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Illumina Body Map 2 (GSE30611)

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Results for EVX2

Z-value: 0.64

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Transcription factors associated with EVX2

Gene Symbol Gene ID Gene Info
EVX2
ENSG00000174279.4 even-skipped homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
EVX2hg38_v1_chr2_-_176083913_176083913-0.309.5e-02Click!

Activity profile of EVX2 motif

Sorted Z-values of EVX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_111998739 3.46 ENST00000393917.6
ENST00000273368.8
TAGLN3
transgelin 3
chr3_+_111999189 3.29 ENST00000455401.6
TAGLN3
transgelin 3
chr3_+_111998915 3.13 ENST00000478951.6
TAGLN3
transgelin 3
chr5_-_97142579 2.77 ENST00000274382.9
LIX1
limb and CNS expressed 1
chr3_+_111999326 2.56 ENST00000494932.1
TAGLN3
transgelin 3
chr6_-_62286161 1.86 ENST00000281156.5
KHDRBS2
KH RNA binding domain containing, signal transduction associated 2
chr1_+_160190567 1.80 ENST00000368078.8
CASQ1
calsequestrin 1
chr5_-_97142753 1.50 ENST00000512378.1
LIX1
limb and CNS expressed 1
chr13_+_77741393 1.41 ENST00000496045.5
SLAIN1
SLAIN motif family member 1
chr13_+_77741331 1.31 ENST00000462234.5
SLAIN1
SLAIN motif family member 1
chr15_+_62758585 0.89 ENST00000472902.1
TLN2
talin 2
chr17_-_10026265 0.87 ENST00000437099.6
ENST00000396115.6
GAS7
growth arrest specific 7
chr11_-_115504389 0.84 ENST00000545380.5
ENST00000452722.7
ENST00000331581.11
ENST00000537058.5
ENST00000536727.5
ENST00000542447.6
CADM1
cell adhesion molecule 1
chr19_-_46634685 0.84 ENST00000300873.4
GNG8
G protein subunit gamma 8
chr12_+_15546344 0.79 ENST00000674388.1
ENST00000542557.5
ENST00000445537.6
ENST00000544244.5
ENST00000442921.7
PTPRO
protein tyrosine phosphatase receptor type O
chrX_-_63755187 0.77 ENST00000635729.1
ENST00000623566.3
ARHGEF9
Cdc42 guanine nucleotide exchange factor 9
chr4_+_112860912 0.72 ENST00000671951.1
ANK2
ankyrin 2
chr4_+_143391506 0.65 ENST00000509992.1
GAB1
GRB2 associated binding protein 1
chr4_+_112860981 0.64 ENST00000671704.1
ANK2
ankyrin 2
chr4_+_112861053 0.61 ENST00000672221.1
ANK2
ankyrin 2
chr4_+_143433491 0.60 ENST00000512843.1
GAB1
GRB2 associated binding protein 1
chr2_+_71276553 0.45 ENST00000494621.5
ENST00000466975.5
ENST00000410075.5
ENST00000466330.5
ZNF638
zinc finger protein 638
chr21_-_31160904 0.41 ENST00000636887.1
TIAM1
TIAM Rac1 associated GEF 1
chr4_-_145180496 0.38 ENST00000447906.8
OTUD4
OTU deubiquitinase 4
chr4_+_94974984 0.38 ENST00000672698.1
BMPR1B
bone morphogenetic protein receptor type 1B
chr6_+_39792298 0.36 ENST00000633794.1
ENST00000274867.9
DAAM2
dishevelled associated activator of morphogenesis 2
chr8_+_91249307 0.31 ENST00000309536.6
ENST00000276609.8
SLC26A7
solute carrier family 26 member 7
chr12_-_53336342 0.30 ENST00000537210.2
ENST00000536324.4
SP7
Sp7 transcription factor
chr1_+_27934980 0.27 ENST00000373894.8
SMPDL3B
sphingomyelin phosphodiesterase acid like 3B
chr12_+_64405046 0.25 ENST00000540203.5
XPOT
exportin for tRNA
chr5_+_141484997 0.24 ENST00000617094.1
ENST00000306593.2
ENST00000610539.1
ENST00000618371.4
PCDHGC4
protocadherin gamma subfamily C, 4
chr1_+_27935110 0.20 ENST00000549094.1
SMPDL3B
sphingomyelin phosphodiesterase acid like 3B
chr6_-_111605859 0.19 ENST00000651359.1
ENST00000650859.1
ENST00000359831.8
ENST00000368761.11
TRAF3IP2
TRAF3 interacting protein 2
chr18_+_13443720 0.13 ENST00000678309.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr8_+_7926337 0.13 ENST00000400120.3
ZNF705B
zinc finger protein 705B
chr17_+_39653080 0.11 ENST00000443521.1
STARD3
StAR related lipid transfer domain containing 3
chr6_-_111606260 0.11 ENST00000340026.10
TRAF3IP2
TRAF3 interacting protein 2
chr17_+_18183052 0.10 ENST00000541285.1
ALKBH5
alkB homolog 5, RNA demethylase
chr12_+_119668109 0.09 ENST00000229328.10
ENST00000630317.1
PRKAB1
protein kinase AMP-activated non-catalytic subunit beta 1
chr15_+_101812202 0.08 ENST00000332238.5
OR4F15
olfactory receptor family 4 subfamily F member 15
chr1_-_159862648 0.06 ENST00000368100.1
VSIG8
V-set and immunoglobulin domain containing 8
chr1_+_27935022 0.05 ENST00000411604.5
ENST00000373888.8
SMPDL3B
sphingomyelin phosphodiesterase acid like 3B

Network of associatons between targets according to the STRING database.

First level regulatory network of EVX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.2 2.0 GO:0036371 protein localization to T-tubule(GO:0036371)
0.1 0.4 GO:1904266 positive regulation of Schwann cell migration(GO:1900149) regulation of Schwann cell chemotaxis(GO:1904266) positive regulation of Schwann cell chemotaxis(GO:1904268) Schwann cell chemotaxis(GO:1990751)
0.1 1.8 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 0.8 GO:0019236 response to pheromone(GO:0019236)
0.1 0.8 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 4.3 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.4 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
0.0 0.5 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.9 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 1.3 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.3 GO:0019532 oxalate transport(GO:0019532)
0.0 1.9 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.8 GO:0014802 terminal cisterna(GO:0014802)
0.0 12.4 GO:0043209 myelin sheath(GO:0043209)
0.0 2.0 GO:0031430 M band(GO:0031430)
0.0 0.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.9 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.5 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 12.9 GO:0051015 actin filament binding(GO:0051015)
0.0 2.0 GO:0030507 spectrin binding(GO:0030507)
0.0 0.4 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.8 GO:0017147 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) Wnt-protein binding(GO:0017147) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 1.3 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0 0.3 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.1 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.8 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.8 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions