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Illumina Body Map 2 (GSE30611)
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Results for EN1_ESX1_GBX1
Z-value: 0.94
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Transcription factors associated with EN1_ESX1_GBX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EN1 | hg38_v1_chr2_-_118847638_118847654 | -0.15 | 4.1e-01 | Click! |
| GBX1 | hg38_v1_chr7_-_151167692_151167697 | 0.12 | 5.3e-01 | Click! |
| ESX1 | hg38_v1_chrX_-_104254921_104254936 | 0.09 | 6.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of EN1_ESX1_GBX1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 12.0 | GO:0071449 | cellular response to lipid hydroperoxide(GO:0071449) |
| 0.6 | 7.5 | GO:0051918 | negative regulation of fibrinolysis(GO:0051918) |
| 0.1 | 6.2 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.3 | 5.2 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.1 | 4.7 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 4.5 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.3 | 4.1 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.2 | 3.9 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
| 0.0 | 3.8 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.6 | 3.6 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.3 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 9.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 9.0 | GO:0097060 | synaptic membrane(GO:0097060) |
| 0.3 | 7.5 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.1 | 6.5 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 5.8 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.5 | 5.5 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.0 | 5.5 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 5.1 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 4.5 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 12.0 | GO:0043295 | glutathione binding(GO:0043295) |
| 0.0 | 9.1 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.2 | 6.5 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 1.0 | 6.2 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.8 | 5.5 | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591) |
| 0.0 | 5.1 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.1 | 4.7 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 4.5 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 4.0 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.1 | 3.9 | GO:0035497 | cAMP response element binding(GO:0035497) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 3.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 2.9 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 2.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 2.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 2.2 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 2.0 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 1.8 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 1.5 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 1.5 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.0 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.3 | 5.6 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 5.5 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.4 | 5.2 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.3 | 5.0 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.2 | 4.6 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 4.3 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.1 | 3.5 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.2 | 3.3 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 3.2 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |