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Illumina Body Map 2 (GSE30611)
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Results for HOXB2_UNCX_HOXD3
Z-value: 1.04
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Transcription factors associated with HOXB2_UNCX_HOXD3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXB2 | hg38_v1_chr17_-_48545077_48545117 | -0.66 | 3.6e-05 | Click! |
| HOXD3 | hg38_v1_chr2_+_176157293_176157332 | -0.25 | 1.6e-01 | Click! |
| UNCX | hg38_v1_chr7_+_1232865_1232881 | 0.24 | 1.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_+_12693327 Show fit | 3.83 |
ENST00000388918.10
|
tyrosinase related protein 1 |
|
| chr4_+_73409340 Show fit | 3.76 |
ENST00000511370.1
|
albumin |
|
| chr9_+_12695702 Show fit | 3.51 |
ENST00000381136.2
|
tyrosinase related protein 1 |
|
| chr12_-_10826358 Show fit | 3.36 |
ENST00000240619.2
|
taste 2 receptor member 10 |
|
| chrM_+_8366 Show fit | 3.31 |
ENST00000361851.1
|
mitochondrially encoded ATP synthase membrane subunit 8 |
|
| chr17_-_66229380 Show fit | 3.07 |
ENST00000205948.11
|
apolipoprotein H |
|
| chr4_-_154612635 Show fit | 2.96 |
ENST00000407946.5
ENST00000405164.5 ENST00000336098.8 ENST00000393846.6 ENST00000404648.7 ENST00000443553.5 |
fibrinogen gamma chain |
|
| chr10_-_95069489 Show fit | 2.67 |
ENST00000371270.6
ENST00000535898.5 ENST00000623108.3 |
cytochrome P450 family 2 subfamily C member 8 |
|
| chr10_-_49762335 Show fit | 2.65 |
ENST00000419399.4
ENST00000432695.2 |
oxoglutarate dehydrogenase L |
|
| chr15_+_58410543 Show fit | 2.47 |
ENST00000356113.10
ENST00000414170.7 |
lipase C, hepatic type |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB2_UNCX_HOXD3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 33.0 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.2 | 13.4 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.2 | 10.9 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.5 | 7.8 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 2.5 | 7.5 | GO:0043438 | acetoacetic acid metabolic process(GO:0043438) |
| 0.0 | 6.9 | GO:0031424 | keratinization(GO:0031424) |
| 0.2 | 6.7 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.0 | 5.1 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.8 | 4.9 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.4 | 4.9 | GO:0051918 | negative regulation of fibrinolysis(GO:0051918) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 23.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 19.0 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 16.4 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.2 | 10.3 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.2 | 9.9 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.1 | 6.8 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 6.2 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 5.7 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.5 | 5.4 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.2 | 5.3 | GO:0033162 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 24.8 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.2 | 12.8 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 8.5 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.1 | 8.2 | GO:0005549 | odorant binding(GO:0005549) |
| 0.5 | 7.8 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.2 | 7.6 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 1.9 | 7.5 | GO:0016716 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716) |
| 0.3 | 6.8 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.3 | 6.1 | GO:0008391 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 0.0 | 5.5 | GO:0008017 | microtubule binding(GO:0008017) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.2 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 6.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 5.1 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 3.7 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 2.7 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 2.5 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 2.0 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 1.6 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.6 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 1.6 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 26.1 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 12.6 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 8.7 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.5 | 8.4 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.1 | 6.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.3 | 5.9 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 4.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 4.7 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.2 | 4.6 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.1 | 4.3 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |