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Illumina Body Map 2 (GSE30611)

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Results for HMGA2

Z-value: 0.89

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Transcription factors associated with HMGA2

Gene Symbol Gene ID Gene Info
ENSG00000149948.14 high mobility group AT-hook 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HMGA2hg38_v1_chr12_+_65825116_658251340.271.3e-01Click!

Activity profile of HMGA2 motif

Sorted Z-values of HMGA2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_1413456 3.84 ENST00000539820.5
ENST00000382269.7
ENST00000345913.8
ENST00000329066.9
ENST00000382201.7
thyroid peroxidase
chr11_-_19201976 3.76 ENST00000647990.1
ENST00000649235.1
ENST00000265968.9
ENST00000649842.1
cysteine and glycine rich protein 3
chr15_-_53759634 2.67 ENST00000557913.5
ENST00000360509.10
WD repeat domain 72
chr10_-_5003850 2.21 ENST00000421196.7
ENST00000455190.2
ENST00000380753.8
aldo-keto reductase family 1 member C2
chr11_-_19202004 1.96 ENST00000648719.1
cysteine and glycine rich protein 3
chr8_-_104467042 1.92 ENST00000521573.2
ENST00000351513.7
dihydropyrimidinase
chr8_+_119207949 1.72 ENST00000534619.5
mal, T cell differentiation protein 2
chr15_+_58410543 1.59 ENST00000356113.10
ENST00000414170.7
lipase C, hepatic type
chr10_-_127892930 1.45 ENST00000368671.4
clarin 3
chr22_-_18936142 1.45 ENST00000438924.5
ENST00000457083.1
ENST00000357068.11
ENST00000420436.5
ENST00000334029.6
ENST00000610940.4
proline dehydrogenase 1
chr14_-_94293071 1.27 ENST00000554723.5
serpin family A member 10
chr12_+_18261511 1.26 ENST00000538779.6
ENST00000433979.6
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr14_-_94293024 1.25 ENST00000393096.5
serpin family A member 10
chr1_-_75932392 1.17 ENST00000284142.7
ankyrin repeat and SOCS box containing 17
chr1_+_196977550 1.09 ENST00000256785.5
complement factor H related 5
chrX_+_2752024 1.08 ENST00000644266.2
ENST00000419513.7
ENST00000509484.3
ENST00000381174.10
Xg glycoprotein (Xg blood group)
chr14_-_94293260 1.04 ENST00000261994.9
serpin family A member 10
chr1_+_196652022 0.89 ENST00000367429.9
ENST00000630130.2
ENST00000359637.2
complement factor H
chr3_+_155083523 0.87 ENST00000680057.1
membrane metalloendopeptidase
chr9_+_105700953 0.85 ENST00000374688.5
transmembrane protein 38B
chrX_-_7927701 0.74 ENST00000537427.5
ENST00000444736.5
ENST00000442940.1
patatin like phospholipase domain containing 4
chr9_-_24545866 0.74 ENST00000543880.7
ENST00000418122.1
IZUMO family member 3
chr7_+_80638510 0.72 ENST00000433696.6
ENST00000538969.5
ENST00000544133.5
CD36 molecule
chr18_+_11851404 0.71 ENST00000526991.3
charged multivesicular body protein 1B
chr16_-_20404731 0.71 ENST00000302451.9
protein disulfide isomerase like, testis expressed
chr2_+_119679154 0.70 ENST00000401466.5
ENST00000424086.5
transmembrane protein 177
chrX_+_23908006 0.67 ENST00000379211.8
ENST00000648352.1
chromosome X open reading frame 58
chr2_+_234978685 0.65 ENST00000409212.5
ENST00000344528.8
ENST00000444916.5
SH3 domain binding protein 4
chr9_-_34729482 0.64 ENST00000378788.4
family with sequence similarity 205 member A
chr19_-_11346406 0.62 ENST00000587948.5
transmembrane protein 205
chrX_-_7927375 0.60 ENST00000381042.9
patatin like phospholipase domain containing 4
chr2_+_169827432 0.60 ENST00000272793.11
ubiquitin protein ligase E3 component n-recognin 3
chr15_-_74367637 0.59 ENST00000268053.11
ENST00000416978.1
cytochrome P450 family 11 subfamily A member 1
chr6_-_49866453 0.58 ENST00000507853.5
cysteine rich secretory protein 1
chr2_+_119679184 0.57 ENST00000445518.1
ENST00000272521.7
ENST00000409951.1
transmembrane protein 177
chr11_-_130916437 0.57 ENST00000533214.1
ENST00000528555.5
ENST00000530356.5
ENST00000265909.9
sorting nexin 19
chr15_-_32403195 0.56 ENST00000512626.2
golgin A8 family member K
chr1_+_103561757 0.55 ENST00000435302.5
amylase alpha 2B
chr14_-_64942783 0.54 ENST00000612794.1
glutathione peroxidase 2
chr15_+_23354846 0.53 ENST00000562295.1
golgin A8 family member S
chr11_+_60327250 0.53 ENST00000684409.1
membrane spanning 4-domains A6E
chr19_+_41376692 0.52 ENST00000447302.6
ENST00000544232.5
ENST00000542945.5
ENST00000540732.3
transmembrane protein 91
novel protein
chr15_+_30604028 0.51 ENST00000566740.2
golgin A8 family member H
chr4_+_40056790 0.49 ENST00000261435.11
ENST00000515550.1
NEDD4 binding protein 2
chr19_-_11346486 0.48 ENST00000590482.5
transmembrane protein 205
chr4_+_78551733 0.48 ENST00000512884.5
ENST00000512542.5
ENST00000503570.6
ENST00000264908.11
annexin A3
chr12_+_69585434 0.48 ENST00000299300.11
ENST00000544368.6
chaperonin containing TCP1 subunit 2
chr6_+_111259474 0.48 ENST00000672554.1
ENST00000673024.1
major facilitator superfamily domain containing 4B
chr17_-_3398410 0.47 ENST00000322608.2
olfactory receptor family 1 subfamily E member 1
chr2_-_182522703 0.46 ENST00000410103.1
phosphodiesterase 1A
chr19_-_12365628 0.45 ENST00000438182.5
zinc finger protein 442
chr15_+_43593054 0.44 ENST00000453782.5
ENST00000300283.10
ENST00000437924.5
creatine kinase, mitochondrial 1B
chr19_-_12365655 0.44 ENST00000242804.9
zinc finger protein 442
chr6_+_31919984 0.43 ENST00000413154.5
complement C2
chrX_-_77895546 0.42 ENST00000358075.11
magnesium transporter 1
chr1_+_54998927 0.42 ENST00000651561.1
barttin CLCNK type accessory subunit beta
chr7_+_80638662 0.42 ENST00000394788.7
CD36 molecule
chr19_-_11346228 0.40 ENST00000588560.5
ENST00000592952.5
transmembrane protein 205
chr1_-_247536440 0.40 ENST00000366487.4
ENST00000641802.1
olfactory receptor family 2 subfamily C member 3
chr1_+_197917355 0.39 ENST00000367388.4
ENST00000367387.6
LIM homeobox 9
chr19_-_11346259 0.38 ENST00000590788.1
ENST00000354882.10
ENST00000586590.5
ENST00000589555.5
ENST00000586956.5
ENST00000593256.6
ENST00000447337.5
ENST00000591677.5
ENST00000586701.1
ENST00000589655.1
transmembrane protein 205
RAB3D, member RAS oncogene family
chrX_+_3006546 0.37 ENST00000381130.3
arylsulfatase family member H
chrX_-_13319952 0.36 ENST00000622204.1
ENST00000380622.5
ataxin 3 like
chr11_+_60492775 0.36 ENST00000526784.5
ENST00000537076.5
ENST00000016913.8
ENST00000530007.1
membrane spanning 4-domains A12
chr11_-_55968514 0.35 ENST00000312345.4
olfactory receptor family 10 subfamily AG member 1
chr2_+_227745845 0.35 ENST00000641981.1
small cysteine and glycine repeat containing 8
chr8_-_54101458 0.34 ENST00000521352.5
ENST00000618741.1
lysophospholipase 1
chr19_-_11346196 0.34 ENST00000586218.5
transmembrane protein 205
chr6_-_127343518 0.33 ENST00000528402.5
ENST00000454591.6
ethylmalonyl-CoA decarboxylase 1
chr15_+_28378664 0.33 ENST00000532622.7
ENST00000526619.6
golgin A8 family member F
chr15_-_32455634 0.32 ENST00000509311.7
golgin A8 family member O
chr6_-_127343590 0.32 ENST00000368291.6
ENST00000454859.8
ethylmalonyl-CoA decarboxylase 1
chrX_-_23907887 0.30 ENST00000379226.9
apolipoprotein O
chr14_+_88385714 0.30 ENST00000045347.11
spermatogenesis associated 7
chr6_-_117573571 0.29 ENST00000467125.1
novel protein, GOPC-ROS1 readthrough
chr10_+_94545777 0.29 ENST00000348459.10
ENST00000419900.5
ENST00000630929.2
helicase, lymphoid specific
chr7_-_57132425 0.28 ENST00000319636.10
zinc finger protein 479
chrX_-_154295085 0.28 ENST00000617225.4
ENST00000619903.4
testis expressed 28
chr11_-_125778788 0.27 ENST00000436890.2
prostate and testis expressed 2
chr11_-_125778818 0.25 ENST00000358524.8
prostate and testis expressed 2
chrX_-_72572794 0.22 ENST00000421523.6
ENST00000648036.1
ENST00000373559.8
ENST00000648139.1
ENST00000650636.1
ENST00000648962.1
ENST00000373560.7
ENST00000373568.7
ENST00000373573.9
ENST00000647654.1
ENST00000647859.1
ENST00000415409.6
ENST00000648298.1
ENST00000649752.1
ENST00000373571.6
ENST00000647980.1
ENST00000650126.1
ENST00000373554.6
ENST00000648870.1
ENST00000373556.8
ENST00000647886.1
ENST00000648452.1
ENST00000647594.1
ENST00000373583.6
ENST00000648922.1
histone deacetylase 8
novel protein
chr7_+_80638633 0.22 ENST00000447544.7
ENST00000482059.6
CD36 molecule
chr10_-_99913971 0.22 ENST00000543621.6
dynamin binding protein
chr10_-_60572599 0.21 ENST00000503366.5
ankyrin 3
chr8_+_66775537 0.19 ENST00000518388.5
serum/glucocorticoid regulated kinase family member 3
chr1_+_12746192 0.18 ENST00000614859.5
chromosome 1 open reading frame 158
chr14_+_19773504 0.18 ENST00000641200.1
olfactory receptor family 4 subfamily M member 1
chr4_+_183905266 0.17 ENST00000308497.9
storkhead box 2
chr15_-_101923113 0.16 ENST00000650172.1
olfactory receptor family 4 subfamily F member 4
chrX_+_147943245 0.16 ENST00000463120.2
FMRP translational regulator 1
chr3_-_157503574 0.15 ENST00000494677.5
ENST00000468233.5
ventricular zone expressed PH domain containing 1
chr10_+_84425148 0.15 ENST00000493409.5
coiled-coil serine rich protein 2
chr5_-_55692731 0.15 ENST00000502247.1
solute carrier family 38 member 9
chr15_+_84235773 0.13 ENST00000510439.7
ENST00000422563.6
golgin A6 family like 4
chr12_+_8157034 0.12 ENST00000396570.7
zinc finger protein 705A
chr15_-_70702273 0.12 ENST00000558758.5
ENST00000379983.6
ENST00000560441.5
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr14_+_99481395 0.11 ENST00000389879.9
ENST00000557441.5
ENST00000555049.5
ENST00000555842.1
cyclin K
chr7_+_120950763 0.11 ENST00000339121.9
ENST00000315870.10
ENST00000445699.5
inhibitor of growth family member 3
chr10_+_35167516 0.10 ENST00000361599.8
cAMP responsive element modulator
chr2_-_182522556 0.10 ENST00000435564.5
phosphodiesterase 1A
chr1_-_21113129 0.10 ENST00000684485.1
eukaryotic translation initiation factor 4 gamma 3
chr4_-_305447 0.09 ENST00000419098.6
zinc finger protein 732
chr19_-_1650667 0.09 ENST00000587235.6
transcription factor 3
chr8_+_33485173 0.08 ENST00000360128.11
MAK16 homolog
chr5_-_103120097 0.07 ENST00000508629.5
ENST00000399004.7
gypsy retrotransposon integrase 1
chr14_-_20641691 0.06 ENST00000320704.3
olfactory receptor family 6 subfamily S member 1
chr7_+_64207090 0.06 ENST00000429565.4
zinc finger protein 735
chr1_+_28510050 0.06 ENST00000419074.5
regulator of chromosome condensation 1
chr15_-_82349437 0.06 ENST00000621197.4
ENST00000610657.2
ENST00000619556.4
golgin A6 family like 10
chr2_+_38889868 0.05 ENST00000409978.7
Rho guanine nucleotide exchange factor 33
chr3_+_160842143 0.05 ENST00000464260.5
ENST00000295839.9
protein phosphatase, Mg2+/Mn2+ dependent 1L
chr6_-_159788439 0.03 ENST00000539948.5
t-complex 1
chr9_+_2157647 0.02 ENST00000452193.5
ENST00000324954.10
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr19_-_42594957 0.01 ENST00000599005.1
CEA cell adhesion molecule 8
chr2_-_287299 0.01 ENST00000405290.5
ALK and LTK ligand 2

Network of associatons between targets according to the STRING database.

First level regulatory network of HMGA2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0006212 uracil catabolic process(GO:0006212)
0.6 3.6 GO:0008218 bioluminescence(GO:0008218)
0.6 5.7 GO:0035995 detection of muscle stretch(GO:0035995)
0.4 2.2 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.4 1.5 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 0.6 GO:1990502 dense core granule maturation(GO:1990502)
0.1 0.4 GO:0035262 gonad morphogenesis(GO:0035262)
0.1 2.7 GO:0070166 enamel mineralization(GO:0070166)
0.1 3.8 GO:0006590 thyroid hormone generation(GO:0006590)
0.1 0.6 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 1.7 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 1.4 GO:2000334 response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.1 1.6 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 0.4 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.1 0.3 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.1 2.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.9 GO:0071492 cellular response to UV-A(GO:0071492)
0.1 0.5 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.1 0.2 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.7 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.0 0.3 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0 0.2 GO:0044830 modulation by host of viral RNA genome replication(GO:0044830) positive regulation of intracellular transport of viral material(GO:1901254)
0.0 0.4 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.4 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.2 GO:1900827 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 1.3 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.7 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 0.3 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.0 1.3 GO:0039694 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0 0.6 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.6 GO:0060046 regulation of acrosome reaction(GO:0060046)
0.0 0.4 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.6 GO:0042359 vitamin D metabolic process(GO:0042359)
0.0 0.3 GO:0042407 cristae formation(GO:0042407)
0.0 0.1 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.0 0.1 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.6 GO:0043090 amino acid import(GO:0043090)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0061617 MICOS complex(GO:0061617)
0.0 0.7 GO:0000815 ESCRT III complex(GO:0000815)
0.0 1.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.5 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 1.6 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.2 GO:1902737 dendritic filopodium(GO:1902737)
0.0 1.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:0002945 cyclin K-CDK13 complex(GO:0002945)
0.0 0.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 5.5 GO:0030018 Z disc(GO:0030018)
0.0 0.4 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.4 GO:0042588 zymogen granule(GO:0042588)
0.0 0.1 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 1.3 GO:0005811 lipid particle(GO:0005811)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.8 GO:0004447 iodide peroxidase activity(GO:0004447)
0.4 2.2 GO:0018636 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)
0.4 1.9 GO:0004157 nucleobase binding(GO:0002054) dihydropyrimidinase activity(GO:0004157)
0.3 1.3 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.3 5.7 GO:0031433 telethonin binding(GO:0031433)
0.2 0.6 GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386)
0.2 0.6 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.1 1.4 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 0.5 GO:0004556 alpha-amylase activity(GO:0004556)
0.1 0.5 GO:0051733 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.1 0.6 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 1.3 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 1.7 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 1.6 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.1 0.5 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 1.5 GO:0071949 FAD binding(GO:0071949)
0.0 0.7 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.9 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.4 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.3 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 3.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.8 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.4 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.6 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.6 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.2 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.1 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 0.5 GO:0044183 protein binding involved in protein folding(GO:0044183)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.8 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 1.9 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 1.6 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.3 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 1.3 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.5 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.6 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.4 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.5 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 1.4 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 0.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects