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Illumina Body Map 2 (GSE30611)

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Results for HDX

Z-value: 0.60

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Transcription factors associated with HDX

Gene Symbol Gene ID Gene Info
ENSG00000165259.14 highly divergent homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HDXhg38_v1_chrX_-_84502442_845025010.336.2e-02Click!

Activity profile of HDX motif

Sorted Z-values of HDX motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_142800957 2.43 ENST00000466254.1
T cell receptor beta constant 2
chr12_+_56763316 2.26 ENST00000322165.1
hydroxysteroid 17-beta dehydrogenase 6
chr3_-_165837412 2.06 ENST00000479451.5
ENST00000488954.1
ENST00000264381.8
butyrylcholinesterase
chr1_-_153390976 1.80 ENST00000368732.5
ENST00000368733.4
S100 calcium binding protein A8
chr1_-_159714581 1.45 ENST00000255030.9
ENST00000437342.1
ENST00000368112.5
ENST00000368111.5
ENST00000368110.1
C-reactive protein
chr2_-_112836702 1.42 ENST00000416750.1
ENST00000263341.7
ENST00000418817.5
interleukin 1 beta
chr1_-_169711603 1.22 ENST00000236147.6
ENST00000650983.1
selectin L
chr11_+_60699605 1.07 ENST00000300226.7
membrane spanning 4-domains A8
chr1_+_62597510 0.93 ENST00000371129.4
angiopoietin like 3
chr1_+_84164684 0.84 ENST00000370680.5
protein kinase cAMP-activated catalytic subunit beta
chr14_+_79279906 0.81 ENST00000428277.6
neurexin 3
chr12_-_102950835 0.80 ENST00000546844.1
phenylalanine hydroxylase
chr12_+_10307950 0.78 ENST00000543420.5
ENST00000543777.5
killer cell lectin like receptor D1
chr3_+_54123452 0.77 ENST00000620722.4
ENST00000490478.5
calcium voltage-gated channel auxiliary subunit alpha2delta 3
chr1_+_84164669 0.74 ENST00000450730.5
protein kinase cAMP-activated catalytic subunit beta
chr5_-_135954962 0.71 ENST00000522943.5
ENST00000514447.2
ENST00000274507.6
leukocyte cell derived chemotaxin 2
chr9_+_6215786 0.71 ENST00000417746.6
ENST00000682010.1
interleukin 33
chr1_+_84164370 0.71 ENST00000446538.5
ENST00000610703.4
ENST00000370682.7
ENST00000394838.6
ENST00000432111.5
protein kinase cAMP-activated catalytic subunit beta
chr7_-_135728177 0.70 ENST00000682651.1
ENST00000354042.8
solute carrier family 13 member 4
chr1_+_84164293 0.69 ENST00000370684.5
ENST00000436133.5
protein kinase cAMP-activated catalytic subunit beta
chr12_+_10307818 0.61 ENST00000350274.9
ENST00000336164.9
killer cell lectin like receptor D1
chr2_+_169069537 0.59 ENST00000428522.5
ENST00000450153.1
ENST00000674881.1
ENST00000421653.5
dehydrogenase/reductase 9
chr12_-_39340963 0.56 ENST00000552961.5
kinesin family member 21A
chr11_+_60699669 0.56 ENST00000529752.5
membrane spanning 4-domains A8
chr8_+_24294044 0.50 ENST00000265769.9
ADAM metallopeptidase domain 28
chr14_+_79279403 0.46 ENST00000281127.11
neurexin 3
chr8_+_24294107 0.45 ENST00000437154.6
ADAM metallopeptidase domain 28
chr7_-_108243234 0.41 ENST00000417701.5
neuronal cell adhesion molecule
chr4_+_70334963 0.41 ENST00000273936.6
calcium binding protein, spermatid associated 1
chr10_+_18400562 0.36 ENST00000377315.5
ENST00000650685.1
calcium voltage-gated channel auxiliary subunit beta 2
chr20_-_37158904 0.35 ENST00000417458.5
maestro heat like repeat family member 8
chr14_+_79279339 0.33 ENST00000557594.5
neurexin 3
chr3_+_107523026 0.32 ENST00000416476.6
BBX high mobility group box domain containing
chr14_+_79279681 0.29 ENST00000679122.1
neurexin 3
chr7_+_80135694 0.25 ENST00000457358.7
G protein subunit alpha i1
chr1_-_205422050 0.22 ENST00000367153.9
LEM domain containing 1
chr3_+_107522936 0.22 ENST00000415149.6
ENST00000402543.5
ENST00000325805.13
ENST00000427402.5
BBX high mobility group box domain containing
chr5_+_141370236 0.19 ENST00000576222.2
ENST00000618934.1
protocadherin gamma subfamily B, 3
chr1_+_197268222 0.19 ENST00000367400.8
ENST00000638467.1
ENST00000367399.6
crumbs cell polarity complex component 1
chrX_+_27590376 0.18 ENST00000451261.6
DDB1 and CUL4 associated factor 8 like 2
chr1_-_48400826 0.17 ENST00000371841.1
spermatogenesis associated 6
chrX_+_100969687 0.16 ENST00000450049.7
ADP ribosylation factor like GTPase 13A
chr2_+_127645864 0.14 ENST00000544369.5
G protein-coupled receptor 17
chr7_-_29969927 0.14 ENST00000438497.5
secernin 1
chr6_+_32969345 0.09 ENST00000678250.1
bromodomain containing 2
chr2_+_127646145 0.07 ENST00000486700.2
ENST00000272644.7
G protein-coupled receptor 17
chr14_+_71321379 0.07 ENST00000557151.5
signal induced proliferation associated 1 like 1
chr5_+_140786291 0.06 ENST00000394633.7
protocadherin alpha 1
chr1_-_209652329 0.05 ENST00000367030.7
ENST00000356082.9
laminin subunit beta 3
chr2_+_112977998 0.05 ENST00000259205.5
ENST00000376489.6
interleukin 36 gamma
chr19_+_36111151 0.01 ENST00000633214.1
ENST00000585332.3
ovo like zinc finger 3
chr10_-_22210021 0.00 ENST00000422359.2
endogenous Bornavirus like nucleoprotein 1
chr19_-_41428730 0.00 ENST00000321702.2
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

Network of associatons between targets according to the STRING database.

First level regulatory network of HDX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0014016 neuroblast differentiation(GO:0014016)
0.5 1.4 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.3 3.0 GO:0097338 response to clozapine(GO:0097338)
0.3 2.3 GO:0006710 androgen catabolic process(GO:0006710)
0.1 0.7 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.1 1.8 GO:0032119 sequestering of zinc ion(GO:0032119)
0.1 0.9 GO:0051005 negative regulation of phospholipase activity(GO:0010519) negative regulation of lipoprotein lipase activity(GO:0051005)
0.1 0.6 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1 1.4 GO:0032930 positive regulation of superoxide anion generation(GO:0032930)
0.0 1.9 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 0.8 GO:0006559 L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.0 0.4 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.7 GO:0008272 sulfate transport(GO:0008272)
0.0 2.4 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 1.2 GO:0033198 response to ATP(GO:0033198)
0.0 0.4 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.2 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0 1.4 GO:0002228 natural killer cell mediated immunity(GO:0002228)
0.0 0.2 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 2.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 0.2 GO:0097224 sperm connecting piece(GO:0097224)
0.0 2.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.4 GO:0043194 axon initial segment(GO:0043194)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.5 GO:0033265 choline binding(GO:0033265)
0.3 1.4 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.2 2.9 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.2 1.8 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.2 1.2 GO:0043208 glycosphingolipid binding(GO:0043208)
0.1 0.8 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.1 3.0 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 1.5 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 1.9 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.7 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 2.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.9 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.4 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.4 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.2 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.2 GO:0032027 myosin light chain binding(GO:0032027)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 3.0 PID IL3 PATHWAY IL3-mediated signaling events
0.0 1.4 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.9 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 2.1 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 3.0 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 2.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.6 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline