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Illumina Body Map 2 (GSE30611)

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Results for HOXA2_HOXB1

Z-value: 1.44

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Transcription factors associated with HOXA2_HOXB1

Gene Symbol Gene ID Gene Info
ENSG00000105996.7 homeobox A2
ENSG00000120094.9 homeobox B1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXA2hg38_v1_chr7_-_27102669_271026910.291.1e-01Click!
HOXB1hg38_v1_chr17_-_48530910_485310260.048.5e-01Click!

Activity profile of HOXA2_HOXB1 motif

Sorted Z-values of HOXA2_HOXB1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_93073111 10.53 ENST00000557420.1
ENST00000542321.6
repulsive guidance molecule BMP co-receptor a
chr6_+_151239951 8.53 ENST00000402676.7
A-kinase anchoring protein 12
chr12_+_101594849 7.95 ENST00000547405.5
ENST00000452455.6
ENST00000392934.7
ENST00000547509.5
ENST00000361685.6
ENST00000549145.5
ENST00000361466.7
ENST00000553190.5
ENST00000545503.6
ENST00000536007.5
ENST00000541119.5
ENST00000551300.5
ENST00000550270.1
myosin binding protein C1
chr6_+_151240368 6.90 ENST00000253332.5
A-kinase anchoring protein 12
chr17_-_39197696 6.20 ENST00000394310.7
ENST00000622445.4
ENST00000344140.5
calcium voltage-gated channel auxiliary subunit beta 1
chr2_-_153478753 5.76 ENST00000325926.4
reprimo, TP53 dependent G2 arrest mediator homolog
chr16_-_67393486 5.72 ENST00000562206.1
ENST00000393957.7
ENST00000290942.9
tubulin polymerization promoting protein family member 3
chr12_-_14885845 5.31 ENST00000539261.6
ENST00000228938.5
matrix Gla protein
chr15_-_93073663 5.15 ENST00000556658.1
repulsive guidance molecule BMP co-receptor a
chrX_-_13817027 4.75 ENST00000493677.5
ENST00000355135.6
ENST00000316715.9
glycoprotein M6B
chr5_-_126595185 4.62 ENST00000510111.6
ENST00000635851.1
ENST00000637964.1
ENST00000413020.6
ENST00000637782.1
ENST00000409134.8
ENST00000637272.1
ENST00000636879.1
ENST00000636743.1
ENST00000636886.1
ENST00000509270.2
aldehyde dehydrogenase 7 family member A1
chr11_-_111911759 4.59 ENST00000650687.2
crystallin alpha B
chr5_-_126595237 4.17 ENST00000637206.1
ENST00000553117.5
aldehyde dehydrogenase 7 family member A1
chr17_-_39197652 3.96 ENST00000394303.8
calcium voltage-gated channel auxiliary subunit beta 1
chr16_+_15502266 3.82 ENST00000452191.6
bMERB domain containing 1
chrX_-_13817346 3.77 ENST00000356942.9
glycoprotein M6B
chr19_-_49441508 3.65 ENST00000221485.8
solute carrier family 17 member 7
chr20_+_36214373 3.62 ENST00000432603.1
erythrocyte membrane protein band 4.1 like 1
chr4_-_89835617 3.57 ENST00000611107.1
ENST00000345009.8
ENST00000505199.5
ENST00000502987.5
synuclein alpha
chr14_-_21048431 3.43 ENST00000555026.5
NDRG family member 2
chr4_-_89836213 3.23 ENST00000618500.4
ENST00000508895.5
synuclein alpha
chr16_+_7510102 3.16 ENST00000682918.1
ENST00000683326.1
ENST00000570626.2
RNA binding fox-1 homolog 1
chr3_-_187670385 3.12 ENST00000287641.4
somatostatin
chr18_+_59220149 2.94 ENST00000256857.7
ENST00000529320.2
ENST00000420468.6
gastrin releasing peptide
chr11_-_127000762 2.86 ENST00000525144.7
kirre like nephrin family adhesion molecule 3
chr17_+_41819201 2.86 ENST00000455106.1
FKBP prolyl isomerase 10
chr7_+_86643902 2.84 ENST00000361669.7
glutamate metabotropic receptor 3
chr20_+_36154630 2.77 ENST00000338074.7
ENST00000636016.2
ENST00000373945.5
erythrocyte membrane protein band 4.1 like 1
chr10_-_121596117 2.71 ENST00000351936.11
fibroblast growth factor receptor 2
chr7_-_86965872 2.65 ENST00000398276.6
ENST00000416314.5
ENST00000425689.1
endosome-lysosome associated apoptosis and autophagy regulator family member 2
chr10_-_103855406 2.60 ENST00000355946.6
ENST00000369774.8
SH3 and PX domains 2A
chrX_-_13817279 2.59 ENST00000475307.1
glycoprotein M6B
chr10_-_77637789 2.33 ENST00000481070.1
ENST00000640969.1
ENST00000286628.14
ENST00000638991.1
ENST00000639913.1
ENST00000480683.2
potassium calcium-activated channel subfamily M alpha 1
chr6_+_122996227 2.30 ENST00000275162.10
clavesin 2
chr10_-_99235846 2.29 ENST00000370552.8
ENST00000370549.5
ENST00000628193.2
heparanase 2 (inactive)
chr2_-_189179754 2.26 ENST00000374866.9
ENST00000618828.1
collagen type V alpha 2 chain
chr10_-_77637721 2.18 ENST00000638848.1
ENST00000639406.1
ENST00000618048.2
ENST00000639120.1
ENST00000640834.1
ENST00000639601.1
ENST00000638514.1
ENST00000457953.6
ENST00000639090.1
ENST00000639489.1
ENST00000372440.6
ENST00000404771.8
ENST00000638203.1
ENST00000638306.1
ENST00000638351.1
ENST00000638606.1
ENST00000639591.1
ENST00000640182.1
ENST00000640605.1
ENST00000640141.1
potassium calcium-activated channel subfamily M alpha 1
chr3_+_156142962 2.15 ENST00000471742.5
potassium voltage-gated channel subfamily A member regulatory beta subunit 1
chr4_-_5019437 2.10 ENST00000506508.1
ENST00000509419.1
ENST00000307746.9
cytokine like 1
chr8_+_103140692 2.09 ENST00000438105.2
ENST00000309982.10
ENST00000297574.6
BAALC binder of MAP3K1 and KLF4
chr8_+_142449430 2.07 ENST00000643448.1
ENST00000517894.5
adhesion G protein-coupled receptor B1
chr13_-_77919390 2.05 ENST00000475537.2
ENST00000646605.1
endothelin receptor type B
chr4_-_137532452 1.98 ENST00000412923.6
ENST00000511115.5
ENST00000344876.9
ENST00000507846.5
ENST00000510305.5
ENST00000611581.1
protocadherin 18
chr15_+_47717344 1.95 ENST00000558816.5
ENST00000536845.7
semaphorin 6D
chr11_-_127000786 1.87 ENST00000525704.2
kirre like nephrin family adhesion molecule 3
chr1_-_182672882 1.86 ENST00000367557.8
ENST00000258302.8
regulator of G protein signaling 8
chr12_-_48999363 1.83 ENST00000421952.3
dendrin
chr10_+_94089067 1.72 ENST00000371375.1
ENST00000675218.1
phospholipase C epsilon 1
chr10_-_77637444 1.69 ENST00000639205.1
ENST00000639498.1
ENST00000372408.7
ENST00000372403.9
ENST00000640626.1
ENST00000404857.6
ENST00000638252.1
ENST00000640029.1
ENST00000640934.1
ENST00000639823.1
ENST00000372437.6
ENST00000639344.1
potassium calcium-activated channel subfamily M alpha 1
chr10_+_94089034 1.66 ENST00000676102.1
ENST00000371385.8
phospholipase C epsilon 1
chr7_+_80135694 1.65 ENST00000457358.7
G protein subunit alpha i1
chr16_+_66395455 1.64 ENST00000539168.1
cadherin 5
chr16_-_49856105 1.63 ENST00000563137.7
zinc finger protein 423
chr6_-_112254555 1.62 ENST00000230538.12
ENST00000389463.9
ENST00000368638.5
ENST00000431543.6
ENST00000453937.2
laminin subunit alpha 4
chr3_+_197968 1.52 ENST00000435603.5
cell adhesion molecule L1 like
chr10_+_18400562 1.49 ENST00000377315.5
ENST00000650685.1
calcium voltage-gated channel auxiliary subunit beta 2
chr7_+_20330893 1.48 ENST00000222573.5
integrin subunit beta 8
chr12_+_6913745 1.44 ENST00000537688.5
enolase 2
chr6_-_112254485 1.42 ENST00000521398.5
ENST00000424408.6
ENST00000243219.7
laminin subunit alpha 4
chr6_-_112254647 1.35 ENST00000455073.1
ENST00000522006.5
ENST00000519932.5
laminin subunit alpha 4
chr2_+_165469647 1.31 ENST00000421875.5
ENST00000314499.11
ENST00000409664.5
ENST00000651982.1
cysteine and serine rich nuclear protein 3
chr10_-_77637902 1.30 ENST00000286627.10
ENST00000639486.1
ENST00000640523.1
potassium calcium-activated channel subfamily M alpha 1
chr1_+_64470120 1.29 ENST00000651257.2
cache domain containing 1
chr2_-_212124901 1.28 ENST00000402597.6
erb-b2 receptor tyrosine kinase 4
chr9_+_121567057 1.26 ENST00000394340.7
ENST00000436835.5
ENST00000259371.6
DAB2 interacting protein
chr1_-_43367689 1.25 ENST00000621943.4
ELOVL fatty acid elongase 1
chr6_+_68635273 1.23 ENST00000370598.6
adhesion G protein-coupled receptor B3
chrX_+_100644183 1.22 ENST00000640889.1
ENST00000373004.5
sushi repeat containing protein X-linked 2
chr2_+_26401909 1.20 ENST00000288710.7
dynein regulatory complex subunit 1
chr14_-_81427390 1.17 ENST00000555447.5
stonin 2
chr1_-_66924791 1.17 ENST00000371023.7
ENST00000371022.3
ENST00000371026.8
dynein axonemal intermediate chain 4
chr10_+_24466487 1.16 ENST00000396446.5
ENST00000396445.5
ENST00000376451.4
KIAA1217
chr7_-_27130733 1.14 ENST00000428284.2
ENST00000360046.10
ENST00000610970.1
homeobox A4
chr2_-_44361555 1.09 ENST00000409957.5
prolyl endopeptidase like
chr3_+_189789734 1.02 ENST00000437221.5
ENST00000392463.6
ENST00000392461.7
ENST00000449992.5
ENST00000456148.1
tumor protein p63
chr12_+_21526287 0.98 ENST00000256969.7
spexin hormone
chrX_-_10677720 0.97 ENST00000453318.6
midline 1
chr13_+_35476740 0.95 ENST00000537702.5
neurobeachin
chr6_+_30894574 0.94 ENST00000514434.1
discoidin domain receptor tyrosine kinase 1
chr14_-_53958757 0.93 ENST00000559642.1
bone morphogenetic protein 4
chr13_-_77919459 0.92 ENST00000643890.1
endothelin receptor type B
chr17_+_39668447 0.91 ENST00000269582.3
ENST00000581428.1
phenylethanolamine N-methyltransferase
chr3_+_150546765 0.91 ENST00000406576.7
ENST00000460851.6
ENST00000482093.5
ENST00000273435.9
eukaryotic translation initiation factor 2A
chr3_+_189789643 0.91 ENST00000354600.10
tumor protein p63
chr1_-_43367956 0.90 ENST00000372458.8
ELOVL fatty acid elongase 1
chr2_-_142131004 0.85 ENST00000434794.1
ENST00000389484.8
LDL receptor related protein 1B
chr11_+_31816266 0.84 ENST00000644607.1
ENST00000646221.1
ENST00000643671.1
ENST00000643931.1
ENST00000642614.1
ENST00000642818.1
ENST00000645848.1
ENST00000506388.2
ENST00000645824.1
ENST00000532942.5
PAX6 upstream antisense RNA
novel protein
chr10_+_122560639 0.81 ENST00000344338.7
ENST00000330163.8
ENST00000652446.2
ENST00000666315.1
ENST00000368955.7
ENST00000368909.7
ENST00000368956.6
ENST00000619379.1
deleted in malignant brain tumors 1
chr9_+_35829217 0.80 ENST00000439587.6
ENST00000643932.2
ENST00000650015.1
ENST00000377991.9
transmembrane protein 8B
chr7_-_13989658 0.80 ENST00000430479.6
ENST00000433547.1
ENST00000405192.6
ETS variant transcription factor 1
chr10_-_97185920 0.79 ENST00000371041.3
ENST00000266058.9
slit guidance ligand 1
chr1_-_43368039 0.77 ENST00000413844.3
ELOVL fatty acid elongase 1
chr7_-_13989891 0.74 ENST00000405218.6
ETS variant transcription factor 1
chr11_+_26188836 0.74 ENST00000672621.1
anoctamin 3
chr9_-_70414657 0.73 ENST00000377126.4
Kruppel like factor 9
chr6_+_32038382 0.70 ENST00000478281.5
ENST00000471671.4
ENST00000435122.3
ENST00000644719.2
cytochrome P450 family 21 subfamily A member 2
chr12_-_27971970 0.70 ENST00000395872.5
ENST00000201015.8
parathyroid hormone like hormone
chr3_+_150546671 0.70 ENST00000487799.5
eukaryotic translation initiation factor 2A
chr9_+_130713016 0.69 ENST00000372348.7
ABL proto-oncogene 1, non-receptor tyrosine kinase
chr16_+_30069539 0.68 ENST00000565355.1
aldolase, fructose-bisphosphate A
chr2_+_36696790 0.66 ENST00000497382.5
ENST00000404084.5
ENST00000379241.7
ENST00000401530.5
vitrin
chr10_-_77637633 0.66 ENST00000638223.1
ENST00000639544.1
ENST00000640807.1
ENST00000434208.6
ENST00000626620.3
ENST00000638575.1
ENST00000638759.1
potassium calcium-activated channel subfamily M alpha 1
chr12_-_57742120 0.63 ENST00000257897.7
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr9_+_137241277 0.60 ENST00000340384.5
tubulin beta 4B class IVb
chr1_-_109041986 0.59 ENST00000400794.7
ENST00000528747.1
ENST00000361054.7
WD repeat domain 47
chr18_+_58196736 0.57 ENST00000675221.1
NEDD4 like E3 ubiquitin protein ligase
chr3_+_148827800 0.57 ENST00000282957.9
ENST00000468341.1
carboxypeptidase B1
chr11_-_93850559 0.55 ENST00000409977.2
V-set and transmembrane domain containing 5
chr2_+_36696758 0.52 ENST00000457137.6
vitrin
chr17_+_60677822 0.52 ENST00000407086.8
ENST00000589222.5
ENST00000626960.2
ENST00000390652.9
BCAS3 microtubule associated cell migration factor
chr10_+_35175586 0.51 ENST00000494479.5
ENST00000463314.5
ENST00000342105.7
ENST00000495301.1
cAMP responsive element modulator
chr10_+_122560751 0.51 ENST00000338354.10
ENST00000664692.1
ENST00000653442.1
ENST00000664974.1
deleted in malignant brain tumors 1
chr20_+_43945677 0.51 ENST00000358131.5
TOX high mobility group box family member 2
chr19_+_37506931 0.46 ENST00000627814.3
ENST00000587143.5
zinc finger protein 793
chr2_+_36696686 0.44 ENST00000379242.7
ENST00000389975.7
vitrin
chr19_-_38847423 0.44 ENST00000647557.1
heterogeneous nuclear ribonucleoprotein L
chr13_+_42781578 0.44 ENST00000313851.3
family with sequence similarity 216 member B
chr13_-_35476682 0.43 ENST00000379919.6
mab-21 like 1
chr12_+_57089094 0.42 ENST00000342556.6
ENST00000300131.8
NGFI-A binding protein 2
chrX_-_66033664 0.42 ENST00000427538.5
V-set and immunoglobulin domain containing 4
chrX_+_96684801 0.40 ENST00000324765.13
diaphanous related formin 2
chr13_+_42781547 0.36 ENST00000537894.5
family with sequence similarity 216 member B
chr1_+_243256034 0.31 ENST00000366541.8
SHH signaling and ciliogenesis regulator SDCCAG8
chr10_+_49988318 0.31 ENST00000374056.10
ENST00000679810.1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 6
chr18_-_55403682 0.28 ENST00000564228.5
ENST00000630828.2
transcription factor 4
chr5_+_146447304 0.26 ENST00000296702.9
ENST00000394421.7
ENST00000679501.2
transcription elongation regulator 1
chr11_-_2140967 0.26 ENST00000381389.5
insulin like growth factor 2
chr10_-_77637558 0.25 ENST00000372421.10
ENST00000639370.1
ENST00000640773.1
ENST00000638895.1
potassium calcium-activated channel subfamily M alpha 1
chr12_+_10505890 0.25 ENST00000538173.1
eukaryotic translation initiation factor 2 subunit gamma B
chr10_+_122560679 0.23 ENST00000657942.1
deleted in malignant brain tumors 1
chr9_+_110668779 0.22 ENST00000416899.7
ENST00000374448.9
muscle associated receptor tyrosine kinase
chr3_+_113211003 0.21 ENST00000464546.5
BOC cell adhesion associated, oncogene regulated
chr3_-_46744755 0.21 ENST00000620911.6
serine protease 45, pseudogene
chr10_-_73698109 0.20 ENST00000374094.9
ArfGAP with GTPase domain, ankyrin repeat and PH domain 5
chr12_+_56007484 0.16 ENST00000262032.9
IKAROS family zinc finger 4
chr1_-_44788168 0.15 ENST00000372207.4
bestrophin 4
chr21_+_18244828 0.15 ENST00000299295.7
chondrolectin
chr5_-_88785493 0.15 ENST00000503554.4
myocyte enhancer factor 2C
chr11_+_47408582 0.14 ENST00000531974.5
ENST00000362021.9
ENST00000531419.5
ENST00000531865.5
ENST00000354884.8
solute carrier family 39 member 13
chr5_+_154802257 0.14 ENST00000518677.1
La ribonucleoprotein 1, translational regulator
chr8_-_22692343 0.14 ENST00000522910.1
early growth response 3
chr17_+_45161864 0.12 ENST00000589230.6
ENST00000591576.5
ENST00000591070.6
ENST00000592695.1
HEXIM P-TEFb complex subunit 2
chr1_-_223363337 0.12 ENST00000608996.5
sushi domain containing 4
chr19_+_35358821 0.11 ENST00000594310.1
free fatty acid receptor 3
chr10_-_99235783 0.11 ENST00000370546.5
ENST00000614306.1
heparanase 2 (inactive)
chr3_+_159764199 0.09 ENST00000639448.1
IQCJ-SCHIP1 readthrough
chr17_-_1684807 0.09 ENST00000577001.1
ENST00000572621.5
ENST00000304992.11
pre-mRNA processing factor 8
chr6_+_33420052 0.09 ENST00000646630.1
ENST00000629380.3
synaptic Ras GTPase activating protein 1
chrX_+_70062457 0.09 ENST00000338352.3
OTU deubiquitinase 6A
chr19_+_51571249 0.08 ENST00000262259.7
ENST00000545217.5
ENST00000596504.1
zinc finger protein 175
chr9_-_124507382 0.08 ENST00000373588.9
ENST00000620110.4
nuclear receptor subfamily 5 group A member 1
chr20_-_32584795 0.08 ENST00000201961.6
ENST00000621426.6
nucleolar protein 4 like
chr10_-_97185507 0.06 ENST00000314867.9
slit guidance ligand 1
chr10_-_73697881 0.06 ENST00000443782.6
ArfGAP with GTPase domain, ankyrin repeat and PH domain 5
chrX_+_96684638 0.05 ENST00000355827.8
ENST00000373061.7
diaphanous related formin 2
chr6_+_33420201 0.04 ENST00000644458.1
ENST00000449372.7
ENST00000628646.2
ENST00000418600.7
synaptic Ras GTPase activating protein 1
chr7_-_78771265 0.03 ENST00000630991.2
ENST00000629359.2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr12_-_27972725 0.03 ENST00000545234.6
parathyroid hormone like hormone
chr3_+_189789672 0.03 ENST00000434928.5
tumor protein p63
chr7_+_33904911 0.02 ENST00000297161.6
BMP binding endothelial regulator
chr2_+_54457190 0.02 ENST00000389980.7
spectrin beta, non-erythrocytic 1
chr2_+_46479565 0.02 ENST00000434431.2
transmembrane protein 247
chr12_-_86256299 0.01 ENST00000552808.6
ENST00000547225.5
MGAT4 family member C

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA2_HOXB1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 8.8 GO:0031456 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
1.6 4.7 GO:0002121 inter-male aggressive behavior(GO:0002121)
1.4 17.9 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
1.3 15.4 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
1.2 3.7 GO:0042137 sequestering of neurotransmitter(GO:0042137)
1.0 2.9 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.6 8.4 GO:0034465 response to carbon monoxide(GO:0034465)
0.6 3.0 GO:0035645 enteric smooth muscle cell differentiation(GO:0035645)
0.6 2.9 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.6 2.3 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.5 3.1 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.5 2.6 GO:0072675 osteoclast fusion(GO:0072675)
0.5 15.7 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.5 2.0 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.5 3.4 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.5 2.7 GO:0060529 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) squamous basal epithelial stem cell differentiation involved in prostate gland acinus development(GO:0060529)
0.3 8.0 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.3 0.9 GO:0042418 epinephrine biosynthetic process(GO:0042418)
0.3 1.3 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.2 0.7 GO:1990051 activation of protein kinase C activity(GO:1990051)
0.2 2.9 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.2 4.6 GO:0007021 tubulin complex assembly(GO:0007021)
0.2 1.8 GO:1990928 response to amino acid starvation(GO:1990928)
0.2 0.9 GO:2000006 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.2 3.4 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.2 1.2 GO:0099558 maintenance of synapse structure(GO:0099558)
0.2 1.3 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.2 5.3 GO:0001502 cartilage condensation(GO:0001502)
0.1 1.5 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.1 1.6 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.1 1.0 GO:1904304 regulation of gastro-intestinal system smooth muscle contraction(GO:1904304) positive regulation of gastro-intestinal system smooth muscle contraction(GO:1904306)
0.1 2.3 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.1 9.7 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.1 1.5 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 2.1 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.1 1.7 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.1 0.7 GO:0051414 response to cortisol(GO:0051414)
0.1 0.4 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.1 6.4 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.1 0.7 GO:0061588 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.1 1.5 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 1.2 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.9 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 6.9 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.6 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 1.5 GO:0001573 ganglioside metabolic process(GO:0001573)
0.0 3.6 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 2.0 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 0.7 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 2.1 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0 0.1 GO:0002879 positive regulation of acute inflammatory response to non-antigenic stimulus(GO:0002879)
0.0 1.5 GO:0031103 axon regeneration(GO:0031103)
0.0 1.6 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.3 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0 2.4 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.0 1.4 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 2.3 GO:0007040 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 0.5 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.1 GO:1990168 protein K27-linked deubiquitination(GO:1990167) protein K33-linked deubiquitination(GO:1990168)
0.0 0.7 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 4.4 GO:0045995 regulation of embryonic development(GO:0045995)
0.0 0.5 GO:0006705 mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212)
0.0 0.1 GO:0007538 primary sex determination(GO:0007538)
0.0 0.4 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 1.1 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.0 1.2 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.1 GO:0007521 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) muscle cell fate determination(GO:0007521) regulation of synaptic activity(GO:0060025)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.3 GO:0005588 collagen type V trimer(GO:0005588)
0.5 1.5 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.3 3.7 GO:0060203 clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.3 5.7 GO:0097427 microtubule bundle(GO:0097427)
0.3 4.6 GO:0097512 cardiac myofibril(GO:0097512)
0.3 8.0 GO:0032982 myosin filament(GO:0032982)
0.2 2.1 GO:1990635 proximal dendrite(GO:1990635)
0.2 1.6 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.2 1.3 GO:1990032 parallel fiber(GO:1990032)
0.1 6.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 1.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 11.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 1.2 GO:0043083 synaptic cleft(GO:0043083)
0.1 1.5 GO:0042589 zymogen granule membrane(GO:0042589)
0.1 4.4 GO:0005605 basal lamina(GO:0005605)
0.1 1.8 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 15.7 GO:0031225 anchored component of membrane(GO:0031225)
0.1 8.1 GO:0005901 caveola(GO:0005901)
0.0 2.6 GO:0002102 podosome(GO:0002102)
0.0 1.6 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.0 GO:0031045 dense core granule(GO:0031045)
0.0 17.5 GO:0045121 membrane raft(GO:0045121)
0.0 18.2 GO:0005938 cell cortex(GO:0005938)
0.0 2.3 GO:0043198 dendritic shaft(GO:0043198)
0.0 2.3 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 2.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 9.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.5 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.7 GO:0031430 M band(GO:0031430)
0.0 2.3 GO:0042734 presynaptic membrane(GO:0042734)
0.0 4.1 GO:0005802 trans-Golgi network(GO:0005802)
0.0 10.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 1.6 GO:0005913 cell-cell adherens junction(GO:0005913)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 6.8 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.8 8.4 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.8 15.7 GO:1990459 transferrin receptor binding(GO:1990459)
0.8 2.4 GO:0030305 heparanase activity(GO:0030305)
0.7 2.8 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.6 15.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.5 1.5 GO:0035375 zymogen binding(GO:0035375)
0.4 3.0 GO:0004962 endothelin receptor activity(GO:0004962)
0.4 3.7 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.3 1.5 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.3 11.2 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.3 8.0 GO:0031432 titin binding(GO:0031432)
0.3 8.8 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.2 2.9 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.2 2.6 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.2 2.7 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.2 0.5 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 4.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 1.3 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 2.0 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 1.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.7 GO:0004515 nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.1 3.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 1.7 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 12.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.9 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 2.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 2.1 GO:0070402 NADPH binding(GO:0070402)
0.1 3.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 1.3 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.1 0.9 GO:0070700 BMP receptor binding(GO:0070700)
0.1 2.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 0.9 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 0.7 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.5 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.0 4.1 GO:0005179 hormone activity(GO:0005179)
0.0 1.1 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.0 0.6 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 7.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.7 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 1.6 GO:0000049 tRNA binding(GO:0000049)
0.0 0.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.5 GO:0008395 steroid hydroxylase activity(GO:0008395)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 16.6 PID BMP PATHWAY BMP receptor signaling
0.1 6.8 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 7.0 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 4.4 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.1 3.2 PID S1P S1P2 PATHWAY S1P2 pathway
0.1 5.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 1.5 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 1.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 3.6 PID RAS PATHWAY Regulation of Ras family activation
0.0 3.0 PID ENDOTHELIN PATHWAY Endothelins
0.0 1.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 2.7 PID FGF PATHWAY FGF signaling pathway
0.0 2.3 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 1.6 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 2.6 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.9 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 4.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.5 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 15.7 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 6.8 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 13.5 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.7 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.1 8.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 2.3 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 3.7 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 2.4 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.1 2.9 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 6.4 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.1 2.0 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 1.7 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.1 2.9 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 2.4 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.9 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 1.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 8.8 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 2.1 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 2.1 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 6.1 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.3 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.5 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.6 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 1.2 REACTOME MYOGENESIS Genes involved in Myogenesis