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Illumina Body Map 2 (GSE30611)

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Results for CBFB

Z-value: 0.57

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Transcription factors associated with CBFB

Gene Symbol Gene ID Gene Info
CBFB
ENSG00000067955.15 core-binding factor subunit beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CBFBhg38_v1_chr16_+_67029133_670291850.048.1e-01Click!

Activity profile of CBFB motif

Sorted Z-values of CBFB motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_46798998 2.62 ENST00000640628.1
ENST00000271153.8
ENST00000371923.9
ENST00000371919.8
ENST00000614163.4
CYP4B1
cytochrome P450 family 4 subfamily B member 1
chr6_-_75202792 2.37 ENST00000416123.6
COL12A1
collagen type XII alpha 1 chain
chr3_-_99850976 2.32 ENST00000487087.5
FILIP1L
filamin A interacting protein 1 like
chr22_+_22880706 2.01 ENST00000390319.2
IGLV3-1
immunoglobulin lambda variable 3-1
chr15_+_49423233 1.57 ENST00000560270.1
ENST00000267843.9
ENST00000560979.1
FGF7
fibroblast growth factor 7
chr22_+_31082860 1.46 ENST00000619644.4
SMTN
smoothelin
chr10_+_17228515 1.35 ENST00000478746.1
VIM
vimentin
chr20_+_46008900 1.26 ENST00000372330.3
MMP9
matrix metallopeptidase 9
chr14_-_24508251 1.11 ENST00000250378.7
ENST00000206446.4
CMA1
chymase 1
chr4_+_70226116 1.04 ENST00000317987.6
FDCSP
follicular dendritic cell secreted protein
chr2_+_173090598 1.02 ENST00000422149.1
MAP3K20
mitogen-activated protein kinase kinase kinase 20
chr10_-_29522527 1.01 ENST00000632315.1
SVIL
supervillin
chr8_+_103372388 0.98 ENST00000520337.1
CTHRC1
collagen triple helix repeat containing 1
chr7_+_120988683 0.95 ENST00000340646.9
ENST00000310396.10
CPED1
cadherin like and PC-esterase domain containing 1
chr11_+_114439424 0.94 ENST00000544196.5
ENST00000265881.10
ENST00000539754.5
ENST00000539275.5
REXO2
RNA exonuclease 2
chrX_+_68829009 0.92 ENST00000204961.5
EFNB1
ephrin B1
chr3_+_157436842 0.91 ENST00000295927.4
PTX3
pentraxin 3
chr10_+_17229267 0.90 ENST00000224237.9
VIM
vimentin
chr11_+_114439515 0.89 ENST00000539119.5
REXO2
RNA exonuclease 2
chr10_+_17228806 0.82 ENST00000497849.1
VIM
vimentin
chr15_+_73684204 0.79 ENST00000537340.6
ENST00000318424.9
CD276
CD276 molecule
chr12_-_55707865 0.73 ENST00000347027.10
ENST00000257879.11
ENST00000553804.6
ITGA7
integrin subunit alpha 7
chr14_-_60649449 0.69 ENST00000645694.3
SIX1
SIX homeobox 1
chr2_-_157444044 0.64 ENST00000264192.8
CYTIP
cytohesin 1 interacting protein
chr17_-_36090133 0.59 ENST00000613922.2
CCL3
C-C motif chemokine ligand 3
chr3_-_190122317 0.55 ENST00000427335.6
P3H2
prolyl 3-hydroxylase 2
chr14_+_85530163 0.50 ENST00000554746.1
FLRT2
fibronectin leucine rich transmembrane protein 2
chr1_+_209686173 0.48 ENST00000615289.4
ENST00000367028.6
ENST00000261465.5
HSD11B1
hydroxysteroid 11-beta dehydrogenase 1
chrX_-_49184789 0.48 ENST00000453382.5
ENST00000432913.5
PRICKLE3
prickle planar cell polarity protein 3
chr5_+_35856883 0.46 ENST00000506850.5
ENST00000303115.8
ENST00000511982.1
IL7R
interleukin 7 receptor
chr15_+_67098582 0.45 ENST00000559092.1
ENST00000560175.5
SMAD3
SMAD family member 3
chr17_+_34255274 0.43 ENST00000580907.5
ENST00000225831.4
CCL2
C-C motif chemokine ligand 2
chr9_-_127778659 0.42 ENST00000314830.13
SH2D3C
SH2 domain containing 3C
chr1_-_21294384 0.41 ENST00000527991.2
ECE1
endothelin converting enzyme 1
chr18_-_48409292 0.41 ENST00000589194.5
ENST00000591279.5
ENST00000590855.5
ENST00000587107.5
ENST00000588970.5
ENST00000586525.5
ENST00000592387.5
ENST00000590800.6
ZBTB7C
zinc finger and BTB domain containing 7C
chr20_+_56412249 0.40 ENST00000679887.1
ENST00000434344.2
CASS4
Cas scaffold protein family member 4
chr2_-_64653906 0.39 ENST00000313349.3
SERTAD2
SERTA domain containing 2
chr21_-_35049238 0.38 ENST00000416754.1
ENST00000437180.5
ENST00000455571.5
ENST00000675419.1
RUNX1
RUNX family transcription factor 1
chr1_-_11796536 0.37 ENST00000641820.1
MTHFR
methylenetetrahydrofolate reductase
chr14_+_85530127 0.37 ENST00000330753.6
FLRT2
fibronectin leucine rich transmembrane protein 2
chr16_+_85611401 0.28 ENST00000405402.6
GSE1
Gse1 coiled-coil protein
chr21_-_35049327 0.27 ENST00000300305.7
RUNX1
RUNX family transcription factor 1
chr6_+_30940970 0.26 ENST00000462446.6
ENST00000304311.3
MUCL3
mucin like 3
chr17_+_77320252 0.26 ENST00000591934.1
SEPTIN9
septin 9
chr2_-_127220293 0.24 ENST00000664447.2
ENST00000409327.2
CYP27C1
cytochrome P450 family 27 subfamily C member 1
chr11_-_58575846 0.24 ENST00000395074.7
LPXN
leupaxin
chr2_+_233917371 0.24 ENST00000324695.9
ENST00000433712.6
TRPM8
transient receptor potential cation channel subfamily M member 8
chr3_+_9933805 0.22 ENST00000684493.1
ENST00000673935.2
ENST00000684181.1
ENST00000683189.1
ENST00000383811.8
ENST00000452070.6
ENST00000682642.1
ENST00000684659.1
ENST00000491527.2
ENST00000326434.9
ENST00000682783.1
ENST00000683835.1
ENST00000682570.1
CRELD1
cysteine rich with EGF like domains 1
chr12_-_14696571 0.21 ENST00000261170.5
GUCY2C
guanylate cyclase 2C
chr13_-_46182136 0.20 ENST00000323076.7
LCP1
lymphocyte cytosolic protein 1
chr3_-_11568764 0.20 ENST00000424529.6
VGLL4
vestigial like family member 4
chr9_-_35079923 0.20 ENST00000378643.8
ENST00000448890.1
FANCG
FA complementation group G
chr1_-_206772484 0.18 ENST00000423557.1
IL10
interleukin 10
chr8_-_28889958 0.17 ENST00000521022.6
INTS9
integrator complex subunit 9
chr8_-_28889909 0.16 ENST00000523436.5
ENST00000521777.5
ENST00000520184.1
INTS9
integrator complex subunit 9
chr12_-_52192007 0.15 ENST00000394815.3
KRT80
keratin 80
chr14_-_59484006 0.15 ENST00000481608.1
L3HYPDH
trans-L-3-hydroxyproline dehydratase
chr12_-_52191981 0.15 ENST00000313234.9
KRT80
keratin 80
chr16_+_53054973 0.15 ENST00000447540.6
ENST00000615216.4
ENST00000566029.5
CHD9
chromodomain helicase DNA binding protein 9
chr18_-_55422262 0.15 ENST00000629343.2
TCF4
transcription factor 4
chr12_-_68159732 0.14 ENST00000229135.4
IFNG
interferon gamma
chr1_-_184754808 0.14 ENST00000318130.13
ENST00000367512.7
EDEM3
ER degradation enhancing alpha-mannosidase like protein 3
chr20_+_56412393 0.13 ENST00000679529.1
CASS4
Cas scaffold protein family member 4
chr14_-_59484317 0.13 ENST00000247194.9
L3HYPDH
trans-L-3-hydroxyproline dehydratase
chr18_-_55422241 0.12 ENST00000628636.2
TCF4
transcription factor 4
chr20_+_56412112 0.12 ENST00000360314.7
CASS4
Cas scaffold protein family member 4
chr2_-_87021844 0.11 ENST00000355705.4
ENST00000409310.6
PLGLB1
plasminogen like B1
chr15_+_73683938 0.11 ENST00000567189.5
CD276
CD276 molecule
chr18_-_55422492 0.10 ENST00000561992.5
ENST00000630712.2
TCF4
transcription factor 4
chr2_+_68365274 0.10 ENST00000234313.8
PLEK
pleckstrin
chr11_-_66336396 0.10 ENST00000627248.1
ENST00000311320.9
RIN1
Ras and Rab interactor 1
chr6_+_27957241 0.09 ENST00000244623.1
OR2B6
olfactory receptor family 2 subfamily B member 6
chr21_+_46326288 0.09 ENST00000652508.1
ENSG00000286224.1
novel protein
chr7_+_117479133 0.09 ENST00000446805.1
CFTR
CF transmembrane conductance regulator
chr17_-_41027198 0.07 ENST00000361883.6
KRTAP1-5
keratin associated protein 1-5
chr11_-_65117639 0.07 ENST00000528598.1
ENST00000310597.6
ZNHIT2
zinc finger HIT-type containing 2
chr6_+_26500296 0.07 ENST00000684113.1
BTN1A1
butyrophilin subfamily 1 member A1
chr9_-_120876356 0.06 ENST00000456291.1
PHF19
PHD finger protein 19
chr8_-_28890164 0.06 ENST00000416984.6
INTS9
integrator complex subunit 9
chr14_+_22281097 0.05 ENST00000390465.2
TRAV38-2DV8
T cell receptor alpha variable 38-2/delta variable 8
chr6_+_52186373 0.03 ENST00000648244.1
IL17A
interleukin 17A
chr2_+_102418642 0.03 ENST00000264260.6
IL18RAP
interleukin 18 receptor accessory protein
chr18_-_55422306 0.02 ENST00000566777.5
ENST00000626584.2
TCF4
transcription factor 4
chr18_-_55422290 0.01 ENST00000625925.2
TCF4
transcription factor 4
chr1_+_159800503 0.01 ENST00000536257.5
ENST00000321935.10
FCRL6
Fc receptor like 6
chr14_+_22450089 0.01 ENST00000390473.1
TRDJ1
T cell receptor delta joining 1
chr7_+_100969565 0.01 ENST00000536621.6
ENST00000379442.7
MUC12
mucin 12, cell surface associated

Network of associatons between targets according to the STRING database.

First level regulatory network of CBFB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.6 GO:0018879 biphenyl metabolic process(GO:0018879)
0.5 1.6 GO:0061033 secretion by lung epithelial cell involved in lung growth(GO:0061033)
0.4 1.1 GO:0050720 interleukin-1 beta biosynthetic process(GO:0050720)
0.3 0.9 GO:1903015 regulation of exo-alpha-sialidase activity(GO:1903015)
0.2 0.7 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.2 3.1 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.1 0.4 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
0.1 1.0 GO:0043932 ossification involved in bone remodeling(GO:0043932)
0.1 1.3 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.1 0.6 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.1 0.9 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.1 0.4 GO:0033274 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.1 0.2 GO:0032701 negative regulation of interleukin-18 production(GO:0032701) negative regulation of cytokine activity(GO:0060302) negative regulation of chemokine (C-C motif) ligand 5 production(GO:0071650)
0.1 0.4 GO:0010816 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.1 0.5 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.0 0.9 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.1 GO:0060559 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) positive regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000309)
0.0 0.7 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.5 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 2.4 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.1 GO:1904382 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.0 0.2 GO:0050955 thermoception(GO:0050955)
0.0 1.8 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 0.2 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 0.4 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0 0.1 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.0 0.5 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 0.4 GO:0016180 snRNA processing(GO:0016180)
0.0 0.2 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.5 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 1.0 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.0 0.1 GO:0033625 positive regulation of integrin activation(GO:0033625)
0.0 1.0 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 2.0 GO:0030449 regulation of complement activation(GO:0030449)
0.0 0.9 GO:0001755 neural crest cell migration(GO:0001755)
0.0 0.1 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.2 GO:0042574 retinal metabolic process(GO:0042574)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.4 GO:0005595 collagen type XII trimer(GO:0005595)
0.1 0.4 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.0 1.0 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.5 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 2.2 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.4 GO:0032039 integrator complex(GO:0032039)
0.0 3.4 GO:0005882 intermediate filament(GO:0005882)
0.0 0.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.7 GO:0008305 integrin complex(GO:0008305)
0.0 1.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.1 GO:1990254 keratin filament binding(GO:1990254)
0.2 0.5 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.2 0.5 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.1 2.4 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.1 0.6 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.1 2.8 GO:0015643 toxic substance binding(GO:0015643)
0.1 0.5 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797)
0.1 0.4 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 0.9 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.3 GO:0016855 racemase and epimerase activity, acting on amino acids and derivatives(GO:0016855) racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661)
0.1 2.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.4 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 0.5 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 0.2 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 1.8 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 1.0 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.1 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.0 1.0 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.7 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.4 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 4.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.5 GO:0008307 structural constituent of muscle(GO:0008307)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.1 PID AURORA B PATHWAY Aurora B signaling
0.0 3.6 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 1.0 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.9 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.7 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.7 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.6 PID IL23 PATHWAY IL23-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.1 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.6 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 2.6 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 2.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.5 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.9 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.5 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL