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Illumina Body Map 2 (GSE30611)

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Results for FOXO4

Z-value: 1.34

Motif logo

Transcription factors associated with FOXO4

Gene Symbol Gene ID Gene Info
ENSG00000184481.17 forkhead box O4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FOXO4hg38_v1_chrX_+_71095838_710958600.575.9e-04Click!

Activity profile of FOXO4 motif

Sorted Z-values of FOXO4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_110920568 5.06 ENST00000548438.1
ENST00000228841.15
myosin light chain 2
chr7_-_95596507 4.65 ENST00000005178.6
pyruvate dehydrogenase kinase 4
chr5_+_137867852 3.75 ENST00000421631.6
ENST00000239926.9
myotilin
chr12_+_12725897 3.66 ENST00000326765.10
apolipoprotein L domain containing 1
chr10_+_122163672 3.52 ENST00000369004.7
ENST00000260733.7
transforming acidic coiled-coil containing protein 2
chr2_+_167248638 3.45 ENST00000295237.10
xin actin binding repeat containing 2
chr20_+_45406560 3.38 ENST00000372717.5
ENST00000360981.8
dysbindin domain containing 2
chr6_+_96562548 3.26 ENST00000541107.5
ENST00000326771.2
four and a half LIM domains 5
chr10_+_122163590 3.20 ENST00000368999.5
transforming acidic coiled-coil containing protein 2
chr5_+_137867868 3.05 ENST00000515645.1
myotilin
chr19_+_13023958 3.05 ENST00000587760.5
ENST00000585575.5
nuclear factor I X
chr6_-_127459364 3.02 ENST00000487331.2
ENST00000483725.8
KIAA0408
chr19_+_7515292 3.02 ENST00000596712.1
zinc finger protein 358
chr11_+_114060204 2.98 ENST00000683318.1
zinc finger and BTB domain containing 16
chr3_-_196515315 2.92 ENST00000397537.3
single-pass membrane protein with coiled-coil domains 1
chr1_+_86468902 2.91 ENST00000394711.2
chloride channel accessory 1
chr2_-_71227055 2.91 ENST00000244221.9
poly(A) binding protein interacting protein 2B
chr4_+_123399488 2.88 ENST00000394339.2
sprouty RTK signaling antagonist 1
chr14_+_32495052 2.83 ENST00000556638.1
A-kinase anchoring protein 6
chr6_+_96563117 2.76 ENST00000450218.6
four and a half LIM domains 5
chr3_-_46566276 2.71 ENST00000395905.8
leucine rich repeat containing 2
chr17_-_17972374 2.70 ENST00000318094.14
ENST00000540946.5
ENST00000379504.8
ENST00000542206.5
ENST00000395739.8
ENST00000581396.5
ENST00000535933.5
ENST00000579586.1
target of myb1 like 2 membrane trafficking protein
chr7_+_37683817 2.61 ENST00000476620.1
ependymin related 1
chr17_+_35147807 2.61 ENST00000394570.7
ENST00000268876.9
unc-45 myosin chaperone B
chr8_+_49072335 2.57 ENST00000399653.8
ENST00000522267.6
ENST00000303202.8
pancreatic progenitor cell differentiation and proliferation factor like
chr17_-_69060906 2.54 ENST00000495634.5
ENST00000453985.6
ENST00000340001.9
ENST00000585714.1
ATP binding cassette subfamily A member 9
chr18_+_34493289 2.51 ENST00000682923.1
ENST00000596745.5
ENST00000283365.14
ENST00000315456.10
ENST00000598774.6
ENST00000684266.1
ENST00000683092.1
ENST00000683379.1
ENST00000684359.1
dystrobrevin alpha
chr18_-_24272179 2.51 ENST00000399443.7
oxysterol binding protein like 1A
chr4_-_151227881 2.46 ENST00000652233.1
ENST00000514152.5
SH3 domain containing 19
chr3_+_159852933 2.45 ENST00000482804.1
schwannomin interacting protein 1
chr1_-_182391323 2.39 ENST00000642379.1
glutamate-ammonia ligase
chr20_+_45407207 2.35 ENST00000372712.6
dysbindin domain containing 2
chr10_+_122163426 2.34 ENST00000360561.7
transforming acidic coiled-coil containing protein 2
chr6_+_36676489 2.28 ENST00000448526.6
cyclin dependent kinase inhibitor 1A
chr12_+_53097656 2.25 ENST00000301464.4
insulin like growth factor binding protein 6
chr1_-_182391783 2.25 ENST00000331872.11
ENST00000339526.8
glutamate-ammonia ligase
chr1_-_182391363 2.23 ENST00000417584.6
glutamate-ammonia ligase
chr4_-_185775271 2.22 ENST00000430503.5
ENST00000319454.10
ENST00000450341.5
sorbin and SH3 domain containing 2
chr14_+_94110728 2.22 ENST00000616764.4
ENST00000618863.1
ENST00000611954.4
ENST00000618200.4
ENST00000621160.4
ENST00000555819.5
ENST00000620396.4
ENST00000612813.4
ENST00000620066.1
interferon alpha inducible protein 27
chr9_+_127611760 2.20 ENST00000625363.2
ENST00000626539.3
syntaxin binding protein 1
chr15_-_29822418 2.19 ENST00000614355.5
ENST00000495972.6
ENST00000346128.10
tight junction protein 1
chr2_+_173090598 2.18 ENST00000422149.1
mitogen-activated protein kinase kinase kinase 20
chr2_+_232662733 2.17 ENST00000410095.5
ENST00000611312.1
EF-hand domain family member D1
chr21_-_26967057 2.17 ENST00000284987.6
ADAM metallopeptidase with thrombospondin type 1 motif 5
chr3_+_124384513 2.16 ENST00000682540.1
ENST00000522553.6
ENST00000682695.1
ENST00000682674.1
ENST00000684382.1
kalirin RhoGEF kinase
chr5_-_10307821 2.12 ENST00000296658.4
carboxymethylenebutenolidase homolog
chr3_+_28348695 2.11 ENST00000383768.7
zinc finger CW-type and PWWP domain containing 2
chr3_+_138349209 2.09 ENST00000474559.1
muscle RAS oncogene homolog
chr16_+_6019016 2.09 ENST00000550418.6
RNA binding fox-1 homolog 1
chr16_+_6019585 2.06 ENST00000547372.5
RNA binding fox-1 homolog 1
chr9_-_92424427 2.03 ENST00000375550.5
osteomodulin
chr2_-_36966471 2.03 ENST00000379213.3
striatin
chr7_+_32979445 2.02 ENST00000418354.5
ENST00000490776.3
FKBP prolyl isomerase 9
chr10_-_88991282 1.98 ENST00000458159.5
ENST00000415557.1
actin alpha 2, smooth muscle
chr14_-_103521342 1.93 ENST00000553610.5
creatine kinase B
chr3_-_52835011 1.87 ENST00000446157.3
musculoskeletal, embryonic nuclear protein 1
chr10_+_80413817 1.87 ENST00000372187.9
peroxiredoxin like 2A
chr6_-_46921926 1.84 ENST00000283296.12
adhesion G protein-coupled receptor F5
chr2_+_65056382 1.82 ENST00000377990.7
ENST00000537589.1
ENST00000260569.4
centrosomal protein 68
chrX_-_38220824 1.79 ENST00000378533.4
ENST00000432886.6
ENST00000544439.5
ENST00000538295.5
sushi repeat containing protein X-linked
chr19_-_42412347 1.77 ENST00000601189.1
ENST00000599211.1
lipase E, hormone sensitive type
chr2_-_182866627 1.77 ENST00000295113.5
frizzled related protein
chr4_-_151325488 1.73 ENST00000604030.7
SH3 domain containing 19
chr11_+_112961247 1.71 ENST00000621518.4
ENST00000618266.4
ENST00000615112.4
ENST00000615285.4
ENST00000619839.4
ENST00000401611.6
ENST00000621128.4
neural cell adhesion molecule 1
chr10_+_84424919 1.67 ENST00000543283.2
ENST00000494586.5
coiled-coil serine rich protein 2
chr1_+_43389874 1.66 ENST00000372450.8
SZT2 subunit of KICSTOR complex
chr12_-_7444139 1.62 ENST00000416109.2
ENST00000313599.8
CD163 molecule like 1
chr10_-_60141004 1.60 ENST00000355288.6
ankyrin 3
chr1_+_92080305 1.56 ENST00000342818.4
ENST00000636805.2
BTB domain containing 8
chr19_-_36032799 1.56 ENST00000592017.5
ENST00000360535.9
CAP-Gly domain containing linker protein 3
chr11_-_119376271 1.55 ENST00000531070.1
ubiquitin specific peptidase 2
chr3_+_28349146 1.46 ENST00000420223.5
zinc finger CW-type and PWWP domain containing 2
chr11_+_77821125 1.46 ENST00000526415.5
ENST00000393427.6
ENST00000527134.5
ENST00000304716.12
ENST00000630098.2
adipogenesis associated Mth938 domain containing
chr8_-_13276491 1.45 ENST00000512044.6
DLC1 Rho GTPase activating protein
chr2_+_135052272 1.44 ENST00000264158.13
ENST00000442034.5
ENST00000425393.1
RAB3 GTPase activating protein catalytic subunit 1
chr7_+_36420163 1.42 ENST00000446635.5
anillin actin binding protein
chr9_-_83817632 1.41 ENST00000376365.7
ENST00000376371.7
G kinase anchoring protein 1
chr14_-_75980993 1.39 ENST00000556285.1
transforming growth factor beta 3
chr1_+_226940279 1.39 ENST00000366778.5
ENST00000366777.4
coenzyme Q8A
chr1_-_56579555 1.38 ENST00000371250.4
phospholipid phosphatase 3
chr6_+_36676455 1.37 ENST00000615513.4
cyclin dependent kinase inhibitor 1A
chr16_+_6019071 1.37 ENST00000547605.5
ENST00000553186.5
RNA binding fox-1 homolog 1
chr12_-_70637405 1.35 ENST00000548122.2
ENST00000551525.5
ENST00000550358.5
ENST00000334414.11
protein tyrosine phosphatase receptor type B
chr1_-_230868991 1.34 ENST00000522201.1
chromosome 1 open reading frame 198
chr2_+_235494024 1.33 ENST00000304032.13
ENST00000409457.5
ENST00000336665.9
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr6_-_167157980 1.33 ENST00000366834.2
G protein-coupled receptor 31
chr2_+_169827432 1.32 ENST00000272793.11
ubiquitin protein ligase E3 component n-recognin 3
chr19_+_49877660 1.32 ENST00000535102.6
TBC1 domain family member 17
chr19_+_49877694 1.32 ENST00000221543.10
TBC1 domain family member 17
chr8_-_133297092 1.29 ENST00000522890.5
ENST00000675983.1
ENST00000518176.5
ENST00000323851.13
ENST00000522476.5
ENST00000518066.5
ENST00000521544.5
ENST00000674605.1
ENST00000518480.5
ENST00000523892.5
N-myc downstream regulated 1
chr8_-_61689768 1.29 ENST00000517847.6
ENST00000389204.8
ENST00000517661.5
ENST00000517903.5
ENST00000522603.5
ENST00000541428.5
ENST00000522349.5
ENST00000522835.5
ENST00000518306.5
aspartate beta-hydroxylase
chr1_+_43389889 1.29 ENST00000562955.2
ENST00000634258.3
SZT2 subunit of KICSTOR complex
chr22_+_44031345 1.29 ENST00000444029.5
parvin beta
chr19_+_18001117 1.28 ENST00000379656.7
arrestin domain containing 2
chr5_-_126595185 1.25 ENST00000510111.6
ENST00000635851.1
ENST00000637964.1
ENST00000413020.6
ENST00000637782.1
ENST00000409134.8
ENST00000637272.1
ENST00000636879.1
ENST00000636743.1
ENST00000636886.1
ENST00000509270.2
aldehyde dehydrogenase 7 family member A1
chr8_-_6563238 1.23 ENST00000629816.3
ENST00000523120.2
angiopoietin 2
chr12_+_861124 1.23 ENST00000676347.1
WNK lysine deficient protein kinase 1
chr1_+_66330711 1.21 ENST00000528771.5
phosphodiesterase 4B
chr4_-_46388713 1.21 ENST00000507069.5
gamma-aminobutyric acid type A receptor subunit alpha2
chr19_+_12610948 1.21 ENST00000600752.1
zinc finger protein 791
chr8_-_6563044 1.19 ENST00000338312.10
angiopoietin 2
chr2_+_181985846 1.17 ENST00000682840.1
ENST00000409137.7
ENST00000280295.7
protein phosphatase 1 regulatory inhibitor subunit 1C
chr7_+_16661182 1.15 ENST00000446596.5
ENST00000452975.6
ENST00000438834.5
basic leucine zipper and W2 domains 2
chr10_-_60572599 1.14 ENST00000503366.5
ankyrin 3
chr17_+_69414690 1.14 ENST00000590474.7
mitogen-activated protein kinase kinase 6
chr4_-_185775376 1.13 ENST00000456596.5
ENST00000414724.5
sorbin and SH3 domain containing 2
chr7_+_120988683 1.12 ENST00000340646.9
ENST00000310396.10
cadherin like and PC-esterase domain containing 1
chr19_-_36032625 1.12 ENST00000593074.5
CAP-Gly domain containing linker protein 3
chr19_+_49877425 1.12 ENST00000622860.4
TBC1 domain family member 17
chr6_+_108560906 1.11 ENST00000406360.2
forkhead box O3
chr5_-_65624288 1.10 ENST00000381018.7
ENST00000274327.11
ENST00000231524.14
tripartite motif containing 23
chr17_-_69141878 1.10 ENST00000590645.1
ENST00000284425.7
ATP binding cassette subfamily A member 6
chr6_+_157716037 1.09 ENST00000614800.4
sorting nexin 9
chr4_-_185775890 1.09 ENST00000437304.6
sorbin and SH3 domain containing 2
chr10_+_110225955 1.09 ENST00000239007.11
MAX interactor 1, dimerization protein
chr21_+_36135071 1.09 ENST00000290354.6
carbonyl reductase 3
chr5_-_59768631 1.08 ENST00000502575.1
ENST00000507116.5
phosphodiesterase 4D
chr17_+_17179527 1.08 ENST00000579361.1
myosin phosphatase Rho interacting protein
chr4_-_138242325 1.07 ENST00000280612.9
solute carrier family 7 member 11
chr5_-_131797030 1.07 ENST00000615660.4
folliculin interacting protein 1
chr7_-_13988863 1.06 ENST00000405358.8
ETS variant transcription factor 1
chr3_+_148730100 1.06 ENST00000474935.5
ENST00000475347.5
ENST00000461609.1
angiotensin II receptor type 1
chr8_-_6563409 1.05 ENST00000325203.9
angiopoietin 2
chr8_-_71547626 1.05 ENST00000647540.1
ENST00000644229.1
EYA transcriptional coactivator and phosphatase 1
chr5_-_126595237 1.04 ENST00000637206.1
ENST00000553117.5
aldehyde dehydrogenase 7 family member A1
chr2_-_36966503 1.04 ENST00000263918.9
striatin
chr14_-_21025490 1.04 ENST00000553442.5
ENST00000555869.5
ENST00000556457.5
ENST00000397844.6
ENST00000554415.5
ENST00000556974.5
ENST00000554419.5
ENST00000298687.9
ENST00000397858.5
ENST00000360463.7
ENST00000350792.7
ENST00000397847.6
NDRG family member 2
chr14_-_60724300 1.03 ENST00000556952.3
ENST00000216513.5
SIX homeobox 4
chr6_+_101398788 1.02 ENST00000369138.5
ENST00000413795.5
ENST00000358361.7
glutamate ionotropic receptor kainate type subunit 2
chr12_+_79045625 1.01 ENST00000552744.5
synaptotagmin 1
chr3_-_28348629 1.01 ENST00000334100.10
5-azacytidine induced 2
chr3_+_138348823 0.99 ENST00000475711.5
ENST00000464896.5
muscle RAS oncogene homolog
chr18_-_33136075 0.98 ENST00000581852.5
coiled-coil domain containing 178
chr10_+_110226079 0.97 ENST00000393134.5
MAX interactor 1, dimerization protein
chr1_-_6360677 0.97 ENST00000377845.7
acyl-CoA thioesterase 7
chr4_-_86358487 0.96 ENST00000641066.1
ENST00000512689.6
ENST00000641803.1
ENST00000640970.1
ENST00000641983.1
mitogen-activated protein kinase 10
chr13_-_45201027 0.96 ENST00000379108.2
potassium channel tetramerization domain containing 4
chr13_-_98978022 0.94 ENST00000682017.1
ENST00000442173.5
ENST00000627024.2
dedicator of cytokinesis 9
chr2_+_156436345 0.94 ENST00000438166.7
glycerol-3-phosphate dehydrogenase 2
chr9_+_706841 0.94 ENST00000382293.7
KN motif and ankyrin repeat domains 1
chr3_+_113211539 0.94 ENST00000682979.1
ENST00000485230.5
BOC cell adhesion associated, oncogene regulated
chr3_-_28348924 0.93 ENST00000414162.5
ENST00000420543.6
5-azacytidine induced 2
chr5_+_102864505 0.93 ENST00000511839.5
peptidylglycine alpha-amidating monooxygenase
chr7_+_135148041 0.93 ENST00000275767.3
transmembrane protein 140
chr5_+_98769273 0.92 ENST00000308234.11
repulsive guidance molecule BMP co-receptor b
chr16_+_28846674 0.90 ENST00000322610.12
SH2B adaptor protein 1
chr5_-_131796965 0.88 ENST00000514667.1
ENST00000511848.1
ENST00000510461.6
novel protein
folliculin interacting protein 1
chr8_-_40897814 0.88 ENST00000297737.11
ENST00000315769.11
zinc finger matrin-type 4
chr20_-_44521989 0.87 ENST00000342374.5
ENST00000255175.5
serine incorporator 3
chr19_+_859654 0.87 ENST00000592860.2
ENST00000327726.11
complement factor D
chr8_+_69492793 0.87 ENST00000616868.1
ENST00000419716.7
ENST00000402687.9
sulfatase 1
chr9_-_13175824 0.86 ENST00000545857.5
multiple PDZ domain crumbs cell polarity complex component
chr9_+_27109135 0.85 ENST00000519097.5
ENST00000615002.4
TEK receptor tyrosine kinase
chr6_+_168017873 0.84 ENST00000351261.4
ENST00000354419.6
kinesin family member 25
chr3_-_28348805 0.84 ENST00000457172.5
ENST00000479665.6
5-azacytidine induced 2
chr3_+_173584433 0.84 ENST00000361589.8
neuroligin 1
chr12_+_53985138 0.84 ENST00000303460.5
homeobox C10
chr1_-_8015633 0.83 ENST00000467067.1
ERBB receptor feedback inhibitor 1
chr2_+_156436423 0.83 ENST00000540309.5
glycerol-3-phosphate dehydrogenase 2
chrX_+_101488044 0.83 ENST00000423738.4
armadillo repeat containing X-linked 4
chr9_+_5510492 0.83 ENST00000397747.5
programmed cell death 1 ligand 2
chr18_+_34493428 0.83 ENST00000682483.1
dystrobrevin alpha
chr2_-_240047027 0.82 ENST00000641019.1
olfactory receptor family 6 subfamily B member 3
chr10_-_24721866 0.82 ENST00000416305.1
ENST00000320481.10
Rho GTPase activating protein 21
chr9_+_27109441 0.82 ENST00000519080.1
TEK receptor tyrosine kinase
chr5_-_131796921 0.81 ENST00000307968.11
ENST00000307954.12
folliculin interacting protein 1
chr18_+_34493386 0.81 ENST00000679936.1
dystrobrevin alpha
chr15_-_30991415 0.81 ENST00000563714.5
myotubularin related protein 10
chr5_+_126465144 0.81 ENST00000511134.1
GRAM domain containing 2B
chr8_-_73582830 0.80 ENST00000523533.5
staufen double-stranded RNA binding protein 2
chr5_-_42811884 0.80 ENST00000514985.6
ENST00000511224.5
ENST00000507920.5
ENST00000510965.1
selenoprotein P
chr5_+_174046659 0.80 ENST00000519717.1
neuronal vesicle trafficking associated 2
chr18_+_31318144 0.80 ENST00000257192.5
desmoglein 1
chr3_+_101574157 0.78 ENST00000265260.8
ENST00000469941.5
ENST00000627393.1
PEST proteolytic signal containing nuclear protein
chr18_-_55635948 0.77 ENST00000565124.4
ENST00000398339.5
transcription factor 4
chr6_-_29045175 0.76 ENST00000377175.2
olfactory receptor family 2 subfamily W member 1
chr14_-_55411817 0.75 ENST00000247178.6
autophagy related 14
chr6_-_52244500 0.75 ENST00000336123.5
interleukin 17F
chr20_+_59628609 0.75 ENST00000541461.5
phosphatase and actin regulator 3
chr15_+_43692886 0.75 ENST00000434505.5
ENST00000411750.5
creatine kinase, mitochondrial 1A
chr1_+_248095184 0.75 ENST00000358120.3
ENST00000641893.1
olfactory receptor family 2 subfamily L member 13
chr1_-_161367872 0.74 ENST00000367974.2
cilia and flagella associated protein 126
chr11_+_77821187 0.74 ENST00000525409.5
adipogenesis associated Mth938 domain containing
chr4_-_69961007 0.74 ENST00000353151.3
casein beta
chr9_-_19786928 0.74 ENST00000341998.6
ENST00000286344.3
solute carrier family 24 member 2
chr2_-_86195400 0.74 ENST00000442664.6
ENST00000409051.6
ENST00000410111.8
ENST00000620815.4
ENST00000449247.6
inner membrane mitochondrial protein
chr11_-_89491131 0.73 ENST00000343727.9
ENST00000531342.5
ENST00000375979.7
NADPH oxidase 4
chr7_+_134866831 0.73 ENST00000435928.1
caldesmon 1
chr20_+_34516394 0.72 ENST00000357156.7
ENST00000300469.13
ENST00000374846.3
dynein light chain roadblock-type 1
chr4_+_171813397 0.72 ENST00000506823.6
polypeptide N-acetylgalactosaminyltransferase like 6
chr3_-_186109067 0.71 ENST00000306376.10
ETS variant transcription factor 5
chr19_+_1205761 0.71 ENST00000326873.12
ENST00000586243.5
serine/threonine kinase 11
chr10_-_75073627 0.71 ENST00000338487.6
dual specificity phosphatase 29
chr19_+_41262656 0.70 ENST00000599719.5
ENST00000601309.5
heterogeneous nuclear ribonucleoprotein U like 1
chr3_+_124384376 0.70 ENST00000682636.1
kalirin RhoGEF kinase
chr1_-_227318125 0.68 ENST00000366764.7
CDC42 binding protein kinase alpha
chr3_-_146222337 0.68 ENST00000498625.1
phospholipid scramblase 4
chr1_+_150257247 0.68 ENST00000647854.1
carbonic anhydrase 14
chr5_-_108367860 0.68 ENST00000496714.2
F-box and leucine rich repeat protein 17
chr6_+_83853576 0.68 ENST00000369687.2
ripply transcriptional repressor 2

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXO4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 6.9 GO:0006542 glutamine biosynthetic process(GO:0006542)
1.2 3.5 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.6 2.9 GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.6 2.3 GO:0031455 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.5 2.2 GO:0044691 tooth eruption(GO:0044691)
0.5 3.6 GO:1903296 regulation of glutamate secretion, neurotransmission(GO:1903294) positive regulation of glutamate secretion, neurotransmission(GO:1903296)
0.5 3.0 GO:0051138 positive regulation of NK T cell differentiation(GO:0051138)
0.5 1.4 GO:0003032 detection of oxygen(GO:0003032)
0.5 2.8 GO:0002904 positive regulation of B cell apoptotic process(GO:0002904)
0.4 2.2 GO:1901350 cell-cell signaling involved in cell-cell junction organization(GO:1901350)
0.4 2.9 GO:0044565 dendritic cell proliferation(GO:0044565)
0.4 3.7 GO:0060574 intestinal epithelial cell maturation(GO:0060574)
0.4 3.6 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.4 5.1 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.4 2.3 GO:0048014 Tie signaling pathway(GO:0048014)
0.4 1.1 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.4 1.4 GO:0031106 septin ring assembly(GO:0000921) septin ring organization(GO:0031106)
0.3 2.0 GO:0090131 glomerular mesangial cell development(GO:0072144) mesenchyme migration(GO:0090131)
0.3 2.9 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.3 2.5 GO:1900827 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.3 1.8 GO:0006127 glycerophosphate shuttle(GO:0006127)
0.3 2.7 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.3 1.3 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.3 1.1 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.3 1.0 GO:0061055 myotome development(GO:0061055)
0.2 1.0 GO:1900535 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.2 1.9 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.2 2.9 GO:0046959 habituation(GO:0046959) negative regulation of growth hormone secretion(GO:0060125)
0.2 0.9 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.2 4.9 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.2 1.1 GO:0072709 cellular response to sorbitol(GO:0072709)
0.2 0.7 GO:0006533 aspartate catabolic process(GO:0006533)
0.2 1.1 GO:1901662 phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
0.2 0.6 GO:1903537 meiotic spindle elongation(GO:0051232) meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538)
0.2 0.6 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.2 0.8 GO:0046603 negative regulation of mitotic centrosome separation(GO:0046603)
0.2 0.8 GO:0048789 cytoskeletal matrix organization at active zone(GO:0048789) neurexin clustering involved in presynaptic membrane assembly(GO:0097115) retrograde trans-synaptic signaling by soluble gas(GO:0098923) retrograde trans-synaptic signaling by trans-synaptic protein complex(GO:0098942) trans-synaptic signaling by soluble gas(GO:0099543)
0.2 1.2 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016)
0.2 0.7 GO:1903487 regulation of lactation(GO:1903487)
0.2 1.3 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.2 5.3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.2 2.9 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 1.8 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.2 1.8 GO:0042758 long-chain fatty acid catabolic process(GO:0042758)
0.2 1.8 GO:0060029 convergent extension involved in organogenesis(GO:0060029)
0.2 1.0 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.2 0.5 GO:0019417 sulfur oxidation(GO:0019417)
0.2 1.8 GO:0071073 positive regulation of phospholipid biosynthetic process(GO:0071073)
0.2 0.8 GO:0016240 autophagosome docking(GO:0016240)
0.1 0.4 GO:2000438 CD24 biosynthetic process(GO:0035724) activation of meiosis involved in egg activation(GO:0060466) negative regulation of monocyte extravasation(GO:2000438) regulation of CD24 biosynthetic process(GO:2000559) positive regulation of CD24 biosynthetic process(GO:2000560)
0.1 0.4 GO:0031550 positive regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031550)
0.1 0.9 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.9 GO:0018032 protein amidation(GO:0018032)
0.1 0.8 GO:0042109 lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.1 5.7 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.8 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) regulation of branching involved in mammary gland duct morphogenesis(GO:0060762) germline stem cell asymmetric division(GO:0098728)
0.1 0.2 GO:0031990 mRNA export from nucleus in response to heat stress(GO:0031990)
0.1 3.6 GO:0042118 endothelial cell activation(GO:0042118)
0.1 1.3 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.1 1.0 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.1 1.4 GO:0008354 germ cell migration(GO:0008354)
0.1 1.1 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.1 0.4 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 0.4 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 0.3 GO:1902173 negative regulation of keratinocyte apoptotic process(GO:1902173)
0.1 0.8 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 2.0 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.1 0.4 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.1 0.4 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 0.9 GO:0009597 detection of virus(GO:0009597)
0.1 0.6 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 1.8 GO:0045475 locomotor rhythm(GO:0045475)
0.1 0.3 GO:0045175 basal protein localization(GO:0045175)
0.1 1.8 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.1 1.3 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.1 0.2 GO:1904717 excitatory chemical synaptic transmission(GO:0098976) regulation of AMPA glutamate receptor clustering(GO:1904717) positive regulation of AMPA glutamate receptor clustering(GO:1904719)
0.1 0.2 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.1 4.7 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.1 0.5 GO:0061083 regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
0.1 1.5 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.1 0.8 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.1 0.8 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.1 1.3 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.1 3.0 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.1 2.3 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 1.0 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 0.3 GO:0035853 chromosome passenger complex localization to spindle midzone(GO:0035853)
0.1 0.7 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.1 5.5 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 3.3 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
0.1 0.4 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.1 0.5 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.1 0.8 GO:0001887 selenium compound metabolic process(GO:0001887)
0.1 0.1 GO:0070245 positive regulation of thymocyte apoptotic process(GO:0070245)
0.1 0.2 GO:1903567 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.1 1.0 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.1 2.2 GO:0042994 cytoplasmic sequestering of transcription factor(GO:0042994)
0.1 0.3 GO:1902617 response to fluoride(GO:1902617)
0.1 0.4 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.7 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.6 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 0.4 GO:0044211 CTP salvage(GO:0044211)
0.0 1.3 GO:0035988 chondrocyte proliferation(GO:0035988)
0.0 1.4 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 1.0 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.2 GO:1903173 phytol metabolic process(GO:0033306) fatty alcohol metabolic process(GO:1903173)
0.0 0.3 GO:0010966 regulation of phosphate transport(GO:0010966)
0.0 0.8 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 1.1 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.8 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.5 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.2 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.0 0.7 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.6 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 0.7 GO:0042407 cristae formation(GO:0042407)
0.0 1.2 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 2.5 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 0.5 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 2.7 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.0 0.3 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.0 2.1 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.0 5.2 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.0 9.0 GO:0021987 cerebral cortex development(GO:0021987)
0.0 2.2 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.0 0.3 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.1 GO:0007343 egg activation(GO:0007343)
0.0 3.4 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.0 0.2 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.0 2.2 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.0 0.4 GO:1901740 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242) negative regulation of myoblast fusion(GO:1901740) regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 0.1 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.0 0.3 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.0 1.1 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 2.9 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.8 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.0 1.1 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 0.1 GO:0043335 protein unfolding(GO:0043335)
0.0 0.2 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.0 0.5 GO:0021957 corticospinal tract morphogenesis(GO:0021957)
0.0 0.3 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.1 GO:0048162 preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162)
0.0 3.1 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 4.1 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.8 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.2 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0 0.6 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.0 1.8 GO:0045840 positive regulation of mitotic nuclear division(GO:0045840)
0.0 0.6 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.0 1.7 GO:0003281 ventricular septum development(GO:0003281)
0.0 1.1 GO:0031572 G2 DNA damage checkpoint(GO:0031572)
0.0 0.7 GO:0060292 long term synaptic depression(GO:0060292)
0.0 0.1 GO:0030071 regulation of mitotic metaphase/anaphase transition(GO:0030071)
0.0 0.8 GO:0019228 neuronal action potential(GO:0019228)
0.0 2.2 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.3 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 2.1 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.0 0.1 GO:0010265 SCF complex assembly(GO:0010265)
0.0 0.6 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.4 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 1.0 GO:0007040 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 0.7 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.4 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.5 GO:0035329 hippo signaling(GO:0035329)
0.0 1.8 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.0 0.2 GO:0007144 female meiosis I(GO:0007144)
0.0 0.3 GO:0007035 vacuolar acidification(GO:0007035)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.7 GO:0070557 PCNA-p21 complex(GO:0070557)
0.3 2.9 GO:1990130 Iml1 complex(GO:1990130)
0.3 5.1 GO:0097512 cardiac myofibril(GO:0097512)
0.3 2.0 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.3 1.8 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.2 2.2 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.2 1.1 GO:0036398 TCR signalosome(GO:0036398)
0.2 0.8 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.2 2.2 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.1 2.8 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 0.7 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 6.9 GO:0097386 glial cell projection(GO:0097386)
0.1 1.4 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 2.9 GO:0042589 zymogen granule membrane(GO:0042589)
0.1 1.3 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.1 0.2 GO:0034657 GID complex(GO:0034657)
0.1 0.7 GO:0016013 syntrophin complex(GO:0016013)
0.1 1.0 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.1 0.7 GO:0061617 MICOS complex(GO:0061617)
0.1 1.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 1.1 GO:0070552 BRISC complex(GO:0070552)
0.1 0.5 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.1 2.5 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 3.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.7 GO:0036157 outer dynein arm(GO:0036157)
0.1 18.3 GO:0030018 Z disc(GO:0030018)
0.1 0.4 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 1.1 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 2.3 GO:0005921 gap junction(GO:0005921)
0.1 1.2 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.7 GO:0030478 actin cap(GO:0030478)
0.0 1.4 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 5.5 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.3 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.0 2.5 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.3 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 0.1 GO:0097489 multivesicular body, internal vesicle lumen(GO:0097489)
0.0 0.3 GO:0005683 U7 snRNP(GO:0005683)
0.0 0.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 5.5 GO:0005776 autophagosome(GO:0005776)
0.0 3.8 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.8 GO:0032433 filopodium tip(GO:0032433)
0.0 0.9 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 0.8 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.4 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.2 GO:0005712 chiasma(GO:0005712)
0.0 0.5 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.2 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.0 1.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 6.0 GO:0042383 sarcolemma(GO:0042383)
0.0 0.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:1990923 PET complex(GO:1990923)
0.0 1.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.1 GO:0035363 histone locus body(GO:0035363)
0.0 7.1 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.8 GO:0030057 desmosome(GO:0030057)
0.0 0.7 GO:0005838 proteasome regulatory particle(GO:0005838)
0.0 0.3 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.2 GO:0001939 female pronucleus(GO:0001939)
0.0 0.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.3 GO:0031010 ISWI-type complex(GO:0031010)
0.0 0.4 GO:0031265 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.0 2.8 GO:0016605 PML body(GO:0016605)
0.0 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.4 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 1.6 GO:0055037 recycling endosome(GO:0055037)
0.0 1.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.8 GO:0005811 lipid particle(GO:0005811)
0.0 0.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 2.5 GO:0043202 lysosomal lumen(GO:0043202)
0.0 1.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 6.9 GO:0005743 mitochondrial inner membrane(GO:0005743)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 6.9 GO:0016880 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.8 4.9 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.7 3.7 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.6 1.8 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.5 2.8 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.4 2.7 GO:0097001 ceramide binding(GO:0097001)
0.4 1.1 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.4 1.8 GO:0052591 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.4 1.1 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.3 2.7 GO:0004111 creatine kinase activity(GO:0004111)
0.2 1.4 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.2 1.4 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.2 1.3 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.2 1.1 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.2 5.1 GO:0032036 myosin heavy chain binding(GO:0032036)
0.2 2.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 3.0 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 0.9 GO:0004598 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.1 5.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 10.2 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 2.8 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 0.3 GO:0071209 U7 snRNA binding(GO:0071209)
0.1 0.6 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 0.4 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.1 0.5 GO:0032558 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.1 1.0 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 0.7 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 1.0 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 1.0 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 1.7 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 0.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 1.1 GO:0019826 oxygen sensor activity(GO:0019826)
0.1 1.2 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 0.7 GO:0004046 aminoacylase activity(GO:0004046)
0.1 2.9 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 2.8 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.1 1.0 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 2.9 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 0.7 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 1.2 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.1 1.2 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 1.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 1.1 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 3.1 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.1 2.0 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 1.7 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.1 0.6 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1 0.4 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 0.1 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.1 0.5 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 3.3 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.1 2.2 GO:0043274 phospholipase binding(GO:0043274)
0.1 0.9 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.8 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 2.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.1 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 0.2 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.0 2.6 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 1.1 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.4 GO:0004849 uridine kinase activity(GO:0004849)
0.0 1.1 GO:0030275 LRR domain binding(GO:0030275)
0.0 0.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.8 GO:0015643 toxic substance binding(GO:0015643)
0.0 5.3 GO:0030165 PDZ domain binding(GO:0030165)
0.0 2.5 GO:0030507 spectrin binding(GO:0030507)
0.0 1.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.4 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.7 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 1.4 GO:0043531 ADP binding(GO:0043531)
0.0 4.4 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 1.4 GO:0030332 cyclin binding(GO:0030332)
0.0 0.7 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.8 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.8 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 2.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.7 GO:0005523 tropomyosin binding(GO:0005523)
0.0 1.7 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.7 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.6 GO:0008198 ferrous iron binding(GO:0008198)
0.0 6.1 GO:0035257 nuclear hormone receptor binding(GO:0035257)
0.0 7.5 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 0.2 GO:0003696 satellite DNA binding(GO:0003696) centromeric DNA binding(GO:0019237)
0.0 0.6 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 2.5 GO:0030276 clathrin binding(GO:0030276)
0.0 2.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.8 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.6 GO:0016805 dipeptidase activity(GO:0016805)
0.0 1.4 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.6 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.3 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0051120 hepoxilin A3 synthase activity(GO:0051120)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.6 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 2.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.5 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.5 GO:0071949 FAD binding(GO:0071949)
0.0 0.1 GO:0032190 acrosin binding(GO:0032190)
0.0 1.7 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.7 GO:0019956 chemokine binding(GO:0019956)
0.0 1.1 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 6.7 GO:0045296 cadherin binding(GO:0045296)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.2 GO:0008430 selenium binding(GO:0008430)
0.0 0.7 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 1.3 GO:0008013 beta-catenin binding(GO:0008013)
0.0 2.0 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 0.6 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.2 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.1 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 2.1 GO:0019838 growth factor binding(GO:0019838)
0.0 0.1 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.0 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 3.2 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 6.2 PID RHOA PATHWAY RhoA signaling pathway
0.1 2.9 PID EPHB FWD PATHWAY EPHB forward signaling
0.1 7.4 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.1 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.1 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 2.2 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 1.0 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 1.2 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 3.5 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 1.2 PID IL23 PATHWAY IL23-mediated signaling events
0.0 2.3 PID FGF PATHWAY FGF signaling pathway
0.0 0.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.0 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.6 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.8 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.8 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.4 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.5 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 2.7 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.3 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.7 PID CDC42 PATHWAY CDC42 signaling events
0.0 0.5 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.8 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 1.5 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.7 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.6 PID BMP PATHWAY BMP receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.9 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.2 6.9 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 3.6 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 5.8 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 4.1 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 2.0 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 3.2 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 3.0 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 2.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 5.1 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.8 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 4.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 2.1 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 2.7 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.1 5.0 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 2.5 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.5 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 2.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 2.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.7 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 1.1 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 1.1 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 1.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.0 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.0 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 1.7 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 1.0 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.8 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.2 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.8 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.6 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.3 REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.0 2.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.1 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.5 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 2.5 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.3 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 1.6 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.5 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 4.1 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0 0.2 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 1.0 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.3 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.1 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.3 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere