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Illumina Body Map 2 (GSE30611)

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Results for DMC1

Z-value: 0.78

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Transcription factors associated with DMC1

Gene Symbol Gene ID Gene Info
DMC1
ENSG00000100206.10 DNA meiotic recombinase 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DMC1hg38_v1_chr22_-_38570118_385701340.494.0e-03Click!

Activity profile of DMC1 motif

Sorted Z-values of DMC1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_95391361 3.43 ENST00000283357.10
FAM81B
family with sequence similarity 81 member B
chr10_+_68106109 3.42 ENST00000540630.5
ENST00000354393.6
MYPN
myopalladin
chr10_-_102837406 2.87 ENST00000369887.4
ENST00000638272.1
ENST00000639393.1
ENST00000638971.1
ENST00000638190.1
CYP17A1
cytochrome P450 family 17 subfamily A member 1
chrX_-_50200358 2.68 ENST00000437370.2
ENST00000376064.7
ENST00000448865.5
AKAP4
A-kinase anchoring protein 4
chrX_-_50200988 2.32 ENST00000358526.7
AKAP4
A-kinase anchoring protein 4
chr17_+_32991844 2.27 ENST00000269053.8
SPACA3
sperm acrosome associated 3
chr20_+_2816343 2.25 ENST00000380585.2
TMEM239
transmembrane protein 239
chrX_+_111876177 2.20 ENST00000635763.2
TRPC5OS
TRPC5 opposite strand
chr1_+_166989254 2.07 ENST00000367872.9
ENST00000447624.1
MAEL
maelstrom spermatogenic transposon silencer
chr2_+_170783781 2.01 ENST00000409885.1
ERICH2
glutamate rich 2
chr6_+_46693835 1.96 ENST00000450697.1
TDRD6
tudor domain containing 6
chr9_-_34729482 1.95 ENST00000378788.4
FAM205A
family with sequence similarity 205 member A
chr1_+_166989089 1.89 ENST00000367870.6
MAEL
maelstrom spermatogenic transposon silencer
chr17_+_32991867 1.81 ENST00000394638.1
SPACA3
sperm acrosome associated 3
chr2_+_119429889 1.67 ENST00000409826.1
ENST00000417645.1
TMEM37
transmembrane protein 37
chr5_+_80319997 1.58 ENST00000296739.6
SPZ1
spermatogenic leucine zipper 1
chrX_-_64230600 1.52 ENST00000362002.3
ASB12
ankyrin repeat and SOCS box containing 12
chr7_-_5970632 1.52 ENST00000455618.2
ENST00000405415.5
ENST00000404406.5
ENST00000542644.1
RSPH10B
radial spoke head 10 homolog B
chr10_+_17809337 1.47 ENST00000569591.3
MRC1
mannose receptor C-type 1
chrX_-_135171398 1.43 ENST00000276241.11
ENST00000344129.2
CT55
cancer/testis antigen 55
chr3_+_148739798 1.31 ENST00000402260.2
AGTR1
angiotensin II receptor type 1
chr20_+_2816302 1.28 ENST00000361033.1
TMEM239
transmembrane protein 239
chr3_-_46812558 1.27 ENST00000641183.1
ENST00000460241.2
ENSG00000284672.1
ENSG00000206549.13
novel transcript
novel protein identical to PRSS50
chr7_+_90154442 1.26 ENST00000297205.7
STEAP1
STEAP family member 1
chr7_+_6754109 1.26 ENST00000403107.5
ENST00000404077.5
ENST00000435395.5
ENST00000418406.1
RSPH10B2
radial spoke head 10 homolog B2
chr2_+_186590022 1.22 ENST00000261023.8
ENST00000374907.7
ITGAV
integrin subunit alpha V
chr11_+_71527267 1.08 ENST00000398536.6
KRTAP5-7
keratin associated protein 5-7
chr1_+_9539431 1.07 ENST00000302692.7
SLC25A33
solute carrier family 25 member 33
chr12_-_9116223 1.06 ENST00000404455.2
A2M
alpha-2-macroglobulin
chr10_-_27983103 1.01 ENST00000672841.1
ODAD2
outer dynein arm docking complex subunit 2
chr6_+_87344812 1.00 ENST00000388923.5
C6orf163
chromosome 6 open reading frame 163
chr2_-_48755718 0.95 ENST00000294954.12
ENST00000403273.5
ENST00000401907.5
LHCGR
luteinizing hormone/choriogonadotropin receptor
chr11_-_74009077 0.93 ENST00000314032.9
ENST00000426995.2
UCP3
uncoupling protein 3
chr12_-_120368069 0.93 ENST00000546985.1
MSI1
musashi RNA binding protein 1
chr2_+_200308943 0.92 ENST00000619961.4
SPATS2L
spermatogenesis associated serine rich 2 like
chr10_+_60778331 0.86 ENST00000519078.6
ENST00000316629.8
ENST00000395284.8
CDK1
cyclin dependent kinase 1
chr11_+_134331874 0.84 ENST00000339772.9
ENST00000535456.7
GLB1L2
galactosidase beta 1 like 2
chr12_-_53507482 0.81 ENST00000267017.4
ENST00000448979.4
NPFF
neuropeptide FF-amide peptide precursor
chr7_-_15561986 0.81 ENST00000342526.8
AGMO
alkylglycerol monooxygenase
chr10_+_60778490 0.80 ENST00000448257.6
ENST00000614696.4
CDK1
cyclin dependent kinase 1
chr3_-_99850976 0.80 ENST00000487087.5
FILIP1L
filamin A interacting protein 1 like
chr12_-_70637405 0.76 ENST00000548122.2
ENST00000551525.5
ENST00000550358.5
ENST00000334414.11
PTPRB
protein tyrosine phosphatase receptor type B
chr10_-_96271553 0.73 ENST00000224337.10
BLNK
B cell linker
chr15_-_42156590 0.72 ENST00000397272.7
PLA2G4F
phospholipase A2 group IVF
chr17_+_79022908 0.70 ENST00000354124.7
ENST00000580454.5
C1QTNF1
C1q and TNF related 1
chr2_-_48755569 0.68 ENST00000428232.2
ENST00000405626.5
LHCGR
luteinizing hormone/choriogonadotropin receptor
chr15_-_33068143 0.64 ENST00000558197.1
FMN1
formin 1
chr7_-_151187212 0.64 ENST00000420175.3
ENST00000275838.5
ASB10
ankyrin repeat and SOCS box containing 10
chr3_-_52535006 0.63 ENST00000307076.8
NT5DC2
5'-nucleotidase domain containing 2
chr13_-_75366973 0.60 ENST00000648194.1
TBC1D4
TBC1 domain family member 4
chr4_+_105552611 0.59 ENST00000265154.6
ENST00000420470.3
ARHGEF38
Rho guanine nucleotide exchange factor 38
chr10_-_96271508 0.58 ENST00000427367.6
ENST00000413476.6
ENST00000371176.6
BLNK
B cell linker
chr10_-_96271398 0.56 ENST00000495266.1
BLNK
B cell linker
chr1_+_81306096 0.56 ENST00000370721.5
ENST00000370727.5
ENST00000370725.5
ENST00000370723.5
ENST00000370728.5
ENST00000370730.5
ADGRL2
adhesion G protein-coupled receptor L2
chr8_-_67062120 0.52 ENST00000357849.9
COPS5
COP9 signalosome subunit 5
chr14_+_73851809 0.49 ENST00000555661.6
ENST00000555228.5
PTGR2
prostaglandin reductase 2
chr10_+_73110375 0.47 ENST00000617744.4
ENST00000544879.5
ENST00000537969.5
ENST00000357321.9
ENST00000349051.9
NUDT13
nudix hydrolase 13
chr17_+_79022814 0.44 ENST00000578229.5
C1QTNF1
C1q and TNF related 1
chr20_-_21397513 0.44 ENST00000351817.5
NKX2-4
NK2 homeobox 4
chr14_+_73851908 0.44 ENST00000267568.8
PTGR2
prostaglandin reductase 2
chr2_-_18560616 0.43 ENST00000381249.4
RDH14
retinol dehydrogenase 14
chr2_-_31414694 0.40 ENST00000379416.4
XDH
xanthine dehydrogenase
chr15_+_41286011 0.40 ENST00000661438.1
ENSG00000285920.2
novel protein
chr3_+_9902619 0.37 ENST00000421412.5
IL17RE
interleukin 17 receptor E
chr3_-_108953762 0.37 ENST00000393963.7
ENST00000471108.1
GUCA1C
guanylate cyclase activator 1C
chr7_-_151187772 0.32 ENST00000377867.7
ASB10
ankyrin repeat and SOCS box containing 10
chr1_-_205994439 0.30 ENST00000617991.4
RAB7B
RAB7B, member RAS oncogene family
chr10_-_73096850 0.29 ENST00000307116.6
ENST00000373008.6
ENST00000394890.7
P4HA1
prolyl 4-hydroxylase subunit alpha 1
chr3_-_108953870 0.27 ENST00000261047.8
GUCA1C
guanylate cyclase activator 1C
chr1_-_160954801 0.26 ENST00000368029.4
ITLN2
intelectin 2
chr10_+_73110494 0.25 ENST00000372997.3
NUDT13
nudix hydrolase 13
chr1_-_46665849 0.25 ENST00000532925.5
ENST00000542495.5
ATPAF1
ATP synthase mitochondrial F1 complex assembly factor 1
chr10_-_73096974 0.22 ENST00000440381.5
ENST00000263556.3
P4HA1
prolyl 4-hydroxylase subunit alpha 1
chr22_+_20116099 0.09 ENST00000430524.6
RANBP1
RAN binding protein 1
chr14_-_21023318 0.09 ENST00000298684.9
ENST00000557169.5
ENST00000553563.5
NDRG2
NDRG family member 2
chr1_+_1287109 0.09 ENST00000379099.3
SCNN1D
sodium channel epithelial 1 subunit delta
chr1_+_18631513 0.08 ENST00000400661.3
PAX7
paired box 7
chr3_+_9902808 0.08 ENST00000383814.8
ENST00000454190.6
ENST00000454992.1
IL17RE
interleukin 17 receptor E
chr5_-_135895834 0.08 ENST00000274520.2
IL9
interleukin 9
chr11_+_101914997 0.08 ENST00000263468.13
CEP126
centrosomal protein 126
chr1_-_11803383 0.07 ENST00000641407.1
ENST00000376583.7
ENST00000423400.7
MTHFR
methylenetetrahydrofolate reductase
chr1_-_182672882 0.06 ENST00000367557.8
ENST00000258302.8
RGS8
regulator of G protein signaling 8
chr7_+_144070313 0.04 ENST00000641441.1
OR2A25
olfactory receptor family 2 subfamily A member 25
chr16_+_2205708 0.01 ENST00000397124.5
ENST00000565250.1
MLST8
MTOR associated protein, LST8 homolog
chr17_-_62065248 0.00 ENST00000397786.7
MED13
mediator complex subunit 13

Network of associatons between targets according to the STRING database.

First level regulatory network of DMC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
0.5 4.1 GO:0009253 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.4 1.2 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.4 1.1 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.3 1.3 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.3 1.1 GO:0001868 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.2 1.7 GO:0090166 Golgi disassembly(GO:0090166)
0.2 4.0 GO:0034587 piRNA metabolic process(GO:0034587)
0.2 1.1 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.2 0.8 GO:0070253 somatostatin secretion(GO:0070253)
0.1 3.4 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.1 0.4 GO:0046110 xanthine metabolic process(GO:0046110)
0.1 2.9 GO:0006702 androgen biosynthetic process(GO:0006702)
0.1 0.8 GO:0046485 ether lipid metabolic process(GO:0046485)
0.1 4.7 GO:0044458 motile cilium assembly(GO:0044458)
0.1 0.8 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.1 0.6 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 0.3 GO:0034164 negative regulation of toll-like receptor 9 signaling pathway(GO:0034164)
0.0 0.6 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.0 0.5 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.9 GO:1990845 adaptive thermogenesis(GO:1990845)
0.0 0.2 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.0 0.5 GO:0097398 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.0 0.6 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.7 GO:0036148 phosphatidylglycerol acyl-chain remodeling(GO:0036148)
0.0 0.5 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.1 GO:0014813 skeletal muscle satellite cell commitment(GO:0014813)
0.0 1.5 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.0 0.9 GO:0006693 prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693)
0.0 0.1 GO:0070829 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.0 0.7 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0030849 autosome(GO:0030849)
0.4 1.7 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.4 1.2 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.4 5.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 0.5 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.1 2.0 GO:0033391 chromatoid body(GO:0033391)
0.1 4.1 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.6 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 1.1 GO:0045095 keratin filament(GO:0045095)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.4 1.6 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.4 1.1 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.2 1.2 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.2 0.9 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.2 4.1 GO:0003796 lysozyme activity(GO:0003796)
0.1 1.1 GO:0019959 interleukin-8 binding(GO:0019959) tumor necrosis factor binding(GO:0043120)
0.1 0.8 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.1 0.9 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.1 0.6 GO:0016524 latrotoxin receptor activity(GO:0016524)
0.1 2.9 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 3.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.8 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.1 0.6 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.1 1.7 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.4 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.1 0.8 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 0.5 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.1 1.9 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 1.5 GO:0005537 mannose binding(GO:0005537)
0.1 0.7 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 0.5 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.5 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 4.8 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.6 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.8 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.1 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.9 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 1.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 2.9 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.6 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.5 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.1 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.6 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.6 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.9 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 1.6 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 1.7 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 1.9 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.1 1.2 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 1.1 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.7 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 1.5 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.4 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism