ISMARA results: CREB1

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Illumina Body Map 2 (GSE30611)

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Results for CREB1

Z-value: 2.09

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Transcription factors associated with CREB1

Gene Symbol	Gene ID	Gene Info
CREB1 Ensembl NCBI GeneCards UniProt	ENSG00000118260.15	cAMP responsive element binding protein 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CREB1	hg38_v1_chr2_+_207529731_207529747	0.23	2.1e-01	Click!

Activity profile of CREB1 motif

Sorted Z-values of CREB1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_-_112183698 Show fit	6.95	ENST00000369425.5 ENST00000348367.9	GPAM Ensembl NCBI GeneCards UniProt Show fit	glycerol-3-phosphate acyltransferase, mitochondrial
chr12_-_132144302 Show fit	3.70	ENST00000397333.4	DDX51 Ensembl NCBI GeneCards UniProt Show fit	DEAD-box helicase 51
chr16_-_68023201 Show fit	3.24	ENST00000332395.7	DDX28 Ensembl NCBI GeneCards UniProt Show fit	DEAD-box helicase 28
chr12_+_132144417 Show fit	3.21	ENST00000330579.6	NOC4L Ensembl NCBI GeneCards UniProt Show fit	nucleolar complex associated 4 homolog
chr17_-_75667088 Show fit	2.71	ENST00000578201.5 ENST00000423245.6 ENST00000317905.10	RECQL5 Ensembl NCBI GeneCards UniProt Show fit	RecQ like helicase 5
chr16_+_19067606 Show fit	2.51	ENST00000321998.10	COQ7 Ensembl NCBI GeneCards UniProt Show fit	coenzyme Q7, hydroxylase
chr8_-_143541425 Show fit	2.40	ENST00000262577.6	ZC3H3 Ensembl NCBI GeneCards UniProt Show fit	zinc finger CCCH-type containing 3
chr12_+_54000096 Show fit	2.35	ENST00000303450.5	HOXC9 Ensembl NCBI GeneCards UniProt Show fit	homeobox C9
chr16_+_19067989 Show fit	2.30	ENST00000569127.1	COQ7 Ensembl NCBI GeneCards UniProt Show fit	coenzyme Q7, hydroxylase
chr9_-_137188540 Show fit	2.23	ENST00000323927.3	ANAPC2 Ensembl NCBI GeneCards UniProt Show fit	anaphase promoting complex subunit 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of CREB1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	8.8	GO:1901663	ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1	7.2	GO:0006400	tRNA modification(GO:0006400)
0.8	6.9	GO:0070236	negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1	6.2	GO:0010501	RNA secondary structure unwinding(GO:0010501)
0.9	4.5	GO:1990414	replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1	4.1	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.8	3.2	GO:1902775	mitochondrial large ribosomal subunit assembly(GO:1902775)
0.1	3.2	GO:0070933	histone H4 deacetylation(GO:0070933)
0.6	3.1	GO:0070901	mitochondrial tRNA methylation(GO:0070901)
0.3	3.0	GO:0090158	endoplasmic reticulum membrane organization(GO:0090158) positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953)

Showing 1 to 10 of 132 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	20.4	GO:0005743	mitochondrial inner membrane(GO:0005743)
1.0	6.0	GO:0043527	tRNA methyltransferase complex(GO:0043527)
0.1	5.1	GO:0042645	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0	5.1	GO:0005759	mitochondrial matrix(GO:0005759)
0.1	4.5	GO:0035861	site of double-strand break(GO:0035861)
0.0	4.0	GO:0016591	DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
1.1	3.2	GO:0030689	Noc complex(GO:0030689)
0.2	2.9	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.1	2.9	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1	2.9	GO:0005680	anaphase-promoting complex(GO:0005680)

Showing 1 to 10 of 80 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	11.2	GO:0004004	ATP-dependent RNA helicase activity(GO:0004004)
0.1	7.9	GO:0004497	monooxygenase activity(GO:0004497)
1.0	6.9	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	4.0	GO:0061630	ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.5	3.9	GO:0009378	four-way junction helicase activity(GO:0009378)
0.2	3.6	GO:0016423	tRNA (guanine) methyltransferase activity(GO:0016423)
0.7	3.4	GO:0016429	tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
0.1	3.2	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	3.2	GO:0004386	helicase activity(GO:0004386)
0.0	3.1	GO:0003743	translation initiation factor activity(GO:0003743)

Showing 1 to 10 of 96 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.9	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	2.4	PID FANCONI PATHWAY	Fanconi anemia pathway
0.0	1.8	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1	1.7	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	1.6	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.0	1.2	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	0.9	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	0.5	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.0	0.3	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.0	0.3	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway

Showing 1 to 10 of 11 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	6.9	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.1	5.3	REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.1	3.2	REACTOME PHOSPHORYLATION OF THE APC C	Genes involved in Phosphorylation of the APC/C
0.1	2.5	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.1	2.4	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.2	2.3	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	1.9	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER
0.1	1.7	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.1	1.5	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes
0.1	1.5	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint

Showing 1 to 10 of 29 entries

Results for CREB1

Z-value: 2.09

Motif logo

Transcription factors associated with CREB1

Activity-expression correlation:

Activity profile of CREB1 motif

Sorted Z-values of CREB1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of CREB1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: