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Illumina Body Map 2 (GSE30611)

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Results for HOXA4

Z-value: 2.03

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Transcription factors associated with HOXA4

Gene Symbol Gene ID Gene Info
ENSG00000197576.14 homeobox A4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXA4hg38_v1_chr7_-_27130182_27130226-0.318.6e-02Click!

Activity profile of HOXA4 motif

Sorted Z-values of HOXA4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_90921079 12.46 ENST00000371697.4
ankyrin repeat domain 1
chr3_+_121593363 12.18 ENST00000338040.6
F-box protein 40
chr3_-_52452828 8.91 ENST00000496590.1
troponin C1, slow skeletal and cardiac type
chr1_+_160190567 8.82 ENST00000368078.8
calsequestrin 1
chr22_+_25742141 8.55 ENST00000536101.5
ENST00000335473.12
ENST00000407587.6
myosin XVIIIB
chr17_-_10518536 8.53 ENST00000226207.6
myosin heavy chain 1
chr2_-_178804623 8.40 ENST00000359218.10
ENST00000342175.11
titin
chr10_-_73655984 8.29 ENST00000394810.3
synaptopodin 2 like
chr3_-_42702778 7.76 ENST00000457462.5
ENST00000441594.6
hedgehog acyltransferase like
chr8_+_78591222 7.36 ENST00000518467.1
cAMP-dependent protein kinase inhibitor alpha
chr17_-_10549612 7.16 ENST00000532183.6
ENST00000397183.6
ENST00000420805.1
myosin heavy chain 2
chr17_-_10549652 6.81 ENST00000245503.10
myosin heavy chain 2
chr1_-_100178215 6.59 ENST00000370138.1
ENST00000370137.6
ENST00000342895.7
ENST00000620882.4
leucine rich repeat containing 39
chr2_+_167187364 5.96 ENST00000672671.1
xin actin binding repeat containing 2
chr11_-_13495984 5.17 ENST00000282091.6
parathyroid hormone
chr11_-_13496018 5.03 ENST00000529816.1
parathyroid hormone
chr17_-_10549694 4.92 ENST00000622564.4
myosin heavy chain 2
chr3_-_42702638 4.79 ENST00000417472.5
ENST00000442469.1
hedgehog acyltransferase like
chr11_+_112175526 4.57 ENST00000532612.5
ENST00000438022.5
beta-carotene oxygenase 2
chr1_+_207034366 4.51 ENST00000545806.5
ENST00000618513.4
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
chr16_+_7332744 4.44 ENST00000436368.6
ENST00000311745.9
ENST00000340209.8
ENST00000620507.4
RNA binding fox-1 homolog 1
chr11_+_112175501 4.41 ENST00000357685.11
ENST00000361053.8
beta-carotene oxygenase 2
chr8_-_42501224 4.38 ENST00000520262.6
ENST00000517366.1
solute carrier family 20 member 2
chr11_+_27041313 3.89 ENST00000528583.5
gamma-butyrobetaine hydroxylase 1
chr1_+_213987929 3.58 ENST00000498508.6
ENST00000366958.9
prospero homeobox 1
chrM_+_5824 3.48 ENST00000361624.2
mitochondrially encoded cytochrome c oxidase I
chr3_+_159839847 3.44 ENST00000445224.6
schwannomin interacting protein 1
chr7_+_95485934 2.98 ENST00000325885.6
ankyrin repeat and SOCS box containing 4
chr14_-_36519679 2.98 ENST00000498187.6
NK2 homeobox 1
chr3_-_120682113 2.90 ENST00000476082.2
homogentisate 1,2-dioxygenase
chr4_+_83536097 2.89 ENST00000395226.6
ENST00000264409.5
glycerol-3-phosphate acyltransferase 3
chr1_+_213988501 2.79 ENST00000261454.8
ENST00000435016.2
prospero homeobox 1
chr15_-_101334157 2.78 ENST00000632686.1
proprotein convertase subtilisin/kexin type 6
chr2_-_68871382 2.69 ENST00000295379.2
bone morphogenetic protein 10
chr14_-_80231052 2.57 ENST00000557010.5
iodothyronine deiodinase 2
chr12_-_86256299 2.51 ENST00000552808.6
ENST00000547225.5
MGAT4 family member C
chr12_-_56643499 2.50 ENST00000551570.5
ATP synthase F1 subunit beta
chr10_-_67696115 2.42 ENST00000433211.7
catenin alpha 3
chr5_-_38557459 2.31 ENST00000511561.1
LIF receptor subunit alpha
chr7_-_13989658 2.27 ENST00000430479.6
ENST00000433547.1
ENST00000405192.6
ETS variant transcription factor 1
chr20_+_58888779 2.27 ENST00000488546.6
ENST00000667293.2
ENST00000481039.6
ENST00000467321.6
GNAS complex locus
chr16_+_7332839 2.27 ENST00000355637.9
RNA binding fox-1 homolog 1
chr7_+_107470050 2.26 ENST00000304402.6
G protein-coupled receptor 22
chr10_-_60572599 2.18 ENST00000503366.5
ankyrin 3
chr20_+_58889100 2.13 ENST00000477931.5
ENST00000485673.6
GNAS complex locus
chrX_-_54998530 2.12 ENST00000545676.5
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr20_+_58889143 2.08 ENST00000470512.6
ENST00000464788.6
ENST00000469431.6
ENST00000478585.6
ENST00000604005.6
GNAS complex locus
chr3_-_120682215 2.07 ENST00000283871.10
homogentisate 1,2-dioxygenase
chr20_+_58889168 2.03 ENST00000480975.5
ENST00000480232.6
ENST00000484504.5
GNAS complex locus
chr11_-_16356538 2.02 ENST00000683767.1
SRY-box transcription factor 6
chr11_+_22666604 2.01 ENST00000454584.6
growth arrest specific 2
chr12_-_86256267 1.98 ENST00000620241.4
MGAT4 family member C
chr16_+_6483379 1.91 ENST00000552089.5
RNA binding fox-1 homolog 1
chr12_+_12785652 1.88 ENST00000356591.5
apolipoprotein L domain containing 1
chr1_-_216805367 1.88 ENST00000360012.7
estrogen related receptor gamma
chr9_+_84669760 1.85 ENST00000304053.10
neurotrophic receptor tyrosine kinase 2
chr4_-_151226427 1.83 ENST00000304527.8
ENST00000409598.8
SH3 domain containing 19
chr2_-_190062721 1.80 ENST00000260950.5
myostatin
chr18_-_31162849 1.76 ENST00000257197.7
ENST00000257198.6
desmocollin 1
chr9_+_84669707 1.76 ENST00000277120.8
ENST00000323115.10
neurotrophic receptor tyrosine kinase 2
chr12_-_86256376 1.73 ENST00000552435.6
MGAT4 family member C
chr20_+_54475584 1.66 ENST00000262593.10
docking protein 5
chr2_+_100821025 1.65 ENST00000427413.5
neuronal PAS domain protein 2
chr10_-_119178791 1.62 ENST00000298510.4
peroxiredoxin 3
chr10_-_114632011 1.61 ENST00000651023.1
actin binding LIM protein 1
chr12_+_111099423 1.52 ENST00000397643.3
cut like homeobox 2
chr10_-_100065394 1.51 ENST00000441382.1
carboxypeptidase N subunit 1
chr5_-_57482808 1.50 ENST00000423391.3
actin beta like 2
chr9_-_113401249 1.48 ENST00000409155.8
ENST00000448137.5
aminolevulinate dehydratase
chr20_+_54475647 1.45 ENST00000395939.5
docking protein 5
chr5_-_1882902 1.43 ENST00000231357.7
iroquois homeobox 4
chr15_+_80059651 1.34 ENST00000561012.5
ENST00000261749.11
ENST00000564367.5
ENST00000558494.5
zinc finger AN1-type containing 6
chr15_+_51377247 1.33 ENST00000396399.6
gliomedin
chr12_+_27524151 1.27 ENST00000545334.5
ENST00000540114.5
ENST00000537927.5
ENST00000228425.11
ENST00000318304.12
ENST00000535047.5
ENST00000542629.5
PPFIA binding protein 1
chr14_+_39265278 1.23 ENST00000554392.5
ENST00000555716.5
ENST00000341749.7
ENST00000557038.5
MIA SH3 domain ER export factor 2
chr15_+_51377410 1.23 ENST00000612989.1
gliomedin
chr2_-_179562576 1.23 ENST00000336917.9
zinc finger protein 385B
chr1_+_155689074 1.18 ENST00000343043.7
ENST00000421487.6
ENST00000535183.5
ENST00000368336.10
ENST00000465375.5
ENST00000470830.5
death associated protein 3
chr14_-_22926413 1.16 ENST00000556043.5
protein arginine methyltransferase 5
chr12_-_102950835 1.14 ENST00000546844.1
phenylalanine hydroxylase
chr17_-_10469558 1.14 ENST00000255381.2
myosin heavy chain 4
chr7_-_141014629 1.12 ENST00000393008.7
mitochondrial ribosomal protein S33
chr7_-_13988863 1.11 ENST00000405358.8
ETS variant transcription factor 1
chr7_+_129375830 1.10 ENST00000466993.5
adenosylhomocysteinase like 2
chr7_+_1232865 1.10 ENST00000316333.9
UNC homeobox
chr12_+_71664352 1.05 ENST00000547843.1
THAP domain containing 2
chr1_+_170663134 1.02 ENST00000367760.7
paired related homeobox 1
chr7_+_8435187 1.02 ENST00000429542.1
neurexophilin 1
chr17_-_69141878 0.98 ENST00000590645.1
ENST00000284425.7
ATP binding cassette subfamily A member 6
chr15_+_51377315 0.98 ENST00000558426.5
gliomedin
chr5_+_151026966 0.97 ENST00000520059.1
glutathione peroxidase 3
chr15_+_36702009 0.96 ENST00000562489.1
CDAN1 interacting nuclease 1
chr11_-_62545629 0.94 ENST00000528508.5
ENST00000533365.5
AHNAK nucleoprotein
chr17_-_41382298 0.94 ENST00000394001.3
keratin 34
chr3_+_9732480 0.94 ENST00000426583.2
bromodomain and PHD finger containing 1
chr6_-_31546716 0.92 ENST00000483251.1
ATPase H+ transporting V1 subunit G2
chrX_+_11822423 0.92 ENST00000656302.1
ENST00000640291.2
FERM and PDZ domain containing 4
chr3_-_115147237 0.89 ENST00000357258.8
zinc finger and BTB domain containing 20
chr7_+_32957385 0.88 ENST00000538336.5
ENST00000242209.9
FKBP prolyl isomerase 9
chr1_-_193106048 0.86 ENST00000367440.3
glutaredoxin 2
chr1_+_245154963 0.86 ENST00000407071.7
kinesin family member 26B
chr6_+_12716554 0.82 ENST00000676159.1
phosphatase and actin regulator 1
chr3_-_115147277 0.81 ENST00000675478.1
zinc finger and BTB domain containing 20
chr7_+_8435063 0.81 ENST00000438764.1
neurexophilin 1
chr1_-_159862648 0.80 ENST00000368100.1
V-set and immunoglobulin domain containing 8
chr9_+_122742303 0.79 ENST00000304720.3
olfactory receptor family 1 subfamily L member 6
chr5_-_59430600 0.79 ENST00000636120.1
phosphodiesterase 4D
chr16_+_67246895 0.76 ENST00000566345.6
solute carrier family 9 member A5
chr5_-_1882744 0.72 ENST00000511126.1
iroquois homeobox 4
chr15_+_80059568 0.68 ENST00000613266.4
ENST00000561060.5
zinc finger AN1-type containing 6
chr12_-_23950906 0.68 ENST00000541847.5
SRY-box transcription factor 5
chr3_+_2511597 0.67 ENST00000434053.5
contactin 4
chr5_+_67004618 0.67 ENST00000261569.11
ENST00000436277.5
microtubule associated serine/threonine kinase family member 4
chr18_+_3247778 0.67 ENST00000217652.8
ENST00000578611.5
ENST00000583449.1
myosin light chain 12A
chr2_+_127646145 0.67 ENST00000486700.2
ENST00000272644.7
G protein-coupled receptor 17
chr15_+_89088417 0.66 ENST00000569550.5
ENST00000565066.5
ENST00000565973.5
ENST00000352732.10
abhydrolase domain containing 2, acylglycerol lipase
chr1_+_167329148 0.66 ENST00000420254.7
POU class 2 homeobox 1
chr14_+_37595847 0.65 ENST00000556845.1
tetratricopeptide repeat domain 6
chr10_-_104085793 0.62 ENST00000650263.1
collagen type XVII alpha 1 chain
chr12_-_10939263 0.62 ENST00000537503.2
taste 2 receptor member 14
chr2_-_25794641 0.61 ENST00000673455.1
ASXL transcriptional regulator 2
chr5_-_124746630 0.60 ENST00000513986.2
zinc finger protein 608
chr3_-_115071333 0.60 ENST00000462705.5
zinc finger and BTB domain containing 20
chr11_-_59615673 0.59 ENST00000263847.6
oxysterol binding protein
chr5_+_159916475 0.58 ENST00000306675.5
adrenoceptor alpha 1B
chr8_-_10655137 0.58 ENST00000382483.4
RP1 like 1
chr3_+_122384167 0.58 ENST00000232125.9
ENST00000477892.5
ENST00000469967.1
family with sequence similarity 162 member A
chr10_+_116545907 0.58 ENST00000369221.2
pancreatic lipase
chr10_-_104085762 0.58 ENST00000393211.3
collagen type XVII alpha 1 chain
chr5_+_55853464 0.57 ENST00000652039.1
interleukin 31 receptor A
chr2_+_53767772 0.56 ENST00000295304.5
ChaC glutathione specific gamma-glutamylcyclotransferase 2
chr7_+_18290089 0.55 ENST00000433709.6
histone deacetylase 9
chr7_+_95485898 0.54 ENST00000428113.5
ankyrin repeat and SOCS box containing 4
chr15_+_80059635 0.53 ENST00000559157.5
zinc finger AN1-type containing 6
chr11_-_5059627 0.53 ENST00000321522.2
olfactory receptor family 52 subfamily E member 2
chr6_+_31546845 0.53 ENST00000376146.8
NFKB inhibitor like 1
chr18_+_13612614 0.51 ENST00000586765.1
ENST00000677910.1
low density lipoprotein receptor class A domain containing 4
chr7_+_129375643 0.50 ENST00000490911.5
adenosylhomocysteinase like 2
chr14_-_20436161 0.49 ENST00000636854.3
kelch like family member 33
chr2_-_2324935 0.47 ENST00000649709.1
myelin transcription factor 1 like
chr15_+_85544036 0.47 ENST00000558166.2
A-kinase anchoring protein 13
chr2_-_2324642 0.47 ENST00000650485.1
ENST00000649207.1
myelin transcription factor 1 like
chr6_-_55875583 0.46 ENST00000370830.4
bone morphogenetic protein 5
chr19_+_33373694 0.45 ENST00000284000.9
CCAAT enhancer binding protein gamma
chr11_+_124611420 0.45 ENST00000284288.3
pannexin 3
chr2_-_2324968 0.44 ENST00000649641.1
myelin transcription factor 1 like
chr17_-_10421944 0.43 ENST00000403437.2
myosin heavy chain 8
chr1_-_151790475 0.39 ENST00000368825.7
ENST00000368823.5
ENST00000368824.8
ENST00000458431.6
ENST00000368827.10
ENST00000440583.6
tudor and KH domain containing
chr12_-_10807286 0.39 ENST00000240615.3
taste 2 receptor member 8
chr11_+_124183219 0.38 ENST00000641351.2
olfactory receptor family 10 subfamily D member 3
chr5_+_68290637 0.38 ENST00000336483.9
phosphoinositide-3-kinase regulatory subunit 1
chr1_-_151346846 0.38 ENST00000436271.5
ENST00000450506.5
ENST00000422595.5
regulatory factor X5
chr6_-_116829037 0.37 ENST00000368549.7
ENST00000530250.1
ENST00000310357.8
G protein-coupled receptor class C group 6 member A
chr1_+_158461574 0.35 ENST00000641432.1
ENST00000641460.1
ENST00000641535.1
ENST00000641971.1
olfactory receptor family 10 subfamily K member 1
chr13_-_83882390 0.35 ENST00000377084.3
SLIT and NTRK like family member 1
chr1_+_167329044 0.34 ENST00000367862.9
POU class 2 homeobox 1
chr11_+_121101243 0.34 ENST00000392793.6
ENST00000642222.1
tectorin alpha
chr11_+_5351508 0.33 ENST00000380219.1
olfactory receptor family 51 subfamily B member 6
chr10_-_49396074 0.32 ENST00000374139.8
dorsal root ganglia homeobox
chr4_+_87832917 0.32 ENST00000395102.8
ENST00000497649.6
ENST00000540395.1
ENST00000560249.5
ENST00000511670.5
ENST00000361056.3
matrix extracellular phosphoglycoprotein
chr4_-_152352800 0.29 ENST00000393956.9
F-box and WD repeat domain containing 7
chr13_-_52848632 0.29 ENST00000377942.7
ENST00000338862.5
protocadherin 8
chr6_+_69233023 0.27 ENST00000604969.1
ENST00000603207.1
adhesion G protein-coupled receptor B3
chr14_+_36661852 0.25 ENST00000361487.7
paired box 9
chr7_-_13986498 0.25 ENST00000420159.6
ENST00000399357.7
ENST00000403527.5
ETS variant transcription factor 1
chr5_+_153491174 0.25 ENST00000521843.6
glutamate ionotropic receptor AMPA type subunit 1
chr7_-_29195186 0.23 ENST00000449801.5
ENST00000409850.5
carboxypeptidase vitellogenic like
chr8_-_94436926 0.20 ENST00000481490.3
fibrinogen silencer binding protein
chrX_+_41688967 0.19 ENST00000378142.9
G protein-coupled receptor 34
chr14_-_21159060 0.17 ENST00000641039.1
ENST00000641697.1
olfactory receptor family 5 subfamily AU member 1
chr10_-_33334382 0.16 ENST00000374823.9
ENST00000374821.9
ENST00000374816.7
neuropilin 1
chr6_+_12716760 0.16 ENST00000332995.12
phosphatase and actin regulator 1
chr7_+_18290416 0.15 ENST00000413509.6
histone deacetylase 9
chr2_-_2324323 0.15 ENST00000648339.1
ENST00000647694.1
myelin transcription factor 1 like
chr3_-_62374293 0.14 ENST00000486811.5
FEZ family zinc finger 2
chr6_+_121437378 0.14 ENST00000650427.1
ENST00000647564.1
gap junction protein alpha 1
chr8_+_76681208 0.13 ENST00000651372.2
zinc finger homeobox 4
chr7_-_75611702 0.13 ENST00000616821.4
ENST00000420909.1
huntingtin interacting protein 1
chr12_-_23951020 0.13 ENST00000441133.2
ENST00000545921.5
SRY-box transcription factor 5
chr8_-_28490220 0.10 ENST00000517673.5
ENST00000380254.7
ENST00000518734.5
ENST00000346498.6
F-box protein 16
chr2_-_210476687 0.10 ENST00000233714.8
ENST00000443314.5
ENST00000441020.7
ENST00000450366.7
ENST00000431941.6
LanC like 1
chr12_-_57051173 0.07 ENST00000433964.5
myosin IA
chr14_+_45135917 0.07 ENST00000267430.10
ENST00000556036.5
ENST00000542564.6
FA complementation group M
chr5_-_88883701 0.07 ENST00000636998.1
myocyte enhancer factor 2C
chr5_+_66958870 0.05 ENST00000405643.5
ENST00000407621.1
ENST00000432426.5
microtubule associated serine/threonine kinase family member 4
chrX_+_41689006 0.04 ENST00000378138.5
ENST00000620846.1
ENST00000649219.1
G protein-coupled receptor 34
chr5_-_146182591 0.04 ENST00000510191.5
ENST00000674277.1
ENST00000674447.1
ENST00000674270.1
ENST00000394434.7
ENST00000674290.1
ENST00000674398.1
ENST00000674174.1
leucyl-tRNA synthetase 1
chr5_-_146182475 0.03 ENST00000674158.1
ENST00000674191.1
ENST00000274562.13
leucyl-tRNA synthetase 1
chr7_+_141719162 0.03 ENST00000493845.1
WEE2 oocyte meiosis inhibiting kinase
chr19_-_1021114 0.03 ENST00000333175.9
ENST00000356663.8
transmembrane protein 259
chrX_-_111410420 0.03 ENST00000371993.7
ENST00000680476.1
doublecortin
chr1_-_41918858 0.02 ENST00000372583.6
HIVEP zinc finger 3
chr14_+_22501542 0.02 ENST00000390498.1
T cell receptor alpha joining 39
chr6_+_50818701 0.02 ENST00000344788.7
transcription factor AP-2 beta
chr12_-_23944301 0.01 ENST00000538083.1
SRY-box transcription factor 5
chr5_+_153490727 0.01 ENST00000340592.9
glutamate ionotropic receptor AMPA type subunit 1
chr12_-_119803383 0.01 ENST00000392520.2
ENST00000678677.1
ENST00000679249.1
ENST00000676849.1
citron rho-interacting serine/threonine kinase

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 12.5 GO:0060262 regulation of N-terminal protein palmitoylation(GO:0060254) negative regulation of N-terminal protein palmitoylation(GO:0060262) negative regulation of protein lipidation(GO:1903060)
3.0 9.0 GO:0016121 tetraterpenoid metabolic process(GO:0016108) carotenoid metabolic process(GO:0016116) carotene catabolic process(GO:0016121) xanthophyll metabolic process(GO:0016122) terpene catabolic process(GO:0046247)
2.2 8.9 GO:0032972 diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
2.1 6.4 GO:0043049 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
2.0 10.2 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
1.2 3.6 GO:0099540 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
1.0 8.4 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
1.0 18.9 GO:0001778 plasma membrane repair(GO:0001778)
0.9 6.6 GO:0033133 positive regulation of glucokinase activity(GO:0033133)
0.7 2.2 GO:0048561 establishment of organ orientation(GO:0048561)
0.7 2.7 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.6 8.8 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.5 8.5 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.5 5.0 GO:0006572 tyrosine catabolic process(GO:0006572)
0.5 1.5 GO:0070541 response to platinum ion(GO:0070541)
0.5 2.8 GO:0032902 nerve growth factor production(GO:0032902)
0.4 12.5 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.4 1.6 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
0.4 2.3 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.4 1.8 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.3 7.4 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.3 3.0 GO:0021759 globus pallidus development(GO:0021759)
0.3 1.5 GO:0030070 insulin processing(GO:0030070)
0.3 3.9 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.3 2.0 GO:0021778 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.3 2.2 GO:0072660 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 4.4 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.2 2.4 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.2 1.6 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.2 3.5 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.2 3.5 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.2 0.5 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
0.1 3.6 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 1.2 GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918)
0.1 1.0 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.1 2.6 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1 3.1 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.1 3.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.6 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.1 1.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 2.5 GO:0051775 response to redox state(GO:0051775)
0.1 0.9 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 2.9 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.1 1.2 GO:0048664 neuron fate determination(GO:0048664)
0.1 1.1 GO:1902221 L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.1 8.6 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 0.9 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.1 0.3 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 0.8 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 2.6 GO:0006625 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.1 0.8 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 1.9 GO:0042118 endothelial cell activation(GO:0042118)
0.1 1.5 GO:0007614 short-term memory(GO:0007614)
0.1 0.5 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.1 6.0 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.1 0.5 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 4.7 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.0 0.1 GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000588)
0.0 0.2 GO:0061552 vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.0 0.8 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.3 GO:0099558 maintenance of synapse structure(GO:0099558)
0.0 2.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.6 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.1 GO:0010652 regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.0 0.6 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
0.0 0.7 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.0 1.6 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 1.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.4 GO:0034214 protein hexamerization(GO:0034214)
0.0 0.6 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.0 0.6 GO:0006751 glutathione catabolic process(GO:0006751)
0.0 1.0 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.5 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.5 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.5 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0 0.9 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.4 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 2.3 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.3 GO:0021559 trigeminal nerve development(GO:0021559)
0.0 0.6 GO:0044126 regulation of growth of symbiont in host(GO:0044126)
0.0 9.6 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 0.7 GO:0007413 axonal fasciculation(GO:0007413)
0.0 1.5 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.6 GO:0048240 sperm capacitation(GO:0048240)
0.0 9.2 GO:0006936 muscle contraction(GO:0006936)
0.0 0.4 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.6 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 0.3 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.0 0.0 GO:0035038 female pronucleus assembly(GO:0035038)
0.0 0.6 GO:0045494 photoreceptor cell maintenance(GO:0045494)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 18.9 GO:0005826 actomyosin contractile ring(GO:0005826)
1.5 8.9 GO:1990584 cardiac Troponin complex(GO:1990584)
1.5 8.8 GO:0014802 terminal cisterna(GO:0014802)
0.4 18.5 GO:0005859 muscle myosin complex(GO:0005859)
0.4 8.5 GO:0016461 unconventional myosin complex(GO:0016461)
0.3 3.5 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.2 3.5 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.2 2.6 GO:0005916 fascia adherens(GO:0005916)
0.1 8.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 31.6 GO:0031674 I band(GO:0031674)
0.1 1.6 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 1.2 GO:0034709 methylosome(GO:0034709)
0.1 0.4 GO:0071547 piP-body(GO:0071547)
0.1 2.3 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 0.7 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 0.9 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 2.2 GO:0005921 gap junction(GO:0005921)
0.0 1.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.9 GO:0043034 costamere(GO:0043034)
0.0 0.4 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 1.5 GO:0005839 proteasome core complex(GO:0005839)
0.0 1.2 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.3 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 3.6 GO:0043195 terminal bouton(GO:0043195)
0.0 2.8 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.1 GO:0071821 FANCM-MHF complex(GO:0071821)
0.0 0.2 GO:0097443 sorting endosome(GO:0097443)
0.0 5.5 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.3 GO:0043083 synaptic cleft(GO:0043083)
0.0 9.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.7 GO:0016459 myosin complex(GO:0016459)
0.0 0.3 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 12.5 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
1.7 5.0 GO:0004411 homogentisate 1,2-dioxygenase activity(GO:0004411)
1.2 3.6 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
1.0 3.9 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.9 8.9 GO:0031013 troponin I binding(GO:0031013)
0.8 6.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.7 6.6 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.6 11.1 GO:0031433 telethonin binding(GO:0031433)
0.6 2.3 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923)
0.5 1.5 GO:1904854 proteasome core complex binding(GO:1904854)
0.5 6.4 GO:0050692 DBD domain binding(GO:0050692)
0.5 4.4 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.4 2.9 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.4 20.5 GO:0000146 microfilament motor activity(GO:0000146)
0.4 2.6 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.3 18.5 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.2 2.4 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.2 7.4 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.2 1.6 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 3.5 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.2 9.0 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.2 1.1 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.2 1.9 GO:0050682 AF-2 domain binding(GO:0050682)
0.2 1.6 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.2 2.8 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 0.6 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.1 1.2 GO:0044020 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243) histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.1 3.0 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.1 0.9 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.1 0.6 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 0.9 GO:0030613 oxidoreductase activity, acting on phosphorus or arsenic in donors(GO:0030613) oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor(GO:0030614)
0.1 3.5 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 18.0 GO:0003774 motor activity(GO:0003774)
0.1 0.4 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.1 6.0 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 0.9 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.1 0.3 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 1.0 GO:0008430 selenium binding(GO:0008430)
0.1 0.3 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 1.4 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 3.5 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.8 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.8 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 1.0 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.6 GO:0008142 oxysterol binding(GO:0008142)
0.0 15.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.6 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.7 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 2.2 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0071253 connexin binding(GO:0071253)
0.0 2.6 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 1.7 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.5 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.7 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 6.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.6 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.2 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.0 0.5 GO:0008301 DNA binding, bending(GO:0008301)
0.0 1.0 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.7 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.6 GO:0001637 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 1.2 GO:0002039 p53 binding(GO:0002039)
0.0 2.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 4.3 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 1.0 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 18.9 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 3.6 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 1.7 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 3.1 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 3.6 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.2 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.3 PID MYC PATHWAY C-MYC pathway
0.0 1.0 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.1 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.4 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.5 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 1.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.2 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.2 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.2 8.1 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.1 9.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 2.6 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 10.0 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 6.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 2.8 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 13.4 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 1.5 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 2.0 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.0 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.6 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 10.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.6 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 5.1 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.0 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 1.2 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.8 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.2 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.4 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 4.1 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.0 0.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.4 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 3.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.6 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.6 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.1 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation