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Illumina Body Map 2 (GSE30611)
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Results for FOXM1_TBL1XR1
Z-value: 2.52
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Transcription factors associated with FOXM1_TBL1XR1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBL1XR1 | hg38_v1_chr3_-_177197429_177197492 | -0.51 | 3.1e-03 | Click! |
| FOXM1 | hg38_v1_chr12_-_2877113_2877182 | 0.10 | 6.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXM1_TBL1XR1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 156.9 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.4 | 70.4 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.3 | 52.0 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.1 | 51.1 | GO:0043312 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 0.7 | 43.6 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.3 | 31.8 | GO:0031295 | T cell costimulation(GO:0031295) |
| 0.1 | 27.9 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 2.0 | 25.5 | GO:2000334 | blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 0.7 | 25.0 | GO:0019835 | cytolysis(GO:0019835) |
| 0.2 | 24.7 | GO:0002250 | adaptive immune response(GO:0002250) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 100.6 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.4 | 77.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 58.8 | GO:0005615 | extracellular space(GO:0005615) |
| 1.1 | 56.0 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.3 | 35.9 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.4 | 35.1 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.4 | 29.2 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.2 | 28.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 27.9 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.2 | 26.5 | GO:0035578 | azurophil granule lumen(GO:0035578) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 163.5 | GO:0003823 | antigen binding(GO:0003823) |
| 1.0 | 65.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.4 | 64.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 55.2 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 49.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 36.1 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.6 | 28.7 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.1 | 28.2 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 2.0 | 23.8 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.1 | 20.9 | GO:0004984 | olfactory receptor activity(GO:0004984) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 74.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.9 | 55.5 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 54.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 43.6 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.5 | 29.5 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.3 | 28.3 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 25.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.3 | 23.8 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.5 | 20.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.3 | 19.9 | PID IL1 PATHWAY | IL1-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 76.8 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.6 | 40.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.3 | 34.6 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.3 | 31.9 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 1.8 | 31.8 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 1.5 | 28.8 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.4 | 28.4 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.3 | 27.4 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 26.3 | REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 0.8 | 23.7 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |