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Illumina Body Map 2 (GSE30611)

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Results for BRCA1

Z-value: 0.53

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Transcription factors associated with BRCA1

Gene Symbol Gene ID Gene Info
ENSG00000012048.23 BRCA1 DNA repair associated

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BRCA1hg38_v1_chr17_-_43170191_431702450.115.7e-01Click!

Activity profile of BRCA1 motif

Sorted Z-values of BRCA1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_124919244 2.01 ENST00000408930.6
hepatocellular carcinoma, down-regulated 1
chr14_-_59630806 1.78 ENST00000342503.8
reticulon 1
chr1_+_159171607 1.66 ENST00000368124.8
ENST00000368125.9
ENST00000416746.1
cell adhesion molecule 3
chr14_-_59630582 1.63 ENST00000395090.5
reticulon 1
chr2_-_157325808 1.45 ENST00000410096.6
ENST00000420719.6
ENST00000409216.5
ENST00000419116.2
ermin
chr2_-_49974083 1.06 ENST00000636345.1
neurexin 1
chr6_+_12717660 0.92 ENST00000674637.1
phosphatase and actin regulator 1
chr19_+_45467988 0.79 ENST00000615753.4
ENST00000585836.5
ENST00000417353.6
ENST00000591858.5
ENST00000443841.6
ENST00000590335.1
ENST00000353609.8
FosB proto-oncogene, AP-1 transcription factor subunit
chr13_-_49444004 0.75 ENST00000410043.5
ENST00000409308.6
calcium binding protein 39 like
chr4_+_625555 0.71 ENST00000496514.6
ENST00000255622.10
phosphodiesterase 6B
chr1_+_84181630 0.70 ENST00000610457.1
protein kinase cAMP-activated catalytic subunit beta
chr10_-_24706622 0.68 ENST00000680286.1
Rho GTPase activating protein 21
chr2_-_157325659 0.67 ENST00000409925.1
ermin
chr10_-_114632011 0.64 ENST00000651023.1
actin binding LIM protein 1
chr3_-_127736329 0.59 ENST00000398101.7
monoglyceride lipase
chr10_+_120851341 0.56 ENST00000263461.11
WD repeat domain 11
chr14_+_31561376 0.54 ENST00000550649.5
ENST00000281081.12
nucleotide binding protein like
chr7_-_78771265 0.51 ENST00000630991.2
ENST00000629359.2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr11_+_101914997 0.50 ENST00000263468.13
centrosomal protein 126
chr5_+_140700437 0.49 ENST00000274712.8
zinc finger matrin-type 2
chr10_-_100529854 0.48 ENST00000370320.4
ENST00000299166.9
ENST00000370322.5
NADH:ubiquinone oxidoreductase subunit B8
chr2_-_144517506 0.47 ENST00000431672.4
ENST00000558170.6
zinc finger E-box binding homeobox 2
chr4_-_48780242 0.46 ENST00000507711.5
ENST00000358350.9
FRY like transcription coactivator
chr10_+_120851427 0.45 ENST00000604585.5
WD repeat domain 11
chr2_-_144517663 0.44 ENST00000427902.5
ENST00000462355.2
ENST00000470879.5
ENST00000409487.7
ENST00000435831.5
ENST00000630572.2
zinc finger E-box binding homeobox 2
chr2_-_49973939 0.43 ENST00000630656.1
neurexin 1
chr11_+_33258304 0.43 ENST00000531504.5
ENST00000456517.2
homeodomain interacting protein kinase 3
chr13_+_27251569 0.42 ENST00000272274.8
ENST00000319826.8
ENST00000326092.8
ribosomal protein L21
chr2_+_108378176 0.42 ENST00000409309.3
sulfotransferase family 1C member 4
chr5_+_126462339 0.42 ENST00000502348.5
GRAM domain containing 2B
chr13_+_27251545 0.42 ENST00000311549.11
ribosomal protein L21
chr4_+_73436244 0.41 ENST00000226359.2
alpha fetoprotein
chr4_+_73436198 0.39 ENST00000395792.7
alpha fetoprotein
chr11_-_13463168 0.36 ENST00000526841.1
ENST00000278174.10
ENST00000529708.5
ENST00000528120.5
BTB domain containing 10
chr2_+_195657308 0.36 ENST00000418005.1
solute carrier family 39 member 10
chrX_-_71068384 0.35 ENST00000276105.3
ENST00000622259.4
sorting nexin 12
chr9_-_83978429 0.35 ENST00000351839.7
heterogeneous nuclear ribonucleoprotein K
chr9_-_21031614 0.35 ENST00000495827.3
3-hydroxyacyl-CoA dehydratase 4
chr3_-_116445458 0.34 ENST00000490035.7
limbic system associated membrane protein
chr8_-_17002327 0.33 ENST00000180166.6
fibroblast growth factor 20
chr11_-_72112750 0.31 ENST00000545680.5
ENST00000543587.5
ENST00000538393.5
ENST00000535234.5
ENST00000227618.8
ENST00000535503.5
anaphase promoting complex subunit 15
chr1_-_170074568 0.27 ENST00000367767.5
ENST00000361580.7
ENST00000538366.5
kinesin associated protein 3
chr3_+_184338826 0.27 ENST00000453072.5
family with sequence similarity 131 member A
chr19_+_47130782 0.26 ENST00000597808.5
ENST00000413379.7
ENST00000600706.5
ENST00000270225.12
ENST00000598840.5
ENST00000600753.1
ENST00000392776.3
SUMO1 activating enzyme subunit 1
chr7_-_78770859 0.26 ENST00000636717.1
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr11_-_61429934 0.26 ENST00000541963.5
ENST00000477890.6
ENST00000439958.8
cleavage and polyadenylation specific factor 7
chr14_+_22040576 0.25 ENST00000390448.3
T cell receptor alpha variable 20
chr7_-_78771058 0.24 ENST00000628781.1
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr11_-_61430008 0.23 ENST00000394888.8
cleavage and polyadenylation specific factor 7
chr2_+_108377947 0.23 ENST00000272452.7
sulfotransferase family 1C member 4
chr6_-_158999748 0.22 ENST00000449822.5
radial spoke head 3
chr7_+_100119607 0.21 ENST00000262932.5
canopy FGF signaling regulator 4
chr3_-_177196451 0.20 ENST00000430069.5
ENST00000630796.2
ENST00000428970.5
TBL1X receptor 1
chr12_-_116881431 0.20 ENST00000257572.5
harakiri, BCL2 interacting protein
chr8_+_96761232 0.20 ENST00000521142.1
carboxypeptidase Q
chr3_-_177196402 0.20 ENST00000437738.5
ENST00000424913.5
ENST00000443315.5
TBL1X receptor 1
chr6_+_33204645 0.18 ENST00000374662.4
hydroxysteroid 17-beta dehydrogenase 8
chr11_+_1099730 0.18 ENST00000674892.1
mucin 2, oligomeric mucus/gel-forming
chr11_+_61430036 0.18 ENST00000541135.5
novel transcript
chr2_-_151261839 0.17 ENST00000331426.6
RNA binding motif protein 43
chr7_-_78771108 0.17 ENST00000626691.2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr8_-_80171106 0.16 ENST00000519303.6
tumor protein D52
chr14_+_22163226 0.16 ENST00000390458.3
T cell receptor alpha variable 29/delta variable 5
chr19_-_34677157 0.16 ENST00000601241.6
secretoglobin family 2B member 2
chr4_-_184649436 0.16 ENST00000308394.9
ENST00000517513.5
ENST00000447121.2
ENST00000393588.8
ENST00000523916.5
caspase 3
chr12_-_80937918 0.16 ENST00000552864.6
lin-7 homolog A, crumbs cell polarity complex component
chr17_+_76376581 0.15 ENST00000591651.5
ENST00000545180.5
sphingosine kinase 1
chr14_-_68794597 0.14 ENST00000336440.3
ZFP36 ring finger protein like 1
chr15_+_57248015 0.13 ENST00000559710.5
ENST00000559703.1
transcription factor 12
chr8_+_96760974 0.13 ENST00000519484.1
carboxypeptidase Q
chr14_+_72926377 0.13 ENST00000353777.7
ENST00000358377.7
ENST00000394234.6
ENST00000509153.5
ENST00000555042.5
DDB1 and CUL4 associated factor 4
chrX_-_143635081 0.12 ENST00000338017.8
SLIT and NTRK like family member 4
chr1_-_160262501 0.12 ENST00000447377.5
DDB1 and CUL4 associated factor 8
chr14_+_88385643 0.12 ENST00000393545.9
ENST00000356583.9
ENST00000555401.5
ENST00000553885.5
spermatogenesis associated 7
chr9_+_2015969 0.12 ENST00000636903.1
ENST00000637352.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr13_-_30464234 0.12 ENST00000399489.5
ENST00000339872.8
high mobility group box 1
chr20_+_58907981 0.11 ENST00000656419.1
GNAS complex locus
chr19_-_37172670 0.11 ENST00000588354.1
ENST00000292841.10
ENST00000356958.8
zinc finger protein 585A
chr18_-_26091175 0.11 ENST00000579061.5
ENST00000542420.6
SS18 subunit of BAF chromatin remodeling complex
chr5_+_146203544 0.11 ENST00000506502.2
novel readthrough transcript
chr1_+_171557845 0.10 ENST00000644916.1
proline rich coiled-coil 2C
chr13_+_102799322 0.09 ENST00000639132.1
BIVM-ERCC5 readthrough
chr12_-_95116967 0.09 ENST00000551521.5
FYVE, RhoGEF and PH domain containing 6
chr11_-_119340914 0.09 ENST00000634633.1
C1q and TNF related 5
chr5_+_146203593 0.09 ENST00000265271.7
RNA binding motif protein 27
chr20_-_49913693 0.09 ENST00000422556.1
spermatogenesis associated 2
chr12_-_66678934 0.09 ENST00000545666.5
ENST00000398016.7
ENST00000359742.9
ENST00000538211.5
glutamate receptor interacting protein 1
chr19_-_12801787 0.08 ENST00000334482.9
ENST00000301522.3
peroxiredoxin 2
chr12_+_401621 0.08 ENST00000412006.6
ENST00000239830.9
coiled-coil domain containing 77
chr17_-_43661915 0.08 ENST00000318579.9
ENST00000393661.2
mesenchyme homeobox 1
chr10_-_73625951 0.07 ENST00000433394.1
ENST00000422491.7
ubiquitin specific peptidase 54
chr2_-_133568393 0.07 ENST00000317721.10
ENST00000405974.7
ENST00000409261.6
ENST00000409213.5
NCK associated protein 5
chr6_-_43014254 0.06 ENST00000642748.1
male-enhanced antigen 1
chr20_-_35438218 0.05 ENST00000374369.8
growth differentiation factor 5
chr2_-_179049986 0.05 ENST00000409284.1
ENST00000443758.6
ENST00000446116.5
coiled-coil domain containing 141
chr1_+_161766282 0.05 ENST00000680688.1
activating transcription factor 6
chr1_+_161766347 0.04 ENST00000679833.1
activating transcription factor 6
chr11_+_73308237 0.04 ENST00000263674.4
Rho guanine nucleotide exchange factor 17
chr19_+_48469354 0.04 ENST00000452733.7
ENST00000641098.1
cytohesin 2
chr9_-_92424427 0.04 ENST00000375550.5
osteomodulin
chr6_+_16129077 0.03 ENST00000356840.8
ENST00000349606.4
myosin regulatory light chain interacting protein
chr6_-_170553216 0.03 ENST00000262193.7
proteasome 20S subunit beta 1
chr2_+_203014721 0.03 ENST00000683091.1
neurobeachin like 1
chr11_-_61429385 0.03 ENST00000413184.6
cleavage and polyadenylation specific factor 7
chr6_-_159000174 0.03 ENST00000367069.7
radial spoke head 3
chr13_+_29428603 0.02 ENST00000380808.6
microtubule associated scaffold protein 2
chr11_-_27700472 0.01 ENST00000418212.5
ENST00000533246.5
brain derived neurotrophic factor
chr14_+_21042352 0.01 ENST00000298690.5
ribonuclease A family member 7
chr13_+_29428709 0.01 ENST00000542829.1
microtubule associated scaffold protein 2
chr22_+_41621163 0.01 ENST00000428575.6
X-ray repair cross complementing 6
chr2_-_24972032 0.00 ENST00000534855.5
DnaJ heat shock protein family (Hsp40) member C27

Network of associatons between targets according to the STRING database.

First level regulatory network of BRCA1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.1 1.5 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 0.3 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.1 0.7 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 1.2 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.1 0.4 GO:1903613 regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615)
0.1 0.7 GO:0097338 response to clozapine(GO:0097338)
0.1 0.9 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.3 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
0.1 0.6 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 0.2 GO:0046521 sphingoid catabolic process(GO:0046521)
0.0 0.8 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.1 GO:0032072 plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072)
0.0 0.1 GO:0097403 cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.0 0.4 GO:0060613 fat pad development(GO:0060613)
0.0 0.3 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.0 0.8 GO:0051412 response to corticosterone(GO:0051412)
0.0 0.2 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.0 0.4 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 1.7 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.7 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 0.2 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.3 GO:0030497 fatty acid elongation(GO:0030497)
0.0 0.5 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.3 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.5 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.3 GO:0035641 locomotory exploration behavior(GO:0035641)
0.0 0.1 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.0 0.4 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.0 0.3 GO:0006590 thyroid hormone generation(GO:0006590)
0.0 0.1 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 GO:0033269 internode region of axon(GO:0033269)
0.1 0.3 GO:0016939 kinesin II complex(GO:0016939)
0.1 1.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.3 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.0 0.2 GO:0070701 mucus layer(GO:0070701)
0.0 0.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.7 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 3.9 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.5 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 0.5 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.3 GO:0019948 SUMO activating enzyme activity(GO:0019948)
0.1 0.2 GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.1 0.2 GO:0016005 phospholipase A2 activator activity(GO:0016005)
0.0 0.3 GO:0102344 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.0 1.5 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.3 GO:0070573 metallodipeptidase activity(GO:0070573)
0.0 0.6 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.7 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.7 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.2 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0 0.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.0 0.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID RHODOPSIN PATHWAY Visual signal transduction: Rods

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.8 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 1.2 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.6 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.5 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.3 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.7 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.4 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters