Project
Illumina Body Map 2 (GSE30611)
Navigation
Downloads
Results for EGR1_EGR4
Z-value: 0.81
Motif logo
Transcription factors associated with EGR1_EGR4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EGR4 | hg38_v1_chr2_-_73293538_73293701 | 0.63 | 9.6e-05 | Click! |
| EGR1 | hg38_v1_chr5_+_138465472_138465487 | -0.21 | 2.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of EGR1_EGR4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.6 | GO:0051823 | regulation of synapse structural plasticity(GO:0051823) |
| 0.4 | 3.5 | GO:0035093 | spermatogenesis, exchange of chromosomal proteins(GO:0035093) |
| 0.3 | 3.1 | GO:0044026 | DNA hypermethylation(GO:0044026) |
| 0.1 | 3.1 | GO:0034199 | activation of protein kinase A activity(GO:0034199) |
| 0.3 | 2.7 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 0.1 | 2.3 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 0.1 | 1.9 | GO:0034720 | histone H3-K4 demethylation(GO:0034720) |
| 0.3 | 1.8 | GO:0061092 | regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092) |
| 0.3 | 1.7 | GO:1901908 | diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911) |
| 0.1 | 1.7 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.7 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.2 | 3.5 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.0 | 3.5 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 2.7 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.1 | 2.4 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.0 | 2.2 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 2.0 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.1 | 1.9 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 1.7 | GO:0030314 | junctional membrane complex(GO:0030314) |
| 0.1 | 1.7 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.5 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.0 | 4.7 | GO:0042393 | histone binding(GO:0042393) |
| 0.9 | 3.5 | GO:0034584 | piRNA binding(GO:0034584) |
| 0.1 | 2.7 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.0 | 2.3 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 2.3 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.2 | 2.0 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.2 | 1.9 | GO:0034648 | histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648) |
| 0.1 | 1.9 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.1 | 1.8 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.3 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 3.0 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 2.7 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 2.3 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.0 | 2.1 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 1.8 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 1.8 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 1.7 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 1.7 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 1.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.0 | 2.4 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 2.3 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.1 | 2.1 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.1 | 2.1 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 2.1 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 1.9 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 1.6 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 1.6 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 1.5 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |