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Illumina Body Map 2 (GSE30611)

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Results for GZF1

Z-value: 0.92

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Transcription factors associated with GZF1

Gene Symbol Gene ID Gene Info
GZF1
ENSG00000125812.16 GDNF inducible zinc finger protein 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GZF1hg38_v1_chr20_+_23362144_233623200.038.8e-01Click!

Activity profile of GZF1 motif

Sorted Z-values of GZF1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_33080445 4.02 ENST00000428835.5
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr1_+_26280059 3.76 ENST00000270792.10
SH3BGRL3
SH3 domain binding glutamate rich protein like 3
chr6_-_33080767 3.60 ENST00000453337.1
ENST00000417724.1
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr1_+_26280117 3.46 ENST00000319041.6
SH3BGRL3
SH3 domain binding glutamate rich protein like 3
chr6_-_33080710 3.46 ENST00000419277.5
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr7_-_27143672 3.02 ENST00000222726.4
HOXA5
homeobox A5
chr3_-_86991135 2.78 ENST00000398399.7
VGLL3
vestigial like family member 3
chr1_+_9651723 2.76 ENST00000377346.9
ENST00000536656.5
ENST00000628140.2
PIK3CD
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
chr3_+_30606574 2.58 ENST00000295754.10
ENST00000359013.4
TGFBR2
transforming growth factor beta receptor 2
chr6_-_41940537 2.01 ENST00000512426.5
CCND3
cyclin D3
chr5_+_119268689 1.98 ENST00000274456.6
TNFAIP8
TNF alpha induced protein 8
chr7_-_26864573 1.90 ENST00000345317.7
SKAP2
src kinase associated phosphoprotein 2
chr6_-_36547400 1.86 ENST00000229812.8
STK38
serine/threonine kinase 38
chr1_+_32292067 1.48 ENST00000373548.8
ENST00000428704.1
HDAC1
histone deacetylase 1
chr8_-_41309434 1.42 ENST00000220772.8
SFRP1
secreted frizzled related protein 1
chr4_-_146521891 1.38 ENST00000394059.8
ENST00000502607.1
ENST00000335472.12
ENST00000432059.6
SLC10A7
solute carrier family 10 member 7
chr3_-_79767987 1.36 ENST00000464233.6
ROBO1
roundabout guidance receptor 1
chr6_-_42451261 1.33 ENST00000372917.8
ENST00000340840.6
ENST00000354325.2
TRERF1
transcriptional regulating factor 1
chr21_+_45074549 1.32 ENST00000348831.9
ENST00000437626.5
ENST00000389863.8
ADARB1
adenosine deaminase RNA specific B1
chr19_+_35666515 1.30 ENST00000617999.4
ENST00000616789.4
UPK1A
uroplakin 1A
chr11_+_102047422 1.29 ENST00000434758.7
ENST00000526781.5
ENST00000534360.1
CFAP300
cilia and flagella associated protein 300
chr1_-_120051714 1.29 ENST00000579475.7
NOTCH2
notch receptor 2
chr10_-_102120246 1.26 ENST00000425280.2
LDB1
LIM domain binding 1
chr4_+_26343156 1.23 ENST00000680928.1
ENST00000681260.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr5_+_119268744 1.23 ENST00000388882.5
TNFAIP8
TNF alpha induced protein 8
chr19_-_51646800 1.19 ENST00000599649.5
ENST00000429354.3
ENST00000360844.6
SIGLEC5
SIGLEC14
sialic acid binding Ig like lectin 5
sialic acid binding Ig like lectin 14
chr1_+_78649818 1.17 ENST00000370747.9
ENST00000438486.1
IFI44
interferon induced protein 44
chr17_-_31321743 1.16 ENST00000247270.3
EVI2A
ecotropic viral integration site 2A
chr19_+_926001 1.16 ENST00000263620.8
ARID3A
AT-rich interaction domain 3A
chr16_+_67842277 1.14 ENST00000303596.3
THAP11
THAP domain containing 11
chr19_-_51630401 1.14 ENST00000683636.1
SIGLEC5
sialic acid binding Ig like lectin 5
chr3_-_86990511 1.08 ENST00000494229.1
VGLL3
vestigial like family member 3
chr10_-_102120318 1.05 ENST00000673968.1
LDB1
LIM domain binding 1
chr3_-_86991109 1.03 ENST00000383698.3
VGLL3
vestigial like family member 3
chr14_-_52069039 0.95 ENST00000216286.10
NID2
nidogen 2
chr5_+_171387757 0.92 ENST00000677297.1
ENST00000521672.6
ENST00000679190.1
ENST00000351986.10
ENST00000676589.1
ENST00000679233.1
ENST00000677357.1
ENST00000296930.10
ENST00000393820.2
ENST00000523622.1
NPM1
nucleophosmin 1
chr7_-_93890160 0.89 ENST00000451238.1
TFPI2
tissue factor pathway inhibitor 2
chr14_-_52069228 0.89 ENST00000617139.4
NID2
nidogen 2
chr4_-_47463649 0.82 ENST00000381571.6
COMMD8
COMM domain containing 8
chr19_-_3786254 0.79 ENST00000585778.5
MATK
megakaryocyte-associated tyrosine kinase
chr11_+_65572349 0.76 ENST00000316409.2
ENST00000449319.2
ENST00000530349.2
FAM89B
family with sequence similarity 89 member B
chrX_+_153972729 0.75 ENST00000369982.5
TMEM187
transmembrane protein 187
chr4_-_146521666 0.73 ENST00000507030.5
SLC10A7
solute carrier family 10 member 7
chr19_-_58573280 0.67 ENST00000594234.5
ENST00000596039.1
ENST00000215057.7
MZF1
myeloid zinc finger 1
chr14_-_53153098 0.66 ENST00000612692.4
ENST00000395606.5
DDHD1
DDHD domain containing 1
chr14_+_49620750 0.66 ENST00000305386.4
MGAT2
alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
chr6_+_30557274 0.61 ENST00000376557.3
PRR3
proline rich 3
chr4_+_26343132 0.55 ENST00000515573.5
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr19_-_58573555 0.54 ENST00000599369.5
MZF1
myeloid zinc finger 1
chr12_-_120224695 0.52 ENST00000552550.5
PXN
paxillin
chr6_+_30557287 0.52 ENST00000376560.8
PRR3
proline rich 3
chr9_-_14307928 0.49 ENST00000637640.1
ENST00000493697.1
ENST00000636057.1
NFIB
nuclear factor I B
chr14_-_31457417 0.49 ENST00000356180.4
DTD2
D-aminoacyl-tRNA deacylase 2
chr1_-_41918666 0.47 ENST00000372584.5
HIVEP3
HIVEP zinc finger 3
chr7_-_6706843 0.44 ENST00000394917.3
ENST00000342651.9
ENST00000405858.6
ZNF12
zinc finger protein 12
chrX_+_153972769 0.42 ENST00000425274.1
TMEM187
transmembrane protein 187
chr14_-_53153281 0.40 ENST00000357758.3
ENST00000673822.2
DDHD1
DDHD domain containing 1
chr5_-_113294895 0.40 ENST00000514701.5
ENST00000302475.8
MCC
MCC regulator of WNT signaling pathway
chr19_-_3786363 0.39 ENST00000310132.11
MATK
megakaryocyte-associated tyrosine kinase
chr1_-_41918858 0.38 ENST00000372583.6
HIVEP3
HIVEP zinc finger 3
chr20_-_32743406 0.36 ENST00000474815.2
ENST00000446419.6
ENST00000278980.11
ENST00000642484.1
ENST00000646357.1
COMMD7
ENSG00000285382.1
COMM domain containing 7
novel protein
chr22_-_42959852 0.35 ENST00000402229.5
ENST00000407585.5
ENST00000453079.1
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr12_-_102120065 0.35 ENST00000552283.6
ENST00000551744.2
NUP37
nucleoporin 37
chr16_+_1612337 0.32 ENST00000674071.1
ENST00000397412.8
CRAMP1
cramped chromatin regulator homolog 1
chr1_-_32336224 0.28 ENST00000329421.8
MARCKSL1
MARCKS like 1
chr12_+_102120172 0.24 ENST00000327680.7
ENST00000541394.5
ENST00000543784.5
PARPBP
PARP1 binding protein
chr16_+_86578543 0.23 ENST00000320241.5
FOXL1
forkhead box L1
chr14_-_31457495 0.22 ENST00000310850.9
DTD2
D-aminoacyl-tRNA deacylase 2
chr7_+_102363874 0.20 ENST00000496391.5
PRKRIP1
PRKR interacting protein 1
chr19_-_3786408 0.20 ENST00000395040.6
MATK
megakaryocyte-associated tyrosine kinase
chr17_-_38748184 0.18 ENST00000618941.4
ENST00000620225.5
ENST00000618506.1
ENST00000616129.4
PCGF2
polycomb group ring finger 2
chr3_+_51671175 0.16 ENST00000614067.4
ENST00000457573.5
ENST00000611400.4
ENST00000412249.5
ENST00000425781.5
ENST00000341333.10
ENST00000415259.5
ENST00000395057.5
ENST00000416589.5
TEX264
testis expressed 264, ER-phagy receptor
chrX_+_54809060 0.15 ENST00000396224.1
MAGED2
MAGE family member D2
chr7_-_81769971 0.13 ENST00000354224.10
ENST00000643024.1
HGF
hepatocyte growth factor
chr19_-_43880142 0.12 ENST00000324394.7
ZNF404
zinc finger protein 404
chr10_-_125161019 0.12 ENST00000411419.6
CTBP2
C-terminal binding protein 2
chr16_-_1611985 0.10 ENST00000426508.7
IFT140
intraflagellar transport 140
chr10_+_92593112 0.10 ENST00000260731.5
KIF11
kinesin family member 11
chr14_-_21511290 0.07 ENST00000298717.9
METTL3
methyltransferase like 3
chr10_+_96000091 0.04 ENST00000424464.5
ENST00000410012.6
ENST00000344386.3
CC2D2B
coiled-coil and C2 domain containing 2B
chr7_+_5045821 0.04 ENST00000353796.7
ENST00000396912.2
ENST00000396904.2
RBAK
RBAK-RBAKDN
RB associated KRAB zinc finger
RBAK-RBAKDN readthrough
chrX_+_81202066 0.01 ENST00000373212.6
SH3BGRL
SH3 domain binding glutamate rich protein like

Network of associatons between targets according to the STRING database.

First level regulatory network of GZF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0060434 bronchus morphogenesis(GO:0060434)
0.8 2.3 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.8 3.0 GO:0060435 bronchiole development(GO:0060435)
0.6 2.8 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.5 1.4 GO:0014034 neural crest cell fate commitment(GO:0014034) regulation of midbrain dopaminergic neuron differentiation(GO:1904956)
0.3 1.3 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.3 0.8 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.2 1.4 GO:0021827 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) negative regulation of negative chemotaxis(GO:0050925)
0.2 1.5 GO:0061198 fungiform papilla formation(GO:0061198)
0.2 1.8 GO:1901189 positive regulation of ephrin receptor signaling pathway(GO:1901189) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.1 0.9 GO:0060699 regulation of endoribonuclease activity(GO:0060699)
0.1 11.1 GO:0032729 positive regulation of interferon-gamma production(GO:0032729)
0.1 1.3 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 1.3 GO:0061314 Notch signaling involved in heart development(GO:0061314)
0.1 7.2 GO:0030834 regulation of actin filament depolymerization(GO:0030834)
0.0 0.5 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 0.7 GO:0006450 regulation of translational fidelity(GO:0006450)
0.0 1.8 GO:0071711 basement membrane organization(GO:0071711)
0.0 2.0 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.0 0.2 GO:0061146 Peyer's patch morphogenesis(GO:0061146)
0.0 0.4 GO:0070836 caveola assembly(GO:0070836)
0.0 0.5 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.8 GO:0090141 positive regulation of mitochondrial fission(GO:0090141)
0.0 0.1 GO:1904688 regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690)
0.0 0.7 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.9 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.0 0.2 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 3.2 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 1.9 GO:0043407 negative regulation of MAP kinase activity(GO:0043407)
0.0 1.4 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.1 GO:0070294 renal sodium ion absorption(GO:0070294)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 11.1 GO:0042613 MHC class II protein complex(GO:0042613)
0.3 2.6 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 1.8 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 2.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 1.5 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.9 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 2.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.2 GO:0001739 sex chromatin(GO:0001739)
0.0 0.3 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 2.3 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 0.5 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 8.1 GO:0030027 lamellipodium(GO:0030027)
0.0 1.1 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.1 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.4 7.1 GO:0032395 MHC class II receptor activity(GO:0032395)
0.3 7.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 2.8 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.2 0.7 GO:0051500 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.2 2.3 GO:0030274 LIM domain binding(GO:0030274)
0.1 1.3 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1 1.4 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 4.0 GO:0042605 peptide antigen binding(GO:0042605)
0.1 1.3 GO:0038049 transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049)
0.1 1.8 GO:0000150 recombinase activity(GO:0000150)
0.1 0.9 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 1.9 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 3.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 1.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.6 GO:0008301 DNA binding, bending(GO:0008301)
0.0 1.5 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.8 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 2.0 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.1 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.0 1.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 2.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.5 GO:0017166 vinculin binding(GO:0017166)
0.0 1.8 GO:0005518 collagen binding(GO:0005518)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1 1.5 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 2.6 PID ALK1 PATHWAY ALK1 signaling events
0.0 2.0 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 3.1 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.8 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 1.4 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 1.4 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.9 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 11.1 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 3.1 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 2.8 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.1 1.9 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 2.6 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 1.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 1.5 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 2.0 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.9 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.7 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.5 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination