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Illumina Body Map 2 (GSE30611)
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Results for GTF2I
Z-value: 1.59
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Transcription factors associated with GTF2I
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GTF2I | hg38_v1_chr7_+_74658004_74658031 | 0.49 | 4.5e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GTF2I
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.0 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.3 | 6.9 | GO:0045634 | regulation of melanocyte differentiation(GO:0045634) |
| 0.6 | 6.5 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 0.1 | 5.9 | GO:0006911 | phagocytosis, engulfment(GO:0006911) |
| 0.0 | 5.6 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 0.9 | 5.3 | GO:0072180 | mesonephric duct morphogenesis(GO:0072180) |
| 0.3 | 5.0 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 0.1 | 4.2 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 0.1 | 4.1 | GO:0010867 | positive regulation of triglyceride biosynthetic process(GO:0010867) |
| 1.3 | 3.9 | GO:0060931 | sinoatrial node cell development(GO:0060931) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 23.1 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 12.3 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 10.3 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 7.6 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.1 | 7.4 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 7.2 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 7.0 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 7.0 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.0 | 6.1 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 5.8 | GO:0000118 | histone deacetylase complex(GO:0000118) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.8 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 8.5 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 8.4 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.0 | 6.9 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 6.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 5.8 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.0 | 4.9 | GO:0005518 | collagen binding(GO:0005518) |
| 0.3 | 4.6 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.1 | 4.4 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.2 | 4.1 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 11.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 7.5 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.1 | 7.3 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 7.3 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 6.6 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.0 | 6.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 5.6 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 5.5 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 4.6 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.1 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 7.9 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 5.9 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 5.7 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.3 | 5.0 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.2 | 5.0 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.2 | 4.1 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.1 | 3.7 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 3.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 3.6 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |