Project
Illumina Body Map 2 (GSE30611)
Navigation
Downloads
Results for BHLHE22_BHLHA15_BHLHE23
Z-value: 0.87
Motif logo
Transcription factors associated with BHLHE22_BHLHA15_BHLHE23
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000180828.3 | basic helix-loop-helix family member e22 | |
| ENSG00000180535.4 | basic helix-loop-helix family member a15 | |
| ENSG00000125533.6 | basic helix-loop-helix family member e23 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BHLHA15 | hg38_v1_chr7_+_98211431_98211474 | 0.47 | 6.3e-03 | Click! |
| BHLHE23 | hg38_v1_chr20_-_63006961_63007035 | 0.07 | 6.9e-01 | Click! |
| BHLHE22 | hg38_v1_chr8_+_64580357_64580374 | 0.03 | 8.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of BHLHE22_BHLHA15_BHLHE23
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.4 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.2 | 6.6 | GO:0002726 | positive regulation of T cell cytokine production(GO:0002726) |
| 1.2 | 4.8 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) |
| 1.6 | 4.7 | GO:0060730 | regulation of intestinal epithelial structure maintenance(GO:0060730) |
| 1.1 | 4.2 | GO:0042631 | cellular response to water deprivation(GO:0042631) |
| 0.3 | 3.8 | GO:2000622 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.1 | 3.2 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 1.0 | 3.1 | GO:1904899 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 0.2 | 3.0 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.0 | 2.1 | GO:0018022 | peptidyl-lysine methylation(GO:0018022) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.1 | GO:0005769 | early endosome(GO:0005769) |
| 0.1 | 5.2 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.2 | 4.8 | GO:0042588 | zymogen granule(GO:0042588) |
| 0.1 | 3.7 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 3.4 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.4 | 2.5 | GO:0036398 | TCR signalosome(GO:0036398) |
| 0.0 | 2.3 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.0 | 2.0 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 1.9 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 1.9 | GO:0045171 | intercellular bridge(GO:0045171) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.3 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.2 | 5.2 | GO:0046625 | sphingolipid binding(GO:0046625) |
| 0.1 | 4.8 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.1 | 3.9 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.2 | 3.1 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.0 | 2.1 | GO:0016279 | protein-lysine N-methyltransferase activity(GO:0016279) |
| 0.2 | 1.9 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 0.1 | 1.7 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.0 | 1.7 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 1.6 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.9 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 4.5 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 3.1 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 2.5 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 2.1 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 2.0 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 1.9 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 0.5 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.5 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.7 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 4.2 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 4.0 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 3.8 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 3.3 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 2.0 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.1 | 1.9 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 1.9 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 1.6 | REACTOME INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.0 | 1.4 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |