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Illumina Body Map 2 (GSE30611)

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Results for HOXB5

Z-value: 0.69

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Transcription factors associated with HOXB5

Gene Symbol Gene ID Gene Info
HOXB5
ENSG00000120075.6 homeobox B5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB5hg38_v1_chr17_-_48593748_48593786-0.309.6e-02Click!

Activity profile of HOXB5 motif

Sorted Z-values of HOXB5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_161223559 4.59 ENST00000469730.2
ENST00000463273.5
ENST00000464492.5
ENST00000367990.7
ENST00000470459.6
ENST00000463812.1
ENST00000468465.5
APOA2
apolipoprotein A2
chr1_-_161223408 3.14 ENST00000491350.1
APOA2
apolipoprotein A2
chr7_+_5282935 2.77 ENST00000396872.8
ENST00000444741.5
ENST00000297195.8
ENST00000406453.3
SLC29A4
solute carrier family 29 member 4
chr5_-_35047935 2.58 ENST00000510428.1
ENST00000231420.11
AGXT2
alanine--glyoxylate aminotransferase 2
chrX_+_48521817 2.40 ENST00000446158.5
ENST00000414061.1
EBP
EBP cholestenol delta-isomerase
chrX_+_48521788 2.32 ENST00000651615.1
ENST00000495186.6
ENSG00000286268.1
EBP
novel protein
EBP cholestenol delta-isomerase
chr10_-_101843765 2.10 ENST00000370046.5
KCNIP2
potassium voltage-gated channel interacting protein 2
chr10_-_101843777 2.00 ENST00000356640.7
KCNIP2
potassium voltage-gated channel interacting protein 2
chr15_-_74725370 1.75 ENST00000567032.5
ENST00000564596.5
ENST00000566503.1
ENST00000395049.8
ENST00000379727.8
ENST00000617691.4
ENST00000395048.6
CYP1A1
cytochrome P450 family 1 subfamily A member 1
chr3_-_165196689 1.61 ENST00000241274.3
SLITRK3
SLIT and NTRK like family member 3
chr3_-_127822455 1.56 ENST00000265052.10
MGLL
monoglyceride lipase
chr19_-_15934410 1.46 ENST00000326742.12
CYP4F11
cytochrome P450 family 4 subfamily F member 11
chr19_-_15934521 1.19 ENST00000402119.9
CYP4F11
cytochrome P450 family 4 subfamily F member 11
chrM_+_12329 1.16 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5
chr3_+_190563440 0.72 ENST00000453359.5
IL1RAP
interleukin 1 receptor accessory protein
chr10_+_112376193 0.68 ENST00000433418.6
ENST00000356116.6
ENST00000354273.5
ACSL5
acyl-CoA synthetase long chain family member 5
chr11_-_35419098 0.67 ENST00000606205.6
ENST00000645303.1
SLC1A2
solute carrier family 1 member 2
chr1_+_162381703 0.67 ENST00000458626.4
C1orf226
chromosome 1 open reading frame 226
chr2_-_74499583 0.64 ENST00000377566.9
LBX2
ladybird homeobox 2
chr11_+_63506046 0.63 ENST00000674247.1
LGALS12
galectin 12
chr11_-_35418966 0.61 ENST00000531628.2
SLC1A2
solute carrier family 1 member 2
chr2_-_187565751 0.61 ENST00000421427.5
TFPI
tissue factor pathway inhibitor
chr2_+_17540670 0.60 ENST00000451533.5
ENST00000295156.9
VSNL1
visinin like 1
chr17_-_7207340 0.58 ENST00000650301.1
DLG4
discs large MAGUK scaffold protein 4
chr11_+_109422174 0.55 ENST00000327419.7
C11orf87
chromosome 11 open reading frame 87
chr4_-_151325488 0.55 ENST00000604030.7
SH3D19
SH3 domain containing 19
chr1_+_235328728 0.55 ENST00000646281.1
TBCE
tubulin folding cofactor E
chr2_-_46941760 0.53 ENST00000444761.6
ENST00000409147.1
MCFD2
multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
chr3_-_187702557 0.52 ENST00000358241.1
RTP2
receptor transporter protein 2
chr3_+_51385282 0.49 ENST00000528157.7
MANF
mesencephalic astrocyte derived neurotrophic factor
chr1_+_21981099 0.48 ENST00000400277.2
CELA3B
chymotrypsin like elastase 3B
chr21_-_44262216 0.48 ENST00000270172.7
DNMT3L
DNA methyltransferase 3 like
chr9_+_4662281 0.48 ENST00000381883.5
PLPP6
phospholipid phosphatase 6
chr7_+_130381092 0.46 ENST00000484324.1
CPA1
carboxypeptidase A1
chr14_+_21030509 0.45 ENST00000481535.5
TPPP2
tubulin polymerization promoting protein family member 2
chr16_-_57971086 0.44 ENST00000564448.5
ENST00000311183.8
CNGB1
cyclic nucleotide gated channel subunit beta 1
chr2_+_17541157 0.44 ENST00000406397.1
VSNL1
visinin like 1
chr17_+_48892761 0.43 ENST00000355938.9
ENST00000393366.7
ENST00000503641.5
ENST00000514808.5
ENST00000506855.1
ATP5MC1
ATP synthase membrane subunit c locus 1
chr14_+_21030201 0.42 ENST00000321760.11
ENST00000460647.6
ENST00000530140.6
ENST00000472458.5
TPPP2
tubulin polymerization promoting protein family member 2
chr1_+_4654732 0.41 ENST00000378190.7
AJAP1
adherens junctions associated protein 1
chr11_-_57322300 0.40 ENST00000527207.1
TNKS1BP1
tankyrase 1 binding protein 1
chr16_-_57971121 0.39 ENST00000251102.13
CNGB1
cyclic nucleotide gated channel subunit beta 1
chr1_+_40691998 0.38 ENST00000534399.5
ENST00000372653.5
NFYC
nuclear transcription factor Y subunit gamma
chr2_-_46941710 0.37 ENST00000409207.5
MCFD2
multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
chrX_-_107982370 0.36 ENST00000302917.1
TEX13B
testis expressed 13B
chr12_-_52321395 0.36 ENST00000293670.3
KRT83
keratin 83
chr17_-_44066595 0.35 ENST00000585388.2
ENST00000293406.8
LSM12
LSM12 homolog
chr15_-_50765656 0.33 ENST00000261854.10
SPPL2A
signal peptide peptidase like 2A
chr19_-_13953302 0.32 ENST00000585607.1
ENST00000538517.6
ENST00000587458.1
ENST00000538371.6
PODNL1
podocan like 1
chr8_-_92095498 0.31 ENST00000520974.5
RUNX1T1
RUNX1 partner transcriptional co-repressor 1
chr6_-_107957252 0.31 ENST00000429168.1
SEC63
SEC63 homolog, protein translocation regulator
chr11_-_57322197 0.30 ENST00000532437.1
TNKS1BP1
tankyrase 1 binding protein 1
chr12_-_7665897 0.30 ENST00000229304.5
APOBEC1
apolipoprotein B mRNA editing enzyme catalytic subunit 1
chr8_-_92095432 0.29 ENST00000518954.5
RUNX1T1
RUNX1 partner transcriptional co-repressor 1
chr8_-_132085655 0.29 ENST00000262283.5
ENSG00000258417.3
novel protein
chrX_+_14529516 0.28 ENST00000218075.9
GLRA2
glycine receptor alpha 2
chr3_+_45945019 0.27 ENST00000458629.1
ENST00000457814.1
CXCR6
C-X-C motif chemokine receptor 6
chr8_-_92095410 0.26 ENST00000518823.5
RUNX1T1
RUNX1 partner transcriptional co-repressor 1
chr11_-_6030758 0.26 ENST00000641900.1
OR56A1
olfactory receptor family 56 subfamily A member 1
chr4_-_67754335 0.25 ENST00000420975.2
ENST00000226413.5
GNRHR
gonadotropin releasing hormone receptor
chr1_-_247458105 0.24 ENST00000641149.1
ENST00000641527.1
OR2B11
olfactory receptor family 2 subfamily B member 11
chr1_-_155688294 0.24 ENST00000311573.9
YY1AP1
YY1 associated protein 1
chr1_+_40691749 0.23 ENST00000372654.5
NFYC
nuclear transcription factor Y subunit gamma
chr11_-_118225086 0.22 ENST00000640745.1
JAML
junction adhesion molecule like
chr1_+_198639162 0.21 ENST00000418674.1
PTPRC
protein tyrosine phosphatase receptor type C
chr19_+_7507082 0.19 ENST00000599312.1
ENSG00000267952.1
novel transcript
chr14_+_22105305 0.19 ENST00000390453.1
TRAV24
T cell receptor alpha variable 24
chr7_+_142580911 0.19 ENST00000621184.1
TRBV12-5
T cell receptor beta variable 12-5
chr2_-_219308963 0.18 ENST00000423636.6
ENST00000442029.5
ENST00000412847.5
PTPRN
protein tyrosine phosphatase receptor type N
chr8_-_92095468 0.18 ENST00000520583.5
ENST00000519061.5
RUNX1T1
RUNX1 partner transcriptional co-repressor 1
chr11_+_4643966 0.18 ENST00000396952.6
OR51E1
olfactory receptor family 51 subfamily E member 1
chr1_+_155610218 0.17 ENST00000649846.1
ENST00000245564.8
ENST00000368341.8
MSTO1
misato mitochondrial distribution and morphology regulator 1
chr1_+_235328399 0.17 ENST00000471812.5
ENST00000358966.6
ENST00000282841.9
ENST00000391855.2
ENST00000647428.1
ENST00000645655.1
ENST00000647186.1
ENST00000646624.1
ENST00000645205.1
ENST00000645351.1
GGPS1
TBCE
geranylgeranyl diphosphate synthase 1
tubulin folding cofactor E
chr6_+_29459771 0.16 ENST00000377132.1
OR2H1
olfactory receptor family 2 subfamily H member 1
chr19_+_13151975 0.16 ENST00000588173.1
IER2
immediate early response 2
chr9_-_127937800 0.15 ENST00000373110.4
ENST00000314392.13
DPM2
dolichyl-phosphate mannosyltransferase subunit 2, regulatory
chr1_+_40691689 0.15 ENST00000427410.6
ENST00000447388.7
ENST00000425457.6
ENST00000453631.5
ENST00000456393.6
NFYC
nuclear transcription factor Y subunit gamma
chr5_-_141682211 0.15 ENST00000239440.9
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr8_-_92095598 0.15 ENST00000520724.5
ENST00000518844.5
RUNX1T1
RUNX1 partner transcriptional co-repressor 1
chr11_-_56748696 0.15 ENST00000641581.1
ENST00000641668.1
OR9G4
olfactory receptor family 9 subfamily G member 4
chr1_-_36385872 0.14 ENST00000373129.7
STK40
serine/threonine kinase 40
chr5_-_141682192 0.14 ENST00000508305.5
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr12_-_6689359 0.14 ENST00000683879.1
ZNF384
zinc finger protein 384
chr3_-_195811889 0.13 ENST00000475231.5
MUC4
mucin 4, cell surface associated
chr6_+_26021641 0.13 ENST00000617569.2
H4C1
H4 clustered histone 1
chr3_-_195811916 0.12 ENST00000463781.8
MUC4
mucin 4, cell surface associated
chr1_-_36385887 0.11 ENST00000373130.7
ENST00000373132.4
STK40
serine/threonine kinase 40
chr5_-_161546970 0.11 ENST00000675303.1
GABRB2
gamma-aminobutyric acid type A receptor subunit beta2
chr8_-_33597750 0.09 ENST00000522982.1
DUSP26
dual specificity phosphatase 26
chr5_+_150190035 0.09 ENST00000230671.7
ENST00000524041.1
SLC6A7
solute carrier family 6 member 7
chr5_-_172283743 0.08 ENST00000393792.3
UBTD2
ubiquitin domain containing 2
chr11_-_128522189 0.06 ENST00000526145.6
ETS1
ETS proto-oncogene 1, transcription factor
chr20_-_50691536 0.06 ENST00000327979.8
RIPOR3
RIPOR family member 3
chr8_+_117135259 0.04 ENST00000519688.5
SLC30A8
solute carrier family 30 member 8
chr15_+_41621134 0.04 ENST00000566718.6
MGA
MAX dimerization protein MGA
chr1_-_155688727 0.02 ENST00000404643.5
ENST00000359205.9
ENST00000407221.5
ENST00000355499.9
YY1AP1
YY1 associated protein 1
chr9_-_110208156 0.02 ENST00000400613.5
C9orf152
chromosome 9 open reading frame 152
chr15_+_41621492 0.01 ENST00000570161.6
MGA
MAX dimerization protein MGA

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.7 GO:2000910 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
0.8 4.7 GO:0033490 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.7 2.6 GO:0042361 menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
0.6 2.6 GO:0009436 glyoxylate catabolic process(GO:0009436)
0.6 1.7 GO:0043449 cellular alkene metabolic process(GO:0043449)
0.4 4.1 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.2 1.6 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 2.8 GO:1901642 nucleoside transmembrane transport(GO:1901642)
0.1 0.3 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.1 0.3 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310) regulation of mRNA modification(GO:0090365)
0.1 0.7 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.1 1.3 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 0.4 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.1 0.2 GO:1904692 positive regulation of type B pancreatic cell proliferation(GO:1904692)
0.1 0.6 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.1 0.8 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.1 0.3 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.0 0.4 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860)
0.0 0.2 GO:2000471 regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473)
0.0 0.5 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.0 0.3 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 0.2 GO:0019348 dolichol metabolic process(GO:0019348)
0.0 0.3 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.1 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.0 0.2 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0 0.6 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 1.0 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
0.0 0.7 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 1.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.2 GO:0097113 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.0 0.3 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 0.7 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 1.6 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.3 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 1.2 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.7 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.2 0.8 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 0.8 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 0.4 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1 0.3 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.1 0.2 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 1.3 GO:0030673 axolemma(GO:0030673)
0.0 0.7 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 4.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.2 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.9 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:0000247 C-8 sterol isomerase activity(GO:0000247) cholestenol delta-isomerase activity(GO:0047750)
1.5 7.7 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.5 4.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.4 2.6 GO:0008453 alanine-glyoxylate transaminase activity(GO:0008453)
0.3 1.7 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.2 2.8 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.2 0.6 GO:0030395 lactose binding(GO:0030395)
0.1 0.8 GO:0005223 intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223)
0.1 0.7 GO:0002114 interleukin-33 receptor activity(GO:0002114)
0.1 1.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 1.6 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.5 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 0.7 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 0.3 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 0.2 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0 2.6 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.3 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.3 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.7 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.1 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.0 0.1 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.3 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 1.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.2 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.3 GO:0019958 C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958)
0.0 0.1 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.1 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.0 0.3 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 4.7 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.8 PID RHODOPSIN PATHWAY Visual signal transduction: Rods

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.7 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 2.6 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 4.6 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.7 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 2.8 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.6 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.9 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.3 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.7 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.5 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.7 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.9 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.6 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 1.3 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters