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Illumina Body Map 2 (GSE30611)
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Results for FOXL1
Z-value: 2.78
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Transcription factors associated with FOXL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXL1 | hg38_v1_chr16_+_86576333_86576368 | -0.16 | 3.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_106360320 Show fit | 17.66 |
ENST00000390615.2
|
immunoglobulin heavy variable 3-33 |
|
| chr2_-_89222461 Show fit | 12.85 |
ENST00000482769.1
|
immunoglobulin kappa variable 2-28 |
|
| chr4_-_99321362 Show fit | 12.62 |
ENST00000625860.2
ENST00000305046.13 ENST00000506651.5 |
alcohol dehydrogenase 1B (class I), beta polypeptide |
|
| chr4_-_70666961 Show fit | 12.57 |
ENST00000510437.5
|
joining chain of multimeric IgA and IgM |
|
| chr4_-_70666492 Show fit | 10.99 |
ENST00000254801.9
ENST00000391614.7 |
joining chain of multimeric IgA and IgM |
|
| chr4_-_99352730 Show fit | 10.92 |
ENST00000510055.5
ENST00000515683.6 ENST00000511397.3 |
alcohol dehydrogenase 1C (class I), gamma polypeptide |
|
| chr2_-_88947820 Show fit | 10.76 |
ENST00000496168.1
|
immunoglobulin kappa variable 1-5 |
|
| chr2_+_89936859 Show fit | 10.48 |
ENST00000474213.1
|
immunoglobulin kappa variable 2D-30 |
|
| chr4_-_99352754 Show fit | 9.64 |
ENST00000639454.1
|
alcohol dehydrogenase 1B (class I), beta polypeptide |
|
| chr2_+_88885397 Show fit | 9.56 |
ENST00000390243.2
|
immunoglobulin kappa variable 4-1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXL1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 294.3 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.3 | 72.6 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 1.8 | 36.9 | GO:0006069 | ethanol oxidation(GO:0006069) |
| 2.6 | 28.9 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 2.2 | 28.6 | GO:2000334 | response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 0.1 | 17.7 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 2.2 | 17.3 | GO:0070171 | negative regulation of tooth mineralization(GO:0070171) |
| 0.1 | 16.2 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.8 | 15.1 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.2 | 12.6 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 123.6 | GO:0005615 | extracellular space(GO:0005615) |
| 1.8 | 97.6 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.5 | 92.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.6 | 31.9 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 7.2 | 28.9 | GO:0071757 | hexameric IgM immunoglobulin complex(GO:0071757) |
| 0.2 | 24.0 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.1 | 21.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 15.6 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 1.2 | 15.1 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 14.4 | GO:0005925 | focal adhesion(GO:0005925) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 280.6 | GO:0003823 | antigen binding(GO:0003823) |
| 1.4 | 97.6 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.3 | 43.8 | GO:0005518 | collagen binding(GO:0005518) |
| 4.1 | 36.9 | GO:0004024 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
| 4.4 | 31.1 | GO:0019862 | IgA binding(GO:0019862) |
| 2.4 | 28.6 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.3 | 13.5 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.4 | 11.6 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.6 | 11.1 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.0 | 10.7 | GO:0003924 | GTPase activity(GO:0003924) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 31.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 19.7 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 16.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 16.1 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.1 | 14.6 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.2 | 13.9 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 12.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 12.3 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.1 | 11.4 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.1 | 10.1 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 43.8 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 2.0 | 36.9 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.2 | 21.5 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 19.1 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.5 | 15.1 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.3 | 13.5 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.5 | 13.3 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.1 | 10.6 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.3 | 10.5 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 10.1 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |