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Illumina Body Map 2 (GSE30611)

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Results for BRCA1

Z-value: 0.53

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Transcription factors associated with BRCA1

Gene Symbol Gene ID Gene Info
BRCA1
ENSG00000012048.23 BRCA1 DNA repair associated

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BRCA1hg38_v1_chr17_-_43170191_431702450.115.7e-01Click!

Activity profile of BRCA1 motif

Sorted Z-values of BRCA1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_124919244 2.01 ENST00000408930.6
HEPN1
hepatocellular carcinoma, down-regulated 1
chr14_-_59630806 1.78 ENST00000342503.8
RTN1
reticulon 1
chr1_+_159171607 1.66 ENST00000368124.8
ENST00000368125.9
ENST00000416746.1
CADM3
cell adhesion molecule 3
chr14_-_59630582 1.63 ENST00000395090.5
RTN1
reticulon 1
chr2_-_157325808 1.45 ENST00000410096.6
ENST00000420719.6
ENST00000409216.5
ENST00000419116.2
ERMN
ermin
chr2_-_49974083 1.06 ENST00000636345.1
NRXN1
neurexin 1
chr6_+_12717660 0.92 ENST00000674637.1
PHACTR1
phosphatase and actin regulator 1
chr19_+_45467988 0.79 ENST00000615753.4
ENST00000585836.5
ENST00000417353.6
ENST00000591858.5
ENST00000443841.6
ENST00000590335.1
ENST00000353609.8
FOSB
FosB proto-oncogene, AP-1 transcription factor subunit
chr13_-_49444004 0.75 ENST00000410043.5
ENST00000409308.6
CAB39L
calcium binding protein 39 like
chr4_+_625555 0.71 ENST00000496514.6
ENST00000255622.10
PDE6B
phosphodiesterase 6B
chr1_+_84181630 0.70 ENST00000610457.1
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr10_-_24706622 0.68 ENST00000680286.1
ARHGAP21
Rho GTPase activating protein 21
chr2_-_157325659 0.67 ENST00000409925.1
ERMN
ermin
chr10_-_114632011 0.64 ENST00000651023.1
ABLIM1
actin binding LIM protein 1
chr3_-_127736329 0.59 ENST00000398101.7
MGLL
monoglyceride lipase
chr10_+_120851341 0.56 ENST00000263461.11
WDR11
WD repeat domain 11
chr14_+_31561376 0.54 ENST00000550649.5
ENST00000281081.12
NUBPL
nucleotide binding protein like
chr7_-_78771265 0.51 ENST00000630991.2
ENST00000629359.2
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr11_+_101914997 0.50 ENST00000263468.13
CEP126
centrosomal protein 126
chr5_+_140700437 0.49 ENST00000274712.8
ZMAT2
zinc finger matrin-type 2
chr10_-_100529854 0.48 ENST00000370320.4
ENST00000299166.9
ENST00000370322.5
NDUFB8
NADH:ubiquinone oxidoreductase subunit B8
chr2_-_144517506 0.47 ENST00000431672.4
ENST00000558170.6
ZEB2
zinc finger E-box binding homeobox 2
chr4_-_48780242 0.46 ENST00000507711.5
ENST00000358350.9
FRYL
FRY like transcription coactivator
chr10_+_120851427 0.45 ENST00000604585.5
WDR11
WD repeat domain 11
chr2_-_144517663 0.44 ENST00000427902.5
ENST00000462355.2
ENST00000470879.5
ENST00000409487.7
ENST00000435831.5
ENST00000630572.2
ZEB2
zinc finger E-box binding homeobox 2
chr2_-_49973939 0.43 ENST00000630656.1
NRXN1
neurexin 1
chr11_+_33258304 0.43 ENST00000531504.5
ENST00000456517.2
HIPK3
homeodomain interacting protein kinase 3
chr13_+_27251569 0.42 ENST00000272274.8
ENST00000319826.8
ENST00000326092.8
RPL21
ribosomal protein L21
chr2_+_108378176 0.42 ENST00000409309.3
SULT1C4
sulfotransferase family 1C member 4
chr5_+_126462339 0.42 ENST00000502348.5
GRAMD2B
GRAM domain containing 2B
chr13_+_27251545 0.42 ENST00000311549.11
RPL21
ribosomal protein L21
chr4_+_73436244 0.41 ENST00000226359.2
AFP
alpha fetoprotein
chr4_+_73436198 0.39 ENST00000395792.7
AFP
alpha fetoprotein
chr11_-_13463168 0.36 ENST00000526841.1
ENST00000278174.10
ENST00000529708.5
ENST00000528120.5
BTBD10
BTB domain containing 10
chr2_+_195657308 0.36 ENST00000418005.1
SLC39A10
solute carrier family 39 member 10
chrX_-_71068384 0.35 ENST00000276105.3
ENST00000622259.4
SNX12
sorting nexin 12
chr9_-_83978429 0.35 ENST00000351839.7
HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr9_-_21031614 0.35 ENST00000495827.3
HACD4
3-hydroxyacyl-CoA dehydratase 4
chr3_-_116445458 0.34 ENST00000490035.7
LSAMP
limbic system associated membrane protein
chr8_-_17002327 0.33 ENST00000180166.6
FGF20
fibroblast growth factor 20
chr11_-_72112750 0.31 ENST00000545680.5
ENST00000543587.5
ENST00000538393.5
ENST00000535234.5
ENST00000227618.8
ENST00000535503.5
ANAPC15
anaphase promoting complex subunit 15
chr1_-_170074568 0.27 ENST00000367767.5
ENST00000361580.7
ENST00000538366.5
KIFAP3
kinesin associated protein 3
chr3_+_184338826 0.27 ENST00000453072.5
FAM131A
family with sequence similarity 131 member A
chr19_+_47130782 0.26 ENST00000597808.5
ENST00000413379.7
ENST00000600706.5
ENST00000270225.12
ENST00000598840.5
ENST00000600753.1
ENST00000392776.3
SAE1
SUMO1 activating enzyme subunit 1
chr7_-_78770859 0.26 ENST00000636717.1
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr11_-_61429934 0.26 ENST00000541963.5
ENST00000477890.6
ENST00000439958.8
CPSF7
cleavage and polyadenylation specific factor 7
chr14_+_22040576 0.25 ENST00000390448.3
TRAV20
T cell receptor alpha variable 20
chr7_-_78771058 0.24 ENST00000628781.1
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr11_-_61430008 0.23 ENST00000394888.8
CPSF7
cleavage and polyadenylation specific factor 7
chr2_+_108377947 0.23 ENST00000272452.7
SULT1C4
sulfotransferase family 1C member 4
chr6_-_158999748 0.22 ENST00000449822.5
RSPH3
radial spoke head 3
chr7_+_100119607 0.21 ENST00000262932.5
CNPY4
canopy FGF signaling regulator 4
chr3_-_177196451 0.20 ENST00000430069.5
ENST00000630796.2
ENST00000428970.5
TBL1XR1
TBL1X receptor 1
chr12_-_116881431 0.20 ENST00000257572.5
HRK
harakiri, BCL2 interacting protein
chr8_+_96761232 0.20 ENST00000521142.1
CPQ
carboxypeptidase Q
chr3_-_177196402 0.20 ENST00000437738.5
ENST00000424913.5
ENST00000443315.5
TBL1XR1
TBL1X receptor 1
chr6_+_33204645 0.18 ENST00000374662.4
HSD17B8
hydroxysteroid 17-beta dehydrogenase 8
chr11_+_1099730 0.18 ENST00000674892.1
MUC2
mucin 2, oligomeric mucus/gel-forming
chr11_+_61430036 0.18 ENST00000541135.5
ENSG00000256591.5
novel transcript
chr2_-_151261839 0.17 ENST00000331426.6
RBM43
RNA binding motif protein 43
chr7_-_78771108 0.17 ENST00000626691.2
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr8_-_80171106 0.16 ENST00000519303.6
TPD52
tumor protein D52
chr14_+_22163226 0.16 ENST00000390458.3
TRAV29DV5
T cell receptor alpha variable 29/delta variable 5
chr19_-_34677157 0.16 ENST00000601241.6
SCGB2B2
secretoglobin family 2B member 2
chr4_-_184649436 0.16 ENST00000308394.9
ENST00000517513.5
ENST00000447121.2
ENST00000393588.8
ENST00000523916.5
CASP3
caspase 3
chr12_-_80937918 0.16 ENST00000552864.6
LIN7A
lin-7 homolog A, crumbs cell polarity complex component
chr17_+_76376581 0.15 ENST00000591651.5
ENST00000545180.5
SPHK1
sphingosine kinase 1
chr14_-_68794597 0.14 ENST00000336440.3
ZFP36L1
ZFP36 ring finger protein like 1
chr15_+_57248015 0.13 ENST00000559710.5
ENST00000559703.1
TCF12
transcription factor 12
chr8_+_96760974 0.13 ENST00000519484.1
CPQ
carboxypeptidase Q
chr14_+_72926377 0.13 ENST00000353777.7
ENST00000358377.7
ENST00000394234.6
ENST00000509153.5
ENST00000555042.5
DCAF4
DDB1 and CUL4 associated factor 4
chrX_-_143635081 0.12 ENST00000338017.8
SLITRK4
SLIT and NTRK like family member 4
chr1_-_160262501 0.12 ENST00000447377.5
DCAF8
DDB1 and CUL4 associated factor 8
chr14_+_88385643 0.12 ENST00000393545.9
ENST00000356583.9
ENST00000555401.5
ENST00000553885.5
SPATA7
spermatogenesis associated 7
chr9_+_2015969 0.12 ENST00000636903.1
ENST00000637352.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr13_-_30464234 0.12 ENST00000399489.5
ENST00000339872.8
HMGB1
high mobility group box 1
chr20_+_58907981 0.11 ENST00000656419.1
GNAS
GNAS complex locus
chr19_-_37172670 0.11 ENST00000588354.1
ENST00000292841.10
ENST00000356958.8
ZNF585A
zinc finger protein 585A
chr18_-_26091175 0.11 ENST00000579061.5
ENST00000542420.6
SS18
SS18 subunit of BAF chromatin remodeling complex
chr5_+_146203544 0.11 ENST00000506502.2
ENSG00000275740.1
novel readthrough transcript
chr1_+_171557845 0.10 ENST00000644916.1
PRRC2C
proline rich coiled-coil 2C
chr13_+_102799322 0.09 ENST00000639132.1
BIVM-ERCC5
BIVM-ERCC5 readthrough
chr12_-_95116967 0.09 ENST00000551521.5
FGD6
FYVE, RhoGEF and PH domain containing 6
chr11_-_119340914 0.09 ENST00000634633.1
C1QTNF5
C1q and TNF related 5
chr5_+_146203593 0.09 ENST00000265271.7
RBM27
RNA binding motif protein 27
chr20_-_49913693 0.09 ENST00000422556.1
SPATA2
spermatogenesis associated 2
chr12_-_66678934 0.09 ENST00000545666.5
ENST00000398016.7
ENST00000359742.9
ENST00000538211.5
GRIP1
glutamate receptor interacting protein 1
chr19_-_12801787 0.08 ENST00000334482.9
ENST00000301522.3
PRDX2
peroxiredoxin 2
chr12_+_401621 0.08 ENST00000412006.6
ENST00000239830.9
CCDC77
coiled-coil domain containing 77
chr17_-_43661915 0.08 ENST00000318579.9
ENST00000393661.2
MEOX1
mesenchyme homeobox 1
chr10_-_73625951 0.07 ENST00000433394.1
ENST00000422491.7
USP54
ubiquitin specific peptidase 54
chr2_-_133568393 0.07 ENST00000317721.10
ENST00000405974.7
ENST00000409261.6
ENST00000409213.5
NCKAP5
NCK associated protein 5
chr6_-_43014254 0.06 ENST00000642748.1
MEA1
male-enhanced antigen 1
chr20_-_35438218 0.05 ENST00000374369.8
GDF5
growth differentiation factor 5
chr2_-_179049986 0.05 ENST00000409284.1
ENST00000443758.6
ENST00000446116.5
CCDC141
coiled-coil domain containing 141
chr1_+_161766282 0.05 ENST00000680688.1
ATF6
activating transcription factor 6
chr1_+_161766347 0.04 ENST00000679833.1
ATF6
activating transcription factor 6
chr11_+_73308237 0.04 ENST00000263674.4
ARHGEF17
Rho guanine nucleotide exchange factor 17
chr19_+_48469354 0.04 ENST00000452733.7
ENST00000641098.1
CYTH2
cytohesin 2
chr9_-_92424427 0.04 ENST00000375550.5
OMD
osteomodulin
chr6_+_16129077 0.03 ENST00000356840.8
ENST00000349606.4
MYLIP
myosin regulatory light chain interacting protein
chr6_-_170553216 0.03 ENST00000262193.7
PSMB1
proteasome 20S subunit beta 1
chr2_+_203014721 0.03 ENST00000683091.1
NBEAL1
neurobeachin like 1
chr11_-_61429385 0.03 ENST00000413184.6
CPSF7
cleavage and polyadenylation specific factor 7
chr6_-_159000174 0.03 ENST00000367069.7
RSPH3
radial spoke head 3
chr13_+_29428603 0.02 ENST00000380808.6
MTUS2
microtubule associated scaffold protein 2
chr11_-_27700472 0.01 ENST00000418212.5
ENST00000533246.5
BDNF
brain derived neurotrophic factor
chr14_+_21042352 0.01 ENST00000298690.5
RNASE7
ribonuclease A family member 7
chr13_+_29428709 0.01 ENST00000542829.1
MTUS2
microtubule associated scaffold protein 2
chr22_+_41621163 0.01 ENST00000428575.6
XRCC6
X-ray repair cross complementing 6
chr2_-_24972032 0.00 ENST00000534855.5
DNAJC27
DnaJ heat shock protein family (Hsp40) member C27

Network of associatons between targets according to the STRING database.

First level regulatory network of BRCA1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.1 1.5 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 0.3 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.1 0.7 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 1.2 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.1 0.4 GO:1903613 regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615)
0.1 0.7 GO:0097338 response to clozapine(GO:0097338)
0.1 0.9 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.3 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
0.1 0.6 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 0.2 GO:0046521 sphingoid catabolic process(GO:0046521)
0.0 0.8 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.1 GO:0032072 plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072)
0.0 0.1 GO:0097403 cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.0 0.4 GO:0060613 fat pad development(GO:0060613)
0.0 0.3 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.0 0.8 GO:0051412 response to corticosterone(GO:0051412)
0.0 0.2 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.0 0.4 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 1.7 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.7 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 0.2 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.3 GO:0030497 fatty acid elongation(GO:0030497)
0.0 0.5 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.3 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.5 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.3 GO:0035641 locomotory exploration behavior(GO:0035641)
0.0 0.1 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.0 0.4 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.0 0.3 GO:0006590 thyroid hormone generation(GO:0006590)
0.0 0.1 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 GO:0033269 internode region of axon(GO:0033269)
0.1 0.3 GO:0016939 kinesin II complex(GO:0016939)
0.1 1.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.3 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.0 0.2 GO:0070701 mucus layer(GO:0070701)
0.0 0.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.7 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 3.9 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.5 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 0.5 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.3 GO:0019948 SUMO activating enzyme activity(GO:0019948)
0.1 0.2 GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.1 0.2 GO:0016005 phospholipase A2 activator activity(GO:0016005)
0.0 0.3 GO:0102344 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.0 1.5 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.3 GO:0070573 metallodipeptidase activity(GO:0070573)
0.0 0.6 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.7 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.7 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.2 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0 0.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.0 0.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID RHODOPSIN PATHWAY Visual signal transduction: Rods

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.8 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 1.2 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.6 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.5 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.3 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.7 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.4 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters