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Illumina Body Map 2 (GSE30611)
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Results for ELK4_ETV5_ELK1_ELK3_ELF4
Z-value: 2.01
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Transcription factors associated with ELK4_ETV5_ELK1_ELK3_ELF4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000158711.14 | ETS transcription factor ELK4 | |
| ENSG00000244405.8 | ETS variant transcription factor 5 | |
| ENSG00000126767.18 | ETS transcription factor ELK1 | |
| ENSG00000111145.8 | ETS transcription factor ELK3 | |
| ENSG00000102034.17 | E74 like ETS transcription factor 4 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ELK1 | hg38_v1_chrX_-_47650488_47650591 | 0.40 | 2.3e-02 | Click! |
| ELK4 | hg38_v1_chr1_-_205631962_205632030 | 0.21 | 2.4e-01 | Click! |
| ETV5 | hg38_v1_chr3_-_186109067_186109117 | -0.19 | 3.0e-01 | Click! |
| ELF4 | hg38_v1_chrX_-_130110361_130110467 | 0.08 | 6.7e-01 | Click! |
| ELK3 | hg38_v1_chr12_+_96194365_96194407 | 0.06 | 7.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ELK4_ETV5_ELK1_ELK3_ELF4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 132.2 | GO:0006355 | regulation of transcription, DNA-templated(GO:0006355) |
| 0.3 | 18.0 | GO:0001510 | RNA methylation(GO:0001510) |
| 0.4 | 16.7 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
| 0.2 | 15.9 | GO:0008033 | tRNA processing(GO:0008033) |
| 0.3 | 14.2 | GO:0006362 | transcription elongation from RNA polymerase I promoter(GO:0006362) |
| 0.2 | 12.5 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 12.1 | GO:0006397 | mRNA processing(GO:0006397) |
| 0.3 | 10.8 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.1 | 10.7 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 0.2 | 10.3 | GO:0071431 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 247.2 | GO:0005634 | nucleus(GO:0005634) |
| 0.1 | 78.6 | GO:0005730 | nucleolus(GO:0005730) |
| 0.5 | 19.8 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.5 | 15.8 | GO:0032040 | small-subunit processome(GO:0032040) |
| 0.1 | 15.4 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.2 | 15.1 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 14.5 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 12.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 10.5 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.2 | 8.4 | GO:1902562 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 251.4 | GO:0003677 | DNA binding(GO:0003677) |
| 0.0 | 78.8 | GO:0003676 | nucleic acid binding(GO:0003676) |
| 0.2 | 23.9 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186) |
| 0.1 | 11.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.3 | 10.9 | GO:0008173 | RNA methyltransferase activity(GO:0008173) |
| 0.5 | 10.5 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.3 | 10.5 | GO:0016891 | endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891) |
| 0.2 | 9.8 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.3 | 9.4 | GO:0004812 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 0.2 | 9.0 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 19.4 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 6.1 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 5.3 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 4.0 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 3.8 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 3.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 3.2 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 3.1 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 3.1 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 3.1 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 86.9 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.3 | 17.4 | REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |
| 0.3 | 12.9 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.0 | 12.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.3 | 9.8 | REACTOME RNA POL I TRANSCRIPTION INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.3 | 8.5 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| 0.3 | 8.2 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.3 | 8.0 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.2 | 7.9 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.2 | 7.2 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |