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Illumina Body Map 2 (GSE30611)
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Results for FOXD1_FOXO1_FOXO6_FOXG1_FOXP1
Z-value: 1.59
Motif logo
Transcription factors associated with FOXD1_FOXO1_FOXO6_FOXG1_FOXP1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
FOXD1
|
ENSG00000251493.5 | forkhead box D1 |
|
FOXO1
|
ENSG00000150907.10 | forkhead box O1 |
|
FOXO6
|
ENSG00000204060.7 | forkhead box O6 |
|
FOXG1
|
ENSG00000176165.12 | forkhead box G1 |
|
FOXP1
|
ENSG00000114861.23 | forkhead box P1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXP1 | hg38_v1_chr3_-_71064915_71064963 | 0.60 | 2.5e-04 | Click! |
| FOXG1 | hg38_v1_chr14_+_28766755_28766802 | -0.52 | 2.0e-03 | Click! |
| FOXO1 | hg38_v1_chr13_-_40666600_40666650 | 0.45 | 9.2e-03 | Click! |
| FOXD1 | hg38_v1_chr5_-_73448769_73448784 | 0.15 | 4.1e-01 | Click! |
| FOXO6 | hg38_v1_chr1_+_41361931_41361931 | -0.01 | 9.8e-01 | Click! |
Activity profile of FOXD1_FOXO1_FOXO6_FOXG1_FOXP1 motif
Sorted Z-values of FOXD1_FOXO1_FOXO6_FOXG1_FOXP1 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXD1_FOXO1_FOXO6_FOXG1_FOXP1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 7.9 | GO:0060876 | semicircular canal formation(GO:0060876) |
| 2.3 | 7.0 | GO:0045957 | regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957) |
| 1.8 | 12.8 | GO:0090095 | regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096) |
| 1.6 | 4.9 | GO:0021758 | caudate nucleus development(GO:0021757) putamen development(GO:0021758) |
| 1.5 | 7.5 | GO:0097403 | cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545) |
| 1.3 | 4.0 | GO:0052151 | positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139) |
| 1.2 | 6.1 | GO:0003245 | cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) |
| 1.1 | 9.7 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 1.1 | 4.2 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 1.0 | 5.8 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 0.9 | 2.7 | GO:0045643 | regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645) |
| 0.9 | 6.2 | GO:0042539 | hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477) |
| 0.9 | 4.3 | GO:0072675 | osteoclast fusion(GO:0072675) |
| 0.8 | 5.1 | GO:0003051 | angiotensin-mediated drinking behavior(GO:0003051) |
| 0.8 | 2.5 | GO:0001544 | initiation of primordial ovarian follicle growth(GO:0001544) |
| 0.8 | 7.1 | GO:0036022 | limb joint morphogenesis(GO:0036022) embryonic skeletal limb joint morphogenesis(GO:0036023) |
| 0.7 | 3.7 | GO:1901964 | apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm development(GO:0048389) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) pattern specification involved in mesonephros development(GO:0061227) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in kidney development(GO:0072098) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901963) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007) |
| 0.7 | 2.8 | GO:0032072 | plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072) |
| 0.7 | 2.7 | GO:0086097 | phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097) |
| 0.7 | 12.3 | GO:0072619 | interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619) |
| 0.7 | 4.7 | GO:0051389 | inactivation of MAPKK activity(GO:0051389) |
| 0.7 | 2.7 | GO:0033031 | positive regulation of neutrophil apoptotic process(GO:0033031) |
| 0.6 | 1.9 | GO:1990922 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 0.6 | 1.8 | GO:1990785 | response to water-immersion restraint stress(GO:1990785) |
| 0.6 | 3.6 | GO:2001153 | regulation of renal water transport(GO:2001151) positive regulation of renal water transport(GO:2001153) |
| 0.6 | 5.3 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.6 | 5.9 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.6 | 2.9 | GO:0010159 | specification of organ position(GO:0010159) |
| 0.6 | 2.8 | GO:0045074 | interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074) |
| 0.6 | 2.3 | GO:0097350 | neutrophil clearance(GO:0097350) |
| 0.6 | 2.8 | GO:0071603 | endothelial cell-cell adhesion(GO:0071603) |
| 0.6 | 3.4 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.5 | 8.7 | GO:0033227 | dsRNA transport(GO:0033227) |
| 0.5 | 1.6 | GO:1903249 | regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283) |
| 0.5 | 5.0 | GO:0008063 | Toll signaling pathway(GO:0008063) |
| 0.5 | 4.0 | GO:0072734 | response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734) |
| 0.5 | 1.0 | GO:0060596 | mammary placode formation(GO:0060596) |
| 0.5 | 3.3 | GO:0000821 | regulation of arginine metabolic process(GO:0000821) |
| 0.5 | 3.3 | GO:1902617 | response to fluoride(GO:1902617) |
| 0.5 | 5.6 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
| 0.5 | 2.8 | GO:0044336 | canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336) |
| 0.5 | 5.1 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 0.5 | 5.0 | GO:0035290 | trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) |
| 0.4 | 5.8 | GO:2000332 | response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 0.4 | 1.8 | GO:0021569 | rhombomere 3 development(GO:0021569) |
| 0.4 | 1.3 | GO:0007518 | myoblast fate determination(GO:0007518) |
| 0.4 | 5.6 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 0.4 | 2.2 | GO:1903613 | regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615) |
| 0.4 | 4.7 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.4 | 4.1 | GO:0045602 | negative regulation of endothelial cell differentiation(GO:0045602) |
| 0.4 | 1.6 | GO:0052250 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.4 | 1.6 | GO:0010193 | response to ozone(GO:0010193) |
| 0.4 | 1.5 | GO:0009956 | radial pattern formation(GO:0009956) |
| 0.4 | 1.2 | GO:1901876 | regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877) |
| 0.4 | 3.5 | GO:0097167 | circadian regulation of translation(GO:0097167) |
| 0.4 | 3.4 | GO:2000973 | regulation of pro-B cell differentiation(GO:2000973) |
| 0.4 | 2.7 | GO:0070966 | nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) |
| 0.4 | 3.4 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.4 | 2.5 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 0.4 | 1.1 | GO:0036323 | vascular endothelial growth factor receptor-1 signaling pathway(GO:0036323) |
| 0.3 | 1.0 | GO:1990654 | sebum secreting cell proliferation(GO:1990654) |
| 0.3 | 6.5 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.3 | 1.3 | GO:0021538 | epithalamus development(GO:0021538) habenula development(GO:0021986) |
| 0.3 | 7.0 | GO:0031507 | heterochromatin assembly(GO:0031507) |
| 0.3 | 7.3 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.3 | 3.1 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.3 | 7.1 | GO:0003417 | growth plate cartilage development(GO:0003417) |
| 0.3 | 1.8 | GO:0003199 | endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) |
| 0.3 | 3.0 | GO:0060770 | negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) |
| 0.3 | 2.4 | GO:0010710 | regulation of collagen catabolic process(GO:0010710) |
| 0.3 | 10.0 | GO:0002347 | response to tumor cell(GO:0002347) |
| 0.3 | 0.9 | GO:1903676 | regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676) |
| 0.3 | 1.7 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 0.3 | 0.9 | GO:0061146 | Peyer's patch morphogenesis(GO:0061146) |
| 0.3 | 0.9 | GO:0098507 | polynucleotide 5' dephosphorylation(GO:0098507) |
| 0.3 | 1.7 | GO:0000117 | regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117) |
| 0.3 | 2.2 | GO:0002318 | myeloid progenitor cell differentiation(GO:0002318) |
| 0.3 | 1.6 | GO:0060355 | positive regulation of cell adhesion molecule production(GO:0060355) |
| 0.3 | 1.1 | GO:0060734 | regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) |
| 0.3 | 4.8 | GO:0021520 | spinal cord motor neuron cell fate specification(GO:0021520) |
| 0.3 | 2.6 | GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) |
| 0.3 | 8.4 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.3 | 1.3 | GO:0035026 | leading edge cell differentiation(GO:0035026) |
| 0.3 | 2.3 | GO:0021759 | globus pallidus development(GO:0021759) |
| 0.2 | 2.2 | GO:0035696 | monocyte extravasation(GO:0035696) |
| 0.2 | 4.3 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.2 | 4.1 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.2 | 3.1 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.2 | 0.7 | GO:0006864 | pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519) |
| 0.2 | 1.2 | GO:1903413 | cellular response to bile acid(GO:1903413) |
| 0.2 | 0.9 | GO:0045355 | negative regulation of interferon-alpha biosynthetic process(GO:0045355) positive regulation of protein K48-linked ubiquitination(GO:1902524) |
| 0.2 | 4.8 | GO:0036500 | ATF6-mediated unfolded protein response(GO:0036500) |
| 0.2 | 2.5 | GO:0042758 | long-chain fatty acid catabolic process(GO:0042758) |
| 0.2 | 1.6 | GO:0044334 | canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) |
| 0.2 | 0.9 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.2 | 0.4 | GO:1904844 | response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845) |
| 0.2 | 0.9 | GO:0098957 | anterograde axonal transport of mitochondrion(GO:0098957) |
| 0.2 | 0.6 | GO:0021763 | subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) left lung morphogenesis(GO:0060460) superior vena cava morphogenesis(GO:0060578) |
| 0.2 | 0.6 | GO:0030885 | regulation of myeloid dendritic cell activation(GO:0030885) |
| 0.2 | 1.4 | GO:0002001 | renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure(GO:0001999) renin secretion into blood stream(GO:0002001) |
| 0.2 | 1.6 | GO:0038110 | interleukin-2-mediated signaling pathway(GO:0038110) |
| 0.2 | 1.8 | GO:0060574 | intestinal epithelial cell maturation(GO:0060574) |
| 0.2 | 6.7 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
| 0.2 | 2.9 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 0.2 | 1.2 | GO:0002277 | myeloid dendritic cell activation involved in immune response(GO:0002277) |
| 0.2 | 5.4 | GO:0032897 | negative regulation of viral transcription(GO:0032897) |
| 0.2 | 1.0 | GO:0046671 | negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671) |
| 0.2 | 4.4 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.2 | 0.6 | GO:1903970 | negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973) |
| 0.2 | 0.9 | GO:1904073 | regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075) |
| 0.2 | 1.5 | GO:0044211 | CTP salvage(GO:0044211) |
| 0.2 | 1.1 | GO:0030037 | actin filament reorganization involved in cell cycle(GO:0030037) |
| 0.2 | 1.8 | GO:0098728 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
| 0.2 | 1.8 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 0.2 | 1.0 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.2 | 0.7 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 0.2 | 1.9 | GO:0002155 | regulation of thyroid hormone mediated signaling pathway(GO:0002155) |
| 0.2 | 0.8 | GO:0021615 | glossopharyngeal nerve morphogenesis(GO:0021615) |
| 0.2 | 0.2 | GO:0002005 | angiotensin catabolic process in blood(GO:0002005) |
| 0.2 | 1.2 | GO:0006196 | AMP catabolic process(GO:0006196) |
| 0.2 | 1.2 | GO:0018032 | protein amidation(GO:0018032) |
| 0.2 | 18.0 | GO:0003254 | regulation of membrane depolarization(GO:0003254) |
| 0.2 | 0.6 | GO:2000297 | negative regulation of synapse maturation(GO:2000297) |
| 0.2 | 1.1 | GO:0030421 | defecation(GO:0030421) |
| 0.2 | 2.4 | GO:1903817 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817) |
| 0.2 | 1.6 | GO:0031086 | nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) |
| 0.2 | 2.6 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 0.2 | 1.2 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.2 | 1.7 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 0.2 | 2.6 | GO:0014894 | response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.2 | 2.4 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.2 | 0.3 | GO:0042704 | uterine wall breakdown(GO:0042704) |
| 0.2 | 0.6 | GO:0001868 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 0.1 | 0.6 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.1 | 3.6 | GO:0050930 | induction of positive chemotaxis(GO:0050930) |
| 0.1 | 1.0 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.1 | 1.3 | GO:0001712 | ectodermal cell fate commitment(GO:0001712) |
| 0.1 | 3.0 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 0.1 | 0.9 | GO:0021691 | cerebellar Purkinje cell layer maturation(GO:0021691) |
| 0.1 | 4.2 | GO:1904776 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 0.1 | 0.8 | GO:0061343 | cell adhesion involved in heart morphogenesis(GO:0061343) |
| 0.1 | 1.0 | GO:0030950 | establishment or maintenance of actin cytoskeleton polarity(GO:0030950) |
| 0.1 | 0.4 | GO:0019087 | transformation of host cell by virus(GO:0019087) |
| 0.1 | 1.2 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
| 0.1 | 1.2 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
| 0.1 | 0.6 | GO:0072365 | regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365) |
| 0.1 | 0.5 | GO:0033037 | polysaccharide localization(GO:0033037) |
| 0.1 | 1.7 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
| 0.1 | 3.9 | GO:0006590 | thyroid hormone generation(GO:0006590) |
| 0.1 | 0.4 | GO:0070384 | Harderian gland development(GO:0070384) |
| 0.1 | 1.3 | GO:0030643 | cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 0.1 | 0.1 | GO:0010726 | positive regulation of hydrogen peroxide metabolic process(GO:0010726) |
| 0.1 | 0.5 | GO:0035790 | platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) |
| 0.1 | 2.0 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
| 0.1 | 0.1 | GO:0002282 | microglial cell activation involved in immune response(GO:0002282) |
| 0.1 | 0.9 | GO:1902237 | positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902237) |
| 0.1 | 2.2 | GO:0033689 | negative regulation of osteoblast proliferation(GO:0033689) |
| 0.1 | 1.4 | GO:0071847 | TNFSF11-mediated signaling pathway(GO:0071847) |
| 0.1 | 2.0 | GO:0019532 | oxalate transport(GO:0019532) |
| 0.1 | 1.4 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
| 0.1 | 5.0 | GO:0071425 | hematopoietic stem cell proliferation(GO:0071425) |
| 0.1 | 8.0 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.1 | 1.1 | GO:0010886 | positive regulation of cholesterol storage(GO:0010886) |
| 0.1 | 2.1 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.1 | 2.0 | GO:0060390 | regulation of SMAD protein import into nucleus(GO:0060390) |
| 0.1 | 4.2 | GO:0060065 | uterus development(GO:0060065) |
| 0.1 | 1.8 | GO:1901223 | negative regulation of NIK/NF-kappaB signaling(GO:1901223) |
| 0.1 | 0.4 | GO:0010716 | negative regulation of extracellular matrix disassembly(GO:0010716) |
| 0.1 | 0.3 | GO:0035048 | splicing factor protein import into nucleus(GO:0035048) |
| 0.1 | 3.1 | GO:0010592 | positive regulation of lamellipodium assembly(GO:0010592) |
| 0.1 | 0.3 | GO:0046521 | sphingoid catabolic process(GO:0046521) |
| 0.1 | 0.8 | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) |
| 0.1 | 1.2 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.1 | 1.1 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 0.1 | 0.3 | GO:0001543 | ovarian follicle rupture(GO:0001543) |
| 0.1 | 1.6 | GO:0090308 | maintenance of DNA methylation(GO:0010216) regulation of methylation-dependent chromatin silencing(GO:0090308) |
| 0.1 | 0.3 | GO:0032416 | negative regulation of sodium:proton antiporter activity(GO:0032416) |
| 0.1 | 0.6 | GO:0048861 | leukemia inhibitory factor signaling pathway(GO:0048861) |
| 0.1 | 0.5 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
| 0.1 | 3.2 | GO:0031954 | positive regulation of protein autophosphorylation(GO:0031954) |
| 0.1 | 5.4 | GO:0016577 | histone demethylation(GO:0016577) |
| 0.1 | 3.1 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
| 0.1 | 1.2 | GO:0098734 | macromolecule depalmitoylation(GO:0098734) |
| 0.1 | 3.4 | GO:0035024 | negative regulation of Rho protein signal transduction(GO:0035024) |
| 0.1 | 1.0 | GO:0031022 | nuclear migration along microfilament(GO:0031022) |
| 0.1 | 1.9 | GO:0003215 | cardiac right ventricle morphogenesis(GO:0003215) |
| 0.1 | 2.4 | GO:0070734 | histone H3-K27 methylation(GO:0070734) |
| 0.1 | 4.6 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
| 0.1 | 0.9 | GO:0043129 | surfactant homeostasis(GO:0043129) |
| 0.1 | 1.4 | GO:0021842 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129) |
| 0.1 | 1.8 | GO:0032354 | response to follicle-stimulating hormone(GO:0032354) |
| 0.1 | 1.5 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
| 0.1 | 1.8 | GO:0035988 | chondrocyte proliferation(GO:0035988) |
| 0.1 | 1.1 | GO:0006707 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 0.1 | 3.8 | GO:0050869 | negative regulation of B cell activation(GO:0050869) |
| 0.1 | 1.5 | GO:0035845 | photoreceptor cell outer segment organization(GO:0035845) |
| 0.1 | 1.0 | GO:0006883 | cellular sodium ion homeostasis(GO:0006883) |
| 0.1 | 0.6 | GO:0071484 | cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) |
| 0.1 | 0.8 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
| 0.1 | 1.5 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.1 | 2.5 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.1 | 1.3 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148) |
| 0.1 | 0.7 | GO:0097012 | cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012) |
| 0.1 | 0.4 | GO:0038098 | sequestering of BMP from receptor via BMP binding(GO:0038098) |
| 0.1 | 3.4 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 0.1 | 0.8 | GO:0048539 | bone marrow development(GO:0048539) |
| 0.1 | 0.3 | GO:0000415 | negative regulation of histone H3-K36 methylation(GO:0000415) |
| 0.1 | 0.3 | GO:0071894 | histone H2B conserved C-terminal lysine ubiquitination(GO:0071894) |
| 0.1 | 1.8 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.1 | 1.1 | GO:1900017 | positive regulation of cytokine production involved in inflammatory response(GO:1900017) |
| 0.1 | 4.5 | GO:1901222 | regulation of NIK/NF-kappaB signaling(GO:1901222) |
| 0.1 | 0.4 | GO:0044860 | regulation of toll-like receptor 3 signaling pathway(GO:0034139) protein localization to plasma membrane raft(GO:0044860) |
| 0.1 | 0.3 | GO:2000491 | positive regulation of hepatic stellate cell activation(GO:2000491) |
| 0.1 | 1.0 | GO:0043578 | nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292) |
| 0.1 | 0.6 | GO:0060005 | vestibular reflex(GO:0060005) |
| 0.1 | 0.7 | GO:0090232 | positive regulation of spindle checkpoint(GO:0090232) |
| 0.1 | 0.3 | GO:0032971 | regulation of muscle filament sliding(GO:0032971) |
| 0.1 | 2.6 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.1 | 0.6 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.1 | 1.8 | GO:1901663 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.1 | 0.4 | GO:0019348 | dolichol metabolic process(GO:0019348) |
| 0.1 | 0.7 | GO:0051798 | positive regulation of hair follicle development(GO:0051798) |
| 0.1 | 0.3 | GO:2001034 | positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034) |
| 0.1 | 1.5 | GO:0032793 | positive regulation of CREB transcription factor activity(GO:0032793) |
| 0.1 | 0.8 | GO:0051573 | negative regulation of histone H3-K9 methylation(GO:0051573) |
| 0.1 | 3.5 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.1 | 0.4 | GO:0014807 | regulation of somitogenesis(GO:0014807) |
| 0.1 | 0.2 | GO:0014057 | positive regulation of acetylcholine secretion, neurotransmission(GO:0014057) |
| 0.1 | 2.2 | GO:0090662 | ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662) |
| 0.1 | 0.2 | GO:0072308 | negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697) |
| 0.1 | 2.1 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.1 | 1.3 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.1 | 3.9 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.1 | 1.1 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 0.1 | 0.4 | GO:0043316 | cytotoxic T cell degranulation(GO:0043316) positive regulation of constitutive secretory pathway(GO:1903435) |
| 0.1 | 1.5 | GO:0042994 | cytoplasmic sequestering of transcription factor(GO:0042994) |
| 0.1 | 0.5 | GO:0032237 | activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341) |
| 0.1 | 1.6 | GO:0010801 | negative regulation of peptidyl-threonine phosphorylation(GO:0010801) |
| 0.1 | 0.5 | GO:0001672 | regulation of chromatin assembly or disassembly(GO:0001672) |
| 0.1 | 0.5 | GO:0051599 | response to hydrostatic pressure(GO:0051599) |
| 0.1 | 0.2 | GO:0015917 | aminophospholipid transport(GO:0015917) regulation of Cdc42 protein signal transduction(GO:0032489) |
| 0.1 | 1.4 | GO:0034656 | nucleobase-containing small molecule catabolic process(GO:0034656) |
| 0.1 | 0.4 | GO:0051418 | interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418) |
| 0.1 | 0.7 | GO:0015074 | DNA integration(GO:0015074) |
| 0.1 | 0.2 | GO:0045208 | MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209) |
| 0.1 | 0.7 | GO:0097324 | melanocyte migration(GO:0097324) positive regulation of lens fiber cell differentiation(GO:1902748) |
| 0.1 | 0.5 | GO:0061737 | leukotriene signaling pathway(GO:0061737) |
| 0.0 | 4.8 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.0 | 0.4 | GO:0097026 | dendritic cell dendrite assembly(GO:0097026) |
| 0.0 | 0.2 | GO:0060684 | epithelial-mesenchymal cell signaling(GO:0060684) |
| 0.0 | 0.6 | GO:1904715 | negative regulation of chaperone-mediated autophagy(GO:1904715) |
| 0.0 | 15.0 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 0.0 | 0.4 | GO:0008050 | female courtship behavior(GO:0008050) |
| 0.0 | 0.8 | GO:0043508 | negative regulation of JUN kinase activity(GO:0043508) |
| 0.0 | 0.6 | GO:0006477 | protein sulfation(GO:0006477) |
| 0.0 | 2.1 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.0 | 5.6 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.0 | 0.2 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
| 0.0 | 0.1 | GO:0060214 | endocardium morphogenesis(GO:0003160) endocardium formation(GO:0060214) |
| 0.0 | 0.5 | GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147) |
| 0.0 | 1.9 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
| 0.0 | 0.2 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
| 0.0 | 1.0 | GO:1904886 | beta-catenin destruction complex disassembly(GO:1904886) |
| 0.0 | 0.2 | GO:2000690 | negative regulation of cardioblast differentiation(GO:0051892) regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691) |
| 0.0 | 0.5 | GO:0007144 | female meiosis I(GO:0007144) |
| 0.0 | 1.4 | GO:0036152 | phosphatidylethanolamine acyl-chain remodeling(GO:0036152) |
| 0.0 | 0.4 | GO:0045779 | negative regulation of bone resorption(GO:0045779) negative regulation of bone remodeling(GO:0046851) |
| 0.0 | 2.1 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.0 | 1.0 | GO:1904355 | positive regulation of telomere capping(GO:1904355) |
| 0.0 | 0.2 | GO:0090156 | cellular sphingolipid homeostasis(GO:0090156) |
| 0.0 | 0.2 | GO:0021563 | glossopharyngeal nerve development(GO:0021563) |
| 0.0 | 0.6 | GO:0001502 | cartilage condensation(GO:0001502) |
| 0.0 | 0.4 | GO:0001866 | NK T cell proliferation(GO:0001866) |
| 0.0 | 0.6 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
| 0.0 | 1.5 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.0 | 2.2 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.0 | 0.2 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 0.0 | 0.5 | GO:0048290 | isotype switching to IgA isotypes(GO:0048290) regulation of isotype switching to IgA isotypes(GO:0048296) positive regulation of isotype switching to IgA isotypes(GO:0048298) |
| 0.0 | 0.3 | GO:0010968 | regulation of microtubule nucleation(GO:0010968) |
| 0.0 | 0.8 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
| 0.0 | 0.3 | GO:2000645 | negative regulation of receptor catabolic process(GO:2000645) |
| 0.0 | 1.9 | GO:0030318 | melanocyte differentiation(GO:0030318) |
| 0.0 | 0.3 | GO:0010579 | regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579) |
| 0.0 | 0.2 | GO:1900369 | negative regulation of RNA interference(GO:1900369) |
| 0.0 | 0.1 | GO:0038193 | thromboxane A2 signaling pathway(GO:0038193) |
| 0.0 | 0.1 | GO:0002032 | desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032) |
| 0.0 | 1.2 | GO:0010863 | positive regulation of phospholipase C activity(GO:0010863) |
| 0.0 | 3.7 | GO:0006911 | phagocytosis, engulfment(GO:0006911) |
| 0.0 | 0.5 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.0 | 0.8 | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552) |
| 0.0 | 3.2 | GO:0048678 | response to axon injury(GO:0048678) |
| 0.0 | 0.2 | GO:0032740 | positive regulation of interleukin-17 production(GO:0032740) |
| 0.0 | 0.2 | GO:0006696 | ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204) |
| 0.0 | 0.4 | GO:0097094 | craniofacial suture morphogenesis(GO:0097094) |
| 0.0 | 0.6 | GO:0002076 | osteoblast development(GO:0002076) |
| 0.0 | 1.1 | GO:0043984 | histone H4-K16 acetylation(GO:0043984) |
| 0.0 | 0.3 | GO:0048009 | insulin-like growth factor receptor signaling pathway(GO:0048009) |
| 0.0 | 0.3 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
| 0.0 | 2.0 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.0 | 0.5 | GO:0006828 | manganese ion transport(GO:0006828) |
| 0.0 | 0.9 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
| 0.0 | 0.2 | GO:1901668 | regulation of superoxide dismutase activity(GO:1901668) |
| 0.0 | 0.7 | GO:0010867 | positive regulation of triglyceride biosynthetic process(GO:0010867) |
| 0.0 | 1.7 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 0.0 | 0.5 | GO:0010839 | negative regulation of keratinocyte proliferation(GO:0010839) |
| 0.0 | 1.0 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.0 | 1.9 | GO:0035722 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
| 0.0 | 0.4 | GO:0060575 | intestinal epithelial cell differentiation(GO:0060575) |
| 0.0 | 0.3 | GO:0045023 | G0 to G1 transition(GO:0045023) |
| 0.0 | 0.8 | GO:0043550 | regulation of lipid kinase activity(GO:0043550) |
| 0.0 | 0.2 | GO:0061314 | protein O-linked glycosylation via threonine(GO:0018243) Notch signaling involved in heart development(GO:0061314) |
| 0.0 | 1.4 | GO:0051646 | mitochondrion localization(GO:0051646) |
| 0.0 | 1.7 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 0.0 | 0.1 | GO:0015770 | disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772) |
| 0.0 | 0.2 | GO:0045717 | negative regulation of fatty acid biosynthetic process(GO:0045717) |
| 0.0 | 0.7 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.0 | 0.3 | GO:0030210 | heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210) |
| 0.0 | 0.4 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.0 | 0.2 | GO:0006701 | progesterone biosynthetic process(GO:0006701) |
| 0.0 | 0.1 | GO:0072752 | cellular response to rapamycin(GO:0072752) response to rapamycin(GO:1901355) |
| 0.0 | 0.3 | GO:0034244 | negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244) |
| 0.0 | 0.5 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.0 | 0.8 | GO:0071539 | protein localization to centrosome(GO:0071539) |
| 0.0 | 0.5 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.0 | 0.3 | GO:0070933 | histone H4 deacetylation(GO:0070933) |
| 0.0 | 0.1 | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) |
| 0.0 | 0.6 | GO:0048011 | neurotrophin TRK receptor signaling pathway(GO:0048011) |
| 0.0 | 0.1 | GO:0009257 | 10-formyltetrahydrofolate biosynthetic process(GO:0009257) |
| 0.0 | 0.7 | GO:0006625 | protein targeting to peroxisome(GO:0006625) peroxisomal transport(GO:0043574) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663) |
| 0.0 | 0.5 | GO:0010832 | negative regulation of myotube differentiation(GO:0010832) |
| 0.0 | 0.4 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 0.0 | 0.5 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 0.0 | 0.2 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.0 | 0.8 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 2.8 | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway(GO:0008277) |
| 0.0 | 0.1 | GO:0033299 | secretion of lysosomal enzymes(GO:0033299) |
| 0.0 | 2.4 | GO:0006338 | chromatin remodeling(GO:0006338) |
| 0.0 | 0.1 | GO:0070493 | thrombin receptor signaling pathway(GO:0070493) |
| 0.0 | 1.5 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.0 | 0.1 | GO:2000852 | regulation of corticosterone secretion(GO:2000852) |
| 0.0 | 0.9 | GO:0010761 | fibroblast migration(GO:0010761) |
| 0.0 | 1.2 | GO:0043647 | inositol phosphate metabolic process(GO:0043647) |
| 0.0 | 0.1 | GO:0055014 | atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014) |
| 0.0 | 3.5 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
| 0.0 | 0.1 | GO:0019509 | L-methionine biosynthetic process from methylthioadenosine(GO:0019509) |
| 0.0 | 0.1 | GO:0042045 | epithelial fluid transport(GO:0042045) |
| 0.0 | 1.8 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 0.1 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.0 | 0.0 | GO:0048239 | negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695) |
| 0.0 | 0.1 | GO:0060318 | regulation of definitive erythrocyte differentiation(GO:0010724) definitive erythrocyte differentiation(GO:0060318) |
| 0.0 | 0.0 | GO:1902525 | regulation of protein monoubiquitination(GO:1902525) |
| 0.0 | 0.6 | GO:0044364 | killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) |
| 0.0 | 0.2 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) |
| 0.0 | 0.6 | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) signal transduction involved in mitotic G1 DNA damage checkpoint(GO:0072431) intracellular signal transduction involved in G1 DNA damage checkpoint(GO:1902400) |
| 0.0 | 0.0 | GO:0090214 | spongiotrophoblast layer developmental growth(GO:0090214) |
| 0.0 | 0.2 | GO:0043562 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.0 | 0.1 | GO:0000160 | phosphorelay signal transduction system(GO:0000160) |
| 0.0 | 0.1 | GO:2000481 | positive regulation of cAMP-dependent protein kinase activity(GO:2000481) |
| 0.0 | 0.3 | GO:0031167 | rRNA methylation(GO:0031167) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 4.2 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.9 | 2.8 | GO:0071665 | gamma-catenin-TCF7L2 complex(GO:0071665) |
| 0.9 | 5.4 | GO:0036398 | TCR signalosome(GO:0036398) |
| 0.8 | 5.3 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
| 0.7 | 2.2 | GO:0016590 | ACF complex(GO:0016590) |
| 0.6 | 5.8 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.6 | 5.7 | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) |
| 0.5 | 1.5 | GO:1902636 | kinociliary basal body(GO:1902636) |
| 0.4 | 6.3 | GO:0030478 | actin cap(GO:0030478) |
| 0.4 | 1.2 | GO:0031251 | PAN complex(GO:0031251) |
| 0.4 | 1.7 | GO:0097629 | extrinsic component of omegasome membrane(GO:0097629) |
| 0.4 | 7.0 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.4 | 3.9 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.4 | 1.8 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 0.4 | 1.1 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.3 | 1.0 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 0.3 | 4.0 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.3 | 5.9 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.3 | 2.1 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.3 | 4.5 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.2 | 2.2 | GO:0016942 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
| 0.2 | 0.7 | GO:0048269 | methionine adenosyltransferase complex(GO:0048269) |
| 0.2 | 1.5 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 0.2 | 10.0 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.2 | 2.7 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.2 | 3.1 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.2 | 1.2 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.2 | 3.1 | GO:0042555 | MCM complex(GO:0042555) |
| 0.2 | 6.7 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.2 | 4.5 | GO:0032982 | myosin filament(GO:0032982) |
| 0.2 | 2.9 | GO:0097451 | glial limiting end-foot(GO:0097451) |
| 0.2 | 3.3 | GO:0008091 | spectrin(GO:0008091) |
| 0.1 | 0.3 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 0.1 | 2.8 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.1 | 0.4 | GO:0036457 | keratohyalin granule(GO:0036457) |
| 0.1 | 2.7 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.1 | 1.6 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 1.2 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.1 | 1.7 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.1 | 2.3 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.1 | 7.5 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.1 | 1.0 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.1 | 0.8 | GO:0070435 | Shc-EGFR complex(GO:0070435) |
| 0.1 | 0.5 | GO:0005712 | chiasma(GO:0005712) |
| 0.1 | 3.1 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.1 | 5.1 | GO:0016592 | mediator complex(GO:0016592) |
| 0.1 | 0.7 | GO:0071595 | Nem1-Spo7 phosphatase complex(GO:0071595) |
| 0.1 | 0.8 | GO:0098575 | lumenal side of lysosomal membrane(GO:0098575) |
| 0.1 | 5.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 1.1 | GO:0072487 | MSL complex(GO:0072487) |
| 0.1 | 10.5 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 1.4 | GO:0016342 | catenin complex(GO:0016342) |
| 0.1 | 0.5 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
| 0.1 | 12.6 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 2.2 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.1 | 2.0 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.1 | 1.0 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.1 | 3.2 | GO:0044665 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.1 | 0.6 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.1 | 5.0 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.1 | 0.3 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 0.1 | 8.1 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.1 | 0.3 | GO:0001940 | male pronucleus(GO:0001940) |
| 0.1 | 1.3 | GO:0070938 | contractile ring(GO:0070938) |
| 0.1 | 6.0 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.1 | 10.3 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.1 | 0.5 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.1 | 2.0 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 0.4 | GO:0000923 | equatorial microtubule organizing center(GO:0000923) |
| 0.0 | 0.8 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.0 | 0.9 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 0.4 | GO:0000974 | Prp19 complex(GO:0000974) |
| 0.0 | 0.2 | GO:0005638 | lamin filament(GO:0005638) |
| 0.0 | 0.4 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.0 | 0.6 | GO:0098642 | network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) |
| 0.0 | 2.0 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 22.0 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 0.2 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.0 | 0.9 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.0 | 3.4 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.0 | 2.0 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 35.1 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 0.7 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 0.5 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.0 | 0.5 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.0 | 0.5 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.0 | 5.4 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.4 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.0 | 5.3 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 0.7 | GO:0045178 | basal part of cell(GO:0045178) |
| 0.0 | 1.2 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 0.3 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 0.2 | GO:0035339 | SPOTS complex(GO:0035339) |
| 0.0 | 0.1 | GO:0005600 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.0 | 2.5 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 0.2 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 0.3 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 0.0 | 0.3 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.0 | 0.3 | GO:0033503 | HULC complex(GO:0033503) |
| 0.0 | 16.0 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 3.4 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 0.6 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 5.3 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.0 | 1.2 | GO:0071565 | SWI/SNF complex(GO:0016514) nBAF complex(GO:0071565) |
| 0.0 | 0.6 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.0 | 2.4 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 0.1 | GO:0070939 | Dsl1p complex(GO:0070939) |
| 0.0 | 7.5 | GO:0001726 | ruffle(GO:0001726) |
| 0.0 | 0.1 | GO:0032449 | CBM complex(GO:0032449) |
| 0.0 | 0.4 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 0.6 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 0.3 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.0 | 6.1 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.0 | 2.4 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 4.7 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 1.9 | GO:0000123 | histone acetyltransferase complex(GO:0000123) |
| 0.0 | 0.2 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.0 | 2.9 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 0.2 | GO:0070695 | FHF complex(GO:0070695) |
| 0.0 | 1.4 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 10.4 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 0.3 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 2.5 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 1.9 | GO:0030863 | cortical cytoskeleton(GO:0030863) |
| 0.0 | 0.2 | GO:0016442 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
| 0.0 | 1.2 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.0 | 0.6 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 0.5 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.0 | 6.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.6 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.0 | 0.2 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
| 0.0 | 0.9 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.0 | 0.1 | GO:1990745 | EARP complex(GO:1990745) |
| 0.0 | 0.6 | GO:0034399 | nuclear periphery(GO:0034399) |
| 0.0 | 1.0 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 2.3 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 0.3 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 1.3 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 3.9 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 0.1 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.0 | 0.1 | GO:0016011 | dystroglycan complex(GO:0016011) sarcoglycan complex(GO:0016012) |
| 0.0 | 0.6 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 1.1 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 0.2 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.0 | 1.3 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 1.1 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 4.1 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.0 | 6.2 | GO:0009986 | cell surface(GO:0009986) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 7.0 | GO:0004877 | complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877) |
| 1.5 | 7.5 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
| 1.2 | 3.6 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 1.1 | 8.7 | GO:0051032 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 1.0 | 5.0 | GO:0005010 | insulin-like growth factor-activated receptor activity(GO:0005010) |
| 0.9 | 2.8 | GO:0005199 | structural constituent of cell wall(GO:0005199) |
| 0.9 | 2.7 | GO:0001596 | angiotensin type I receptor activity(GO:0001596) |
| 0.8 | 5.1 | GO:0008241 | peptidyl-dipeptidase activity(GO:0008241) |
| 0.8 | 2.5 | GO:0033878 | hormone-sensitive lipase activity(GO:0033878) |
| 0.8 | 4.7 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.7 | 3.9 | GO:0070573 | metallodipeptidase activity(GO:0070573) |
| 0.6 | 3.8 | GO:0047696 | beta-adrenergic receptor kinase activity(GO:0047696) |
| 0.5 | 1.6 | GO:0036487 | nitric-oxide synthase inhibitor activity(GO:0036487) |
| 0.5 | 3.0 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.5 | 5.8 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.5 | 14.2 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.5 | 1.4 | GO:0030617 | transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity(GO:0030617) |
| 0.5 | 1.4 | GO:0050528 | acyloxyacyl hydrolase activity(GO:0050528) |
| 0.4 | 3.1 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.4 | 3.1 | GO:0043426 | MRF binding(GO:0043426) |
| 0.4 | 3.4 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.4 | 1.5 | GO:0002046 | opsin binding(GO:0002046) |
| 0.4 | 6.2 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.4 | 1.8 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 0.4 | 1.1 | GO:0036327 | VEGF-A-activated receptor activity(GO:0036326) VEGF-B-activated receptor activity(GO:0036327) placental growth factor-activated receptor activity(GO:0036332) |
| 0.3 | 23.8 | GO:0070888 | E-box binding(GO:0070888) |
| 0.3 | 1.7 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
| 0.3 | 1.0 | GO:0005174 | CD40 receptor binding(GO:0005174) |
| 0.3 | 6.4 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.3 | 7.9 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.3 | 11.1 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.3 | 3.1 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.3 | 0.9 | GO:0004651 | polynucleotide 5'-phosphatase activity(GO:0004651) |
| 0.3 | 4.8 | GO:0016312 | inositol bisphosphate phosphatase activity(GO:0016312) |
| 0.3 | 0.8 | GO:0005026 | transforming growth factor beta receptor activity, type II(GO:0005026) |
| 0.3 | 1.1 | GO:0004307 | diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307) |
| 0.3 | 2.1 | GO:0004883 | glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
| 0.3 | 0.8 | GO:0004796 | thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134) |
| 0.3 | 3.3 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.3 | 4.8 | GO:0055106 | ubiquitin-protein transferase regulator activity(GO:0055106) |
| 0.2 | 2.2 | GO:0004727 | prenylated protein tyrosine phosphatase activity(GO:0004727) |
| 0.2 | 7.3 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.2 | 0.7 | GO:0015218 | pyrimidine nucleotide transmembrane transporter activity(GO:0015218) |
| 0.2 | 1.3 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
| 0.2 | 3.1 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.2 | 6.5 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.2 | 5.0 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.2 | 2.8 | GO:0000405 | bubble DNA binding(GO:0000405) supercoiled DNA binding(GO:0097100) |
| 0.2 | 1.8 | GO:0098821 | activin receptor activity, type I(GO:0016361) BMP receptor activity(GO:0098821) |
| 0.2 | 4.3 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.2 | 1.6 | GO:0005534 | galactose binding(GO:0005534) |
| 0.2 | 6.3 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.2 | 0.6 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.2 | 5.8 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.2 | 2.5 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.2 | 2.8 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.2 | 1.6 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.2 | 2.3 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.2 | 1.1 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.2 | 1.2 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.2 | 0.7 | GO:0004967 | glucagon receptor activity(GO:0004967) |
| 0.2 | 5.0 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
| 0.2 | 1.2 | GO:0050659 | N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659) |
| 0.2 | 1.0 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.2 | 0.9 | GO:0008267 | poly-glutamine tract binding(GO:0008267) |
| 0.2 | 5.7 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.2 | 1.2 | GO:0004598 | peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598) |
| 0.2 | 1.0 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
| 0.2 | 1.3 | GO:0045029 | UDP-activated nucleotide receptor activity(GO:0045029) |
| 0.2 | 0.5 | GO:0005017 | platelet-derived growth factor-activated receptor activity(GO:0005017) |
| 0.2 | 3.0 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.2 | 17.5 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.1 | 0.6 | GO:0004923 | leukemia inhibitory factor receptor activity(GO:0004923) |
| 0.1 | 0.9 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 0.1 | 5.0 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.1 | 5.1 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.1 | 0.7 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.1 | 4.5 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 3.3 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 0.1 | 1.5 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.1 | 1.1 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.1 | 1.2 | GO:0042608 | T cell receptor binding(GO:0042608) |
| 0.1 | 3.8 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.1 | 4.0 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.1 | 0.5 | GO:0001632 | leukotriene B4 receptor activity(GO:0001632) |
| 0.1 | 3.4 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.1 | 1.9 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.1 | 6.9 | GO:0043548 | phosphatidylinositol 3-kinase binding(GO:0043548) |
| 0.1 | 6.2 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 2.0 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
| 0.1 | 0.5 | GO:0055100 | adiponectin binding(GO:0055100) |
| 0.1 | 0.4 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
| 0.1 | 1.9 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.1 | 0.1 | GO:0035651 | AP-3 adaptor complex binding(GO:0035651) |
| 0.1 | 2.7 | GO:0031434 | mitogen-activated protein kinase kinase binding(GO:0031434) |
| 0.1 | 3.8 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.1 | 1.1 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.1 | 0.6 | GO:0035614 | snRNA stem-loop binding(GO:0035614) |
| 0.1 | 5.4 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.1 | 1.2 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
| 0.1 | 0.5 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
| 0.1 | 1.0 | GO:0047623 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.1 | 0.5 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 0.1 | 1.1 | GO:0004969 | histamine receptor activity(GO:0004969) |
| 0.1 | 1.2 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.1 | 7.7 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.1 | 2.0 | GO:0044213 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213) |
| 0.1 | 6.4 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.1 | 3.3 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.1 | 0.9 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.1 | 0.8 | GO:1990829 | C-rich single-stranded DNA binding(GO:1990829) |
| 0.1 | 0.5 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.1 | 2.7 | GO:0030275 | LRR domain binding(GO:0030275) |
| 0.1 | 5.8 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.1 | 1.3 | GO:0015321 | sodium-dependent phosphate transmembrane transporter activity(GO:0015321) |
| 0.1 | 0.2 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.1 | 1.7 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.1 | 0.8 | GO:0034485 | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485) |
| 0.1 | 0.6 | GO:0019959 | interleukin-8 binding(GO:0019959) tumor necrosis factor binding(GO:0043120) |
| 0.1 | 0.4 | GO:0003976 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976) |
| 0.1 | 1.3 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.1 | 1.6 | GO:0098748 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.1 | 0.2 | GO:0090556 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556) |
| 0.1 | 7.8 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 0.8 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.1 | 2.6 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.1 | 1.0 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.1 | 0.6 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.1 | 1.2 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 0.1 | GO:0031762 | alpha-1A adrenergic receptor binding(GO:0031691) follicle-stimulating hormone receptor binding(GO:0031762) |
| 0.1 | 2.5 | GO:0001221 | transcription cofactor binding(GO:0001221) |
| 0.1 | 7.7 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 0.1 | 2.9 | GO:0005521 | lamin binding(GO:0005521) |
| 0.1 | 1.3 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.1 | 2.1 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) |
| 0.1 | 1.9 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.1 | 0.6 | GO:0030267 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.1 | 2.0 | GO:0019789 | SUMO transferase activity(GO:0019789) |
| 0.1 | 4.7 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.1 | 1.1 | GO:0030169 | low-density lipoprotein particle binding(GO:0030169) |
| 0.1 | 2.4 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 0.9 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.1 | 1.4 | GO:0017110 | nucleoside-diphosphatase activity(GO:0017110) |
| 0.1 | 0.2 | GO:0016497 | substance K receptor activity(GO:0016497) |
| 0.1 | 0.6 | GO:0060002 | plus-end directed microfilament motor activity(GO:0060002) |
| 0.1 | 2.0 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.1 | 0.3 | GO:0017098 | sulfonylurea receptor binding(GO:0017098) |
| 0.1 | 0.5 | GO:0003696 | satellite DNA binding(GO:0003696) |
| 0.1 | 1.1 | GO:0031702 | angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702) |
| 0.1 | 0.3 | GO:0004096 | catalase activity(GO:0004096) |
| 0.1 | 3.1 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.1 | 0.3 | GO:0004906 | interferon-gamma receptor activity(GO:0004906) |
| 0.1 | 0.8 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
| 0.1 | 1.0 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.1 | 1.6 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.1 | 1.2 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.1 | 0.3 | GO:0004905 | type I interferon receptor activity(GO:0004905) |
| 0.1 | 0.8 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.0 | 1.3 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.0 | 1.5 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.0 | 0.8 | GO:0004308 | exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) |
| 0.0 | 0.1 | GO:0061629 | RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629) |
| 0.0 | 0.6 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 0.0 | 0.3 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
| 0.0 | 0.2 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 0.0 | 1.1 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.0 | 1.0 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.0 | 0.5 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.0 | 0.3 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.0 | 1.6 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.0 | 3.8 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) ATP-dependent helicase activity(GO:0008026) RNA-dependent ATPase activity(GO:0008186) purine NTP-dependent helicase activity(GO:0070035) |
| 0.0 | 0.2 | GO:0004356 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
| 0.0 | 1.8 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.0 | 0.5 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.0 | 0.4 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.0 | 5.1 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 6.6 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 1.5 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 1.4 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 0.6 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 3.0 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 2.9 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.1 | GO:0004961 | thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961) |
| 0.0 | 0.7 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.0 | 1.5 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 4.5 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.0 | 0.5 | GO:0016634 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634) |
| 0.0 | 4.9 | GO:0001104 | RNA polymerase II transcription cofactor activity(GO:0001104) |
| 0.0 | 1.5 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.0 | 5.2 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.0 | 0.9 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.0 | 0.5 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.0 | 1.7 | GO:0035257 | nuclear hormone receptor binding(GO:0035257) |
| 0.0 | 1.8 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.0 | 0.2 | GO:0051996 | farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996) |
| 0.0 | 0.4 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.0 | 1.5 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 0.0 | 2.5 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.0 | 0.3 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.0 | 0.3 | GO:0016433 | rRNA (adenine) methyltransferase activity(GO:0016433) |
| 0.0 | 0.1 | GO:0050309 | glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309) |
| 0.0 | 0.7 | GO:0001871 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.0 | 3.3 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.2 | GO:0005047 | signal recognition particle binding(GO:0005047) |
| 0.0 | 0.4 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) |
| 0.0 | 8.2 | GO:0061659 | ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
| 0.0 | 0.5 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.0 | 1.5 | GO:0043531 | ADP binding(GO:0043531) |
| 0.0 | 0.4 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.0 | 0.2 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 0.0 | 1.1 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.0 | 0.3 | GO:0016015 | morphogen activity(GO:0016015) |
| 0.0 | 6.9 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.0 | 0.6 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 6.0 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 0.2 | GO:0003726 | double-stranded RNA adenosine deaminase activity(GO:0003726) |
| 0.0 | 5.3 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 0.1 | GO:0015157 | sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157) |
| 0.0 | 0.7 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 0.8 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.0 | 0.6 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.0 | 8.3 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.0 | 0.3 | GO:0001591 | dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591) |
| 0.0 | 5.7 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 0.0 | 0.3 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.0 | 0.1 | GO:0004329 | formate-tetrahydrofolate ligase activity(GO:0004329) |
| 0.0 | 0.5 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 0.9 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.1 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.0 | 0.5 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.0 | 0.1 | GO:0070139 | ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139) |
| 0.0 | 0.5 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 0.5 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.0 | 0.3 | GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656) |
| 0.0 | 0.3 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 0.2 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.0 | 0.6 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
| 0.0 | 0.2 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 0.1 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
| 0.0 | 2.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.1 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
| 0.0 | 0.6 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 0.4 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.0 | 0.1 | GO:0070996 | type 1 melanocortin receptor binding(GO:0070996) |
| 0.0 | 0.0 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 0.4 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 0.6 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.0 | 5.1 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 0.2 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 0.0 | GO:0009383 | rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) |
| 0.0 | 0.0 | GO:0008513 | secondary active organic cation transmembrane transporter activity(GO:0008513) |
| 0.0 | 0.3 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 0.1 | GO:0001594 | trace-amine receptor activity(GO:0001594) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 19.4 | PID MYC PATHWAY | C-MYC pathway |
| 0.3 | 13.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.2 | 34.4 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 4.9 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.2 | 4.9 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.2 | 12.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.2 | 7.1 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.2 | 15.9 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 8.0 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 1.6 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.1 | 3.1 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 4.0 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 1.0 | PID FOXO PATHWAY | FoxO family signaling |
| 0.1 | 6.3 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 6.9 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 1.6 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.1 | 5.8 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 9.7 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 2.8 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.1 | 5.2 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 6.3 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 0.8 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 1.3 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 1.0 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.1 | 3.7 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 0.5 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.1 | 5.3 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.1 | 5.8 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 5.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 3.0 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 4.8 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 4.1 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 1.3 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.1 | 2.0 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.1 | 10.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 1.1 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 1.7 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 3.8 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.0 | 0.7 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.0 | 17.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.9 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 2.7 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 4.6 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 3.3 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 1.1 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.0 | 1.6 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 0.7 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 2.0 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 0.3 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.0 | 2.0 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 1.7 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 0.2 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 0.9 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 1.1 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.0 | 10.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.6 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 2.1 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.5 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 2.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 5.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 1.1 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 0.5 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 4.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.4 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 0.3 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 0.3 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 0.5 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 0.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.7 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 0.4 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.4 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 0.1 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.2 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 9.0 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.4 | 31.0 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.3 | 5.0 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.3 | 2.7 | REACTOME SPRY REGULATION OF FGF SIGNALING | Genes involved in Spry regulation of FGF signaling |
| 0.3 | 7.6 | REACTOME DESTABILIZATION OF MRNA BY BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 0.3 | 3.6 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.2 | 6.0 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.2 | 4.8 | REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA | Genes involved in Activation of Chaperones by ATF6-alpha |
| 0.2 | 13.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 8.8 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.2 | 2.5 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.2 | 11.2 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.2 | 4.3 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.2 | 3.1 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.2 | 2.8 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.2 | 4.8 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.2 | 5.4 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.2 | 3.0 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.1 | 7.9 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.1 | 4.0 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.1 | 14.2 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 0.8 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 | Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) |
| 0.1 | 7.4 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.1 | 6.4 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.1 | 1.7 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.1 | 2.5 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.1 | 5.7 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 1.3 | REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
| 0.1 | 5.0 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 1.7 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.1 | 2.5 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 12.1 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 17.3 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 2.6 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.1 | 1.5 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.1 | 1.8 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.1 | 3.9 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.1 | 3.4 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 4.6 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 2.6 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 2.5 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 2.8 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.1 | 0.8 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.1 | 1.1 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 6.6 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 3.1 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 2.3 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 1.6 | REACTOME PI3K EVENTS IN ERBB4 SIGNALING | Genes involved in PI3K events in ERBB4 signaling |
| 0.0 | 1.1 | REACTOME PERK REGULATED GENE EXPRESSION | Genes involved in PERK regulated gene expression |
| 0.0 | 0.5 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.0 | 0.5 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.0 | 0.5 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.0 | 10.3 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 0.8 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 1.1 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 1.0 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.0 | 0.1 | REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | Genes involved in Thromboxane signalling through TP receptor |
| 0.0 | 0.5 | REACTOME EICOSANOID LIGAND BINDING RECEPTORS | Genes involved in Eicosanoid ligand-binding receptors |
| 0.0 | 0.8 | REACTOME COSTIMULATION BY THE CD28 FAMILY | Genes involved in Costimulation by the CD28 family |
| 0.0 | 1.4 | REACTOME SIGNALLING BY NGF | Genes involved in Signalling by NGF |
| 0.0 | 0.3 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.0 | 0.5 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.0 | 0.4 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.0 | 1.1 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.0 | 2.1 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 1.0 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 0.3 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.0 | 1.1 | REACTOME CELL CELL JUNCTION ORGANIZATION | Genes involved in Cell-cell junction organization |
| 0.0 | 0.9 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 1.1 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 1.3 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 1.9 | REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | Genes involved in Cyclin E associated events during G1/S transition |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 1.1 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 2.3 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 0.6 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 0.4 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.0 | 0.3 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.0 | 0.8 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 0.2 | REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX | Genes involved in Formation of the HIV-1 Early Elongation Complex |
| 0.0 | 5.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.4 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.0 | 0.5 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 1.4 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 0.2 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 1.0 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 1.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.8 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.2 | REACTOME P38MAPK EVENTS | Genes involved in p38MAPK events |
| 0.0 | 2.2 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 0.2 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.0 | 0.3 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 0.7 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 0.5 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.0 | 0.6 | REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM | Genes involved in Chondroitin sulfate/dermatan sulfate metabolism |
| 0.0 | 0.5 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 0.0 | 0.3 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 0.5 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.0 | 0.2 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 1.0 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 0.3 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |