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Illumina Body Map 2 (GSE30611)

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Results for DMBX1

Z-value: 0.59

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Transcription factors associated with DMBX1

Gene Symbol Gene ID Gene Info
DMBX1
ENSG00000197587.11 diencephalon/mesencephalon homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DMBX1hg38_v1_chr1_+_46489800_464898420.531.8e-03Click!

Activity profile of DMBX1 motif

Sorted Z-values of DMBX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_3372666 2.25 ENST00000399974.5
MTRNR2L4
MT-RNR2 like 4
chr2_-_174846405 2.00 ENST00000409597.5
ENST00000413882.6
CHN1
chimerin 1
chr5_+_170232912 1.25 ENST00000524171.5
ENST00000517575.4
ENST00000518395.2
ENST00000593851.5
C5orf58
chromosome 5 open reading frame 58
chr12_-_21334858 1.19 ENST00000445053.1
ENST00000458504.5
ENST00000422327.5
ENST00000683939.1
SLCO1A2
solute carrier organic anion transporter family member 1A2
chr14_-_106511856 1.11 ENST00000390622.2
IGHV1-46
immunoglobulin heavy variable 1-46
chr12_-_54981838 1.06 ENST00000316577.12
TESPA1
thymocyte expressed, positive selection associated 1
chr7_+_148339452 0.98 ENST00000463592.3
CNTNAP2
contactin associated protein 2
chr20_-_45101112 0.86 ENST00000306117.5
ENST00000537075.3
KCNS1
potassium voltage-gated channel modifier subfamily S member 1
chr12_-_62192762 0.85 ENST00000416284.8
TAFA2
TAFA chemokine like family member 2
chr5_-_55692731 0.79 ENST00000502247.1
SLC38A9
solute carrier family 38 member 9
chr7_-_135728177 0.77 ENST00000682651.1
ENST00000354042.8
SLC13A4
solute carrier family 13 member 4
chr18_-_37565765 0.77 ENST00000361795.9
ENST00000420428.7
CELF4
CUGBP Elav-like family member 4
chr11_+_61481110 0.76 ENST00000338608.7
ENST00000432063.6
PPP1R32
protein phosphatase 1 regulatory subunit 32
chr12_-_49187369 0.74 ENST00000547939.6
TUBA1A
tubulin alpha 1a
chr14_+_21736136 0.71 ENST00000390426.2
TRAV4
T cell receptor alpha variable 4
chr20_+_33217325 0.69 ENST00000375452.3
ENST00000375454.8
BPIFA3
BPI fold containing family A member 3
chrX_-_103311004 0.68 ENST00000372674.5
BEX2
brain expressed X-linked 2
chr18_+_54591159 0.67 ENST00000321600.1
ENST00000648945.2
DYNAP
dynactin associated protein
chr14_+_21797272 0.66 ENST00000390430.2
TRAV8-1
T cell receptor alpha variable 8-1
chr5_-_55692620 0.63 ENST00000503817.5
ENST00000512595.5
SLC38A9
solute carrier family 38 member 9
chr12_+_57578238 0.62 ENST00000675907.1
KIF5A
kinesin family member 5A
chr14_+_96797304 0.61 ENST00000553683.2
ENST00000680538.1
ENST00000681195.1
ENST00000679727.1
ENST00000680509.1
ENST00000557222.6
ENST00000680683.1
ENST00000680335.1
ENST00000216639.8
ENST00000679736.1
ENST00000681176.1
ENST00000557352.2
ENST00000679903.1
ENST00000681419.1
ENST00000680849.1
ENST00000681493.1
ENST00000679770.1
ENST00000681355.1
ENST00000681344.1
VRK1
VRK serine/threonine kinase 1
chr18_-_37565628 0.60 ENST00000334919.9
ENST00000591282.5
ENST00000588597.5
CELF4
CUGBP Elav-like family member 4
chr7_+_142450941 0.57 ENST00000390368.2
TRBV6-5
T cell receptor beta variable 6-5
chr18_-_37565714 0.57 ENST00000591287.5
ENST00000601019.5
ENST00000601392.5
CELF4
CUGBP Elav-like family member 4
chr16_-_31065011 0.56 ENST00000539836.3
ENST00000535577.5
ENST00000442862.2
ZNF668
zinc finger protein 668
chr1_+_19882374 0.52 ENST00000375120.4
OTUD3
OTU deubiquitinase 3
chr10_-_97270638 0.51 ENST00000371027.5
ARHGAP19
Rho GTPase activating protein 19
chr17_+_50834581 0.50 ENST00000426127.1
WFIKKN2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr2_+_130755531 0.49 ENST00000321420.5
AMER3
APC membrane recruitment protein 3
chr19_+_40778216 0.48 ENST00000594800.5
ENST00000357052.8
ENST00000602173.5
RAB4B
RAB4B, member RAS oncogene family
chr2_-_27264083 0.48 ENST00000432351.5
SLC30A3
solute carrier family 30 member 3
chr7_-_100177336 0.48 ENST00000292377.4
GPC2
glypican 2
chr4_+_625555 0.48 ENST00000496514.6
ENST00000255622.10
PDE6B
phosphodiesterase 6B
chr19_-_42412347 0.47 ENST00000601189.1
ENST00000599211.1
LIPE
lipase E, hormone sensitive type
chr17_-_50129792 0.47 ENST00000503131.1
SAMD14
sterile alpha motif domain containing 14
chr1_+_206214723 0.47 ENST00000572793.2
SRGAP2
SLIT-ROBO Rho GTPase activating protein 2
chr3_+_188947199 0.46 ENST00000433971.5
TPRG1
tumor protein p63 regulated 1
chr11_+_121576760 0.46 ENST00000532694.5
ENST00000534286.5
SORL1
sortilin related receptor 1
chr18_-_37565825 0.44 ENST00000603232.6
CELF4
CUGBP Elav-like family member 4
chr11_+_44565627 0.44 ENST00000532544.5
ENST00000525210.5
ENST00000227155.9
ENST00000527737.5
ENST00000524704.5
CD82
CD82 molecule
chr3_-_19934189 0.43 ENST00000295824.14
EFHB
EF-hand domain family member B
chr12_-_118190510 0.42 ENST00000540561.5
ENST00000537952.1
ENST00000537822.1
TAOK3
TAO kinase 3
chr6_+_130018565 0.41 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL3
L3MBTL histone methyl-lysine binding protein 3
chr5_+_176313080 0.39 ENST00000332772.4
SIMC1
SUMO interacting motifs containing 1
chrX_-_15854743 0.39 ENST00000450644.2
AP1S2
adaptor related protein complex 1 subunit sigma 2
chr3_-_49021045 0.37 ENST00000440857.5
DALRD3
DALR anticodon binding domain containing 3
chr8_-_124565699 0.36 ENST00000519168.5
MTSS1
MTSS I-BAR domain containing 1
chr7_+_142469521 0.34 ENST00000390371.3
TRBV6-6
T cell receptor beta variable 6-6
chr17_-_4739866 0.34 ENST00000574412.6
ENST00000293778.12
CXCL16
C-X-C motif chemokine ligand 16
chr16_-_31064952 0.34 ENST00000426488.6
ZNF668
zinc finger protein 668
chr12_-_76067469 0.33 ENST00000551524.5
NAP1L1
nucleosome assembly protein 1 like 1
chr14_-_106875069 0.33 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chr19_+_45498439 0.33 ENST00000451287.7
PPM1N
protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)
chr15_+_81182579 0.32 ENST00000302987.9
IL16
interleukin 16
chr3_-_56977354 0.32 ENST00000473779.5
ARHGEF3
Rho guanine nucleotide exchange factor 3
chr11_+_44565591 0.32 ENST00000342935.7
CD82
CD82 molecule
chr3_+_49020443 0.31 ENST00000326912.8
NDUFAF3
NADH:ubiquinone oxidoreductase complex assembly factor 3
chrX_-_15854791 0.31 ENST00000545766.7
ENST00000380291.5
ENST00000672987.1
ENST00000329235.6
AP1S2
adaptor related protein complex 1 subunit sigma 2
chr12_+_53300027 0.31 ENST00000549488.5
MYG1
MYG1 exonuclease
chr6_+_42746958 0.31 ENST00000614467.4
BICRAL
BRD4 interacting chromatin remodeling complex associated protein like
chr3_-_151203201 0.30 ENST00000480322.1
ENST00000309180.6
GPR171
G protein-coupled receptor 171
chr15_+_73873604 0.26 ENST00000535547.6
ENST00000562056.1
TBC1D21
TBC1 domain family member 21
chr17_+_4740005 0.26 ENST00000269289.10
ZMYND15
zinc finger MYND-type containing 15
chr20_+_35968566 0.26 ENST00000373973.7
ENST00000349339.5
ENST00000489667.1
ENST00000538900.1
CNBD2
cyclic nucleotide binding domain containing 2
chr17_+_4740042 0.26 ENST00000592813.5
ZMYND15
zinc finger MYND-type containing 15
chr18_-_72865680 0.26 ENST00000397929.5
NETO1
neuropilin and tolloid like 1
chr15_+_73873557 0.25 ENST00000300504.7
TBC1D21
TBC1 domain family member 21
chr10_+_84245038 0.25 ENST00000650682.1
ENST00000358110.7
ENST00000651237.1
ENST00000652122.1
ENST00000652092.2
ENST00000359452.9
ENST00000483744.6
RGR
retinal G protein coupled receptor
chr1_-_47314089 0.25 ENST00000360380.7
ENST00000371877.8
ENST00000447475.7
STIL
STIL centriolar assembly protein
chr1_-_28058087 0.25 ENST00000373864.5
EYA3
EYA transcriptional coactivator and phosphatase 3
chr19_-_17075038 0.24 ENST00000593360.1
HAUS8
HAUS augmin like complex subunit 8
chr5_+_72107453 0.22 ENST00000296755.12
ENST00000511641.2
MAP1B
microtubule associated protein 1B
chr19_-_17075418 0.20 ENST00000253669.10
HAUS8
HAUS augmin like complex subunit 8
chr12_+_7789393 0.20 ENST00000229307.9
NANOG
Nanog homeobox
chr1_-_121184292 0.19 ENST00000452190.2
ENST00000619376.4
ENST00000369390.7
FAM72B
family with sequence similarity 72 member B
chr1_+_206203541 0.18 ENST00000573034.8
SRGAP2
SLIT-ROBO Rho GTPase activating protein 2
chr17_-_40703744 0.18 ENST00000264651.3
KRT24
keratin 24
chrX_-_65534721 0.18 ENST00000677969.1
ENST00000374807.9
ENST00000374804.9
ENST00000677087.1
ENST00000374811.8
ENST00000676986.1
ENST00000678823.1
ENST00000678570.1
LAS1L
LAS1 like ribosome biogenesis factor
chr11_-_45918789 0.17 ENST00000532681.5
PEX16
peroxisomal biogenesis factor 16
chr4_-_75990919 0.17 ENST00000395711.8
ENST00000356260.10
SDAD1
SDA1 domain containing 1
chr1_-_143971965 0.17 ENST00000369175.4
ENST00000584486.6
FAM72C
family with sequence similarity 72 member C
chr8_+_85987287 0.17 ENST00000521564.1
ATP6V0D2
ATPase H+ transporting V0 subunit d2
chr19_-_50637939 0.17 ENST00000338916.8
SYT3
synaptotagmin 3
chr8_-_100145802 0.17 ENST00000428847.3
FBXO43
F-box protein 43
chr15_-_48810583 0.17 ENST00000558591.1
CEP152
centrosomal protein 152
chr21_-_33643926 0.16 ENST00000438788.1
CRYZL1
crystallin zeta like 1
chr1_+_121184964 0.16 ENST00000367123.8
SRGAP2C
SLIT-ROBO Rho GTPase activating protein 2C
chr15_+_92900189 0.15 ENST00000626874.2
ENST00000627622.1
ENST00000629346.2
ENST00000628375.2
ENST00000420239.7
ENST00000394196.9
CHD2
chromodomain helicase DNA binding protein 2
chr3_-_149752443 0.14 ENST00000473414.6
COMMD2
COMM domain containing 2
chr3_+_136930469 0.14 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chr1_-_206202827 0.13 ENST00000431655.2
ENST00000367128.8
FAM72A
family with sequence similarity 72 member A
chr2_-_70553638 0.12 ENST00000444975.5
ENST00000445399.5
ENST00000295400.11
ENST00000418333.6
TGFA
transforming growth factor alpha
chr19_+_17337539 0.10 ENST00000324894.13
ENST00000358792.11
ENST00000600625.5
GTPBP3
GTP binding protein 3, mitochondrial
chr4_-_53365976 0.10 ENST00000401642.8
ENST00000388940.8
ENST00000503450.1
SCFD2
sec1 family domain containing 2
chr2_-_207624983 0.08 ENST00000448007.6
ENST00000432416.5
ENST00000411432.5
ENST00000458426.5
ENST00000406927.6
ENST00000425132.5
METTL21A
methyltransferase like 21A
chr15_-_60391127 0.07 ENST00000559350.5
ENST00000558986.5
ENST00000560389.5
ANXA2
annexin A2
chr18_+_31447732 0.06 ENST00000257189.5
DSG3
desmoglein 3
chr10_+_102226293 0.06 ENST00000370005.4
ELOVL3
ELOVL fatty acid elongase 3
chr5_-_140564245 0.06 ENST00000412920.7
ENST00000511201.2
ENST00000354402.9
ENST00000356738.6
APBB3
amyloid beta precursor protein binding family B member 3
chr2_-_70553440 0.05 ENST00000450929.5
TGFA
transforming growth factor alpha
chr18_-_55587335 0.05 ENST00000638154.3
TCF4
transcription factor 4
chr10_+_102132994 0.05 ENST00000413464.6
ENST00000278070.7
PPRC1
PPARG related coactivator 1
chr17_-_7239279 0.05 ENST00000613632.4
ENST00000571362.5
ENST00000576955.5
ENST00000320316.8
PHF23
PHD finger protein 23
chr1_-_145095528 0.04 ENST00000612199.4
ENST00000641863.1
SRGAP2B
SLIT-ROBO Rho GTPase activating protein 2B
chr1_+_145095967 0.04 ENST00000400889.3
FAM72D
family with sequence similarity 72 member D
chr17_-_41309253 0.04 ENST00000391352.1
KRTAP16-1
keratin associated protein 16-1
chr9_-_21994345 0.04 ENST00000579755.2
ENST00000530628.2
CDKN2A
cyclin dependent kinase inhibitor 2A
chr4_-_169757873 0.02 ENST00000393381.3
HPF1
histone PARylation factor 1
chr1_-_45499931 0.02 ENST00000626657.2
CCDC163
coiled-coil domain containing 163
chr11_-_101907934 0.01 ENST00000534527.1
ANGPTL5
angiopoietin like 5
chr19_-_5286163 0.01 ENST00000592099.5
ENST00000588012.5
ENST00000262963.10
ENST00000587303.5
ENST00000590509.5
PTPRS
protein tyrosine phosphatase receptor type S

Network of associatons between targets according to the STRING database.

First level regulatory network of DMBX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.2 2.4 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.2 0.6 GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.2 0.5 GO:1902997 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
0.1 0.5 GO:1990167 protein K6-linked deubiquitination(GO:0044313) protein K27-linked deubiquitination(GO:1990167)
0.1 1.0 GO:0071109 superior temporal gyrus development(GO:0071109)
0.1 0.8 GO:0021816 extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816)
0.1 0.6 GO:0043987 histone H3-S10 phosphorylation(GO:0043987)
0.1 0.5 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.1 0.4 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.1 0.3 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.4 GO:0030035 microspike assembly(GO:0030035)
0.0 0.1 GO:1903676 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.0 0.2 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.0 0.8 GO:0008272 sulfate transport(GO:0008272)
0.0 2.0 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.2 GO:0033504 floor plate development(GO:0033504)
0.0 0.5 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.4 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 1.2 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.9 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 1.2 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.2 GO:0001714 endodermal cell fate specification(GO:0001714)
0.0 0.2 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.3 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.2 GO:0098535 de novo centriole assembly(GO:0098535)
0.0 0.3 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.2 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.0 0.4 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.3 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.5 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 0.2 GO:0000478 endonucleolytic cleavage involved in rRNA processing(GO:0000478)
0.0 0.1 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.0 0.7 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.2 GO:0061162 establishment of monopolar cell polarity(GO:0061162)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 GO:0071986 Ragulator complex(GO:0071986)
0.0 1.0 GO:0033010 paranodal junction(GO:0033010)
0.0 0.5 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.6 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.6 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.4 GO:0070652 HAUS complex(GO:0070652)
0.0 0.5 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0098536 deuterosome(GO:0098536)
0.0 1.1 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.3 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.5 GO:0097381 photoreceptor disc membrane(GO:0097381)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.4 GO:0042835 BRE binding(GO:0042835)
0.2 0.5 GO:0015633 zinc transporting ATPase activity(GO:0015633)
0.2 0.5 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.1 0.6 GO:0031493 nucleosomal histone binding(GO:0031493)
0.1 0.4 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.4 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 1.2 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.8 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 2.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.5 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.2 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.5 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.3 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.5 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.3 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.0 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.5 PID RHODOPSIN PATHWAY Visual signal transduction: Rods

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.7 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.7 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.2 REACTOME OPSINS Genes involved in Opsins
0.0 0.5 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.5 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.6 REACTOME KINESINS Genes involved in Kinesins
0.0 0.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 3.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels