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Illumina Body Map 2 (GSE30611)

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Results for GAUAUGU

Z-value: 0.32

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miRNA associated with seed GAUAUGU

NamemiRBASE accession
hsa-miR-190a-5p
MIMAT0000458
hsa-miR-190b
MIMAT0004929

Activity profile of GAUAUGU motif

Sorted Z-values of GAUAUGU motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_28177102 1.01 ENST00000413878.2
ENST00000269141.8
CDH2
cadherin 2
chr14_+_54567612 0.74 ENST00000251091.9
ENST00000392067.7
ENST00000631086.2
SAMD4A
sterile alpha motif domain containing 4A
chr20_-_49482645 0.73 ENST00000371741.6
KCNB1
potassium voltage-gated channel subfamily B member 1
chrX_-_33128360 0.68 ENST00000378677.6
DMD
dystrophin
chr5_+_175796310 0.65 ENST00000359546.8
CPLX2
complexin 2
chr3_-_126357399 0.48 ENST00000296233.4
KLF15
Kruppel like factor 15
chr13_-_102401599 0.39 ENST00000376131.8
FGF14
fibroblast growth factor 14
chr11_-_31811314 0.37 ENST00000640368.2
ENST00000379123.10
ENST00000379115.9
ENST00000419022.6
ENST00000643871.1
ENST00000640610.1
ENST00000639034.2
PAX6
paired box 6
chr10_+_123666355 0.35 ENST00000284674.2
GPR26
G protein-coupled receptor 26
chr5_-_45696326 0.35 ENST00000673735.1
ENST00000303230.6
HCN1
hyperpolarization activated cyclic nucleotide gated potassium channel 1
chr12_-_31591129 0.34 ENST00000389082.10
DENND5B
DENN domain containing 5B
chr14_+_79279403 0.34 ENST00000281127.11
NRXN3
neurexin 3
chr15_+_36594868 0.31 ENST00000566807.5
ENST00000643612.1
ENST00000567389.5
ENST00000562877.5
CDIN1
CDAN1 interacting nuclease 1
chr6_+_72622047 0.28 ENST00000370398.6
KCNQ5
potassium voltage-gated channel subfamily Q member 5
chr6_+_68635273 0.26 ENST00000370598.6
ADGRB3
adhesion G protein-coupled receptor B3
chr3_-_160565560 0.25 ENST00000334256.9
ENST00000676866.1
ENST00000469804.1
KPNA4
karyopherin subunit alpha 4
chr2_+_178194460 0.24 ENST00000392505.6
ENST00000359685.7
ENST00000357080.8
ENST00000190611.9
ENST00000409045.7
OSBPL6
oxysterol binding protein like 6
chr12_-_110583305 0.22 ENST00000354300.5
PPTC7
protein phosphatase targeting COQ7
chr13_+_34942263 0.21 ENST00000379939.7
ENST00000400445.7
NBEA
neurobeachin
chr11_-_30016945 0.21 ENST00000328224.7
KCNA4
potassium voltage-gated channel subfamily A member 4
chr2_-_196592671 0.20 ENST00000260983.8
ENST00000644030.1
HECW2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr3_+_173398438 0.18 ENST00000457714.5
NLGN1
neuroligin 1
chr8_+_60678705 0.16 ENST00000423902.7
CHD7
chromodomain helicase DNA binding protein 7
chr14_+_66508127 0.12 ENST00000459628.5
ENST00000478722.6
GPHN
gephyrin
chr18_-_75209126 0.12 ENST00000322342.4
ZADH2
zinc binding alcohol dehydrogenase domain containing 2
chr2_+_148021001 0.10 ENST00000407073.5
MBD5
methyl-CpG binding domain protein 5
chr4_+_127782270 0.09 ENST00000508549.5
ENST00000296464.9
HSPA4L
heat shock protein family A (Hsp70) member 4 like
chr11_-_107018462 0.08 ENST00000526355.7
GUCY1A2
guanylate cyclase 1 soluble subunit alpha 2
chr12_+_27244222 0.06 ENST00000545470.5
ENST00000389032.8
ENST00000540996.5
STK38L
serine/threonine kinase 38 like
chr4_+_169620527 0.02 ENST00000360642.7
ENST00000512813.5
ENST00000513761.6
CLCN3
chloride voltage-gated channel 3
chr22_+_40177917 0.01 ENST00000454349.7
ENST00000335727.13
TNRC6B
trinucleotide repeat containing adaptor 6B
chr4_+_98995709 0.01 ENST00000296411.11
ENST00000625963.1
METAP1
methionyl aminopeptidase 1
chr11_-_70661762 0.01 ENST00000357171.7
ENST00000412252.5
ENST00000449833.6
ENST00000338508.8
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr1_-_32817311 0.00 ENST00000373477.9
ENST00000675785.1
YARS1
tyrosyl-tRNA synthetase 1
chr8_-_92103217 0.00 ENST00000615601.4
ENST00000523629.5
RUNX1T1
RUNX1 partner transcriptional co-repressor 1
chr21_-_38498415 0.00 ENST00000398905.5
ENST00000398907.5
ENST00000453032.6
ENST00000288319.12
ERG
ETS transcription factor ERG

Network of associatons between targets according to the STRING database.

First level regulatory network of GAUAUGU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.1 1.0 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0 0.2 GO:0097115 cytoskeletal matrix organization at active zone(GO:0048789) neurexin clustering involved in presynaptic membrane assembly(GO:0097115) retrograde trans-synaptic signaling by trans-synaptic protein complex(GO:0098942)
0.0 0.7 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.1 GO:0018315 molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579)
0.0 0.3 GO:0099558 maintenance of synapse structure(GO:0099558)
0.0 0.4 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.0 0.7 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.2 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.0 0.4 GO:0003322 pancreatic A cell development(GO:0003322)
0.0 0.3 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.1 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.0 0.5 GO:0072112 renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) negative regulation of peptidyl-lysine acetylation(GO:2000757)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0098855 HCN channel complex(GO:0098855)
0.1 0.7 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.7 GO:0016013 syntrophin complex(GO:0016013)
0.0 1.0 GO:0016342 catenin complex(GO:0016342)
0.0 0.7 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.3 GO:0043083 synaptic cleft(GO:0043083)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 0.1 GO:0061599 nitrate reductase activity(GO:0008940) molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599)
0.0 1.0 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.7 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.1 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.0 0.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.7 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.3 GO:0097109 neuroligin family protein binding(GO:0097109)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID NCADHERIN PATHWAY N-cadherin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.2 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels