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Illumina Body Map 2 (GSE30611)

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Results for GLIS3

Z-value: 0.69

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Transcription factors associated with GLIS3

Gene Symbol Gene ID Gene Info
ENSG00000107249.24 GLIS family zinc finger 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GLIS3hg38_v1_chr9_-_4299873_4299916-0.192.9e-01Click!

Activity profile of GLIS3 motif

Sorted Z-values of GLIS3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_31413806 1.40 ENST00000536384.2
serine incorporator 2
chr12_+_109139397 1.11 ENST00000377854.9
ENST00000377848.7
acetyl-CoA carboxylase beta
chr21_+_36699100 1.03 ENST00000290399.11
SIM bHLH transcription factor 2
chr19_-_10503186 0.97 ENST00000592055.2
ENST00000171111.10
kelch like ECH associated protein 1
chr18_-_63158208 0.93 ENST00000678301.1
BCL2 apoptosis regulator
chr12_+_54008961 0.90 ENST00000040584.6
homeobox C8
chr11_+_68684534 0.88 ENST00000265643.4
galanin and GMAP prepropeptide
chr17_+_4771878 0.87 ENST00000270560.4
transmembrane 4 L six family member 5
chr20_+_21126074 0.85 ENST00000619189.5
kizuna centrosomal protein
chr20_+_21126037 0.83 ENST00000611685.4
ENST00000616848.4
kizuna centrosomal protein
chr19_-_10502745 0.81 ENST00000393623.6
kelch like ECH associated protein 1
chr13_-_20192928 0.79 ENST00000382848.5
gap junction protein beta 2
chr20_+_21125981 0.78 ENST00000619574.4
kizuna centrosomal protein
chr20_+_21125999 0.77 ENST00000620891.4
kizuna centrosomal protein
chr1_+_107056656 0.69 ENST00000370078.2
protein arginine methyltransferase 6
chr3_+_127629161 0.68 ENST00000342480.7
podocalyxin like 2
chrX_-_126552801 0.67 ENST00000371126.3
DDB1 and CUL4 associated factor 12 like 1
chr16_+_89620584 0.66 ENST00000393092.7
dipeptidase 1
chr15_-_43590155 0.65 ENST00000453080.5
ENST00000360135.8
ENST00000360301.8
ENST00000417085.2
ENST00000431962.1
ENST00000334933.8
ENST00000381879.8
ENST00000420765.5
diphosphoinositol pentakisphosphate kinase 1
chr15_-_90935130 0.63 ENST00000646620.1
HD domain containing 3
chr14_+_104724221 0.59 ENST00000330877.7
adenylosuccinate synthase 1
chr4_+_163343882 0.58 ENST00000338566.8
neuropeptide Y receptor Y5
chr18_+_11752041 0.57 ENST00000423027.8
G protein subunit alpha L
chr15_+_90935277 0.57 ENST00000418476.2
unc-45 myosin chaperone A
chr15_+_83447411 0.52 ENST00000324537.5
SH3 domain containing GRB2 like 3, endophilin A3
chr22_+_22644475 0.52 ENST00000618722.4
ENST00000652219.1
ENST00000480559.6
ENST00000448514.2
ENST00000652249.1
ENST00000651213.1
gamma-glutamyltransferase light chain 2
chr11_+_68903849 0.51 ENST00000675615.1
ENST00000255078.8
immunoglobulin mu DNA binding protein 2
chr19_-_10502685 0.50 ENST00000591039.1
ENST00000591419.2
kelch like ECH associated protein 1
chr17_+_47941562 0.49 ENST00000225573.5
ENST00000434554.7
ENST00000642017.2
pyridoxamine 5'-phosphate oxidase
chr18_+_11751494 0.49 ENST00000269162.9
G protein subunit alpha L
chr9_-_95516959 0.49 ENST00000437951.6
ENST00000430669.6
ENST00000468211.6
patched 1
chr12_+_52949107 0.48 ENST00000388835.4
keratin 18
chr20_-_46089905 0.47 ENST00000372291.3
ENST00000290231.11
nuclear receptor coactivator 5
chr18_+_11751467 0.46 ENST00000535121.5
G protein subunit alpha L
chr5_+_172959416 0.45 ENST00000265100.6
ENST00000519239.5
ribosomal protein L26 like 1
chrX_+_119236245 0.44 ENST00000535419.2
progesterone receptor membrane component 1
chr17_+_47941506 0.44 ENST00000583599.6
pyridoxamine 5'-phosphate oxidase
chr8_-_29263063 0.42 ENST00000524189.6
kinesin family member 13B
chrX_+_119236274 0.42 ENST00000217971.8
progesterone receptor membrane component 1
chr3_-_25783434 0.41 ENST00000396649.7
ENST00000280700.10
ENST00000428257.5
N-glycanase 1
chr16_-_90008988 0.40 ENST00000568662.2
dysbindin domain containing 1
chr1_-_19799872 0.40 ENST00000294543.11
transmembrane and coiled-coil domains 4
chr7_+_107044689 0.40 ENST00000265717.5
protein kinase cAMP-dependent type II regulatory subunit beta
chr11_-_68903796 0.39 ENST00000362034.7
mitochondrial ribosomal protein L21
chr17_+_47941694 0.35 ENST00000584061.6
pyridoxamine 5'-phosphate oxidase
chr16_-_3235143 0.34 ENST00000414144.7
ENST00000431561.7
ENST00000396870.8
zinc finger protein 200
chr17_-_35119733 0.34 ENST00000460118.6
ENST00000335858.11
RAD51 paralog D
chr6_+_33204645 0.33 ENST00000374662.4
hydroxysteroid 17-beta dehydrogenase 8
chr6_+_24494939 0.32 ENST00000348925.2
ENST00000357578.8
aldehyde dehydrogenase 5 family member A1
chr17_+_82860354 0.32 ENST00000576996.5
tubulin folding cofactor D
chr1_-_160285120 0.29 ENST00000368072.10
peroxisomal biogenesis factor 19
chr3_-_25783381 0.29 ENST00000308710.9
ENST00000676225.1
N-glycanase 1
chr8_-_29263087 0.29 ENST00000521515.1
kinesin family member 13B
chr19_+_11798514 0.28 ENST00000323169.10
ENST00000450087.1
zinc finger protein 491
chr9_-_113299196 0.27 ENST00000441031.3
ring finger protein 183
chr17_-_79952007 0.26 ENST00000574241.6
TBC1 domain family member 16
chr17_-_35119801 0.26 ENST00000592577.5
ENST00000590016.5
ENST00000345365.11
RAD51 paralog D
chr2_-_85602681 0.24 ENST00000334462.10
ENST00000306353.7
transmembrane protein 150A
chr3_+_173398438 0.24 ENST00000457714.5
neuroligin 1
chr5_-_132777371 0.23 ENST00000620483.4
septin 8
chr8_+_11769639 0.22 ENST00000436750.7
nei like DNA glycosylase 2
chr1_-_45522870 0.22 ENST00000424390.2
peroxiredoxin 1
chr8_+_117135259 0.22 ENST00000519688.5
solute carrier family 30 member 8
chr2_-_85602351 0.21 ENST00000409668.1
transmembrane protein 150A
chr17_+_50835578 0.21 ENST00000311378.5
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr1_-_53945584 0.20 ENST00000371377.3
heat shock protein family B (small) member 11
chr2_-_240820205 0.20 ENST00000647731.1
ENST00000648680.1
ENST00000649306.1
ENST00000648129.1
ENST00000498729.9
ENST00000320389.12
ENST00000648364.1
ENST00000647885.1
ENST00000404283.9
ENST00000649096.1
kinesin family member 1A
chr19_-_37906646 0.20 ENST00000303868.5
WD repeat domain 87
chr5_-_132777344 0.20 ENST00000378706.5
septin 8
chr16_+_69187125 0.19 ENST00000336278.8
syntrophin beta 2
chr19_+_13764502 0.19 ENST00000040663.8
ENST00000319545.12
methylthioribose-1-phosphate isomerase 1
chr1_-_53945567 0.18 ENST00000371378.6
heat shock protein family B (small) member 11
chr1_-_42335189 0.18 ENST00000361776.5
ENST00000445886.5
ENST00000361346.6
forkhead box J3
chr19_-_37906588 0.17 ENST00000447313.7
WD repeat domain 87
chr5_-_132777404 0.17 ENST00000296873.11
septin 8
chr19_+_41354145 0.16 ENST00000604123.5
transmembrane protein 91
chr10_+_22321056 0.16 ENST00000376663.8
BMI1 proto-oncogene, polycomb ring finger
chr19_-_55580829 0.16 ENST00000592239.1
ENST00000325421.7
zinc finger protein 579
chr19_-_14114156 0.16 ENST00000589994.6
protein kinase cAMP-activated catalytic subunit alpha
chr5_+_41925223 0.16 ENST00000296812.6
ENST00000281623.8
ENST00000509134.1
F-box protein 4
chr9_+_129142016 0.14 ENST00000434095.2
protein phosphatase 2 phosphatase activator
chr17_-_5111836 0.14 ENST00000575898.5
zinc finger protein 232
chr8_+_117134989 0.13 ENST00000456015.7
solute carrier family 30 member 8
chr10_-_125161019 0.13 ENST00000411419.6
C-terminal binding protein 2
chr19_+_1275508 0.13 ENST00000409293.6
family with sequence similarity 174 member C
chr5_-_132777215 0.12 ENST00000458488.2
septin 8
chr10_-_74163 0.11 ENST00000564130.2
tubulin beta 8 class VIII
chr8_+_117135020 0.11 ENST00000518396.5
solute carrier family 30 member 8
chr7_+_151061217 0.11 ENST00000482950.5
ENST00000463414.5
solute carrier family 4 member 2
chr1_-_42335869 0.11 ENST00000372573.5
forkhead box J3
chr6_+_24494839 0.11 ENST00000491546.5
aldehyde dehydrogenase 5 family member A1
chr16_-_1095647 0.10 ENST00000621771.1
C1q and TNF related 8
chr8_-_73878816 0.10 ENST00000602593.6
ENST00000651945.1
ENST00000419880.7
ENST00000517608.5
ENST00000650817.1
ubiquitin conjugating enzyme E2 W
chr17_-_81959769 0.09 ENST00000477214.5
notum, palmitoleoyl-protein carboxylesterase
chr12_-_47758828 0.09 ENST00000389212.7
ENST00000449771.7
Rap guanine nucleotide exchange factor 3
chr9_-_136764515 0.09 ENST00000316144.6
lipocalin 15
chr8_+_11769696 0.09 ENST00000455213.6
ENST00000403422.7
ENST00000528323.5
ENST00000284503.7
nei like DNA glycosylase 2
chr17_+_47941721 0.08 ENST00000641511.1
pyridoxamine 5'-phosphate oxidase
chr17_-_3916455 0.08 ENST00000225538.4
purinergic receptor P2X 1
chr18_+_3451647 0.08 ENST00000345133.9
ENST00000330513.10
ENST00000549546.5
TGFB induced factor homeobox 1
chr17_+_50834581 0.07 ENST00000426127.1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr5_-_132777866 0.06 ENST00000448933.5
septin 8
chr11_+_818906 0.06 ENST00000336615.9
patatin like phospholipase domain containing 2
chr10_-_125161056 0.06 ENST00000530884.1
C-terminal binding protein 2
chr1_-_45521854 0.04 ENST00000372079.1
ENST00000319248.13
peroxiredoxin 1
chr15_-_43589942 0.04 ENST00000429176.5
diphosphoinositol pentakisphosphate kinase 1
chr7_+_151061499 0.04 ENST00000488420.1
solute carrier family 4 member 2
chr9_+_129141637 0.02 ENST00000419582.5
protein phosphatase 2 phosphatase activator
chr9_+_129141954 0.02 ENST00000432651.5
ENST00000435132.5
protein phosphatase 2 phosphatase activator
chr6_+_44223770 0.01 ENST00000652453.1
ENST00000393841.6
ENST00000371724.6
ENST00000642777.1
ENST00000645692.1
solute carrier family 29 member 1 (Augustine blood group)
chr9_-_136304084 0.00 ENST00000638797.2
ENST00000624277.3
coiled-coil domain containing 187
chr18_+_3451585 0.00 ENST00000551541.5
TGFB induced factor homeobox 1

Network of associatons between targets according to the STRING database.

First level regulatory network of GLIS3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.2 0.7 GO:0034970 histone H3-R2 methylation(GO:0034970)
0.2 1.4 GO:0008614 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 biosynthetic process(GO:0042819)
0.2 0.7 GO:0016999 antibiotic metabolic process(GO:0016999)
0.2 0.9 GO:0051795 positive regulation of catagen(GO:0051795)
0.2 0.9 GO:0046671 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.2 0.5 GO:0043000 Golgi to plasma membrane CFTR protein transport(GO:0043000)
0.2 1.1 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.2 2.3 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.8 GO:0044752 response to human chorionic gonadotropin(GO:0044752)
0.1 0.6 GO:0014050 negative regulation of glutamate secretion(GO:0014050)
0.1 0.5 GO:0010157 response to chlorate(GO:0010157)
0.1 0.6 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.1 0.4 GO:0006540 acetate metabolic process(GO:0006083) glutamate decarboxylation to succinate(GO:0006540)
0.1 0.2 GO:0048789 cytoskeletal matrix organization at active zone(GO:0048789) neurexin clustering involved in presynaptic membrane assembly(GO:0097115) retrograde trans-synaptic signaling by trans-synaptic protein complex(GO:0098942)
0.1 0.7 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 0.4 GO:0097338 response to clozapine(GO:0097338)
0.0 1.5 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.2 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.1 GO:1990697 protein depalmitoleylation(GO:1990697)
0.0 0.5 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.0 0.5 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.7 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.1 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
0.0 0.3 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.3 GO:0045046 protein import into peroxisome membrane(GO:0045046)
0.0 0.2 GO:0030472 mitotic spindle organization in nucleus(GO:0030472)
0.0 0.7 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.0 0.1 GO:0002442 serotonin production involved in inflammatory response(GO:0002351) serotonin secretion involved in inflammatory response(GO:0002442) serotonin secretion by platelet(GO:0002554)
0.0 0.3 GO:0045008 depyrimidination(GO:0045008)
0.0 0.4 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.3 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.2 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.2 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.8 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.2 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.5 GO:0044294 dendritic growth cone(GO:0044294)
0.0 0.9 GO:0046930 pore complex(GO:0046930)
0.0 0.5 GO:0032797 SMN complex(GO:0032797)
0.0 0.8 GO:0005922 connexon complex(GO:0005922)
0.0 0.7 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 2.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.1 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.2 GO:0032433 filopodium tip(GO:0032433)
0.0 0.2 GO:0097470 ribbon synapse(GO:0097470)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0004733 pyridoxamine-phosphate oxidase activity(GO:0004733)
0.2 0.7 GO:0000224 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity(GO:0000224)
0.2 0.6 GO:0008893 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity(GO:0008893) diphosphoric monoester hydrolase activity(GO:0016794)
0.2 0.7 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.2 1.1 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.1 0.6 GO:0001601 peptide YY receptor activity(GO:0001601)
0.1 0.9 GO:0004966 galanin receptor activity(GO:0004966)
0.1 0.3 GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.1 1.4 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 0.7 GO:0070573 metallodipeptidase activity(GO:0070573)
0.1 0.5 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 0.7 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.1 0.5 GO:0005119 smoothened binding(GO:0005119) hedgehog family protein binding(GO:0097108)
0.0 0.8 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.1 GO:1990699 palmitoleyl hydrolase activity(GO:1990699)
0.0 0.5 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 1.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.6 GO:0000150 recombinase activity(GO:0000150)
0.0 0.3 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.2 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.2 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.0 1.1 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 0.4 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.3 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 0.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.5 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.7 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.9 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.5 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.9 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.8 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 1.1 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.6 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 1.4 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.5 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis