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Illumina Body Map 2 (GSE30611)

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Results for GLIS3

Z-value: 0.69

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Transcription factors associated with GLIS3

Gene Symbol Gene ID Gene Info
GLIS3
ENSG00000107249.24 GLIS family zinc finger 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GLIS3hg38_v1_chr9_-_4299873_4299916-0.192.9e-01Click!

Activity profile of GLIS3 motif

Sorted Z-values of GLIS3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_31413806 1.40 ENST00000536384.2
SERINC2
serine incorporator 2
chr12_+_109139397 1.11 ENST00000377854.9
ENST00000377848.7
ACACB
acetyl-CoA carboxylase beta
chr21_+_36699100 1.03 ENST00000290399.11
SIM2
SIM bHLH transcription factor 2
chr19_-_10503186 0.97 ENST00000592055.2
ENST00000171111.10
KEAP1
kelch like ECH associated protein 1
chr18_-_63158208 0.93 ENST00000678301.1
BCL2
BCL2 apoptosis regulator
chr12_+_54008961 0.90 ENST00000040584.6
HOXC8
homeobox C8
chr11_+_68684534 0.88 ENST00000265643.4
GAL
galanin and GMAP prepropeptide
chr17_+_4771878 0.87 ENST00000270560.4
TM4SF5
transmembrane 4 L six family member 5
chr20_+_21126074 0.85 ENST00000619189.5
KIZ
kizuna centrosomal protein
chr20_+_21126037 0.83 ENST00000611685.4
ENST00000616848.4
KIZ
kizuna centrosomal protein
chr19_-_10502745 0.81 ENST00000393623.6
KEAP1
kelch like ECH associated protein 1
chr13_-_20192928 0.79 ENST00000382848.5
GJB2
gap junction protein beta 2
chr20_+_21125981 0.78 ENST00000619574.4
KIZ
kizuna centrosomal protein
chr20_+_21125999 0.77 ENST00000620891.4
KIZ
kizuna centrosomal protein
chr1_+_107056656 0.69 ENST00000370078.2
PRMT6
protein arginine methyltransferase 6
chr3_+_127629161 0.68 ENST00000342480.7
PODXL2
podocalyxin like 2
chrX_-_126552801 0.67 ENST00000371126.3
DCAF12L1
DDB1 and CUL4 associated factor 12 like 1
chr16_+_89620584 0.66 ENST00000393092.7
DPEP1
dipeptidase 1
chr15_-_43590155 0.65 ENST00000453080.5
ENST00000360135.8
ENST00000360301.8
ENST00000417085.2
ENST00000431962.1
ENST00000334933.8
ENST00000381879.8
ENST00000420765.5
PPIP5K1
diphosphoinositol pentakisphosphate kinase 1
chr15_-_90935130 0.63 ENST00000646620.1
HDDC3
HD domain containing 3
chr14_+_104724221 0.59 ENST00000330877.7
ADSS1
adenylosuccinate synthase 1
chr4_+_163343882 0.58 ENST00000338566.8
NPY5R
neuropeptide Y receptor Y5
chr18_+_11752041 0.57 ENST00000423027.8
GNAL
G protein subunit alpha L
chr15_+_90935277 0.57 ENST00000418476.2
UNC45A
unc-45 myosin chaperone A
chr15_+_83447411 0.52 ENST00000324537.5
SH3GL3
SH3 domain containing GRB2 like 3, endophilin A3
chr22_+_22644475 0.52 ENST00000618722.4
ENST00000652219.1
ENST00000480559.6
ENST00000448514.2
ENST00000652249.1
ENST00000651213.1
GGTLC2
gamma-glutamyltransferase light chain 2
chr11_+_68903849 0.51 ENST00000675615.1
ENST00000255078.8
IGHMBP2
immunoglobulin mu DNA binding protein 2
chr19_-_10502685 0.50 ENST00000591039.1
ENST00000591419.2
KEAP1
kelch like ECH associated protein 1
chr17_+_47941562 0.49 ENST00000225573.5
ENST00000434554.7
ENST00000642017.2
PNPO
pyridoxamine 5'-phosphate oxidase
chr18_+_11751494 0.49 ENST00000269162.9
GNAL
G protein subunit alpha L
chr9_-_95516959 0.49 ENST00000437951.6
ENST00000430669.6
ENST00000468211.6
PTCH1
patched 1
chr12_+_52949107 0.48 ENST00000388835.4
KRT18
keratin 18
chr20_-_46089905 0.47 ENST00000372291.3
ENST00000290231.11
NCOA5
nuclear receptor coactivator 5
chr18_+_11751467 0.46 ENST00000535121.5
GNAL
G protein subunit alpha L
chr5_+_172959416 0.45 ENST00000265100.6
ENST00000519239.5
RPL26L1
ribosomal protein L26 like 1
chrX_+_119236245 0.44 ENST00000535419.2
PGRMC1
progesterone receptor membrane component 1
chr17_+_47941506 0.44 ENST00000583599.6
PNPO
pyridoxamine 5'-phosphate oxidase
chr8_-_29263063 0.42 ENST00000524189.6
KIF13B
kinesin family member 13B
chrX_+_119236274 0.42 ENST00000217971.8
PGRMC1
progesterone receptor membrane component 1
chr3_-_25783434 0.41 ENST00000396649.7
ENST00000280700.10
ENST00000428257.5
NGLY1
N-glycanase 1
chr16_-_90008988 0.40 ENST00000568662.2
DBNDD1
dysbindin domain containing 1
chr1_-_19799872 0.40 ENST00000294543.11
TMCO4
transmembrane and coiled-coil domains 4
chr7_+_107044689 0.40 ENST00000265717.5
PRKAR2B
protein kinase cAMP-dependent type II regulatory subunit beta
chr11_-_68903796 0.39 ENST00000362034.7
MRPL21
mitochondrial ribosomal protein L21
chr17_+_47941694 0.35 ENST00000584061.6
PNPO
pyridoxamine 5'-phosphate oxidase
chr16_-_3235143 0.34 ENST00000414144.7
ENST00000431561.7
ENST00000396870.8
ZNF200
zinc finger protein 200
chr17_-_35119733 0.34 ENST00000460118.6
ENST00000335858.11
RAD51D
RAD51 paralog D
chr6_+_33204645 0.33 ENST00000374662.4
HSD17B8
hydroxysteroid 17-beta dehydrogenase 8
chr6_+_24494939 0.32 ENST00000348925.2
ENST00000357578.8
ALDH5A1
aldehyde dehydrogenase 5 family member A1
chr17_+_82860354 0.32 ENST00000576996.5
TBCD
tubulin folding cofactor D
chr1_-_160285120 0.29 ENST00000368072.10
PEX19
peroxisomal biogenesis factor 19
chr3_-_25783381 0.29 ENST00000308710.9
ENST00000676225.1
NGLY1
N-glycanase 1
chr8_-_29263087 0.29 ENST00000521515.1
KIF13B
kinesin family member 13B
chr19_+_11798514 0.28 ENST00000323169.10
ENST00000450087.1
ZNF491
zinc finger protein 491
chr9_-_113299196 0.27 ENST00000441031.3
RNF183
ring finger protein 183
chr17_-_79952007 0.26 ENST00000574241.6
TBC1D16
TBC1 domain family member 16
chr17_-_35119801 0.26 ENST00000592577.5
ENST00000590016.5
ENST00000345365.11
RAD51D
RAD51 paralog D
chr2_-_85602681 0.24 ENST00000334462.10
ENST00000306353.7
TMEM150A
transmembrane protein 150A
chr3_+_173398438 0.24 ENST00000457714.5
NLGN1
neuroligin 1
chr5_-_132777371 0.23 ENST00000620483.4
SEPTIN8
septin 8
chr8_+_11769639 0.22 ENST00000436750.7
NEIL2
nei like DNA glycosylase 2
chr1_-_45522870 0.22 ENST00000424390.2
PRDX1
peroxiredoxin 1
chr8_+_117135259 0.22 ENST00000519688.5
SLC30A8
solute carrier family 30 member 8
chr2_-_85602351 0.21 ENST00000409668.1
TMEM150A
transmembrane protein 150A
chr17_+_50835578 0.21 ENST00000311378.5
WFIKKN2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr1_-_53945584 0.20 ENST00000371377.3
HSPB11
heat shock protein family B (small) member 11
chr2_-_240820205 0.20 ENST00000647731.1
ENST00000648680.1
ENST00000649306.1
ENST00000648129.1
ENST00000498729.9
ENST00000320389.12
ENST00000648364.1
ENST00000647885.1
ENST00000404283.9
ENST00000649096.1
KIF1A
kinesin family member 1A
chr19_-_37906646 0.20 ENST00000303868.5
WDR87
WD repeat domain 87
chr5_-_132777344 0.20 ENST00000378706.5
SEPTIN8
septin 8
chr16_+_69187125 0.19 ENST00000336278.8
SNTB2
syntrophin beta 2
chr19_+_13764502 0.19 ENST00000040663.8
ENST00000319545.12
MRI1
methylthioribose-1-phosphate isomerase 1
chr1_-_53945567 0.18 ENST00000371378.6
HSPB11
heat shock protein family B (small) member 11
chr1_-_42335189 0.18 ENST00000361776.5
ENST00000445886.5
ENST00000361346.6
FOXJ3
forkhead box J3
chr19_-_37906588 0.17 ENST00000447313.7
WDR87
WD repeat domain 87
chr5_-_132777404 0.17 ENST00000296873.11
SEPTIN8
septin 8
chr19_+_41354145 0.16 ENST00000604123.5
TMEM91
transmembrane protein 91
chr10_+_22321056 0.16 ENST00000376663.8
BMI1
BMI1 proto-oncogene, polycomb ring finger
chr19_-_55580829 0.16 ENST00000592239.1
ENST00000325421.7
ZNF579
zinc finger protein 579
chr19_-_14114156 0.16 ENST00000589994.6
PRKACA
protein kinase cAMP-activated catalytic subunit alpha
chr5_+_41925223 0.16 ENST00000296812.6
ENST00000281623.8
ENST00000509134.1
FBXO4
F-box protein 4
chr9_+_129142016 0.14 ENST00000434095.2
PTPA
protein phosphatase 2 phosphatase activator
chr17_-_5111836 0.14 ENST00000575898.5
ZNF232
zinc finger protein 232
chr8_+_117134989 0.13 ENST00000456015.7
SLC30A8
solute carrier family 30 member 8
chr10_-_125161019 0.13 ENST00000411419.6
CTBP2
C-terminal binding protein 2
chr19_+_1275508 0.13 ENST00000409293.6
FAM174C
family with sequence similarity 174 member C
chr5_-_132777215 0.12 ENST00000458488.2
SEPTIN8
septin 8
chr10_-_74163 0.11 ENST00000564130.2
TUBB8
tubulin beta 8 class VIII
chr8_+_117135020 0.11 ENST00000518396.5
SLC30A8
solute carrier family 30 member 8
chr7_+_151061217 0.11 ENST00000482950.5
ENST00000463414.5
SLC4A2
solute carrier family 4 member 2
chr1_-_42335869 0.11 ENST00000372573.5
FOXJ3
forkhead box J3
chr6_+_24494839 0.11 ENST00000491546.5
ALDH5A1
aldehyde dehydrogenase 5 family member A1
chr16_-_1095647 0.10 ENST00000621771.1
C1QTNF8
C1q and TNF related 8
chr8_-_73878816 0.10 ENST00000602593.6
ENST00000651945.1
ENST00000419880.7
ENST00000517608.5
ENST00000650817.1
UBE2W
ubiquitin conjugating enzyme E2 W
chr17_-_81959769 0.09 ENST00000477214.5
NOTUM
notum, palmitoleoyl-protein carboxylesterase
chr12_-_47758828 0.09 ENST00000389212.7
ENST00000449771.7
RAPGEF3
Rap guanine nucleotide exchange factor 3
chr9_-_136764515 0.09 ENST00000316144.6
LCN15
lipocalin 15
chr8_+_11769696 0.09 ENST00000455213.6
ENST00000403422.7
ENST00000528323.5
ENST00000284503.7
NEIL2
nei like DNA glycosylase 2
chr17_+_47941721 0.08 ENST00000641511.1
PNPO
pyridoxamine 5'-phosphate oxidase
chr17_-_3916455 0.08 ENST00000225538.4
P2RX1
purinergic receptor P2X 1
chr18_+_3451647 0.08 ENST00000345133.9
ENST00000330513.10
ENST00000549546.5
TGIF1
TGFB induced factor homeobox 1
chr17_+_50834581 0.07 ENST00000426127.1
WFIKKN2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr5_-_132777866 0.06 ENST00000448933.5
SEPTIN8
septin 8
chr11_+_818906 0.06 ENST00000336615.9
PNPLA2
patatin like phospholipase domain containing 2
chr10_-_125161056 0.06 ENST00000530884.1
CTBP2
C-terminal binding protein 2
chr1_-_45521854 0.04 ENST00000372079.1
ENST00000319248.13
PRDX1
peroxiredoxin 1
chr15_-_43589942 0.04 ENST00000429176.5
PPIP5K1
diphosphoinositol pentakisphosphate kinase 1
chr7_+_151061499 0.04 ENST00000488420.1
SLC4A2
solute carrier family 4 member 2
chr9_+_129141637 0.02 ENST00000419582.5
PTPA
protein phosphatase 2 phosphatase activator
chr9_+_129141954 0.02 ENST00000432651.5
ENST00000435132.5
PTPA
protein phosphatase 2 phosphatase activator
chr6_+_44223770 0.01 ENST00000652453.1
ENST00000393841.6
ENST00000371724.6
ENST00000642777.1
ENST00000645692.1
SLC29A1
solute carrier family 29 member 1 (Augustine blood group)
chr9_-_136304084 0.00 ENST00000638797.2
ENST00000624277.3
CCDC187
coiled-coil domain containing 187
chr18_+_3451585 0.00 ENST00000551541.5
TGIF1
TGFB induced factor homeobox 1

Network of associatons between targets according to the STRING database.

First level regulatory network of GLIS3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.2 0.7 GO:0034970 histone H3-R2 methylation(GO:0034970)
0.2 1.4 GO:0008614 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 biosynthetic process(GO:0042819)
0.2 0.7 GO:0016999 antibiotic metabolic process(GO:0016999)
0.2 0.9 GO:0051795 positive regulation of catagen(GO:0051795)
0.2 0.9 GO:0046671 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.2 0.5 GO:0043000 Golgi to plasma membrane CFTR protein transport(GO:0043000)
0.2 1.1 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.2 2.3 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.8 GO:0044752 response to human chorionic gonadotropin(GO:0044752)
0.1 0.6 GO:0014050 negative regulation of glutamate secretion(GO:0014050)
0.1 0.5 GO:0010157 response to chlorate(GO:0010157)
0.1 0.6 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.1 0.4 GO:0006540 acetate metabolic process(GO:0006083) glutamate decarboxylation to succinate(GO:0006540)
0.1 0.2 GO:0048789 cytoskeletal matrix organization at active zone(GO:0048789) neurexin clustering involved in presynaptic membrane assembly(GO:0097115) retrograde trans-synaptic signaling by trans-synaptic protein complex(GO:0098942)
0.1 0.7 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 0.4 GO:0097338 response to clozapine(GO:0097338)
0.0 1.5 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.2 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.1 GO:1990697 protein depalmitoleylation(GO:1990697)
0.0 0.5 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.0 0.5 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.7 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.1 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
0.0 0.3 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.3 GO:0045046 protein import into peroxisome membrane(GO:0045046)
0.0 0.2 GO:0030472 mitotic spindle organization in nucleus(GO:0030472)
0.0 0.7 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.0 0.1 GO:0002442 serotonin production involved in inflammatory response(GO:0002351) serotonin secretion involved in inflammatory response(GO:0002442) serotonin secretion by platelet(GO:0002554)
0.0 0.3 GO:0045008 depyrimidination(GO:0045008)
0.0 0.4 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.3 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.2 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.2 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.8 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.2 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.5 GO:0044294 dendritic growth cone(GO:0044294)
0.0 0.9 GO:0046930 pore complex(GO:0046930)
0.0 0.5 GO:0032797 SMN complex(GO:0032797)
0.0 0.8 GO:0005922 connexon complex(GO:0005922)
0.0 0.7 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 2.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.1 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.2 GO:0032433 filopodium tip(GO:0032433)
0.0 0.2 GO:0097470 ribbon synapse(GO:0097470)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0004733 pyridoxamine-phosphate oxidase activity(GO:0004733)
0.2 0.7 GO:0000224 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity(GO:0000224)
0.2 0.6 GO:0008893 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity(GO:0008893) diphosphoric monoester hydrolase activity(GO:0016794)
0.2 0.7 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.2 1.1 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.1 0.6 GO:0001601 peptide YY receptor activity(GO:0001601)
0.1 0.9 GO:0004966 galanin receptor activity(GO:0004966)
0.1 0.3 GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.1 1.4 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 0.7 GO:0070573 metallodipeptidase activity(GO:0070573)
0.1 0.5 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 0.7 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.1 0.5 GO:0005119 smoothened binding(GO:0005119) hedgehog family protein binding(GO:0097108)
0.0 0.8 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.1 GO:1990699 palmitoleyl hydrolase activity(GO:1990699)
0.0 0.5 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 1.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.6 GO:0000150 recombinase activity(GO:0000150)
0.0 0.3 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.2 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.2 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.0 1.1 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 0.4 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.3 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 0.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.5 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.7 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.9 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.5 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.9 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.8 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 1.1 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.6 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 1.4 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.5 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis