ISMARA results: GATA1

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Illumina Body Map 2 (GSE30611)

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Results for GATA1_GATA4

Z-value: 2.30

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Transcription factors associated with GATA1_GATA4

Gene Symbol	Gene ID	Gene Info
GATA1 Ensembl NCBI GeneCards UniProt	ENSG00000102145.15	GATA binding protein 1
GATA4 Ensembl NCBI GeneCards UniProt	ENSG00000136574.19	GATA binding protein 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GATA4	hg38_v1_chr8_+_11704151_11704242	0.19	2.9e-01	Click!
GATA1	hg38_v1_chrX_+_48786562_48786576	0.17	3.6e-01	Click!

Activity profile of GATA1_GATA4 motif

Sorted Z-values of GATA1_GATA4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_55157725 Show fit	12.73	ENST00000344887.10 ENST00000665070.1	TNNI3 Ensembl NCBI GeneCards UniProt Show fit	troponin I3, cardiac type
chr11_-_116837586 Show fit	8.61	ENST00000375320.5 ENST00000359492.6 ENST00000375329.6 ENST00000375323.5 ENST00000236850.5	APOA1 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein A1
chr11_-_47352693 Show fit	8.00	ENST00000256993.8 ENST00000399249.6 ENST00000545968.6	MYBPC3 Ensembl NCBI GeneCards UniProt Show fit	myosin binding protein C3
chr12_-_114403898 Show fit	7.86	ENST00000526441.1	TBX5 Ensembl NCBI GeneCards UniProt Show fit	T-box transcription factor 5
chr10_-_97771954 Show fit	7.04	ENST00000266066.4	SFRP5 Ensembl NCBI GeneCards UniProt Show fit	secreted frizzled related protein 5
chr4_-_64409381 Show fit	6.27	ENST00000509536.1	TECRL Ensembl NCBI GeneCards UniProt Show fit	trans-2,3-enoyl-CoA reductase like
chr10_+_47322450 Show fit	6.09	ENST00000581492.3	GDF2 Ensembl NCBI GeneCards UniProt Show fit	growth differentiation factor 2
chr18_+_22169580 Show fit	5.96	ENST00000269216.10	GATA6 Ensembl NCBI GeneCards UniProt Show fit	GATA binding protein 6
chr4_-_64409444 Show fit	5.93	ENST00000381210.8 ENST00000507440.5	TECRL Ensembl NCBI GeneCards UniProt Show fit	trans-2,3-enoyl-CoA reductase like
chr17_+_4771878 Show fit	5.73	ENST00000270560.4	TM4SF5 Ensembl NCBI GeneCards UniProt Show fit	transmembrane 4 L six family member 5

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA1_GATA4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	15.9	GO:0032780	negative regulation of ATPase activity(GO:0032780)
3.7	14.6	GO:0009822	alkaloid catabolic process(GO:0009822)
0.3	14.4	GO:0061049	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.6	11.4	GO:0034196	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.6	11.3	GO:0001867	complement activation, lectin pathway(GO:0001867)
0.4	10.7	GO:0042761	very long-chain fatty acid biosynthetic process(GO:0042761)
1.3	9.2	GO:0032971	regulation of muscle filament sliding(GO:0032971)
1.7	8.6	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
1.1	8.6	GO:0072513	positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
2.6	7.9	GO:0003218	cardiac left ventricle formation(GO:0003218)

Showing 1 to 10 of 303 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	31.8	GO:0030018	Z disc(GO:0030018)
0.0	30.4	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.1	20.5	GO:0032993	protein-DNA complex(GO:0032993)
2.3	13.9	GO:1990584	cardiac Troponin complex(GO:1990584)
0.1	13.1	GO:0031672	A band(GO:0031672)
0.1	12.8	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.2	10.3	GO:0031092	platelet alpha granule membrane(GO:0031092)
2.4	9.6	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.0	9.5	GO:0005667	transcription factor complex(GO:0005667)
2.2	8.6	GO:0034365	discoidal high-density lipoprotein particle(GO:0034365)

Showing 1 to 10 of 98 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	18.0	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	14.1	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
2.1	12.7	GO:0030172	troponin C binding(GO:0030172)
0.1	11.2	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0	9.5	GO:0004866	endopeptidase inhibitor activity(GO:0004866)
2.3	9.2	GO:0070643	vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.2	8.7	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.0	8.7	GO:0030246	carbohydrate binding(GO:0030246)
1.7	8.6	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
0.3	8.4	GO:0070330	aromatase activity(GO:0070330)

Showing 1 to 10 of 235 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	25.3	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	10.2	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	8.4	PID IL23 PATHWAY	IL23-mediated signaling events
0.0	7.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	6.5	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	6.3	PID ALK1 PATHWAY	ALK1 signaling events
0.1	6.3	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.1	5.2	PID EPO PATHWAY	EPO signaling pathway
0.2	5.1	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	5.1	NABA MATRISOME ASSOCIATED	Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors

Showing 1 to 10 of 43 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	20.6	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.1	16.9	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.6	16.8	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.2	12.9	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	12.4	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.2	11.5	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.7	9.6	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.3	9.2	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.1	7.3	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.3	6.6	REACTOME COMMON PATHWAY	Genes involved in Common Pathway

Showing 1 to 10 of 73 entries

Results for GATA1_GATA4

Z-value: 2.30

Motif logo

Transcription factors associated with GATA1_GATA4

Activity-expression correlation:

Activity profile of GATA1_GATA4 motif

Sorted Z-values of GATA1_GATA4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA1_GATA4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: