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Illumina Body Map 2 (GSE30611)
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Results for E2F6
Z-value: 1.67
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Transcription factors associated with E2F6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F6 | hg38_v1_chr2_-_11466156_11466177 | -0.11 | 5.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr21_+_45981736 Show fit | 3.96 |
ENST00000361866.8
|
collagen type VI alpha 1 chain |
|
| chr11_+_46381645 Show fit | 3.71 |
ENST00000617138.4
ENST00000395566.9 ENST00000395569.8 |
midkine |
|
| chr1_-_20486197 Show fit | 3.61 |
ENST00000375078.4
|
calcium/calmodulin dependent protein kinase II inhibitor 1 |
|
| chr1_+_210232776 Show fit | 3.60 |
ENST00000367012.4
|
SERTA domain containing 4 |
|
| chr15_-_64775574 Show fit | 3.46 |
ENST00000300069.5
|
RNA binding protein, mRNA processing factor 2 |
|
| chr12_+_57611420 Show fit | 3.34 |
ENST00000286494.9
|
Rho guanine nucleotide exchange factor 25 |
|
| chrX_-_133985449 Show fit | 2.94 |
ENST00000631057.2
|
glypican 3 |
|
| chr1_+_202010575 Show fit | 2.75 |
ENST00000367283.7
ENST00000367284.10 |
E74 like ETS transcription factor 3 |
|
| chr1_+_113979391 Show fit | 2.71 |
ENST00000393300.6
ENST00000369551.5 |
olfactomedin like 3 |
|
| chr8_+_94641199 Show fit | 2.68 |
ENST00000646773.1
ENST00000454170.7 |
epithelial splicing regulatory protein 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 12.7 | GO:0030421 | defecation(GO:0030421) |
| 0.2 | 6.9 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.1 | 6.3 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.2 | 5.6 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 0.1 | 5.6 | GO:0006027 | glycosaminoglycan catabolic process(GO:0006027) |
| 1.0 | 5.2 | GO:0044830 | modulation by host of viral RNA genome replication(GO:0044830) positive regulation of intracellular transport of viral material(GO:1901254) |
| 0.5 | 5.1 | GO:0036484 | trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) |
| 0.3 | 5.1 | GO:0009414 | response to water deprivation(GO:0009414) |
| 0.8 | 5.0 | GO:0072180 | mesonephric duct morphogenesis(GO:0072180) |
| 0.4 | 4.8 | GO:0061141 | lung ciliated cell differentiation(GO:0061141) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 15.7 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 11.8 | GO:0009986 | cell surface(GO:0009986) |
| 0.0 | 11.1 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 10.1 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.0 | 9.3 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.2 | 8.4 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 8.4 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 8.0 | GO:0005902 | microvillus(GO:0005902) |
| 0.2 | 7.5 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 24.9 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 16.9 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.4 | 8.0 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.1 | 8.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 7.5 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.0 | 6.3 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 6.2 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.2 | 5.9 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.1 | 5.8 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.1 | 5.5 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 23.2 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 15.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 14.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 13.3 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 10.0 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.0 | 9.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 9.2 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 8.7 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.0 | 6.8 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.1 | 6.7 | ST GA12 PATHWAY | G alpha 12 Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 13.2 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 12.8 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 8.2 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 6.7 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.0 | 6.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 5.9 | REACTOME GAP JUNCTION TRAFFICKING | Genes involved in Gap junction trafficking |
| 0.2 | 5.2 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 5.2 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 5.1 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.2 | 4.6 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |