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Illumina Body Map 2 (GSE30611)

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Results for ATF4

Z-value: 1.24

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Transcription factors associated with ATF4

Gene Symbol Gene ID Gene Info
ATF4
ENSG00000128272.17 activating transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ATF4hg38_v1_chr22_+_39520553_395206040.232.1e-01Click!

Activity profile of ATF4 motif

Sorted Z-values of ATF4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_40953463 9.01 ENST00000617768.5
CHAC1
ChaC glutathione specific gamma-glutamylcyclotransferase 1
chr8_-_38150943 4.25 ENST00000276449.9
STAR
steroidogenic acute regulatory protein
chr15_+_40952962 4.16 ENST00000444189.7
CHAC1
ChaC glutathione specific gamma-glutamylcyclotransferase 1
chr10_-_14838561 3.94 ENST00000378442.5
CDNF
cerebral dopamine neurotrophic factor
chr17_+_48055945 3.73 ENST00000580037.1
NFE2L1
nuclear factor, erythroid 2 like 1
chr17_+_1762012 3.58 ENST00000571360.5
SERPINF1
serpin family F member 1
chr10_+_49299159 3.55 ENST00000374144.8
C10orf71
chromosome 10 open reading frame 71
chr16_-_28539004 3.18 ENST00000395641.2
NUPR1
nuclear protein 1, transcriptional regulator
chr16_-_70289480 3.05 ENST00000261772.13
ENST00000675953.1
ENST00000675691.1
ENST00000675133.1
ENST00000674512.1
ENST00000675045.1
ENST00000675853.1
ENST00000565361.3
ENST00000674963.1
ENST00000674691.1
AARS1
alanyl-tRNA synthetase 1
chr10_-_14838003 2.88 ENST00000465530.2
CDNF
cerebral dopamine neurotrophic factor
chr10_-_99430617 2.81 ENST00000370508.7
GOT1
glutamic-oxaloacetic transaminase 1
chr17_-_81937320 2.68 ENST00000577624.5
ENST00000403172.8
ENST00000619204.4
ENST00000629768.2
PYCR1
pyrroline-5-carboxylate reductase 1
chr17_-_81937221 2.54 ENST00000402252.6
ENST00000583564.5
ENST00000585244.1
ENST00000337943.9
ENST00000579698.5
PYCR1
pyrroline-5-carboxylate reductase 1
chr17_+_1762052 2.49 ENST00000254722.9
ENST00000576406.5
ENST00000571149.5
SERPINF1
serpin family F member 1
chr16_+_46884323 2.47 ENST00000340124.9
GPT2
glutamic--pyruvic transaminase 2
chr21_-_30492008 2.46 ENST00000334063.6
KRTAP19-3
keratin associated protein 19-3
chr17_-_81937277 2.39 ENST00000405481.8
ENST00000329875.13
ENST00000585215.5
PYCR1
pyrroline-5-carboxylate reductase 1
chr9_-_92293674 2.37 ENST00000683679.1
ENST00000683565.1
ENST00000684557.1
ENST00000682578.1
ENST00000443024.7
ENST00000375643.7
ENST00000683469.1
IARS1
isoleucyl-tRNA synthetase 1
chr1_-_178871060 2.27 ENST00000234816.7
ANGPTL1
angiopoietin like 1
chr19_+_33374312 2.25 ENST00000585933.2
CEBPG
CCAAT enhancer binding protein gamma
chrX_-_81201886 2.11 ENST00000451455.1
ENST00000358130.7
ENST00000436386.5
HMGN5
high mobility group nucleosome binding domain 5
chr16_-_28538951 2.06 ENST00000324873.8
NUPR1
nuclear protein 1, transcriptional regulator
chr12_-_49903853 2.05 ENST00000320634.8
FAIM2
Fas apoptotic inhibitory molecule 2
chr11_-_57324907 2.05 ENST00000358252.8
TNKS1BP1
tankyrase 1 binding protein 1
chr1_-_178871022 2.01 ENST00000367629.1
ANGPTL1
angiopoietin like 1
chr3_-_48088824 1.87 ENST00000439356.2
ENST00000395734.7
ENST00000426837.6
MAP4
microtubule associated protein 4
chr11_-_3057386 1.85 ENST00000529772.5
ENST00000278224.13
ENST00000380525.9
CARS1
cysteinyl-tRNA synthetase 1
chr10_+_94089034 1.79 ENST00000676102.1
ENST00000371385.8
PLCE1
phospholipase C epsilon 1
chr10_+_94089067 1.76 ENST00000371375.1
ENST00000675218.1
PLCE1
phospholipase C epsilon 1
chr3_-_48089203 1.69 ENST00000468075.2
ENST00000360240.10
MAP4
microtubule associated protein 4
chr7_+_30594823 1.66 ENST00000675810.1
ENST00000674815.1
ENST00000454308.6
ENST00000389266.8
ENST00000675693.1
ENST00000675651.1
ENST00000674851.1
GARS1
glycyl-tRNA synthetase 1
chr8_+_30638562 1.59 ENST00000517349.2
SMIM18
small integral membrane protein 18
chr17_-_42676980 1.55 ENST00000587627.1
ENST00000591022.6
ENST00000293349.10
PLEKHH3
pleckstrin homology, MyTH4 and FERM domain containing H3
chr7_-_56034133 1.55 ENST00000421626.5
PSPH
phosphoserine phosphatase
chr5_+_33440696 1.51 ENST00000502553.5
ENST00000514259.5
TARS1
threonyl-tRNA synthetase 1
chr2_-_240820945 1.50 ENST00000428768.2
ENST00000650053.1
ENST00000650130.1
KIF1A
kinesin family member 1A
chr12_-_49904217 1.49 ENST00000550635.6
FAIM2
Fas apoptotic inhibitory molecule 2
chr12_-_46268989 1.48 ENST00000549049.5
ENST00000439706.5
ENST00000398637.10
SLC38A1
solute carrier family 38 member 1
chr3_-_48088800 1.48 ENST00000423088.5
MAP4
microtubule associated protein 4
chr1_+_162632454 1.42 ENST00000367921.8
ENST00000367922.7
DDR2
discoidin domain receptor tyrosine kinase 2
chr2_-_240820205 1.39 ENST00000647731.1
ENST00000648680.1
ENST00000649306.1
ENST00000648129.1
ENST00000498729.9
ENST00000320389.12
ENST00000648364.1
ENST00000647885.1
ENST00000404283.9
ENST00000649096.1
KIF1A
kinesin family member 1A
chr19_+_33373694 1.39 ENST00000284000.9
CEBPG
CCAAT enhancer binding protein gamma
chr21_-_43075831 1.36 ENST00000398158.5
ENST00000398165.8
CBS
cystathionine beta-synthase
chr5_+_174724549 1.35 ENST00000239243.7
ENST00000507785.2
MSX2
msh homeobox 2
chr5_+_33440947 1.34 ENST00000455217.6
ENST00000265112.8
TARS1
threonyl-tRNA synthetase 1
chr1_+_154272589 1.34 ENST00000457918.6
ENST00000483970.6
ENST00000328703.12
ENST00000435087.1
ENST00000532105.1
HAX1
HCLS1 associated protein X-1
chr9_-_34665985 1.31 ENST00000416454.5
ENST00000544078.2
ENST00000421828.7
ENST00000423809.5
ENSG00000187186.15
novel protein
chr21_-_6467509 1.27 ENST00000624406.3
ENST00000398168.5
ENST00000624934.3
CBSL
cystathionine beta-synthase like
chr11_+_62881686 1.27 ENST00000536981.6
ENST00000539891.6
SLC3A2
solute carrier family 3 member 2
chr1_-_220046432 1.14 ENST00000609181.5
ENST00000366923.8
EPRS1
glutamyl-prolyl-tRNA synthetase 1
chr12_-_57520480 1.12 ENST00000642841.1
ENST00000547303.5
ENST00000552740.5
ENST00000547526.1
ENST00000346473.8
ENST00000551116.5
ENSG00000285133.1
DDIT3
novel protein
DNA damage inducible transcript 3
chr11_+_22666604 1.10 ENST00000454584.6
GAS2
growth arrest specific 2
chr11_-_128867364 1.09 ENST00000440599.6
ENST00000324036.7
KCNJ1
potassium inwardly rectifying channel subfamily J member 1
chrX_-_15314543 1.07 ENST00000344384.8
ASB11
ankyrin repeat and SOCS box containing 11
chr5_-_146182591 1.07 ENST00000510191.5
ENST00000674277.1
ENST00000674447.1
ENST00000674270.1
ENST00000394434.7
ENST00000674290.1
ENST00000674398.1
ENST00000674174.1
LARS1
leucyl-tRNA synthetase 1
chr22_-_29061831 1.06 ENST00000216071.5
C22orf31
chromosome 22 open reading frame 31
chr11_-_128867268 1.06 ENST00000392665.6
ENST00000392666.6
KCNJ1
potassium inwardly rectifying channel subfamily J member 1
chr5_-_146182475 1.05 ENST00000674158.1
ENST00000674191.1
ENST00000274562.13
LARS1
leucyl-tRNA synthetase 1
chr16_+_67660946 1.01 ENST00000602551.5
ENST00000219255.3
ENST00000458121.7
PARD6A
par-6 family cell polarity regulator alpha
chr9_+_78297117 0.98 ENST00000376588.4
PSAT1
phosphoserine aminotransferase 1
chr9_+_78297143 0.97 ENST00000347159.6
PSAT1
phosphoserine aminotransferase 1
chr12_-_46269105 0.97 ENST00000546893.5
SLC38A1
solute carrier family 38 member 1
chr18_-_57621741 0.97 ENST00000587194.1
ENST00000591599.5
ENST00000588661.5
ENST00000256854.10
NARS1
asparaginyl-tRNA synthetase 1
chr7_-_99408548 0.97 ENST00000626285.1
ENST00000350498.8
PDAP1
PDGFA associated protein 1
chr3_-_33645433 0.96 ENST00000635664.1
ENST00000485378.6
ENST00000313350.10
ENST00000487200.5
CLASP2
cytoplasmic linker associated protein 2
chr10_-_21517825 0.92 ENST00000444772.3
SKIDA1
SKI/DACH domain containing 1
chr1_-_216805367 0.86 ENST00000360012.7
ESRRG
estrogen related receptor gamma
chr10_+_61901678 0.84 ENST00000644638.1
ENST00000681100.1
ENST00000279873.12
ARID5B
AT-rich interaction domain 5B
chr8_-_126557691 0.84 ENST00000652209.1
LRATD2
LRAT domain containing 2
chr10_-_112183698 0.83 ENST00000369425.5
ENST00000348367.9
GPAM
glycerol-3-phosphate acyltransferase, mitochondrial
chr12_+_10212867 0.80 ENST00000545047.5
ENST00000266458.10
ENST00000629504.1
ENST00000543602.5
ENST00000545887.1
GABARAPL1
GABA type A receptor associated protein like 1
chr20_+_23362144 0.80 ENST00000338121.10
ENST00000424216.1
GZF1
GDNF inducible zinc finger protein 1
chr17_+_58238694 0.78 ENST00000581008.1
LPO
lactoperoxidase
chr5_+_140547632 0.76 ENST00000310331.3
EIF4EBP3
eukaryotic translation initiation factor 4E binding protein 3
chr5_+_33441062 0.74 ENST00000626210.1
ENST00000627006.2
TARS1
threonyl-tRNA synthetase 1
chr19_+_11239602 0.74 ENST00000252453.12
ANGPTL8
angiopoietin like 8
chr3_-_33645253 0.70 ENST00000333778.10
CLASP2
cytoplasmic linker associated protein 2
chr1_-_206970457 0.65 ENST00000324852.9
ENST00000450945.3
ENST00000400962.8
FCAMR
Fc fragment of IgA and IgM receptor
chr6_+_72366730 0.64 ENST00000414192.2
RIMS1
regulating synaptic membrane exocytosis 1
chr10_+_14838365 0.63 ENST00000441647.1
HSPA14
heat shock protein family A (Hsp70) member 14
chr7_-_138701352 0.62 ENST00000421622.5
ENST00000674285.1
SVOPL
SVOP like
chr11_-_17533869 0.60 ENST00000526181.1
USH1C
USH1 protein network component harmonin
chr12_-_24949026 0.60 ENST00000539780.5
ENST00000546285.1
ENST00000342945.9
ENST00000261192.12
BCAT1
branched chain amino acid transaminase 1
chr1_-_32817311 0.59 ENST00000373477.9
ENST00000675785.1
YARS1
tyrosyl-tRNA synthetase 1
chr5_+_144205250 0.58 ENST00000507359.3
KCTD16
potassium channel tetramerization domain containing 16
chr12_+_57520698 0.58 ENST00000548887.5
MBD6
methyl-CpG binding domain protein 6
chrX_+_24054931 0.55 ENST00000253039.9
ENST00000423068.1
EIF2S3
eukaryotic translation initiation factor 2 subunit gamma
chr4_-_152536045 0.55 ENST00000603548.6
ENST00000281708.10
FBXW7
F-box and WD repeat domain containing 7
chr12_+_57230336 0.54 ENST00000555773.5
ENST00000554975.5
ENST00000449049.7
SHMT2
serine hydroxymethyltransferase 2
chr10_+_14838288 0.51 ENST00000640019.3
ENST00000493178.1
ENST00000378372.8
ENSG00000284024.4
HSPA14
novel protein
heat shock protein family A (Hsp70) member 14
chr1_+_52056255 0.47 ENST00000489308.6
BTF3L4
basic transcription factor 3 like 4
chr11_+_22667069 0.44 ENST00000533363.5
GAS2
growth arrest specific 2
chr12_+_10212836 0.43 ENST00000421801.6
ENST00000544284.5
GABARAPL1
GABA type A receptor associated protein like 1
chr5_+_44808930 0.43 ENST00000507110.6
MRPS30
mitochondrial ribosomal protein S30
chrX_-_33339525 0.42 ENST00000288447.9
DMD
dystrophin
chr12_+_106601137 0.41 ENST00000357881.8
RFX4
regulatory factor X4
chr19_-_54081365 0.40 ENST00000432826.2
TARM1
T cell-interacting, activating receptor on myeloid cells 1
chr10_+_100347225 0.38 ENST00000370355.3
SCD
stearoyl-CoA desaturase
chr12_+_57230301 0.38 ENST00000553474.5
SHMT2
serine hydroxymethyltransferase 2
chr17_-_79993634 0.37 ENST00000571872.1
TBC1D16
TBC1 domain family member 16
chr3_+_148697784 0.37 ENST00000497524.5
ENST00000418473.7
ENST00000349243.8
ENST00000404754.2
AGTR1
angiotensin II receptor type 1
chr12_+_57230274 0.35 ENST00000557427.5
SHMT2
serine hydroxymethyltransferase 2
chr19_+_48755512 0.34 ENST00000593756.6
FGF21
fibroblast growth factor 21
chr2_+_6978624 0.30 ENST00000433456.1
RNF144A
ring finger protein 144A
chr19_+_48756067 0.28 ENST00000222157.5
FGF21
fibroblast growth factor 21
chr1_+_233904656 0.28 ENST00000366618.8
SLC35F3
solute carrier family 35 member F3
chr19_-_8698789 0.24 ENST00000324436.5
ACTL9
actin like 9
chr19_-_8698705 0.24 ENST00000612068.1
ACTL9
actin like 9
chr2_-_215436061 0.24 ENST00000421182.5
ENST00000432072.6
ENST00000323926.10
ENST00000336916.8
ENST00000357867.8
ENST00000359671.5
ENST00000446046.5
ENST00000354785.11
ENST00000356005.8
ENST00000443816.5
ENST00000426059.1
FN1
fibronectin 1
chr12_+_57229694 0.24 ENST00000557487.5
ENST00000328923.8
ENST00000555634.5
ENST00000556689.5
SHMT2
serine hydroxymethyltransferase 2
chr12_+_57230124 0.23 ENST00000553529.5
ENST00000554310.5
SHMT2
serine hydroxymethyltransferase 2
chr7_-_48029102 0.23 ENST00000297325.9
ENST00000412142.5
ENST00000395572.6
SUN3
Sad1 and UNC84 domain containing 3
chr7_+_48171451 0.23 ENST00000435803.6
ABCA13
ATP binding cassette subfamily A member 13
chr1_+_239719542 0.23 ENST00000448020.1
CHRM3
cholinergic receptor muscarinic 3
chr1_-_44031352 0.21 ENST00000372306.7
ENST00000475075.6
SLC6A9
solute carrier family 6 member 9
chr7_-_18027839 0.20 ENST00000506618.5
PRPS1L1
phosphoribosyl pyrophosphate synthetase 1 like 1
chr11_+_119084873 0.18 ENST00000652429.1
ENST00000442944.7
ENST00000537841.5
ENST00000542729.5
ENST00000546302.6
ENST00000536813.6
ENST00000544387.5
ENST00000543090.5
HMBS
hydroxymethylbilane synthase
chr12_+_10212483 0.18 ENST00000545859.5
GABARAPL1
GABA type A receptor associated protein like 1
chr14_-_91947383 0.17 ENST00000267620.14
FBLN5
fibulin 5
chr11_+_119085200 0.16 ENST00000650101.1
HMBS
hydroxymethylbilane synthase
chr16_-_705726 0.16 ENST00000397621.6
ENST00000324361.9
FBXL16
F-box and leucine rich repeat protein 16
chr19_+_1450113 0.15 ENST00000590469.6
ENST00000590877.5
ENST00000233607.6
APC2
APC regulator of WNT signaling pathway 2
chr1_-_167914089 0.14 ENST00000476818.2
ENST00000367848.1
ENST00000367851.9
ENST00000545172.5
ADCY10
adenylate cyclase 10
chr11_-_77474087 0.13 ENST00000356341.8
PAK1
p21 (RAC1) activated kinase 1
chr12_+_56468561 0.13 ENST00000338146.7
SPRYD4
SPRY domain containing 4
chr1_-_19923617 0.13 ENST00000375116.3
PLA2G2E
phospholipase A2 group IIE
chr22_+_41833079 0.11 ENST00000612482.4
ENST00000361204.9
SREBF2
sterol regulatory element binding transcription factor 2
chr12_+_57230086 0.10 ENST00000414700.7
ENST00000557703.5
SHMT2
serine hydroxymethyltransferase 2
chr9_+_36169382 0.05 ENST00000335119.4
CCIN
calicin
chr1_+_162631984 0.04 ENST00000415555.5
DDR2
discoidin domain receptor tyrosine kinase 2
chr2_+_46542474 0.04 ENST00000238738.9
RHOQ
ras homolog family member Q
chr5_+_154755272 0.02 ENST00000518297.6
LARP1
La ribonucleoprotein 1, translational regulator
chr6_+_159890964 0.01 ENST00000434562.2
ENST00000674077.2
ENSG00000236823.2
MAS1
novel transcript
MAS1 proto-oncogene, G protein-coupled receptor

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.3 GO:0018963 phthalate metabolic process(GO:0018963)
0.9 2.8 GO:0006532 fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533)
0.7 6.7 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.7 5.0 GO:0051012 microtubule sliding(GO:0051012)
0.7 6.1 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.6 13.2 GO:0006751 glutathione catabolic process(GO:0006751)
0.5 3.6 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.5 2.5 GO:0042851 L-alanine metabolic process(GO:0042851) L-alanine catabolic process(GO:0042853)
0.4 1.1 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.4 2.6 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.4 3.6 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.3 1.4 GO:0051795 embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795)
0.3 5.3 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.2 5.2 GO:2000194 regulation of female gonad development(GO:2000194)
0.2 0.6 GO:1904106 protein localization to microvillus(GO:1904106)
0.2 3.5 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.2 1.3 GO:0060356 leucine import(GO:0060356)
0.2 1.1 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.2 3.1 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 0.5 GO:2000639 negative regulation of triglyceride biosynthetic process(GO:0010868) regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 0.6 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.1 0.3 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.1 0.6 GO:1904640 response to methionine(GO:1904640)
0.1 1.0 GO:1904781 positive regulation of protein localization to centrosome(GO:1904781)
0.1 6.8 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.1 0.8 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.4 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.1 3.7 GO:0006783 heme biosynthetic process(GO:0006783)
0.1 0.2 GO:1904237 regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904235) positive regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904237)
0.1 1.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 2.1 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 0.1 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.0 2.9 GO:0008089 anterograde axonal transport(GO:0008089)
0.0 2.1 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 2.5 GO:0001504 neurotransmitter uptake(GO:0001504)
0.0 0.4 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0 0.2 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.3 GO:0015888 thiamine transport(GO:0015888)
0.0 0.1 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 2.1 GO:0010107 potassium ion import(GO:0010107)
0.0 0.7 GO:0050746 regulation of lipoprotein metabolic process(GO:0050746)
0.0 0.4 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.2 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.6 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 1.3 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.8 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.8 GO:0060612 adipose tissue development(GO:0060612)
0.0 0.1 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.9 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 2.5 GO:0031424 keratinization(GO:0031424)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:1990617 CHOP-ATF4 complex(GO:1990617)
0.4 4.3 GO:0030061 mitochondrial crista(GO:0030061)
0.3 6.1 GO:0043203 axon hillock(GO:0043203)
0.1 1.8 GO:0070552 BRISC complex(GO:0070552)
0.1 1.7 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 0.5 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 0.5 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 2.1 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.2 GO:0032279 asymmetric synapse(GO:0032279)
0.0 13.2 GO:0005802 trans-Golgi network(GO:0005802)
0.0 2.9 GO:1904115 axon cytoplasm(GO:1904115)
0.0 5.0 GO:0072686 mitotic spindle(GO:0072686)
0.0 1.4 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.8 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.4 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 1.0 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 4.0 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.0 GO:0033150 cytoskeletal calyx(GO:0033150)
0.0 0.6 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.1 GO:0071953 elastic fiber(GO:0071953)
0.0 0.4 GO:0010369 chromocenter(GO:0010369)
0.0 2.8 GO:0043679 axon terminus(GO:0043679)
0.0 2.5 GO:0005882 intermediate filament(GO:0005882)
0.0 1.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 2.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 7.6 GO:0005759 mitochondrial matrix(GO:0005759)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 13.2 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
1.0 7.6 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.9 2.8 GO:0080130 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.8 2.5 GO:0047635 L-alanine:2-oxoglutarate aminotransferase activity(GO:0004021) alanine-oxo-acid transaminase activity(GO:0047635)
0.4 2.6 GO:0004122 cystathionine beta-synthase activity(GO:0004122)
0.3 1.5 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.2 1.8 GO:0004372 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.2 2.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.2 2.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 4.3 GO:0017127 cholesterol transporter activity(GO:0017127)
0.1 0.4 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.1 0.6 GO:0052656 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 0.8 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.1 0.3 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.1 3.6 GO:0008301 DNA binding, bending(GO:0008301)
0.1 0.9 GO:0050682 AF-2 domain binding(GO:0050682)
0.1 1.5 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 3.8 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 2.0 GO:0008483 transaminase activity(GO:0008483)
0.1 0.5 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 2.6 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
0.1 1.3 GO:0019966 interleukin-1 binding(GO:0019966)
0.1 1.3 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 2.1 GO:0002162 dystroglycan binding(GO:0002162)
0.1 1.1 GO:0008140 cAMP response element binding protein binding(GO:0008140) leucine zipper domain binding(GO:0043522)
0.1 0.4 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.1 1.4 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.8 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 2.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 3.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 6.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0000247 C-8 sterol isomerase activity(GO:0000247)
0.0 0.2 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.8 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 6.0 GO:0008083 growth factor activity(GO:0008083)
0.0 1.0 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 2.9 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.0 GO:0032427 GBD domain binding(GO:0032427)
0.0 6.4 GO:0008017 microtubule binding(GO:0008017)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.6 PID RAS PATHWAY Regulation of Ras family activation
0.0 3.5 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 0.1 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.3 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.6 PID CD40 PATHWAY CD40/CD40L signaling
0.0 1.0 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.5 PID MYC PATHWAY C-MYC pathway
0.0 1.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 15.4 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 4.3 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.1 1.1 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 2.1 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.5 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.4 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 1.0 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 2.1 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 1.0 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.6 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.6 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine