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Illumina Body Map 2 (GSE30611)

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Results for HNF1A_HNF1B

Z-value: 8.65

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Transcription factors associated with HNF1A_HNF1B

Gene Symbol Gene ID Gene Info
HNF1A
ENSG00000135100.19 HNF1 homeobox A
HNF1B
ENSG00000275410.6 HNF1 homeobox B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HNF1Ahg38_v1_chr12_+_120978686_1209787490.941.3e-15Click!
HNF1Bhg38_v1_chr17_-_37745018_377450690.655.4e-05Click!

Activity profile of HNF1A_HNF1B motif

Sorted Z-values of HNF1A_HNF1B motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_71784046 136.59 ENST00000513476.5
ENST00000273951.13
GC
GC vitamin D binding protein
chr4_+_154563003 112.31 ENST00000302068.9
ENST00000509493.1
FGB
fibrinogen beta chain
chr17_-_66229380 110.67 ENST00000205948.11
APOH
apolipoprotein H
chr4_-_154590735 107.00 ENST00000403106.8
ENST00000622532.1
ENST00000651975.1
FGA
fibrinogen alpha chain
chr4_+_73481737 101.92 ENST00000226355.5
AFM
afamin
chr1_-_159714581 94.78 ENST00000255030.9
ENST00000437342.1
ENST00000368112.5
ENST00000368111.5
ENST00000368110.1
CRP
C-reactive protein
chr16_-_20576277 81.81 ENST00000566384.5
ENST00000565232.5
ENST00000567001.5
ENST00000565322.5
ENST00000569344.5
ENST00000329697.10
ENST00000568882.1
ACSM2B
acyl-CoA synthetase medium chain family member 2B
chr6_+_160702238 79.77 ENST00000366924.6
ENST00000308192.14
ENST00000418964.1
PLG
plasminogen
chr19_-_35812838 79.19 ENST00000653904.2
PRODH2
proline dehydrogenase 2
chr2_+_233760265 72.42 ENST00000305208.10
ENST00000360418.4
UGT1A1
UDP glucuronosyltransferase family 1 member A1
chr14_-_57493827 70.72 ENST00000526336.1
ENST00000216445.8
CCDC198
coiled-coil domain containing 198
chr2_+_233692881 68.57 ENST00000305139.11
UGT1A6
UDP glucuronosyltransferase family 1 member A6
chr16_+_20451461 68.16 ENST00000574251.5
ENST00000573854.6
ACSM2A
acyl-CoA synthetase medium chain family member 2A
chr16_+_20451563 62.10 ENST00000417235.6
ENST00000219054.10
ACSM2A
acyl-CoA synthetase medium chain family member 2A
chr1_+_207104226 60.33 ENST00000367070.8
C4BPA
complement component 4 binding protein alpha
chr14_-_57493742 60.16 ENST00000534126.5
ENST00000422976.6
CCDC198
coiled-coil domain containing 198
chr2_+_233617626 59.97 ENST00000373450.5
UGT1A8
UDP glucuronosyltransferase family 1 member A8
chr4_+_73404255 59.48 ENST00000621628.4
ENST00000621085.4
ENST00000415165.6
ENST00000295897.9
ENST00000503124.5
ENST00000509063.5
ENST00000401494.7
ALB
albumin
chr20_+_44401222 57.78 ENST00000316099.9
HNF4A
hepatocyte nuclear factor 4 alpha
chr4_+_186266183 57.63 ENST00000403665.7
ENST00000492972.6
ENST00000264692.8
F11
coagulation factor XI
chr2_+_233729042 54.49 ENST00000482026.6
UGT1A3
UDP glucuronosyltransferase family 1 member A3
chr16_+_20451596 53.35 ENST00000575690.5
ENST00000571894.1
ACSM2A
acyl-CoA synthetase medium chain family member 2A
chr1_-_204213943 51.86 ENST00000308302.4
GOLT1A
golgi transport 1A
chr14_-_94388589 51.18 ENST00000402629.1
ENST00000556091.1
ENST00000393087.9
ENST00000554720.1
SERPINA1
serpin family A member 1
chrX_-_106038721 50.73 ENST00000372563.2
SERPINA7
serpin family A member 7
chr1_+_207104287 50.72 ENST00000421786.5
C4BPA
complement component 4 binding protein alpha
chr20_-_7940444 47.69 ENST00000378789.4
HAO1
hydroxyacid oxidase 1
chr14_-_94293071 47.04 ENST00000554723.5
SERPINA10
serpin family A member 10
chr14_-_94293024 46.79 ENST00000393096.5
SERPINA10
serpin family A member 10
chr20_+_43558968 46.33 ENST00000647834.1
ENST00000373100.7
ENST00000648083.1
ENST00000648530.1
SGK2
serum/glucocorticoid regulated kinase 2
chr9_-_121050264 45.97 ENST00000223642.3
C5
complement C5
chr10_+_99782628 45.93 ENST00000648689.1
ENST00000647814.1
ABCC2
ATP binding cassette subfamily C member 2
chr20_+_44401269 45.86 ENST00000443598.6
ENST00000415691.2
HNF4A
hepatocyte nuclear factor 4 alpha
chr2_-_88128049 44.33 ENST00000393750.3
ENST00000295834.8
FABP1
fatty acid binding protein 1
chr10_+_113553039 43.31 ENST00000351270.4
HABP2
hyaluronan binding protein 2
chr5_+_177086867 42.85 ENST00000503708.5
ENST00000393648.6
ENST00000514472.1
ENST00000502906.5
ENST00000292408.9
ENST00000510911.5
FGFR4
fibroblast growth factor receptor 4
chr8_-_17895487 42.67 ENST00000427924.5
ENST00000381841.4
FGL1
fibrinogen like 1
chr14_-_94293260 41.37 ENST00000261994.9
SERPINA10
serpin family A member 10
chrX_-_15664798 40.98 ENST00000380342.4
CLTRN
collectrin, amino acid transport regulator
chr2_+_87748087 40.51 ENST00000359481.9
PLGLB2
plasminogen like B2
chr4_-_109801978 40.41 ENST00000510800.1
ENST00000512148.5
ENST00000394634.7
ENST00000394635.8
ENST00000645635.1
CFI
ENSG00000285330.1
complement factor I
novel protein
chr20_+_44355692 39.60 ENST00000316673.8
ENST00000609795.5
ENST00000457232.5
ENST00000609262.5
HNF4A
hepatocyte nuclear factor 4 alpha
chr3_+_186666003 39.39 ENST00000232003.5
HRG
histidine rich glycoprotein
chr15_+_58431985 39.10 ENST00000433326.2
ENST00000299022.10
LIPC
lipase C, hepatic type
chr17_+_4788926 37.76 ENST00000331264.8
GLTPD2
glycolipid transfer protein domain containing 2
chr10_+_133527355 37.66 ENST00000252945.8
ENST00000421586.5
ENST00000418356.1
CYP2E1
cytochrome P450 family 2 subfamily E member 1
chr17_+_42900791 36.93 ENST00000592383.5
ENST00000253801.7
ENST00000585489.1
G6PC1
glucose-6-phosphatase catalytic subunit 1
chr5_+_176549323 36.16 ENST00000261944.9
CDHR2
cadherin related family member 2
chr16_+_20451532 34.32 ENST00000576361.5
ACSM2A
acyl-CoA synthetase medium chain family member 2A
chr2_-_87021844 33.88 ENST00000355705.4
ENST00000409310.6
PLGLB1
plasminogen like B1
chr16_+_20764036 32.91 ENST00000440284.6
ACSM3
acyl-CoA synthetase medium chain family member 3
chr2_+_27496830 31.62 ENST00000264717.7
GCKR
glucokinase regulator
chr1_-_197067234 31.40 ENST00000367412.2
F13B
coagulation factor XIII B chain
chr1_+_62597510 30.35 ENST00000371129.4
ANGPTL3
angiopoietin like 3
chr16_+_20763990 30.32 ENST00000289416.10
ACSM3
acyl-CoA synthetase medium chain family member 3
chr7_-_50565381 30.01 ENST00000444124.7
DDC
dopa decarboxylase
chr4_-_68951763 29.95 ENST00000251566.9
UGT2A3
UDP glucuronosyltransferase family 2 member A3
chr10_+_97584314 29.26 ENST00000370647.8
HOGA1
4-hydroxy-2-oxoglutarate aldolase 1
chr2_+_233718734 29.25 ENST00000373409.8
UGT1A4
UDP glucuronosyltransferase family 1 member A4
chr19_+_11239602 29.25 ENST00000252453.12
ANGPTL8
angiopoietin like 8
chr11_-_117824734 27.84 ENST00000292079.7
FXYD2
FXYD domain containing ion transport regulator 2
chr12_+_100473708 27.37 ENST00000548884.5
ENST00000392986.8
NR1H4
nuclear receptor subfamily 1 group H member 4
chr2_+_233712905 27.09 ENST00000373414.4
UGT1A5
UDP glucuronosyltransferase family 1 member A5
chr20_+_44401397 26.90 ENST00000682427.1
ENST00000681977.1
ENST00000684136.1
ENST00000684046.1
ENST00000684476.1
ENST00000619550.5
ENST00000682169.1
HNF4A
hepatocyte nuclear factor 4 alpha
chr17_+_1742836 26.69 ENST00000324015.7
ENST00000450523.6
ENST00000453723.5
ENST00000453066.6
ENST00000382061.5
SERPINF2
serpin family F member 2
chr4_+_3441960 25.91 ENST00000382774.8
ENST00000511533.1
HGFAC
HGF activator
chr7_+_45888479 25.74 ENST00000275525.8
ENST00000468955.1
IGFBP1
insulin like growth factor binding protein 1
chr6_-_160664270 25.40 ENST00000316300.10
LPA
lipoprotein(a)
chr4_+_99574812 25.27 ENST00000422897.6
ENST00000265517.10
MTTP
microsomal triglyceride transfer protein
chr6_-_25874212 25.05 ENST00000361703.10
ENST00000397060.8
SLC17A3
solute carrier family 17 member 3
chr16_-_69351778 24.91 ENST00000288025.4
TMED6
transmembrane p24 trafficking protein 6
chr6_+_31655888 24.66 ENST00000375916.4
APOM
apolipoprotein M
chr6_-_25930611 24.64 ENST00000360488.7
SLC17A2
solute carrier family 17 member 2
chr6_-_25930678 24.61 ENST00000377850.8
SLC17A2
solute carrier family 17 member 2
chr14_+_94561435 23.70 ENST00000557004.6
ENST00000555095.5
ENST00000298841.5
ENST00000554220.5
ENST00000553780.5
SERPINA4
SERPINA5
serpin family A member 4
serpin family A member 5
chr1_-_19815270 23.51 ENST00000375121.4
RNF186
ring finger protein 186
chr12_+_100473951 23.46 ENST00000648861.1
ENST00000546380.1
NR1H4
nuclear receptor subfamily 1 group H member 4
chr1_+_56854764 22.17 ENST00000361249.4
C8A
complement C8 alpha chain
chr14_-_64942720 21.97 ENST00000557049.1
ENST00000389614.6
GPX2
glutathione peroxidase 2
chr14_+_20688756 21.96 ENST00000397990.5
ENST00000555597.1
ANG
RNASE4
angiogenin
ribonuclease A family member 4
chr21_-_46155567 21.77 ENST00000291670.9
ENST00000397748.5
ENST00000397743.1
ENST00000397746.8
FTCD
formimidoyltransferase cyclodeaminase
chr16_+_21233672 21.19 ENST00000311620.7
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr6_+_25754699 21.13 ENST00000439485.6
ENST00000377905.9
SLC17A4
solute carrier family 17 member 4
chr11_+_46719193 20.98 ENST00000311907.10
ENST00000530231.5
ENST00000442468.1
F2
coagulation factor II, thrombin
chr1_+_55039511 20.93 ENST00000302118.5
PCSK9
proprotein convertase subtilisin/kexin type 9
chr14_-_64942783 20.28 ENST00000612794.1
GPX2
glutathione peroxidase 2
chr7_-_44541262 20.20 ENST00000289547.8
ENST00000546276.5
ENST00000423141.1
NPC1L1
NPC1 like intracellular cholesterol transporter 1
chr7_+_45888360 20.10 ENST00000457280.5
IGFBP1
insulin like growth factor binding protein 1
chr15_+_48206286 19.86 ENST00000396577.7
ENST00000380993.8
SLC12A1
solute carrier family 12 member 1
chr1_+_207088825 19.83 ENST00000367078.8
C4BPB
complement component 4 binding protein beta
chr1_+_119368773 19.33 ENST00000457318.5
ENST00000622548.4
ENST00000325945.4
HAO2
hydroxyacid oxidase 2
chr12_+_100473916 18.70 ENST00000549996.5
NR1H4
nuclear receptor subfamily 1 group H member 4
chr6_-_116060859 18.60 ENST00000606080.2
FRK
fyn related Src family tyrosine kinase
chr14_+_39233908 18.18 ENST00000280082.4
MIA2
MIA SH3 domain ER export factor 2
chr20_+_43559060 17.67 ENST00000485914.2
SGK2
serum/glucocorticoid regulated kinase 2
chr4_-_68670648 17.54 ENST00000338206.6
UGT2B15
UDP glucuronosyltransferase family 2 member B15
chr12_+_100503352 17.44 ENST00000551379.5
ENST00000188403.7
NR1H4
nuclear receptor subfamily 1 group H member 4
chr1_+_207089233 17.08 ENST00000243611.9
ENST00000367076.7
C4BPB
complement component 4 binding protein beta
chr1_+_18480930 16.86 ENST00000400664.3
KLHDC7A
kelch domain containing 7A
chr6_-_52087569 16.82 ENST00000340994.4
ENST00000371117.8
PKHD1
PKHD1 ciliary IPT domain containing fibrocystin/polyductin
chr9_-_114099275 16.65 ENST00000468460.2
ENST00000640217.2
KIF12
kinesin family member 12
chr12_+_21131187 16.58 ENST00000256958.3
SLCO1B1
solute carrier organic anion transporter family member 1B1
chr6_+_54308429 16.53 ENST00000259782.9
ENST00000370864.3
TINAG
tubulointerstitial nephritis antigen
chr7_-_44541318 16.09 ENST00000381160.8
NPC1L1
NPC1 like intracellular cholesterol transporter 1
chr6_-_52763473 16.01 ENST00000493422.3
GSTA2
glutathione S-transferase alpha 2
chr11_+_114296347 15.86 ENST00000299964.4
NNMT
nicotinamide N-methyltransferase
chr10_-_50885656 15.25 ENST00000374001.6
ENST00000395489.6
ENST00000282641.6
ENST00000395495.5
ENST00000373995.7
ENST00000414883.1
A1CF
APOBEC1 complementation factor
chr1_+_207089283 15.16 ENST00000391923.1
C4BPB
complement component 4 binding protein beta
chr16_-_66918876 14.80 ENST00000570262.5
ENST00000299752.9
ENST00000394055.7
CDH16
cadherin 16
chr4_+_168092530 14.62 ENST00000359299.8
ANXA10
annexin A10
chr16_-_66918839 14.61 ENST00000565235.2
ENST00000568632.5
ENST00000565796.5
CDH16
cadherin 16
chr5_-_139383284 14.25 ENST00000353963.7
ENST00000348729.8
SLC23A1
solute carrier family 23 member 1
chr11_+_64555684 14.23 ENST00000377585.7
SLC22A11
solute carrier family 22 member 11
chr12_+_20810698 13.48 ENST00000540853.5
ENST00000381545.8
SLCO1B3
solute carrier organic anion transporter family member 1B3
chr17_+_75646235 13.43 ENST00000556126.2
ENST00000579469.2
SMIM6
small integral membrane protein 6
chr9_-_114099057 13.41 ENST00000374118.8
KIF12
kinesin family member 12
chr15_+_58138368 12.98 ENST00000219919.9
ENST00000536493.1
AQP9
aquaporin 9
chr17_-_352784 12.94 ENST00000577079.5
ENST00000331302.12
ENST00000618002.4
ENST00000536489.6
RPH3AL
rabphilin 3A like (without C2 domains)
chr4_+_39406917 12.70 ENST00000257408.5
KLB
klotho beta
chr10_+_97584347 11.56 ENST00000370649.3
ENST00000370646.9
ENSG00000249967.1
HOGA1
novel protein
4-hydroxy-2-oxoglutarate aldolase 1
chr7_-_27180013 11.28 ENST00000470747.4
ENSG00000257184.3
HOXA10-HOXA9 readthrough
chr4_-_99352730 11.22 ENST00000510055.5
ENST00000515683.6
ENST00000511397.3
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr11_+_64555924 11.08 ENST00000301891.9
SLC22A11
solute carrier family 22 member 11
chr11_-_26722051 10.93 ENST00000396005.8
SLC5A12
solute carrier family 5 member 12
chr12_+_100503416 10.86 ENST00000551184.1
NR1H4
nuclear receptor subfamily 1 group H member 4
chr12_+_100473875 10.20 ENST00000649582.1
NR1H4
nuclear receptor subfamily 1 group H member 4
chr11_+_64591214 10.06 ENST00000377574.6
ENST00000473690.5
SLC22A12
solute carrier family 22 member 12
chr16_+_82035267 10.03 ENST00000566213.1
HSD17B2
hydroxysteroid 17-beta dehydrogenase 2
chr7_-_150323489 10.00 ENST00000683684.1
ENST00000478393.5
ACTR3C
actin related protein 3C
chr11_-_26723361 9.94 ENST00000533617.5
SLC5A12
solute carrier family 5 member 12
chr4_-_99290975 9.87 ENST00000209668.3
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr1_+_162381703 9.76 ENST00000458626.4
C1orf226
chromosome 1 open reading frame 226
chr3_-_74521140 9.73 ENST00000263665.6
CNTN3
contactin 3
chr16_+_82034978 9.70 ENST00000563491.5
HSD17B2
hydroxysteroid 17-beta dehydrogenase 2
chr7_-_155809072 9.51 ENST00000430104.5
SHH
sonic hedgehog signaling molecule
chr6_+_54307856 9.44 ENST00000370869.7
TINAG
tubulointerstitial nephritis antigen
chr10_-_50885619 9.28 ENST00000373997.8
A1CF
APOBEC1 complementation factor
chr15_+_58138169 9.09 ENST00000558772.5
AQP9
aquaporin 9
chr19_+_6464229 8.88 ENST00000600229.6
ENST00000356762.7
CRB3
crumbs cell polarity complex component 3
chr16_-_87936529 8.76 ENST00000649794.3
ENST00000649158.1
ENST00000648177.1
CA5A
carbonic anhydrase 5A
chr2_+_132416795 8.44 ENST00000329321.4
GPR39
G protein-coupled receptor 39
chr8_-_123737378 8.25 ENST00000419625.6
ENST00000262219.10
ANXA13
annexin A13
chr4_-_993430 8.24 ENST00000361661.6
ENST00000622731.4
SLC26A1
solute carrier family 26 member 1
chr2_-_99301195 8.01 ENST00000308528.9
LYG1
lysozyme g1
chr14_+_39233884 7.93 ENST00000553728.1
MIA2
MIA SH3 domain ER export factor 2
chr11_+_126327863 7.91 ENST00000648516.1
DCPS
decapping enzyme, scavenger
chr11_+_560956 7.77 ENST00000397582.7
ENST00000397583.8
RASSF7
Ras association domain family member 7
chr17_+_70075215 7.71 ENST00000283936.5
ENST00000615244.4
ENST00000392671.6
KCNJ16
potassium inwardly rectifying channel subfamily J member 16
chr10_-_70888546 7.67 ENST00000299299.4
PCBD1
pterin-4 alpha-carbinolamine dehydratase 1
chr22_-_23973183 7.19 ENST00000428792.1
DDT
D-dopachrome tautomerase
chr16_+_20899852 7.07 ENST00000568663.5
LYRM1
LYR motif containing 1
chr2_+_37950432 6.88 ENST00000407257.5
ENST00000417700.6
ENST00000234195.7
ENST00000442857.5
RMDN2
regulator of microtubule dynamics 2
chr7_-_150323725 6.75 ENST00000477871.1
ACTR3C
actin related protein 3C
chr3_-_142963663 6.74 ENST00000340634.6
PAQR9
progestin and adipoQ receptor family member 9
chr4_-_993376 6.73 ENST00000398520.6
ENST00000398516.3
SLC26A1
solute carrier family 26 member 1
chr4_-_1173168 6.62 ENST00000514490.5
ENST00000431380.5
ENST00000503765.5
SPON2
spondin 2
chr17_+_70075317 6.45 ENST00000589377.1
KCNJ16
potassium inwardly rectifying channel subfamily J member 16
chr2_-_162074182 6.33 ENST00000360534.8
DPP4
dipeptidyl peptidase 4
chr22_-_38110675 6.20 ENST00000381669.8
BAIAP2L2
BAR/IMD domain containing adaptor protein 2 like 2
chr17_+_28473635 6.20 ENST00000314669.10
ENST00000545060.2
SLC13A2
solute carrier family 13 member 2
chr2_-_162074394 6.16 ENST00000676810.1
DPP4
dipeptidyl peptidase 4
chr11_+_64591250 6.09 ENST00000336464.7
SLC22A12
solute carrier family 22 member 12
chr21_+_38256698 6.00 ENST00000613499.4
ENST00000612702.4
ENST00000398925.5
ENST00000398928.5
ENST00000328656.8
ENST00000443341.5
KCNJ15
potassium inwardly rectifying channel subfamily J member 15
chr6_+_131250375 5.96 ENST00000474850.2
AKAP7
A-kinase anchoring protein 7
chr7_-_27180230 5.66 ENST00000396344.4
HOXA10
homeobox A10
chr13_+_95433593 5.14 ENST00000376873.7
CLDN10
claudin 10
chrX_-_124963768 5.07 ENST00000371130.7
ENST00000422452.2
TENM1
teneurin transmembrane protein 1
chr11_-_26721999 5.03 ENST00000280467.10
SLC5A12
solute carrier family 5 member 12
chr19_+_6464491 5.02 ENST00000308243.7
CRB3
crumbs cell polarity complex component 3
chr7_-_123199960 4.90 ENST00000194130.7
SLC13A1
solute carrier family 13 member 1
chr12_+_18242955 4.85 ENST00000676171.1
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr17_+_28473278 4.78 ENST00000444914.7
SLC13A2
solute carrier family 13 member 2
chr5_+_177087412 4.62 ENST00000513166.1
FGFR4
fibroblast growth factor receptor 4
chr5_+_132369691 4.58 ENST00000245407.8
SLC22A5
solute carrier family 22 member 5
chr2_-_96505345 4.58 ENST00000310865.7
ENST00000451794.6
NEURL3
neuralized E3 ubiquitin protein ligase 3
chr16_+_89630263 4.45 ENST00000261615.5
DPEP1
dipeptidase 1
chr21_+_38256984 4.42 ENST00000398938.7
KCNJ15
potassium inwardly rectifying channel subfamily J member 15
chrX_+_134237047 4.38 ENST00000370809.4
ENST00000517294.5
CCDC160
coiled-coil domain containing 160
chr6_-_154430495 4.38 ENST00000424998.3
CNKSR3
CNKSR family member 3
chr1_-_153613095 4.16 ENST00000368706.9
S100A16
S100 calcium binding protein A16
chr19_+_49513154 4.14 ENST00000426395.7
ENST00000600273.5
ENST00000599988.5
FCGRT
Fc fragment of IgG receptor and transporter
chr2_+_181985846 4.06 ENST00000682840.1
ENST00000409137.7
ENST00000280295.7
PPP1R1C
protein phosphatase 1 regulatory inhibitor subunit 1C
chr4_-_22443110 3.93 ENST00000508133.5
ADGRA3
adhesion G protein-coupled receptor A3
chr5_+_73813518 3.88 ENST00000296799.8
ARHGEF28
Rho guanine nucleotide exchange factor 28
chr16_-_55875358 3.84 ENST00000319165.13
ENST00000290567.14
CES5A
carboxylesterase 5A
chr22_+_44702186 3.63 ENST00000336985.11
ENST00000403696.5
ENST00000457960.5
ENST00000361473.9
PRR5
PRR5-ARHGAP8
proline rich 5
PRR5-ARHGAP8 readthrough
chr7_-_128910676 3.56 ENST00000620378.1
ENST00000610776.4
ENST00000613019.4
KCP
kielin cysteine rich BMP regulator
chr22_+_32043253 3.56 ENST00000266088.9
SLC5A1
solute carrier family 5 member 1
chr17_-_28406160 3.55 ENST00000618626.1
ENST00000612814.5
SLC46A1
solute carrier family 46 member 1
chr4_-_99352754 3.43 ENST00000639454.1
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide
chr6_+_63521738 3.42 ENST00000648894.1
ENST00000639568.2
PTP4A1
protein tyrosine phosphatase 4A1
chr12_-_8540873 3.38 ENST00000545274.5
ENST00000446457.6
ENST00000299663.8
CLEC4E
C-type lectin domain family 4 member E
chr3_-_157503339 3.36 ENST00000392833.6
VEPH1
ventricular zone expressed PH domain containing 1
chr14_+_24120956 3.32 ENST00000558325.2
ENSG00000259371.2
novel protein
chr2_-_162074050 3.28 ENST00000676768.1
DPP4
dipeptidyl peptidase 4
chr3_-_157503574 2.98 ENST00000494677.5
ENST00000468233.5
VEPH1
ventricular zone expressed PH domain containing 1
chr16_+_67518415 2.96 ENST00000562116.1
RIPOR1
RHO family interacting cell polarization regulator 1
chr3_-_157503375 2.89 ENST00000362010.7
VEPH1
ventricular zone expressed PH domain containing 1
chr7_-_122304738 2.86 ENST00000442488.7
FEZF1
FEZ family zinc finger 1
chr3_+_188212641 2.71 ENST00000420410.5
LPP
LIM domain containing preferred translocation partner in lipoma

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF1A_HNF1B

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
34.4 137.4 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
26.0 311.8 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
22.5 135.2 GO:0008218 bioluminescence(GO:0008218)
19.8 59.5 GO:0019836 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
19.8 217.9 GO:0036112 medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
19.8 79.2 GO:0010133 proline catabolic process to glutamate(GO:0010133)
18.1 163.1 GO:0045959 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959)
18.0 108.0 GO:0038185 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
16.8 50.4 GO:0016999 antibiotic metabolic process(GO:0016999)
16.5 197.7 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
16.1 225.9 GO:0043152 induction of bacterial agglutination(GO:0043152)
14.2 170.1 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
13.6 40.8 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
12.1 36.2 GO:0090675 intermicrovillar adhesion(GO:0090675)
10.0 30.0 GO:0052314 phytoalexin metabolic process(GO:0052314)
7.7 46.0 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
7.5 37.7 GO:0010193 response to ozone(GO:0010193)
7.1 21.2 GO:1904106 protein localization to microvillus(GO:1904106)
7.0 20.9 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
6.8 47.5 GO:1903412 response to bile acid(GO:1903412)
6.6 52.9 GO:0009441 glycolate metabolic process(GO:0009441)
6.2 24.7 GO:0034444 regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
5.9 94.8 GO:0008228 opsonization(GO:0008228)
4.9 68.7 GO:0015747 urate transport(GO:0015747)
4.8 67.3 GO:0070327 thyroid hormone transport(GO:0070327)
4.7 14.2 GO:0070904 L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
4.4 22.1 GO:0015722 canalicular bile acid transport(GO:0015722)
4.0 47.8 GO:0052695 cellular glucuronidation(GO:0052695)
4.0 135.5 GO:0042359 vitamin D metabolic process(GO:0042359)
4.0 23.7 GO:0061107 seminal vesicle development(GO:0061107)
3.8 30.3 GO:0055091 phospholipid homeostasis(GO:0055091)
3.6 25.3 GO:0034378 chylomicron assembly(GO:0034378)
3.6 14.4 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
3.5 31.6 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
3.2 9.5 GO:0016539 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908) right lung development(GO:0060458) primary prostatic bud elongation(GO:0060516) epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738) positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
3.1 22.0 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
3.1 21.8 GO:0043606 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
2.8 64.5 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)
2.6 7.9 GO:0036245 cellular response to menadione(GO:0036245)
2.5 44.3 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
2.4 71.6 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
2.0 24.5 GO:0016554 cytidine to uridine editing(GO:0016554)
1.6 15.8 GO:0036343 negative regulation of extracellular matrix disassembly(GO:0010716) psychomotor behavior(GO:0036343)
1.6 106.5 GO:0051180 vitamin transport(GO:0051180)
1.5 27.8 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
1.5 4.6 GO:0060730 regulation of intestinal epithelial structure maintenance(GO:0060730)
1.5 15.0 GO:0034036 purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
1.5 29.2 GO:0050746 regulation of lipoprotein metabolic process(GO:0050746)
1.5 36.3 GO:0030299 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
1.4 22.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
1.3 45.8 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
1.2 16.0 GO:1901687 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
1.2 24.5 GO:0006069 ethanol oxidation(GO:0006069)
1.1 19.7 GO:0006703 estrogen biosynthetic process(GO:0006703)
1.1 18.0 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.9 8.0 GO:0000270 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.9 7.7 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.8 63.2 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.7 15.9 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.6 51.2 GO:0006953 acute-phase response(GO:0006953)
0.6 15.3 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.5 81.8 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.5 4.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.5 3.6 GO:0001951 intestinal D-glucose absorption(GO:0001951)
0.5 27.2 GO:0010107 potassium ion import(GO:0010107)
0.4 42.2 GO:1990748 cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.3 4.9 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.3 1.6 GO:0036233 glycine import(GO:0036233)
0.3 19.4 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.3 56.1 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.3 39.0 GO:0030449 regulation of complement activation(GO:0030449)
0.2 16.8 GO:0010824 regulation of centrosome duplication(GO:0010824)
0.2 10.2 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 6.2 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.2 1.6 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.2 1.1 GO:0038161 prolactin signaling pathway(GO:0038161)
0.2 3.6 GO:0038203 TORC2 signaling(GO:0038203)
0.2 1.9 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.1 7.2 GO:0042438 melanin biosynthetic process(GO:0042438)
0.1 1.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 5.7 GO:0060065 uterus development(GO:0060065)
0.1 5.1 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 20.0 GO:0009062 fatty acid catabolic process(GO:0009062)
0.1 13.9 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.1 8.8 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 6.0 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 17.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 1.5 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.1 5.1 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 19.9 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 1.4 GO:0015866 ADP transport(GO:0015866)
0.1 3.0 GO:0051683 establishment of Golgi localization(GO:0051683)
0.1 5.4 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.1 4.8 GO:0039694 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.1 8.9 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.1 0.7 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 26.4 GO:0007018 microtubule-based movement(GO:0007018)
0.1 9.1 GO:0017158 regulation of calcium ion-dependent exocytosis(GO:0017158)
0.0 7.8 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.0 3.9 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 3.4 GO:0002292 T cell differentiation involved in immune response(GO:0002292)
0.0 0.8 GO:0050832 defense response to fungus(GO:0050832)
0.0 3.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 2.4 GO:0034605 cellular response to heat(GO:0034605)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
22.2 288.7 GO:0005577 fibrinogen complex(GO:0005577)
14.4 100.7 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
7.6 68.1 GO:0005579 membrane attack complex(GO:0005579)
6.2 24.7 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
6.1 24.5 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
6.1 134.4 GO:0031089 platelet dense granule lumen(GO:0031089)
6.0 36.2 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
3.9 61.7 GO:0046581 intercellular canaliculus(GO:0046581)
3.8 72.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
3.1 22.0 GO:0032311 angiogenin-PRI complex(GO:0032311)
2.4 21.8 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
2.3 108.0 GO:0005719 nuclear euchromatin(GO:0005719)
2.2 44.3 GO:0045179 apical cortex(GO:0045179)
1.8 463.0 GO:0072562 blood microparticle(GO:0072562)
1.3 39.1 GO:0034364 high-density lipoprotein particle(GO:0034364)
1.1 27.8 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.9 26.1 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.9 67.0 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.9 25.4 GO:1990777 plasma lipoprotein particle(GO:0034358) lipoprotein particle(GO:1990777)
0.9 90.4 GO:0031526 brush border membrane(GO:0031526)
0.8 19.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.7 16.8 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.5 404.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.5 5.2 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.5 51.2 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.4 185.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.4 52.1 GO:0044217 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.3 6.2 GO:0071439 clathrin complex(GO:0071439)
0.2 26.8 GO:0005871 kinesin complex(GO:0005871)
0.2 14.2 GO:0009925 basal plasma membrane(GO:0009925)
0.2 18.6 GO:0035580 specific granule lumen(GO:0035580)
0.2 329.2 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.2 4.4 GO:0031528 microvillus membrane(GO:0031528)
0.2 21.3 GO:0005604 basement membrane(GO:0005604)
0.2 67.1 GO:0030133 transport vesicle(GO:0030133)
0.2 41.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 77.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.2 16.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 70.1 GO:0016324 apical plasma membrane(GO:0016324)
0.1 261.3 GO:0005615 extracellular space(GO:0005615)
0.1 3.6 GO:0031932 TORC2 complex(GO:0031932)
0.1 1.9 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 8.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 40.4 GO:0000139 Golgi membrane(GO:0000139)
0.0 6.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 7.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.1 GO:0031904 endosome lumen(GO:0031904)
0.0 5.7 GO:0005667 transcription factor complex(GO:0005667)
0.0 124.3 GO:0005576 extracellular region(GO:0005576)
0.0 3.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 5.1 GO:0005923 bicellular tight junction(GO:0005923)
0.0 5.1 GO:0016363 nuclear matrix(GO:0016363)
0.0 160.5 GO:0005654 nucleoplasm(GO:0005654)
0.0 3.9 GO:0000922 spindle pole(GO:0000922)
0.0 14.6 GO:0005739 mitochondrion(GO:0005739)
0.0 18.3 GO:0005887 integral component of plasma membrane(GO:0005887)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
34.1 136.6 GO:1902271 D3 vitamins binding(GO:1902271)
26.6 79.8 GO:1904854 proteasome core complex binding(GO:1904854)
25.5 101.9 GO:0008431 vitamin E binding(GO:0008431)
24.2 363.0 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
23.7 94.8 GO:0033265 choline binding(GO:0033265)
22.3 67.0 GO:0052853 (S)-2-hydroxy-acid oxidase activity(GO:0003973) very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854)
18.4 110.7 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
18.0 108.0 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
7.9 31.6 GO:0070095 fructose-6-phosphate binding(GO:0070095)
6.9 325.9 GO:0001972 retinoic acid binding(GO:0001972)
6.6 19.9 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
6.3 44.3 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
5.8 40.8 GO:0016833 oxo-acid-lyase activity(GO:0016833)
5.2 20.9 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189)
4.8 96.6 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
4.7 14.2 GO:0008520 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
4.4 22.1 GO:0005350 pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
3.9 19.7 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
3.7 22.0 GO:0004522 ribonuclease A activity(GO:0004522)
3.5 45.8 GO:0031995 insulin-like growth factor II binding(GO:0031995)
3.2 219.1 GO:0005504 fatty acid binding(GO:0005504)
3.2 47.5 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
3.1 21.8 GO:0016841 ammonia-lyase activity(GO:0016841)
3.0 41.5 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
2.7 24.5 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
2.6 64.5 GO:0034185 apolipoprotein binding(GO:0034185)
2.4 7.2 GO:0033981 D-dopachrome decarboxylase activity(GO:0033981)
2.4 14.4 GO:0008422 beta-glucosidase activity(GO:0008422)
2.3 79.2 GO:0071949 FAD binding(GO:0071949)
2.2 11.0 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
2.2 45.9 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
1.9 64.0 GO:0017081 chloride channel regulator activity(GO:0017081)
1.9 303.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.8 37.7 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
1.7 57.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)
1.7 16.6 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
1.6 57.6 GO:0070008 serine-type exopeptidase activity(GO:0070008)
1.4 30.4 GO:0004859 phospholipase inhibitor activity(GO:0004859)
1.3 27.8 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
1.3 21.0 GO:0070053 thrombospondin receptor activity(GO:0070053)
1.3 7.7 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
1.2 42.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
1.2 18.0 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
1.1 36.3 GO:0031489 myosin V binding(GO:0031489)
1.1 27.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
1.1 9.5 GO:0043237 laminin-1 binding(GO:0043237)
1.0 19.9 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.9 12.9 GO:0030274 LIM domain binding(GO:0030274)
0.9 26.0 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.8 46.0 GO:0008009 chemokine activity(GO:0008009)
0.8 17.5 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.7 112.3 GO:0051087 chaperone binding(GO:0051087)
0.7 20.2 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.6 22.2 GO:0001848 complement binding(GO:0001848)
0.6 7.9 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.6 38.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.6 4.6 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.5 3.5 GO:0015350 methotrexate transporter activity(GO:0015350)
0.4 8.0 GO:0003796 lysozyme activity(GO:0003796)
0.4 8.8 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.4 16.0 GO:0004364 glutathione transferase activity(GO:0004364)
0.4 30.0 GO:0016831 carboxy-lyase activity(GO:0016831)
0.4 1.6 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.3 4.8 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.3 5.4 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.3 1.1 GO:0004925 prolactin receptor activity(GO:0004925)
0.3 24.7 GO:0016209 antioxidant activity(GO:0016209)
0.2 74.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 22.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 21.7 GO:0005548 phospholipid transporter activity(GO:0005548)
0.2 1.2 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.2 1.6 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.2 26.8 GO:0003777 microtubule motor activity(GO:0003777)
0.2 6.6 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.2 18.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 70.1 GO:0030674 protein binding, bridging(GO:0030674)
0.2 24.5 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 6.0 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 1.0 GO:0031419 cobalamin binding(GO:0031419)
0.1 5.2 GO:0005158 insulin receptor binding(GO:0005158)
0.1 1.4 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.1 13.4 GO:0008170 N-methyltransferase activity(GO:0008170)
0.1 8.5 GO:0005179 hormone activity(GO:0005179)
0.1 6.7 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 11.9 GO:0017124 SH3 domain binding(GO:0017124)
0.1 3.0 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 3.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 3.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 20.5 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.7 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 63.2 GO:0003723 RNA binding(GO:0003723)
0.0 2.1 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 220.6 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
3.1 283.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.5 105.2 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
1.4 103.4 PID CD40 PATHWAY CD40/CD40L signaling
1.2 97.5 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
1.2 112.8 PID HNF3A PATHWAY FOXA1 transcription factor network
1.0 89.3 PID IL6 7 PATHWAY IL6-mediated signaling events
0.9 348.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.6 60.2 PID FGF PATHWAY FGF signaling pathway
0.5 13.1 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.4 42.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 33.6 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.2 53.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.4 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 5.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 4.8 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 5.0 PID E2F PATHWAY E2F transcription factor network
0.0 3.6 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 7.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.1 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 2.4 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
14.3 271.7 REACTOME COMMON PATHWAY Genes involved in Common Pathway
10.8 312.1 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
7.8 203.5 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
6.8 162.9 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
4.9 87.8 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
4.5 125.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
3.0 170.1 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
3.0 136.6 REACTOME STEROID HORMONES Genes involved in Steroid hormones
2.6 64.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
2.3 47.5 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
2.2 57.6 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
2.1 37.7 REACTOME XENOBIOTICS Genes involved in Xenobiotics
1.7 46.0 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
1.6 25.4 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
1.4 24.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
1.3 22.1 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
1.3 30.0 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
1.1 113.7 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.9 45.9 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.8 14.4 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
0.8 15.8 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.7 31.6 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.7 111.6 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.6 7.9 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.5 27.3 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.5 8.8 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.4 27.8 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.4 19.0 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.4 8.0 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 67.7 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 17.8 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 33.8 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.2 4.8 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 24.5 REACTOME MRNA PROCESSING Genes involved in mRNA Processing
0.1 21.0 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.6 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 3.6 REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
0.0 1.1 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.7 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 1.2 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 2.2 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events