedicator of cytokinesis 10
chr7_-_36724543 1.57 ENST00000612871.4
AOAH
acyloxyacyl hydrolase
chr19_-_23687163 1.55 ENST00000601010.5
ENST00000601935.5
ENST00000600313.5
ENST00000596211.5
ENST00000359788.9
ENST00000599168.1
ZNF675
zinc finger protein 675
chr12_-_6470667 1.52 ENST00000361716.8
ENST00000396308.4
VAMP1
vesicle associated membrane protein 1
chr14_-_106511856 1.46 ENST00000390622.2
IGHV1-46
immunoglobulin heavy variable 1-46
chr20_+_59628609 1.38 ENST00000541461.5
PHACTR3
phosphatase and actin regulator 3
chr12_+_20695553 1.29 ENST00000545102.1
SLCO1C1
solute carrier organic anion transporter family member 1C1
chr12_-_6470643 1.27 ENST00000535180.5
ENST00000400911.7
VAMP1
vesicle associated membrane protein 1
chr12_-_75209701 1.27 ENST00000350228.6
ENST00000298972.5
KCNC2
potassium voltage-gated channel subfamily C member 2
chr13_-_29586788 1.26 ENST00000450494.1
SLC7A1
solute carrier family 7 member 1
chr3_-_49429252 1.25 ENST00000615713.4
NICN1
nicolin 1
chr15_-_51751525 1.18 ENST00000454181.6
LYSMD2
LysM domain containing 2
chr20_+_46008900 1.16 ENST00000372330.3
MMP9
matrix metallopeptidase 9
chr15_-_51751434 1.16 ENST00000558126.1
LYSMD2
LysM domain containing 2
chrX_+_108582484 1.11 ENST00000483338.1
COL4A5
collagen type IV alpha 5 chain
chr18_+_74534594 1.10 ENST00000582365.1
CNDP1
carnosine dipeptidase 1
chr4_-_65670478 1.08 ENST00000613740.5
ENST00000622150.4
ENST00000511294.1
EPHA5
EPH receptor A5
chr7_+_149872955 1.06 ENST00000421974.7
ENST00000456496.7
ATP6V0E2
ATPase H+ transporting V0 subunit e2
chr2_+_165294031 1.05 ENST00000283256.10
SCN2A
sodium voltage-gated channel alpha subunit 2
chr1_-_51990679 1.03 ENST00000371655.4
RAB3B
RAB3B, member RAS oncogene family
chrX_-_153926254 1.03 ENST00000393721.5
ENST00000370028.7
ENST00000350060.10
ARHGAP4
Rho GTPase activating protein 4
chr8_+_90940517 1.03 ENST00000521366.1
NECAB1
N-terminal EF-hand calcium binding protein 1
chr5_+_119355313 1.03 ENST00000504642.1
TNFAIP8
TNF alpha induced protein 8
chr20_+_45408276 1.02 ENST00000372710.5
ENST00000443296.1
DBNDD2
dysbindin domain containing 2
chr12_-_101830926 1.00 ENST00000299314.12
GNPTAB
N-acetylglucosamine-1-phosphate transferase subunits alpha and beta
chr9_-_110999458 0.97 ENST00000374430.6
LPAR1
lysophosphatidic acid receptor 1
chr12_+_40310431 0.95 ENST00000681696.1
LRRK2
leucine rich repeat kinase 2
chr13_-_46182136 0.94 ENST00000323076.7
LCP1
lymphocyte cytosolic protein 1
chr3_-_33645433 0.93 ENST00000635664.1
ENST00000485378.6
ENST00000313350.10
ENST00000487200.5
CLASP2
cytoplasmic linker associated protein 2
chr6_+_167111789 0.92 ENST00000400926.5
CCR6
C-C motif chemokine receptor 6
chr7_-_65006678 0.90 ENST00000394323.3
ERV3-1
endogenous retrovirus group 3 member 1, envelope
chr6_-_149484965 0.85 ENST00000409806.8
ZC3H12D
zinc finger CCCH-type containing 12D
chr18_-_72638510 0.83 ENST00000581073.1
CBLN2
cerebellin 2 precursor
chr1_-_154627906 0.83 ENST00000679899.1
ADAR
adenosine deaminase RNA specific
chrX_-_153926220 0.82 ENST00000370016.5
ARHGAP4
Rho GTPase activating protein 4
chr5_+_119354771 0.81 ENST00000503646.1
TNFAIP8
TNF alpha induced protein 8
chr10_+_89283685 0.80 ENST00000638108.1
IFIT2
interferon induced protein with tetratricopeptide repeats 2
chr13_+_52455429 0.78 ENST00000468284.1
ENST00000378034.7
ENST00000378037.9
ENST00000258607.10
CKAP2
cytoskeleton associated protein 2
chr22_+_39926591 0.78 ENST00000420971.5
GRAP2
GRB2 related adaptor protein 2
chr7_+_142469521 0.77 ENST00000390371.3
TRBV6-6
T cell receptor beta variable 6-6
chr14_+_22112280 0.75 ENST00000390454.2
TRAV25
T cell receptor alpha variable 25
chr1_+_207496229 0.74 ENST00000367051.6
ENST00000367053.6
ENST00000367052.6
CR1
complement C3b/C4b receptor 1 (Knops blood group)
chr8_+_53851786 0.74 ENST00000297313.8
ENST00000344277.10
RGS20
regulator of G protein signaling 20
chr3_+_141262614 0.73 ENST00000504264.5
PXYLP1
2-phosphoxylose phosphatase 1
chr16_+_32066065 0.69 ENST00000354689.6
IGHV3OR16-9
immunoglobulin heavy variable 3/OR16-9 (non-functional)
chr8_+_123768431 0.66 ENST00000334705.12
ENST00000521166.5
FAM91A1
family with sequence similarity 91 member A1
chr1_+_207496147 0.66 ENST00000400960.7
ENST00000367049.9
CR1
complement C3b/C4b receptor 1 (Knops blood group)
chr3_-_49429304 0.65 ENST00000636166.1
ENST00000273598.8
ENST00000436744.2
ENSG00000283189.2
NICN1
novel protein
nicolin 1
chr1_+_111473972 0.65 ENST00000369718.4
C1orf162
chromosome 1 open reading frame 162
chrX_-_153926757 0.64 ENST00000461052.5
ENST00000422091.1
ARHGAP4
Rho GTPase activating protein 4
chr13_-_26221703 0.64 ENST00000381570.7
ENST00000346166.7
RNF6
ring finger protein 6
chr5_+_140786136 0.64 ENST00000378133.4
ENST00000504120.4
PCDHA1
protocadherin alpha 1
chr4_-_87529443 0.63 ENST00000434434.5
SPARCL1
SPARC like 1
chr6_+_46129930 0.61 ENST00000321037.5
ENPP4
ectonucleotide pyrophosphatase/phosphodiesterase 4
chr1_-_154627945 0.61 ENST00000681683.1
ENST00000368471.8
ENST00000649042.1
ENST00000680270.1
ENST00000649022.2
ENST00000681056.1
ENST00000649724.1
ADAR
adenosine deaminase RNA specific
chr1_-_243163310 0.60 ENST00000492145.1
ENST00000490813.5
ENST00000464936.5
CEP170
centrosomal protein 170
chr5_-_78549151 0.58 ENST00000515007.6
LHFPL2
LHFPL tetraspan subfamily member 2
chr3_+_107599309 0.58 ENST00000406780.5
BBX
BBX high mobility group box domain containing
chr16_+_50025217 0.57 ENST00000427478.7
CNEP1R1
CTD nuclear envelope phosphatase 1 regulatory subunit 1
chr13_+_111241185 0.55 ENST00000478679.5
ARHGEF7
Rho guanine nucleotide exchange factor 7
chr6_+_27810041 0.54 ENST00000369163.3
H3C10
H3 clustered histone 10
chr4_-_119322128 0.54 ENST00000274024.4
FABP2
fatty acid binding protein 2
chr4_-_87529460 0.52 ENST00000418378.5
SPARCL1
SPARC like 1
chr14_-_100569780 0.51 ENST00000355173.7
BEGAIN
brain enriched guanylate kinase associated
chr1_+_207496268 0.51 ENST00000529814.1
CR1
complement C3b/C4b receptor 1 (Knops blood group)
chr1_-_154627576 0.51 ENST00000648311.1
ADAR
adenosine deaminase RNA specific
chr9_+_87497222 0.50 ENST00000358077.9
DAPK1
death associated protein kinase 1
chr22_+_24806265 0.50 ENST00000400359.4
SGSM1
small G protein signaling modulator 1
chr9_-_76652516 0.48 ENST00000424866.1
PRUNE2
prune homolog 2 with BCH domain
chr3_-_36739791 0.48 ENST00000416516.2
DCLK3
doublecortin like kinase 3
chr20_+_8789517 0.48 ENST00000437439.2
PLCB1
phospholipase C beta 1
chr2_-_135876382 0.47 ENST00000264156.3
MCM6
minichromosome maintenance complex component 6
chr2_-_165204042 0.46 ENST00000283254.12
ENST00000453007.1
SCN3A
sodium voltage-gated channel alpha subunit 3
chr6_+_26538338 0.46 ENST00000377575.3
HMGN4
high mobility group nucleosomal binding domain 4
chr16_+_57092570 0.46 ENST00000290776.13
ENST00000535318.6
CPNE2
copine 2
chr4_-_87529383 0.46 ENST00000541496.1
SPARCL1
SPARC like 1
chr1_+_162497805 0.45 ENST00000538489.5
ENST00000489294.2
UHMK1
U2AF homology motif kinase 1
chr3_+_136819069 0.45 ENST00000393079.3
ENST00000446465.3
SLC35G2
solute carrier family 35 member G2
chr7_-_87220567 0.44 ENST00000433078.5
TMEM243
transmembrane protein 243
chr13_-_48413105 0.44 ENST00000620633.5
LPAR6
lysophosphatidic acid receptor 6
chr4_-_65670339 0.43 ENST00000273854.7
EPHA5
EPH receptor A5
chr14_+_22105305 0.43 ENST00000390453.1
TRAV24
T cell receptor alpha variable 24
chr12_-_24949026 0.42 ENST00000539780.5
ENST00000546285.1
ENST00000342945.9
ENST00000261192.12
BCAT1
branched chain amino acid transaminase 1
chr8_+_24384275 0.41 ENST00000256412.8
ADAMDEC1
ADAM like decysin 1
chr1_+_78649818 0.40 ENST00000370747.9
ENST00000438486.1
IFI44
interferon induced protein 44
chr4_-_75724362 0.40 ENST00000677583.1
G3BP2
G3BP stress granule assembly factor 2
chr4_+_70721953 0.39 ENST00000381006.8
ENST00000226328.8
RUFY3
RUN and FYVE domain containing 3
chr4_-_174829212 0.38 ENST00000340217.5
ENST00000274093.8
GLRA3
glycine receptor alpha 3
chr19_-_43883964 0.37 ENST00000587539.2
ZNF404
zinc finger protein 404
chr2_-_197675578 0.35 ENST00000295049.9
RFTN2
raftlin family member 2
chr18_-_55321640 0.35 ENST00000637169.2
TCF4
transcription factor 4
chr16_-_89418292 0.35 ENST00000683497.1
ENST00000642443.1
ENST00000644784.1
ENST00000647238.1
ENSG00000288715.1
ANKRD11
novel protein
ankyrin repeat domain 11
chr12_-_76068933 0.34 ENST00000552056.5
NAP1L1
nucleosome assembly protein 1 like 1
chr16_+_11345429 0.33 ENST00000576027.1
ENST00000312499.6
ENST00000648619.1
RMI2
RecQ mediated genome instability 2
chr17_+_47694053 0.33 ENST00000578982.5
TBKBP1
TBK1 binding protein 1
chr6_-_127342398 0.33 ENST00000531582.1
ECHDC1
ethylmalonyl-CoA decarboxylase 1
chr16_+_50025271 0.33 ENST00000562576.5
CNEP1R1
CTD nuclear envelope phosphatase 1 regulatory subunit 1
chr11_-_85665077 0.32 ENST00000527447.2
CREBZF
CREB/ATF bZIP transcription factor
chr2_-_199456046 0.30 ENST00000428695.5
SATB2
SATB homeobox 2
chr5_-_64768619 0.28 ENST00000513458.9
SREK1IP1
SREK1 interacting protein 1
chr1_-_85708382 0.28 ENST00000370574.4
ENST00000431532.6
ZNHIT6
zinc finger HIT-type containing 6
chr8_-_109648746 0.28 ENST00000528045.5
SYBU
syntabulin
chr16_+_14708944 0.28 ENST00000526520.5
ENST00000531598.6
NPIPA3
nuclear pore complex interacting protein family member A3
chr19_+_13151975 0.27 ENST00000588173.1
IER2
immediate early response 2
chr19_+_11345223 0.27 ENST00000588790.5
CCDC159
coiled-coil domain containing 159
chr6_-_118710065 0.27 ENST00000392500.7
ENST00000368488.9
ENST00000434604.5
CEP85L
centrosomal protein 85 like
chr21_+_29300111 0.25 ENST00000451655.5
BACH1
BTB domain and CNC homolog 1
chr8_-_140718345 0.25 ENST00000521562.5
PTK2
protein tyrosine kinase 2
chr5_+_141392616 0.25 ENST00000398604.3
PCDHGA8
protocadherin gamma subfamily A, 8
chr1_-_35031905 0.24 ENST00000317538.9
ENST00000357182.9
ZMYM6
zinc finger MYM-type containing 6
chr3_+_88149947 0.24 ENST00000318887.8
ENST00000486971.1
C3orf38
chromosome 3 open reading frame 38
chr14_-_81436447 0.23 ENST00000649389.1
ENST00000557055.5
STON2
stonin 2
chr1_-_21783134 0.23 ENST00000308271.14
USP48
ubiquitin specific peptidase 48
chr3_-_19934189 0.23 ENST00000295824.14
EFHB
EF-hand domain family member B
chr2_-_240821363 0.21 ENST00000675940.1
KIF1A
kinesin family member 1A
chr11_-_117098415 0.20 ENST00000445177.6
ENST00000375300.6
ENST00000446921.6
SIK3
SIK family kinase 3
chr8_-_140764386 0.19 ENST00000520151.5
ENST00000519024.5
ENST00000519465.5
PTK2
protein tyrosine kinase 2
chr11_+_94305592 0.19 ENST00000328458.5
ENST00000440961.6
IZUMO1R
IZUMO1 receptor, JUNO
chr1_-_161238196 0.18 ENST00000367983.9
ENST00000506209.5
ENST00000367980.6
ENST00000628566.2
NR1I3
nuclear receptor subfamily 1 group I member 3
chr6_-_11044275 0.18 ENST00000354666.4
ELOVL2
ELOVL fatty acid elongase 2
chr6_-_131628165 0.18 ENST00000368053.8
ENST00000354577.8
ENST00000368060.7
ENST00000368068.8
MED23
mediator complex subunit 23
chr21_+_29300770 0.18 ENST00000447177.5
BACH1
BTB domain and CNC homolog 1
chr2_+_11534039 0.17 ENST00000381486.7
GREB1
growth regulating estrogen receptor binding 1
chr19_-_52048561 0.16 ENST00000594154.5
ENST00000598745.5
ENST00000597273.1
ZNF432
zinc finger protein 432
chr21_-_18485878 0.16 ENST00000422787.1
TMPRSS15
transmembrane serine protease 15
chr6_+_28267044 0.15 ENST00000316606.10
ZSCAN26
zinc finger and SCAN domain containing 26
chr1_-_161238223 0.15 ENST00000515452.1
NR1I3
nuclear receptor subfamily 1 group I member 3
chr17_+_75459707 0.14 ENST00000581519.5
TMEM94
transmembrane protein 94
chr20_-_35147285 0.14 ENST00000374491.3
ENST00000374492.8
EDEM2
ER degradation enhancing alpha-mannosidase like protein 2
chr20_-_10420737 0.14 ENST00000649912.1
ENSG00000285723.1
novel protein
chr6_-_16328281 0.13 ENST00000642969.1
ENST00000683730.1
ATXN1
ENSG00000288708.1
ataxin 1
novel protein
chr1_+_174874434 0.13 ENST00000478442.5
ENST00000465412.5
RABGAP1L
RAB GTPase activating protein 1 like
chr2_-_197676012 0.13 ENST00000429081.1
RFTN2
raftlin family member 2
chr1_+_241652275 0.13 ENST00000366552.6
ENST00000437684.7
WDR64
WD repeat domain 64
chr6_-_106325735 0.12 ENST00000635758.2
ENST00000369076.8
ENST00000636437.1
ATG5
autophagy related 5
chr3_-_88149815 0.12 ENST00000467332.1
ENST00000462901.5
CGGBP1
CGG triplet repeat binding protein 1
chr2_+_37950476 0.12 ENST00000402091.3
RMDN2
regulator of microtubule dynamics 2
chr4_-_47463649 0.11 ENST00000381571.6
COMMD8
COMM domain containing 8
chr14_+_45135917 0.11 ENST00000267430.10
ENST00000556036.5
ENST00000542564.6
FANCM
FA complementation group M
chr5_+_68292486 0.10 ENST00000519025.5
PIK3R1
phosphoinositide-3-kinase regulatory subunit 1
chr19_-_52048803 0.09 ENST00000221315.10
ZNF432
zinc finger protein 432
chrY_-_23694579 0.07 ENST00000343584.10
PRYP3
PTPN13 like Y-linked pseudogene 3
chr19_-_10380558 0.07 ENST00000524462.5
ENST00000525621.6
ENST00000531836.5
TYK2
tyrosine kinase 2
chr19_-_10380454 0.06 ENST00000530829.1
ENST00000529370.5
TYK2
tyrosine kinase 2
chr2_-_165953750 0.06 ENST00000243344.8
ENST00000679799.1
ENST00000679840.1
ENST00000681606.1
ENST00000680448.1
TTC21B
tetratricopeptide repeat domain 21B
chr14_-_24442662 0.05 ENST00000554698.5
SDR39U1
short chain dehydrogenase/reductase family 39U member 1
chr11_+_18172837 0.04 ENST00000314254.3
MRGPRX4
MAS related GPR family member X4
chr10_-_45535346 0.04 ENST00000453424.7
ENST00000395769.6
MARCHF8
membrane associated ring-CH-type finger 8
chr1_-_169734064 0.03 ENST00000333360.12
SELE
selectin E
chr14_-_55191534 0.03 ENST00000395425.6
ENST00000247191.7
DLGAP5
DLG associated protein 5
chr9_-_65285209 0.02 ENST00000377420.1
FOXD4L5
forkhead box D4 like 5
chr17_+_35844077 0.01 ENST00000604694.1
TAF15
TATA-box binding protein associated factor 15
chr11_+_6926417 0.01 ENST00000610573.4
ENST00000278319.10
ZNF215
zinc finger protein 215
chr8_+_103372388 0.01 ENST00000520337.1
CTHRC1
collagen triple helix repeat containing 1
chr17_+_56153458 0.01 ENST00000318698.6
ENST00000682825.1
ENST00000566473.6
ANKFN1
ankyrin repeat and fibronectin type III domain containing 1
chr19_-_46746421 0.01 ENST00000263280.11
STRN4
striatin 4

Network of associatons between targets according to the STRING database.

First level regulatory network of AIRE

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.4 GO:1903937 response to acrylamide(GO:1903937)
0.6 1.9 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) regulation of dendritic cell dendrite assembly(GO:2000547)
0.6 1.9 GO:0030451 regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957)
0.3 1.9 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.3 1.3 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.3 0.9 GO:1903124 regulation of thioredoxin peroxidase activity(GO:1903123) negative regulation of thioredoxin peroxidase activity(GO:1903124) negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation(GO:1903125) Wnt signalosome assembly(GO:1904887) negative regulation of peroxidase activity(GO:2000469)
0.3 1.0 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.2 1.0 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.2 2.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.2 1.0 GO:1904566 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.2 1.6 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.2 1.9 GO:0039663 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.2 0.9 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.2 1.3 GO:1903826 arginine transmembrane transport(GO:1903826)
0.2 0.5 GO:2000560 CD24 biosynthetic process(GO:0035724) activation of meiosis involved in egg activation(GO:0060466) negative regulation of monocyte extravasation(GO:2000438) regulation of CD24 biosynthetic process(GO:2000559) positive regulation of CD24 biosynthetic process(GO:2000560)
0.2 2.5 GO:0010764 negative regulation of fibroblast migration(GO:0010764)
0.1 5.8 GO:0090383 phagosome acidification(GO:0090383)
0.1 2.8 GO:0035493 SNARE complex assembly(GO:0035493)
0.1 1.2 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.1 0.6 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.1 1.3 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 0.4 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.1 1.6 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.1 0.4 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.1 1.1 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.1 0.9 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 1.5 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 2.8 GO:0008089 anterograde axonal transport(GO:0008089)
0.0 0.8 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.0 0.1 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
0.0 0.7 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.4 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 0.9 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.3 GO:0048254 snoRNA localization(GO:0048254)
0.0 0.5 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.9 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.0 1.1 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 0.1 GO:2000619 negative regulation of histone H4-K16 acetylation(GO:2000619)
0.0 0.5 GO:0033227 dsRNA transport(GO:0033227)
0.0 0.6 GO:1904424 regulation of GTP binding(GO:1904424)
0.0 0.9 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0 0.8 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 0.4 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 0.4 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.6 GO:0006152 purine nucleoside catabolic process(GO:0006152) purine ribonucleoside catabolic process(GO:0046130)
0.0 2.2 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.2 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.4 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 0.5 GO:0045948 positive regulation of translational initiation(GO:0045948)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.4 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.3 0.9 GO:0099400 cytoplasmic side of mitochondrial outer membrane(GO:0032473) caveola neck(GO:0099400)
0.3 1.1 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.2 1.9 GO:0044530 supraspliceosomal complex(GO:0044530)
0.2 0.9 GO:0036338 viral envelope(GO:0019031) viral membrane(GO:0036338)
0.1 4.7 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.1 0.9 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.1 10.4 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 1.1 GO:0005587 collagen type IV trimer(GO:0005587)
0.1 0.9 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 0.9 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 0.5 GO:0089701 U2AF(GO:0089701)
0.1 1.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 2.2 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.6 GO:0000322 storage vacuole(GO:0000322)
0.0 2.8 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.3 GO:0070761 pre-snoRNP complex(GO:0070761)
0.0 0.1 GO:0071821 FANCM-MHF complex(GO:0071821)
0.0 0.5 GO:0042555 MCM complex(GO:0042555)
0.0 0.1 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.0 2.5 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 1.3 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.9 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.3 GO:0097433 dense body(GO:0097433)
0.0 0.7 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 4.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.0 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.9 GO:0044291 cell-cell contact zone(GO:0044291)
0.0 0.1 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 1.0 GO:1904724 tertiary granule lumen(GO:1904724)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.9 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.6 1.9 GO:0004877 complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877)
0.3 0.9 GO:0034211 GTP-dependent protein kinase activity(GO:0034211) peroxidase inhibitor activity(GO:0036479)
0.3 4.7 GO:0019957 C-C chemokine binding(GO:0019957)
0.2 1.9 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.2 1.0 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 1.3 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.1 1.3 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 1.4 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 1.5 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 4.5 GO:0043274 phospholipase binding(GO:0043274)
0.1 0.4 GO:0052656 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 0.3 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.1 0.4 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 2.2 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.5 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.1 0.3 GO:0004882 androgen receptor activity(GO:0004882)
0.0 2.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.5 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 1.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 1.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.1 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 1.0 GO:0031489 myosin V binding(GO:0031489)
0.0 1.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 4.1 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820)
0.0 0.9 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.7 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 3.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.4 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 2.8 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.3 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.0 0.4 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.5 GO:0016805 dipeptidase activity(GO:0016805)
0.0 1.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.1 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.2 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.4 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.5 GO:0005521 lamin binding(GO:0005521)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.5 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 2.2 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 2.6 SIG CHEMOTAXIS Genes related to chemotaxis
0.0 1.6 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 1.2 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 2.0 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 1.1 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.9 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.1 4.7 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 4.4 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 2.8 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 1.9 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 1.3 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 2.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.5 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 7.3 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.5 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 1.2 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.5 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 2.9 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 2.5 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 1.1 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.3 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.3 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.8 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.4 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.4 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.2 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism