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Illumina Body Map 2 (GSE30611)
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Results for FOSB
Z-value: 0.89
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Transcription factors associated with FOSB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOSB | hg38_v1_chr19_+_45470102_45470265 | -0.48 | 5.4e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_27282419 Show fit | 1.70 |
ENST00000380075.7
ENST00000296098.4 |
tripartite motif containing 54 |
|
| chr8_-_17895403 Show fit | 1.54 |
ENST00000381840.5
ENST00000398054.5 |
fibrinogen like 1 |
|
| chr2_-_219308963 Show fit | 1.47 |
ENST00000423636.6
ENST00000442029.5 ENST00000412847.5 |
protein tyrosine phosphatase receptor type N |
|
| chr8_-_17895487 Show fit | 1.47 |
ENST00000427924.5
ENST00000381841.4 |
fibrinogen like 1 |
|
| chr20_-_653189 Show fit | 1.43 |
ENST00000381962.4
|
sulfiredoxin 1 |
|
| chr9_-_114078293 Show fit | 1.41 |
ENST00000265132.8
|
alpha-1-microglobulin/bikunin precursor |
|
| chr17_+_4950147 Show fit | 1.38 |
ENST00000522301.5
|
enolase 3 |
|
| chr7_+_116672357 Show fit | 1.36 |
ENST00000456159.1
|
MET proto-oncogene, receptor tyrosine kinase |
|
| chr11_-_102843597 Show fit | 1.26 |
ENST00000299855.10
|
matrix metallopeptidase 3 |
|
| chr17_-_35063648 Show fit | 1.24 |
ENST00000394597.7
|
ring finger and FYVE like domain containing E3 ubiquitin protein ligase |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOSB
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.4 | 2.0 | GO:1903028 | positive regulation of opsonization(GO:1903028) |
| 0.1 | 2.0 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.1 | 1.7 | GO:0048875 | chemical homeostasis within a tissue(GO:0048875) |
| 0.0 | 1.7 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.0 | 1.6 | GO:0061718 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.5 | 1.5 | GO:1904692 | positive regulation of type B pancreatic cell proliferation(GO:1904692) |
| 0.1 | 1.5 | GO:0035092 | sperm chromatin condensation(GO:0035092) |
| 0.1 | 1.5 | GO:0060297 | regulation of sarcomere organization(GO:0060297) |
| 0.1 | 1.4 | GO:0090521 | glomerular visceral epithelial cell migration(GO:0090521) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.0 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 2.9 | GO:0042641 | actomyosin(GO:0042641) |
| 0.0 | 2.4 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 2.4 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 1.9 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 1.6 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.0 | 1.5 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 1.4 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 1.4 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.0 | 1.4 | GO:0005643 | nuclear pore(GO:0005643) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 1.9 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 1.7 | GO:0043531 | ADP binding(GO:0043531) |
| 0.1 | 1.6 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.1 | 1.6 | GO:0004791 | thioredoxin-disulfide reductase activity(GO:0004791) |
| 0.0 | 1.6 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.2 | 1.4 | GO:0047493 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.2 | 1.4 | GO:0019862 | IgA binding(GO:0019862) |
| 0.0 | 1.4 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 1.4 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.0 | 2.0 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 1.8 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.7 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 1.2 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 1.1 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 1.0 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
| 0.0 | 1.0 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 0.9 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.9 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.8 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 1.7 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 1.7 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 1.6 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 1.4 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.0 | 1.4 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 1.3 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 1.2 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.1 | 1.2 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.0 | 1.2 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |