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Illumina Body Map 2 (GSE30611)
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Results for GATA6
Z-value: 1.23
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Transcription factors associated with GATA6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GATA6 | hg38_v1_chr18_+_22169580_22169596 | -0.02 | 9.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_102311502 Show fit | 5.85 |
ENST00000404917.6
ENST00000410040.5 |
interleukin 1 receptor like 1 interleukin 18 receptor 1 |
|
| chr10_-_97771954 Show fit | 5.19 |
ENST00000266066.4
|
secreted frizzled related protein 5 |
|
| chr13_-_46142834 Show fit | 4.56 |
ENST00000674665.1
|
lymphocyte cytosolic protein 1 |
|
| chr2_+_102311546 Show fit | 4.15 |
ENST00000233954.6
ENST00000447231.5 |
interleukin 1 receptor like 1 |
|
| chr12_-_54295748 Show fit | 3.82 |
ENST00000540264.2
ENST00000312156.8 |
nuclear factor, erythroid 2 |
|
| chr11_-_116837586 Show fit | 3.67 |
ENST00000375320.5
ENST00000359492.6 ENST00000375329.6 ENST00000375323.5 ENST00000236850.5 |
apolipoprotein A1 |
|
| chr7_-_100641507 Show fit | 3.66 |
ENST00000431692.5
ENST00000223051.8 |
transferrin receptor 2 |
|
| chr9_-_114930508 Show fit | 3.51 |
ENST00000223795.3
ENST00000618336.4 |
TNF superfamily member 8 |
|
| chr17_+_4771878 Show fit | 3.48 |
ENST00000270560.4
|
transmembrane 4 L six family member 5 |
|
| chr1_-_167518583 Show fit | 3.29 |
ENST00000392122.3
|
CD247 molecule |
Network of associatons between targets according to the STRING database.
First level regulatory network of GATA6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 10.0 | GO:0038172 | interleukin-33-mediated signaling pathway(GO:0038172) |
| 0.1 | 6.2 | GO:0070207 | protein homotrimerization(GO:0070207) |
| 0.7 | 5.2 | GO:0044333 | Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) |
| 0.5 | 4.8 | GO:0000821 | regulation of arginine metabolic process(GO:0000821) |
| 0.2 | 4.2 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.1 | 3.8 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 0.7 | 3.7 | GO:0010903 | negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903) |
| 0.6 | 3.7 | GO:0098707 | ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707) |
| 0.1 | 3.5 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.3 | 3.1 | GO:0015691 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.5 | 6.2 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.1 | 4.6 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.9 | 3.7 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.2 | 3.7 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.0 | 3.4 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 2.9 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.6 | 2.8 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.2 | 2.8 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
| 0.1 | 2.6 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 10.0 | GO:0002113 | interleukin-33 binding(GO:0002113) |
| 0.0 | 6.2 | GO:1990782 | protein tyrosine kinase binding(GO:1990782) |
| 0.2 | 5.2 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.2 | 4.8 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 0.1 | 3.8 | GO:0050699 | WW domain binding(GO:0050699) |
| 1.2 | 3.7 | GO:0004998 | transferrin receptor activity(GO:0004998) |
| 0.7 | 3.7 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 0.1 | 3.5 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 3.1 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.2 | 3.0 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.1 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 6.7 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 3.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 3.5 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 3.0 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 2.4 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 2.2 | PID EPO PATHWAY | EPO signaling pathway |
| 0.0 | 2.0 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 1.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.8 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.5 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.3 | 6.2 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 4.8 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 4.6 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 4.1 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 3.9 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 3.1 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 2.5 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 1.9 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 1.7 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |