ISMARA results: HIF1A

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Illumina Body Map 2 (GSE30611)

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Results for HIF1A

Z-value: 0.64

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Transcription factors associated with HIF1A

Gene Symbol	Gene ID	Gene Info
HIF1A Ensembl NCBI GeneCards UniProt	ENSG00000100644.17	hypoxia inducible factor 1 subunit alpha

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HIF1A	hg38_v1_chr14_+_61695777_61695813	0.17	3.5e-01	Click!

Activity profile of HIF1A motif

Sorted Z-values of HIF1A motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_71785167 Show fit	4.90	ENST00000353065.7	PROK2 Ensembl NCBI GeneCards UniProt Show fit	prokineticin 2
chr3_-_71785139 Show fit	4.46	ENST00000295619.4	PROK2 Ensembl NCBI GeneCards UniProt Show fit	prokineticin 2
chr1_-_8879170 Show fit	2.35	ENST00000489867.2	ENO1 Ensembl NCBI GeneCards UniProt Show fit	enolase 1
chr11_+_75768769 Show fit	2.16	ENST00000228027.12	DGAT2 Ensembl NCBI GeneCards UniProt Show fit	diacylglycerol O-acyltransferase 2
chr11_+_75768718 Show fit	2.12	ENST00000376262.7	DGAT2 Ensembl NCBI GeneCards UniProt Show fit	diacylglycerol O-acyltransferase 2
chr11_+_75768531 Show fit	2.03	ENST00000604935.5	DGAT2 Ensembl NCBI GeneCards UniProt Show fit	diacylglycerol O-acyltransferase 2
chr12_+_6868154 Show fit	1.93	ENST00000462761.5	TPI1 Ensembl NCBI GeneCards UniProt Show fit	triosephosphate isomerase 1
chr9_-_120714457 Show fit	1.74	ENST00000373930.4	MEGF9 Ensembl NCBI GeneCards UniProt Show fit	multiple EGF like domains 9
chr18_-_3013114 Show fit	1.56	ENST00000677752.1	LPIN2 Ensembl NCBI GeneCards UniProt Show fit	lipin 2
chr14_+_92323154 Show fit	1.52	ENST00000532405.6 ENST00000676001.1 ENST00000531433.5	SLC24A4 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 24 member 4

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HIF1A

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	9.4	GO:0045987	positive regulation of smooth muscle contraction(GO:0045987)
1.1	6.3	GO:0071400	cellular response to oleic acid(GO:0071400)
0.4	4.5	GO:0010756	positive regulation of plasminogen activation(GO:0010756)
0.1	2.7	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.5	2.5	GO:0046166	glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.2	2.5	GO:2000622	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.2	2.1	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	2.0	GO:0002181	cytoplasmic translation(GO:0002181)
0.1	1.9	GO:0097186	amelogenesis(GO:0097186)
0.4	1.7	GO:0042450	arginine biosynthetic process via ornithine(GO:0042450)

Showing 1 to 10 of 127 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.2	GO:0005811	lipid particle(GO:0005811)
0.4	4.5	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.1	2.2	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.1	2.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	2.1	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	1.8	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	1.7	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	1.7	GO:0000118	histone deacetylase complex(GO:0000118)
0.1	1.2	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	1.2	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)

Showing 1 to 10 of 49 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.9	GO:0001664	G-protein coupled receptor binding(GO:0001664)
1.1	6.3	GO:0050252	retinol O-fatty-acyltransferase activity(GO:0050252)
0.4	4.5	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	2.9	GO:0003735	structural constituent of ribosome(GO:0003735)
0.8	2.5	GO:0004807	triose-phosphate isomerase activity(GO:0004807)
0.7	2.1	GO:0004119	cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.0	2.1	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.1	2.0	GO:0008494	translation activator activity(GO:0008494)
0.6	1.7	GO:0004056	argininosuccinate lyase activity(GO:0004056)
0.6	1.7	GO:0008859	exoribonuclease II activity(GO:0008859)

Showing 1 to 10 of 87 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.5	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	2.9	PID EPHA FWDPATHWAY	EPHA forward signaling
0.0	2.0	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	1.6	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.0	1.2	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	0.9	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.0	0.8	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	0.7	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	0.5	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.5	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Showing 1 to 10 of 11 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.9	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
0.1	7.7	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	3.3	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0	3.2	REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.1	2.7	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.0	2.1	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	1.7	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.0	1.7	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	1.6	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.1	1.6	REACTOME PURINE SALVAGE	Genes involved in Purine salvage

Showing 1 to 10 of 34 entries

Results for HIF1A

Z-value: 0.64

Motif logo

Transcription factors associated with HIF1A

Activity-expression correlation:

Activity profile of HIF1A motif

Sorted Z-values of HIF1A motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HIF1A

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: