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Illumina Body Map 2 (GSE30611)
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Results for ATF2_ATF1_ATF3
Z-value: 1.52
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Transcription factors associated with ATF2_ATF1_ATF3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ATF1 | hg38_v1_chr12_+_50764509_50764613 | 0.67 | 2.7e-05 | Click! |
| ATF3 | hg38_v1_chr1_+_212608628_212608915 | -0.40 | 2.2e-02 | Click! |
| ATF2 | hg38_v1_chr2_-_175168338_175168382 | 0.22 | 2.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_139135063 Show fit | 6.86 |
ENST00000367658.3
|
hdc homolog, cell cycle regulator |
|
| chr19_+_1941118 Show fit | 5.35 |
ENST00000255641.13
|
casein kinase 1 gamma 2 |
|
| chr7_+_142529268 Show fit | 5.02 |
ENST00000612787.1
|
T cell receptor beta variable 7-9 |
|
| chr7_+_142352802 Show fit | 5.02 |
ENST00000634605.1
|
T cell receptor beta variable 7-2 |
|
| chr12_-_122896066 Show fit | 4.10 |
ENST00000267202.7
ENST00000535765.5 |
VPS37B subunit of ESCRT-I |
|
| chr11_-_77474041 Show fit | 3.87 |
ENST00000278568.8
|
p21 (RAC1) activated kinase 1 |
|
| chr7_+_142313144 Show fit | 3.43 |
ENST00000390357.3
|
T cell receptor beta variable 4-1 |
|
| chr22_+_44172932 Show fit | 3.33 |
ENST00000422871.5
|
parvin gamma |
|
| chr14_+_67619911 Show fit | 3.29 |
ENST00000261783.4
|
arginase 2 |
|
| chr14_-_105856183 Show fit | 3.26 |
ENST00000637539.2
ENST00000390559.6 |
immunoglobulin heavy constant mu |
Network of associatons between targets according to the STRING database.
First level regulatory network of ATF2_ATF1_ATF3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.1 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 11.3 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.3 | 8.3 | GO:0010867 | positive regulation of triglyceride biosynthetic process(GO:0010867) |
| 0.1 | 7.1 | GO:0006687 | glycosphingolipid metabolic process(GO:0006687) |
| 0.7 | 7.0 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 1.1 | 6.6 | GO:0000973 | posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973) |
| 1.6 | 6.5 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 0.1 | 6.5 | GO:0030148 | sphingolipid biosynthetic process(GO:0030148) |
| 0.4 | 5.9 | GO:0060339 | negative regulation of type I interferon-mediated signaling pathway(GO:0060339) |
| 0.3 | 5.6 | GO:0032688 | negative regulation of interferon-beta production(GO:0032688) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.0 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.1 | 13.8 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.3 | 10.4 | GO:0044232 | organelle membrane contact site(GO:0044232) |
| 0.1 | 9.7 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 9.0 | GO:0016607 | nuclear speck(GO:0016607) |
| 1.0 | 8.3 | GO:0071595 | Nem1-Spo7 phosphatase complex(GO:0071595) |
| 0.0 | 8.3 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.1 | 6.7 | GO:0071437 | invadopodium(GO:0071437) |
| 0.8 | 6.6 | GO:0044614 | nuclear pore cytoplasmic filaments(GO:0044614) |
| 0.1 | 6.2 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.7 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 14.2 | GO:0001012 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012) |
| 0.1 | 11.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 11.7 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 10.1 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.4 | 8.4 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.1 | 8.4 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.1 | 7.3 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.1 | 7.1 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.2 | 7.0 | GO:0031210 | phosphatidylcholine binding(GO:0031210) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.5 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.2 | 10.9 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 10.8 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 9.9 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 8.6 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 6.9 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 6.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 6.1 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 5.0 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 4.7 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.3 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.2 | 11.5 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.1 | 9.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.3 | 6.8 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.1 | 6.6 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 6.2 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.1 | 5.7 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 5.3 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.2 | 4.9 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.2 | 4.8 | REACTOME SIGNALLING TO P38 VIA RIT AND RIN | Genes involved in Signalling to p38 via RIT and RIN |