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Illumina Body Map 2 (GSE30611)
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Results for GATA3
Z-value: 2.26
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Transcription factors associated with GATA3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GATA3 | hg38_v1_chr10_+_8045345_8045393 | -0.34 | 5.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_89213917 Show fit | 6.49 |
ENST00000498435.1
|
immunoglobulin kappa variable 1-27 |
|
| chr1_+_26317950 Show fit | 5.61 |
ENST00000374213.3
|
CD52 molecule |
|
| chr7_+_142800957 Show fit | 5.36 |
ENST00000466254.1
|
T cell receptor beta constant 2 |
|
| chr2_-_89117844 Show fit | 4.75 |
ENST00000490686.1
|
immunoglobulin kappa variable 1-17 |
|
| chr2_+_90159840 Show fit | 4.69 |
ENST00000377032.5
|
immunoglobulin kappa variable 1D-12 |
|
| chr14_+_22462932 Show fit | 4.53 |
ENST00000390477.2
|
T cell receptor delta constant |
|
| chrX_+_129779930 Show fit | 4.37 |
ENST00000356892.4
|
SAM and SH3 domain containing 3 |
|
| chr2_+_89862438 Show fit | 3.94 |
ENST00000448155.2
|
immunoglobulin kappa variable 1D-39 |
|
| chr2_-_89268506 Show fit | 3.90 |
ENST00000473726.1
|
immunoglobulin kappa variable 1-33 |
|
| chr7_+_142791635 Show fit | 3.84 |
ENST00000633705.1
|
T cell receptor beta constant 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GATA3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 140.7 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.3 | 55.9 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.2 | 24.1 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.1 | 11.6 | GO:0045576 | mast cell activation(GO:0045576) |
| 0.4 | 11.5 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.1 | 9.7 | GO:0038094 | Fc-gamma receptor signaling pathway(GO:0038094) |
| 0.1 | 9.6 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.4 | 9.5 | GO:0002717 | positive regulation of natural killer cell mediated immunity(GO:0002717) |
| 0.0 | 9.5 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.2 | 8.1 | GO:0045577 | regulation of B cell differentiation(GO:0045577) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 65.9 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 30.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 28.4 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 23.0 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 15.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 14.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 14.0 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 1.0 | 11.6 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.2 | 10.4 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.4 | 9.5 | GO:0042101 | T cell receptor complex(GO:0042101) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 125.2 | GO:0003823 | antigen binding(GO:0003823) |
| 0.9 | 66.6 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 12.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.7 | 12.3 | GO:0019864 | IgG binding(GO:0019864) |
| 0.0 | 12.3 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.1 | 12.2 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 8.7 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.5 | 7.6 | GO:0042608 | T cell receptor binding(GO:0042608) |
| 0.0 | 7.4 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 7.4 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 23.9 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.2 | 15.5 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.2 | 13.9 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.3 | 12.3 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 10.1 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.4 | 9.9 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 9.1 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 9.0 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.2 | 8.3 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 8.2 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 25.6 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.2 | 23.5 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 16.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.7 | 15.4 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 11.4 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 9.5 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.3 | 8.7 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 8.5 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.2 | 7.4 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.2 | 6.8 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |