ISMARA results: HOXB6

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Illumina Body Map 2 (GSE30611)

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Results for HOXB6_PRRX2

Z-value: 3.14

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Transcription factors associated with HOXB6_PRRX2

Gene Symbol	Gene ID	Gene Info
HOXB6 Ensembl NCBI GeneCards UniProt	ENSG00000108511.10	homeobox B6
PRRX2 Ensembl NCBI GeneCards UniProt	ENSG00000167157.11	paired related homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PRRX2	hg38_v1_chr9_+_129665603_129665672	-0.33	6.2e-02	Click!
HOXB6	hg38_v1_chr17_-_48604959_48605000	-0.26	1.4e-01	Click!

Activity profile of HOXB6_PRRX2 motif

Sorted Z-values of HOXB6_PRRX2 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_+_7332744 Show fit	21.63	ENST00000436368.6 ENST00000311745.9 ENST00000340209.8 ENST00000620507.4	RBFOX1 Ensembl NCBI GeneCards UniProt Show fit	RNA binding fox-1 homolog 1
chr12_-_16608183 Show fit	19.79	ENST00000354662.5 ENST00000538051.5	LMO3 Ensembl NCBI GeneCards UniProt Show fit	LIM domain only 3
chr12_-_16608073 Show fit	19.47	ENST00000441439.6	LMO3 Ensembl NCBI GeneCards UniProt Show fit	LIM domain only 3
chr2_-_49974182 Show fit	18.38	ENST00000412315.5 ENST00000378262.7	NRXN1 Ensembl NCBI GeneCards UniProt Show fit	neurexin 1
chr2_-_49974155 Show fit	18.07	ENST00000635519.1	NRXN1 Ensembl NCBI GeneCards UniProt Show fit	neurexin 1
chr7_+_107470050 Show fit	16.63	ENST00000304402.6	GPR22 Ensembl NCBI GeneCards UniProt Show fit	G protein-coupled receptor 22
chr2_+_161416273 Show fit	16.08	ENST00000389554.8	TBR1 Ensembl NCBI GeneCards UniProt Show fit	T-box brain transcription factor 1
chr16_+_7303245 Show fit	14.91	ENST00000674626.1	RBFOX1 Ensembl NCBI GeneCards UniProt Show fit	RNA binding fox-1 homolog 1
chr5_-_88824266 Show fit	14.73	ENST00000509373.1 ENST00000636541.1	MEF2C Ensembl NCBI GeneCards UniProt Show fit	myocyte enhancer factor 2C
chr4_-_175812236 Show fit	13.59	ENST00000505375.5	GPM6A Ensembl NCBI GeneCards UniProt Show fit	glycoprotein M6A
chr5_-_88824334 Show fit	13.49	ENST00000506716.5	MEF2C Ensembl NCBI GeneCards UniProt Show fit	myocyte enhancer factor 2C
chr16_+_7332839 Show fit	13.14	ENST00000355637.9	RBFOX1 Ensembl NCBI GeneCards UniProt Show fit	RNA binding fox-1 homolog 1
chr2_-_2324323 Show fit	12.52	ENST00000648339.1 ENST00000647694.1	MYT1L Ensembl NCBI GeneCards UniProt Show fit	myelin transcription factor 1 like
chr18_+_34710249 Show fit	12.18	ENST00000680346.1 ENST00000348997.9 ENST00000681274.1 ENST00000680822.1 ENST00000680767.2 ENST00000597599.5 ENST00000444659.6	DTNA Ensembl NCBI GeneCards UniProt Show fit	dystrobrevin alpha
chr4_-_175812746 Show fit	12.04	ENST00000393658.6	GPM6A Ensembl NCBI GeneCards UniProt Show fit	glycoprotein M6A
chr17_-_10518536 Show fit	11.83	ENST00000226207.6	MYH1 Ensembl NCBI GeneCards UniProt Show fit	myosin heavy chain 1
chr3_+_159069252 Show fit	11.46	ENST00000640015.1 ENST00000476809.7 ENST00000485419.7	IQCJ-SCHIP1 Ensembl NCBI GeneCards UniProt Show fit	IQCJ-SCHIP1 readthrough
chr2_-_49974083 Show fit	10.74	ENST00000636345.1	NRXN1 Ensembl NCBI GeneCards UniProt Show fit	neurexin 1
chr7_-_31340678 Show fit	10.47	ENST00000297142.4	NEUROD6 Ensembl NCBI GeneCards UniProt Show fit	neuronal differentiation 6
chr2_+_167135901 Show fit	10.10	ENST00000628543.2	XIRP2 Ensembl NCBI GeneCards UniProt Show fit	xin actin binding repeat containing 2
chr3_+_35679690 Show fit	9.90	ENST00000413378.5 ENST00000417925.5	ARPP21 Ensembl NCBI GeneCards UniProt Show fit	cAMP regulated phosphoprotein 21
chr16_+_7510102 Show fit	9.89	ENST00000682918.1 ENST00000683326.1 ENST00000570626.2	RBFOX1 Ensembl NCBI GeneCards UniProt Show fit	RNA binding fox-1 homolog 1
chr12_+_101666203 Show fit	9.76	ENST00000549608.1	MYBPC1 Ensembl NCBI GeneCards UniProt Show fit	myosin binding protein C1
chr3_+_35679614 Show fit	9.73	ENST00000474696.5 ENST00000412048.5 ENST00000396482.6 ENST00000432682.5	ARPP21 Ensembl NCBI GeneCards UniProt Show fit	cAMP regulated phosphoprotein 21
chr1_+_65264694 Show fit	9.71	ENST00000263441.11 ENST00000395325.7	DNAJC6 Ensembl NCBI GeneCards UniProt Show fit	DnaJ heat shock protein family (Hsp40) member C6
chr2_-_2324642 Show fit	9.46	ENST00000650485.1 ENST00000649207.1	MYT1L Ensembl NCBI GeneCards UniProt Show fit	myelin transcription factor 1 like
chr3_+_159839847 Show fit	9.45	ENST00000445224.6	SCHIP1 Ensembl NCBI GeneCards UniProt Show fit	schwannomin interacting protein 1
chr8_+_84705920 Show fit	8.98	ENST00000523850.5 ENST00000521376.1	RALYL Ensembl NCBI GeneCards UniProt Show fit	RALY RNA binding protein like
chr11_+_131370478 Show fit	8.97	ENST00000374791.7 ENST00000683400.1 ENST00000436745.5	NTM Ensembl NCBI GeneCards UniProt Show fit	neurotrimin
chr12_-_16606795 Show fit	8.71	ENST00000447609.5	LMO3 Ensembl NCBI GeneCards UniProt Show fit	LIM domain only 3
chr2_-_182427014 Show fit	8.53	ENST00000409365.5 ENST00000351439.9	PDE1A Ensembl NCBI GeneCards UniProt Show fit	phosphodiesterase 1A
chr2_+_209579598 Show fit	8.53	ENST00000445941.5 ENST00000673860.1	MAP2 Ensembl NCBI GeneCards UniProt Show fit	microtubule associated protein 2
chr2_-_223602284 Show fit	8.46	ENST00000421386.1 ENST00000305409.3 ENST00000433889.1	SCG2 Ensembl NCBI GeneCards UniProt Show fit	secretogranin II
chr16_-_51151259 Show fit	8.44	ENST00000251020.9	SALL1 Ensembl NCBI GeneCards UniProt Show fit	spalt like transcription factor 1
chr19_+_13023958 Show fit	8.40	ENST00000587760.5 ENST00000585575.5	NFIX Ensembl NCBI GeneCards UniProt Show fit	nuclear factor I X
chr6_+_12716554 Show fit	8.30	ENST00000676159.1	PHACTR1 Ensembl NCBI GeneCards UniProt Show fit	phosphatase and actin regulator 1
chr5_+_36606355 Show fit	8.21	ENST00000681909.1 ENST00000513903.5 ENST00000681795.1 ENST00000680125.1 ENST00000612708.5 ENST00000680232.1 ENST00000681776.1 ENST00000681926.1 ENST00000679958.1 ENST00000265113.9 ENST00000504121.5 ENST00000512374.1 ENST00000613445.5 ENST00000679983.1	SLC1A3 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 1 member 3
chr1_+_50108856 Show fit	8.13	ENST00000650764.1 ENST00000494555.2 ENST00000371824.7 ENST00000371823.8 ENST00000652693.1	ELAVL4 Ensembl NCBI GeneCards UniProt Show fit	ELAV like RNA binding protein 4
chr8_+_79611036 Show fit	8.04	ENST00000220876.12 ENST00000518111.5	STMN2 Ensembl NCBI GeneCards UniProt Show fit	stathmin 2
chr13_+_35476740 Show fit	8.02	ENST00000537702.5	NBEA Ensembl NCBI GeneCards UniProt Show fit	neurobeachin
chr3_-_73433904 Show fit	7.93	ENST00000479530.5	PDZRN3 Ensembl NCBI GeneCards UniProt Show fit	PDZ domain containing ring finger 3
chr5_-_161546708 Show fit	7.89	ENST00000393959.6	GABRB2 Ensembl NCBI GeneCards UniProt Show fit	gamma-aminobutyric acid type A receptor subunit beta2
chr2_-_174846405 Show fit	7.86	ENST00000409597.5 ENST00000413882.6	CHN1 Ensembl NCBI GeneCards UniProt Show fit	chimerin 1
chr18_-_55422306 Show fit	7.64	ENST00000566777.5 ENST00000626584.2	TCF4 Ensembl NCBI GeneCards UniProt Show fit	transcription factor 4
chr5_+_174724549 Show fit	7.64	ENST00000239243.7 ENST00000507785.2	MSX2 Ensembl NCBI GeneCards UniProt Show fit	msh homeobox 2
chr18_-_26657401 Show fit	7.39	ENST00000580191.5	KCTD1 Ensembl NCBI GeneCards UniProt Show fit	potassium channel tetramerization domain containing 1
chr12_-_16609869 Show fit	7.21	ENST00000534946.5	LMO3 Ensembl NCBI GeneCards UniProt Show fit	LIM domain only 3
chr2_-_77522347 Show fit	7.09	ENST00000409093.1 ENST00000409884.6 ENST00000409088.3	LRRTM4 Ensembl NCBI GeneCards UniProt Show fit	leucine rich repeat transmembrane neuronal 4
chrM_+_9207 Show fit	7.03	ENST00000362079.2	MT-CO3 Ensembl NCBI GeneCards UniProt Show fit	mitochondrially encoded cytochrome c oxidase III
chr13_-_83882390 Show fit	7.02	ENST00000377084.3	SLITRK1 Ensembl NCBI GeneCards UniProt Show fit	SLIT and NTRK like family member 1
chr10_+_24466487 Show fit	6.98	ENST00000396446.5 ENST00000396445.5 ENST00000376451.4	KIAA1217 Ensembl NCBI GeneCards UniProt Show fit	KIAA1217
chrX_+_136197020 Show fit	6.86	ENST00000370676.7	FHL1 Ensembl NCBI GeneCards UniProt Show fit	four and a half LIM domains 1
chr7_+_114414997 Show fit	6.85	ENST00000462331.5 ENST00000393491.7 ENST00000403559.8 ENST00000408937.7 ENST00000393498.6 ENST00000393495.7 ENST00000378237.7	FOXP2 Ensembl NCBI GeneCards UniProt Show fit	forkhead box P2
chr7_-_84492718 Show fit	6.80	ENST00000424555.5	SEMA3A Ensembl NCBI GeneCards UniProt Show fit	semaphorin 3A
chr8_+_78591222 Show fit	6.80	ENST00000518467.1	PKIA Ensembl NCBI GeneCards UniProt Show fit	cAMP-dependent protein kinase inhibitor alpha
chr3_+_111998915 Show fit	6.80	ENST00000478951.6	TAGLN3 Ensembl NCBI GeneCards UniProt Show fit	transgelin 3
chr12_-_16605939 Show fit	6.79	ENST00000541295.5 ENST00000535535.5	LMO3 Ensembl NCBI GeneCards UniProt Show fit	LIM domain only 3
chrX_+_136169624 Show fit	6.78	ENST00000394153.6	FHL1 Ensembl NCBI GeneCards UniProt Show fit	four and a half LIM domains 1
chr3_+_111998739 Show fit	6.74	ENST00000393917.6 ENST00000273368.8	TAGLN3 Ensembl NCBI GeneCards UniProt Show fit	transgelin 3
chr1_-_217076889 Show fit	6.67	ENST00000493748.5 ENST00000463665.5	ESRRG Ensembl NCBI GeneCards UniProt Show fit	estrogen related receptor gamma
chr18_-_55422492 Show fit	6.67	ENST00000561992.5 ENST00000630712.2	TCF4 Ensembl NCBI GeneCards UniProt Show fit	transcription factor 4
chrX_+_28587411 Show fit	6.66	ENST00000378993.6	IL1RAPL1 Ensembl NCBI GeneCards UniProt Show fit	interleukin 1 receptor accessory protein like 1
chr18_+_34593312 Show fit	6.62	ENST00000591816.6 ENST00000588125.5 ENST00000684610.1 ENST00000683705.1 ENST00000598334.5 ENST00000588684.5 ENST00000554864.7 ENST00000399121.9 ENST00000595022.5	DTNA Ensembl NCBI GeneCards UniProt Show fit	dystrobrevin alpha
chr5_-_161546970 Show fit	6.56	ENST00000675303.1	GABRB2 Ensembl NCBI GeneCards UniProt Show fit	gamma-aminobutyric acid type A receptor subunit beta2
chr5_+_162067458 Show fit	6.50	ENST00000639975.1 ENST00000639111.2 ENST00000639683.1	GABRG2 Ensembl NCBI GeneCards UniProt Show fit	gamma-aminobutyric acid type A receptor subunit gamma2
chr1_+_50103903 Show fit	6.46	ENST00000371827.5	ELAVL4 Ensembl NCBI GeneCards UniProt Show fit	ELAV like RNA binding protein 4
chr8_-_42501224 Show fit	6.41	ENST00000520262.6 ENST00000517366.1	SLC20A2 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 20 member 2
chr2_+_209580024 Show fit	6.38	ENST00000392194.5	MAP2 Ensembl NCBI GeneCards UniProt Show fit	microtubule associated protein 2
chr13_-_83882456 Show fit	6.33	ENST00000674365.1	SLITRK1 Ensembl NCBI GeneCards UniProt Show fit	SLIT and NTRK like family member 1
chr11_-_16356538 Show fit	6.30	ENST00000683767.1	SOX6 Ensembl NCBI GeneCards UniProt Show fit	SRY-box transcription factor 6
chr1_-_216723437 Show fit	6.28	ENST00000459955.5 ENST00000366937.5 ENST00000391890.7	ESRRG Ensembl NCBI GeneCards UniProt Show fit	estrogen related receptor gamma
chr2_-_2324968 Show fit	6.25	ENST00000649641.1	MYT1L Ensembl NCBI GeneCards UniProt Show fit	myelin transcription factor 1 like
chr1_-_203086001 Show fit	6.24	ENST00000241651.5	MYOG Ensembl NCBI GeneCards UniProt Show fit	myogenin
chr18_-_3874270 Show fit	6.17	ENST00000400149.7 ENST00000400155.5 ENST00000400150.7	DLGAP1 Ensembl NCBI GeneCards UniProt Show fit	DLG associated protein 1
chr12_-_16606102 Show fit	6.15	ENST00000537304.6	LMO3 Ensembl NCBI GeneCards UniProt Show fit	LIM domain only 3
chr2_+_181985846 Show fit	6.12	ENST00000682840.1 ENST00000409137.7 ENST00000280295.7	PPP1R1C Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase 1 regulatory inhibitor subunit 1C
chr6_+_12716760 Show fit	6.09	ENST00000332995.12	PHACTR1 Ensembl NCBI GeneCards UniProt Show fit	phosphatase and actin regulator 1
chr3_+_111999189 Show fit	6.09	ENST00000455401.6	TAGLN3 Ensembl NCBI GeneCards UniProt Show fit	transgelin 3
chr13_+_77741212 Show fit	6.09	ENST00000441784.5	SLAIN1 Ensembl NCBI GeneCards UniProt Show fit	SLAIN motif family member 1
chr12_+_78977785 Show fit	6.03	ENST00000551304.5	SYT1 Ensembl NCBI GeneCards UniProt Show fit	synaptotagmin 1
chr5_-_124748800 Show fit	5.95	ENST00000509799.5	ZNF608 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 608
chr5_-_88883701 Show fit	5.95	ENST00000636998.1	MEF2C Ensembl NCBI GeneCards UniProt Show fit	myocyte enhancer factor 2C
chr12_-_99154867 Show fit	5.94	ENST00000549025.6	ANKS1B Ensembl NCBI GeneCards UniProt Show fit	ankyrin repeat and sterile alpha motif domain containing 1B
chrX_+_136197039 Show fit	5.85	ENST00000370683.6	FHL1 Ensembl NCBI GeneCards UniProt Show fit	four and a half LIM domains 1
chr13_-_35855758 Show fit	5.80	ENST00000615680.4	DCLK1 Ensembl NCBI GeneCards UniProt Show fit	doublecortin like kinase 1
chr5_-_97142579 Show fit	5.79	ENST00000274382.9	LIX1 Ensembl NCBI GeneCards UniProt Show fit	limb and CNS expressed 1
chr2_+_165572329 Show fit	5.79	ENST00000342316.8	CSRNP3 Ensembl NCBI GeneCards UniProt Show fit	cysteine and serine rich nuclear protein 3
chr2_+_209579399 Show fit	5.77	ENST00000360351.8	MAP2 Ensembl NCBI GeneCards UniProt Show fit	microtubule associated protein 2
chr2_-_157325808 Show fit	5.67	ENST00000410096.6 ENST00000420719.6 ENST00000409216.5 ENST00000419116.2	ERMN Ensembl NCBI GeneCards UniProt Show fit	ermin
chr5_-_24644968 Show fit	5.63	ENST00000264463.8	CDH10 Ensembl NCBI GeneCards UniProt Show fit	cadherin 10
chr5_+_162067764 Show fit	5.55	ENST00000639213.2 ENST00000414552.6	GABRG2 Ensembl NCBI GeneCards UniProt Show fit	gamma-aminobutyric acid type A receptor subunit gamma2
chr3_+_173398438 Show fit	5.55	ENST00000457714.5	NLGN1 Ensembl NCBI GeneCards UniProt Show fit	neuroligin 1
chrX_+_136169891 Show fit	5.54	ENST00000449474.5	FHL1 Ensembl NCBI GeneCards UniProt Show fit	four and a half LIM domains 1
chr5_+_162067500 Show fit	5.49	ENST00000639384.1 ENST00000640985.1 ENST00000638772.1	GABRG2 Ensembl NCBI GeneCards UniProt Show fit	gamma-aminobutyric acid type A receptor subunit gamma2
chrM_+_5824 Show fit	5.47	ENST00000361624.2	MT-CO1 Ensembl NCBI GeneCards UniProt Show fit	mitochondrially encoded cytochrome c oxidase I
chrX_+_136169664 Show fit	5.44	ENST00000456445.5	FHL1 Ensembl NCBI GeneCards UniProt Show fit	four and a half LIM domains 1
chr18_-_24311495 Show fit	5.41	ENST00000357041.8	OSBPL1A Ensembl NCBI GeneCards UniProt Show fit	oxysterol binding protein like 1A
chr2_-_2324935 Show fit	5.41	ENST00000649709.1	MYT1L Ensembl NCBI GeneCards UniProt Show fit	myelin transcription factor 1 like
chr13_-_102401599 Show fit	5.39	ENST00000376131.8	FGF14 Ensembl NCBI GeneCards UniProt Show fit	fibroblast growth factor 14
chr5_-_41794211 Show fit	5.39	ENST00000512084.5	OXCT1 Ensembl NCBI GeneCards UniProt Show fit	3-oxoacid CoA-transferase 1
chrX_+_136169833 Show fit	5.34	ENST00000628032.2	FHL1 Ensembl NCBI GeneCards UniProt Show fit	four and a half LIM domains 1
chr13_-_35476682 Show fit	5.33	ENST00000379919.6	MAB21L1 Ensembl NCBI GeneCards UniProt Show fit	mab-21 like 1
chr5_-_88883420 Show fit	5.28	ENST00000437473.6	MEF2C Ensembl NCBI GeneCards UniProt Show fit	myocyte enhancer factor 2C
chr22_-_35840577 Show fit	5.27	ENST00000405409.6	RBFOX2 Ensembl NCBI GeneCards UniProt Show fit	RNA binding fox-1 homolog 2
chr3_+_69936583 Show fit	5.23	ENST00000314557.10 ENST00000394351.9	MITF Ensembl NCBI GeneCards UniProt Show fit	melanocyte inducing transcription factor
chrX_+_136196750 Show fit	5.19	ENST00000539015.5	FHL1 Ensembl NCBI GeneCards UniProt Show fit	four and a half LIM domains 1
chr5_+_161850597 Show fit	5.18	ENST00000634335.1 ENST00000635880.1	GABRA1 Ensembl NCBI GeneCards UniProt Show fit	gamma-aminobutyric acid type A receptor subunit alpha1
chr10_-_20897288 Show fit	5.16	ENST00000377122.9	NEBL Ensembl NCBI GeneCards UniProt Show fit	nebulette
chr11_-_83682385 Show fit	5.15	ENST00000426717.6	DLG2 Ensembl NCBI GeneCards UniProt Show fit	discs large MAGUK scaffold protein 2
chr18_+_31591869 Show fit	5.14	ENST00000237014.8	TTR Ensembl NCBI GeneCards UniProt Show fit	transthyretin
chr5_-_161546671 Show fit	5.08	ENST00000517547.5	GABRB2 Ensembl NCBI GeneCards UniProt Show fit	gamma-aminobutyric acid type A receptor subunit beta2
chr13_-_35855627 Show fit	5.06	ENST00000379893.5	DCLK1 Ensembl NCBI GeneCards UniProt Show fit	doublecortin like kinase 1
chr3_+_35679638 Show fit	5.05	ENST00000432450.5	ARPP21 Ensembl NCBI GeneCards UniProt Show fit	cAMP regulated phosphoprotein 21
chr18_-_3845321 Show fit	5.02	ENST00000539435.5 ENST00000400147.6	DLGAP1 Ensembl NCBI GeneCards UniProt Show fit	DLG associated protein 1
chr6_+_12957301 Show fit	5.01	ENST00000676234.1	PHACTR1 Ensembl NCBI GeneCards UniProt Show fit	phosphatase and actin regulator 1
chr12_+_80707625 Show fit	5.00	ENST00000228641.4	MYF6 Ensembl NCBI GeneCards UniProt Show fit	myogenic factor 6
chr6_-_46325641 Show fit	4.98	ENST00000330430.10 ENST00000405162.2	RCAN2 Ensembl NCBI GeneCards UniProt Show fit	regulator of calcineurin 2
chrM_+_10759 Show fit	4.98	ENST00000361381.2	MT-ND4 Ensembl NCBI GeneCards UniProt Show fit	mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4
chr12_-_86256299 Show fit	4.97	ENST00000552808.6 ENST00000547225.5	MGAT4C Ensembl NCBI GeneCards UniProt Show fit	MGAT4 family member C
chr4_+_157220691 Show fit	4.97	ENST00000509417.5 ENST00000645636.1 ENST00000296526.12 ENST00000264426.14	GRIA2 Ensembl NCBI GeneCards UniProt Show fit	glutamate ionotropic receptor AMPA type subunit 2
chr18_+_34493289 Show fit	4.94	ENST00000682923.1 ENST00000596745.5 ENST00000283365.14 ENST00000315456.10 ENST00000598774.6 ENST00000684266.1 ENST00000683092.1 ENST00000683379.1 ENST00000684359.1	DTNA Ensembl NCBI GeneCards UniProt Show fit	dystrobrevin alpha
chr3_-_197184131 Show fit	4.92	ENST00000452595.5	DLG1 Ensembl NCBI GeneCards UniProt Show fit	discs large MAGUK scaffold protein 1
chr3_+_63443306 Show fit	4.92	ENST00000472899.5 ENST00000479198.5 ENST00000460711.5 ENST00000465156.1	SYNPR Ensembl NCBI GeneCards UniProt Show fit	synaptoporin
chr16_-_29899532 Show fit	4.91	ENST00000308713.9 ENST00000617533.5	SEZ6L2 Ensembl NCBI GeneCards UniProt Show fit	seizure related 6 homolog like 2
chr9_+_127264740 Show fit	4.90	ENST00000373387.9	GARNL3 Ensembl NCBI GeneCards UniProt Show fit	GTPase activating Rap/RanGAP domain like 3
chr12_-_16607087 Show fit	4.89	ENST00000540445.5	LMO3 Ensembl NCBI GeneCards UniProt Show fit	LIM domain only 3
chr18_+_34710307 Show fit	4.88	ENST00000679796.1	DTNA Ensembl NCBI GeneCards UniProt Show fit	dystrobrevin alpha
chr11_-_85627322 Show fit	4.88	ENST00000376104.7	DLG2 Ensembl NCBI GeneCards UniProt Show fit	discs large MAGUK scaffold protein 2
chr7_+_123601815 Show fit	4.85	ENST00000451215.6	ASB15 Ensembl NCBI GeneCards UniProt Show fit	ankyrin repeat and SOCS box containing 15
chr4_+_41612892 Show fit	4.84	ENST00000509454.5 ENST00000396595.7 ENST00000381753.8	LIMCH1 Ensembl NCBI GeneCards UniProt Show fit	LIM and calponin homology domains 1
chr7_-_108240049 Show fit	4.83	ENST00000379022.8	NRCAM Ensembl NCBI GeneCards UniProt Show fit	neuronal cell adhesion molecule
chr9_+_100442271 Show fit	4.81	ENST00000502978.1	MSANTD3-TMEFF1 Ensembl NCBI GeneCards UniProt Show fit	MSANTD3-TMEFF1 readthrough
chr8_-_40897814 Show fit	4.81	ENST00000297737.11 ENST00000315769.11	ZMAT4 Ensembl NCBI GeneCards UniProt Show fit	zinc finger matrin-type 4
chr2_+_54558348 Show fit	4.81	ENST00000333896.5	SPTBN1 Ensembl NCBI GeneCards UniProt Show fit	spectrin beta, non-erythrocytic 1
chr15_+_62561361 Show fit	4.81	ENST00000561311.5	TLN2 Ensembl NCBI GeneCards UniProt Show fit	talin 2
chr11_-_31804067 Show fit	4.78	ENST00000639548.1 ENST00000640125.1 ENST00000481563.6 ENST00000639079.1 ENST00000638762.1 ENST00000638346.1	PAX6 Ensembl NCBI GeneCards UniProt Show fit	paired box 6
chr22_-_35840218 Show fit	4.77	ENST00000414461.6 ENST00000416721.6 ENST00000449924.6 ENST00000262829.11 ENST00000397305.3	RBFOX2 Ensembl NCBI GeneCards UniProt Show fit	RNA binding fox-1 homolog 2
chr10_+_24239181 Show fit	4.75	ENST00000438429.5	KIAA1217 Ensembl NCBI GeneCards UniProt Show fit	KIAA1217
chr4_+_41256921 Show fit	4.73	ENST00000284440.9 ENST00000508768.5 ENST00000512788.1	UCHL1 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin C-terminal hydrolase L1
chr4_+_87832917 Show fit	4.73	ENST00000395102.8 ENST00000497649.6 ENST00000540395.1 ENST00000560249.5 ENST00000511670.5 ENST00000361056.3	MEPE Ensembl NCBI GeneCards UniProt Show fit	matrix extracellular phosphoglycoprotein
chr8_-_18887018 Show fit	4.70	ENST00000523619.5	PSD3 Ensembl NCBI GeneCards UniProt Show fit	pleckstrin and Sec7 domain containing 3
chr18_-_55422290 Show fit	4.68	ENST00000625925.2	TCF4 Ensembl NCBI GeneCards UniProt Show fit	transcription factor 4
chr11_-_129192291 Show fit	4.64	ENST00000682385.1	ARHGAP32 Ensembl NCBI GeneCards UniProt Show fit	Rho GTPase activating protein 32
chr2_-_77522320 Show fit	4.64	ENST00000409911.5	LRRTM4 Ensembl NCBI GeneCards UniProt Show fit	leucine rich repeat transmembrane neuronal 4
chr12_-_117361641 Show fit	4.62	ENST00000618760.4	NOS1 Ensembl NCBI GeneCards UniProt Show fit	nitric oxide synthase 1
chr2_+_169509693 Show fit	4.58	ENST00000284669.2	KLHL41 Ensembl NCBI GeneCards UniProt Show fit	kelch like family member 41
chr4_-_152352800 Show fit	4.58	ENST00000393956.9	FBXW7 Ensembl NCBI GeneCards UniProt Show fit	F-box and WD repeat domain containing 7
chr20_+_10218948 Show fit	4.56	ENST00000430336.1	SNAP25 Ensembl NCBI GeneCards UniProt Show fit	synaptosome associated protein 25
chr21_-_34526850 Show fit	4.55	ENST00000481448.5 ENST00000381132.6	RCAN1 Ensembl NCBI GeneCards UniProt Show fit	regulator of calcineurin 1
chr5_-_88823763 Show fit	4.54	ENST00000635898.1 ENST00000626391.2 ENST00000628656.2	MEF2C Ensembl NCBI GeneCards UniProt Show fit	myocyte enhancer factor 2C
chr7_+_123601836 Show fit	4.54	ENST00000434204.5	ASB15 Ensembl NCBI GeneCards UniProt Show fit	ankyrin repeat and SOCS box containing 15
chr5_+_137867852 Show fit	4.51	ENST00000421631.6 ENST00000239926.9	MYOT Ensembl NCBI GeneCards UniProt Show fit	myotilin
chr14_-_64879900 Show fit	4.50	ENST00000644917.1 ENST00000389720.4	SPTB Ensembl NCBI GeneCards UniProt Show fit	spectrin beta, erythrocytic
chr4_-_185956348 Show fit	4.50	ENST00000431902.5 ENST00000284776.11 ENST00000415274.5	SORBS2 Ensembl NCBI GeneCards UniProt Show fit	sorbin and SH3 domain containing 2
chr17_-_10549612 Show fit	4.48	ENST00000532183.6 ENST00000397183.6 ENST00000420805.1	MYH2 Ensembl NCBI GeneCards UniProt Show fit	myosin heavy chain 2
chr1_-_101846957 Show fit	4.46	ENST00000338858.9	OLFM3 Ensembl NCBI GeneCards UniProt Show fit	olfactomedin 3
chr2_-_142131004 Show fit	4.46	ENST00000434794.1 ENST00000389484.8	LRP1B Ensembl NCBI GeneCards UniProt Show fit	LDL receptor related protein 1B
chr12_-_16610037 Show fit	4.45	ENST00000540590.1	LMO3 Ensembl NCBI GeneCards UniProt Show fit	LIM domain only 3
chr3_+_111999326 Show fit	4.42	ENST00000494932.1	TAGLN3 Ensembl NCBI GeneCards UniProt Show fit	transgelin 3
chr2_-_151973780 Show fit	4.41	ENST00000637514.1 ENST00000636350.1 ENST00000434468.2 ENST00000637762.1 ENST00000637779.1 ENST00000637547.1 ENST00000636901.1 ENST00000397327.7 ENST00000636721.1 ENST00000636380.1 ENST00000637284.1 ENST00000636617.1 ENST00000636947.1 ENST00000638091.1 ENST00000636108.1 ENST00000638040.1 ENST00000636773.1 ENST00000637418.1 ENST00000637216.1	CACNB4 Ensembl NCBI GeneCards UniProt Show fit	calcium voltage-gated channel auxiliary subunit beta 4
chr11_-_84273188 Show fit	4.40	ENST00000330014.11 ENST00000418306.6 ENST00000531015.5	DLG2 Ensembl NCBI GeneCards UniProt Show fit	discs large MAGUK scaffold protein 2
chr3_+_42149222 Show fit	4.40	ENST00000449246.5 ENST00000613405.4	TRAK1 Ensembl NCBI GeneCards UniProt Show fit	trafficking kinesin protein 1
chr11_-_8263858 Show fit	4.38	ENST00000534484.1 ENST00000335790.8	LMO1 Ensembl NCBI GeneCards UniProt Show fit	LIM domain only 1
chr14_+_28766755 Show fit	4.37	ENST00000313071.7	FOXG1 Ensembl NCBI GeneCards UniProt Show fit	forkhead box G1
chr6_-_56851888 Show fit	4.36	ENST00000312431.10 ENST00000520645.5	DST Ensembl NCBI GeneCards UniProt Show fit	dystonin
chr6_-_6006878 Show fit	4.36	ENST00000244766.7	NRN1 Ensembl NCBI GeneCards UniProt Show fit	neuritin 1
chr12_+_78863962 Show fit	4.35	ENST00000393240.7	SYT1 Ensembl NCBI GeneCards UniProt Show fit	synaptotagmin 1
chr6_-_75493629 Show fit	4.32	ENST00000393004.6	FILIP1 Ensembl NCBI GeneCards UniProt Show fit	filamin A interacting protein 1
chr18_+_61333424 Show fit	4.30	ENST00000262717.9	CDH20 Ensembl NCBI GeneCards UniProt Show fit	cadherin 20
chr5_-_88884525 Show fit	4.30	ENST00000502983.5	MEF2C Ensembl NCBI GeneCards UniProt Show fit	myocyte enhancer factor 2C
chr7_+_28412511 Show fit	4.30	ENST00000357727.7	CREB5 Ensembl NCBI GeneCards UniProt Show fit	cAMP responsive element binding protein 5
chr6_+_12957347 Show fit	4.28	ENST00000482982.2	PHACTR1 Ensembl NCBI GeneCards UniProt Show fit	phosphatase and actin regulator 1
chr2_-_212538841 Show fit	4.28	ENST00000436443.5	ERBB4 Ensembl NCBI GeneCards UniProt Show fit	erb-b2 receptor tyrosine kinase 4
chr12_+_80716906 Show fit	4.27	ENST00000228644.4	MYF5 Ensembl NCBI GeneCards UniProt Show fit	myogenic factor 5
chrX_-_32412220 Show fit	4.27	ENST00000619831.5	DMD Ensembl NCBI GeneCards UniProt Show fit	dystrophin
chr10_-_67696115 Show fit	4.27	ENST00000433211.7	CTNNA3 Ensembl NCBI GeneCards UniProt Show fit	catenin alpha 3
chr3_-_197183806 Show fit	4.24	ENST00000671246.1 ENST00000660553.1	DLG1 Ensembl NCBI GeneCards UniProt Show fit	discs large MAGUK scaffold protein 1
chrM_+_8489 Show fit	4.22	ENST00000361899.2	MT-ATP6 Ensembl NCBI GeneCards UniProt Show fit	mitochondrially encoded ATP synthase membrane subunit 6
chr2_+_173090598 Show fit	4.22	ENST00000422149.1	MAP3K20 Ensembl NCBI GeneCards UniProt Show fit	mitogen-activated protein kinase kinase kinase 20
chr19_+_13024573 Show fit	4.21	ENST00000358552.7 ENST00000360105.8 ENST00000588228.5 ENST00000676441.1 ENST00000591028.1	NFIX Ensembl NCBI GeneCards UniProt Show fit	nuclear factor I X
chr21_+_33025927 Show fit	4.21	ENST00000430860.1 ENST00000382357.4 ENST00000333337.3	OLIG2 Ensembl NCBI GeneCards UniProt Show fit	oligodendrocyte transcription factor 2
chr4_+_71339014 Show fit	4.18	ENST00000340595.4	SLC4A4 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 4 member 4
chr5_+_173890545 Show fit	4.17	ENST00000519152.5	CPEB4 Ensembl NCBI GeneCards UniProt Show fit	cytoplasmic polyadenylation element binding protein 4
chr10_+_68109433 Show fit	4.15	ENST00000613327.4 ENST00000358913.10 ENST00000373675.3	MYPN Ensembl NCBI GeneCards UniProt Show fit	myopalladin
chr11_-_35420050 Show fit	4.15	ENST00000395753.6 ENST00000395750.6 ENST00000645634.1	SLC1A2 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 1 member 2
chr1_+_151060357 Show fit	4.13	ENST00000368921.5	MLLT11 Ensembl NCBI GeneCards UniProt Show fit	MLLT11 transcription factor 7 cofactor
chr1_+_204870831 Show fit	4.12	ENST00000404076.5 ENST00000539706.6	NFASC Ensembl NCBI GeneCards UniProt Show fit	neurofascin
chr2_+_172860038 Show fit	4.12	ENST00000538974.5 ENST00000540783.5	RAPGEF4 Ensembl NCBI GeneCards UniProt Show fit	Rap guanine nucleotide exchange factor 4
chr3_+_69936629 Show fit	4.12	ENST00000394348.2 ENST00000531774.1	MITF Ensembl NCBI GeneCards UniProt Show fit	melanocyte inducing transcription factor
chr18_+_58341038 Show fit	4.11	ENST00000679791.1	NEDD4L Ensembl NCBI GeneCards UniProt Show fit	NEDD4 like E3 ubiquitin protein ligase
chr1_+_160190567 Show fit	4.10	ENST00000368078.8	CASQ1 Ensembl NCBI GeneCards UniProt Show fit	calsequestrin 1
chr12_-_117361614 Show fit	4.08	ENST00000317775.11	NOS1 Ensembl NCBI GeneCards UniProt Show fit	nitric oxide synthase 1
chr10_-_60389833 Show fit	4.08	ENST00000280772.7	ANK3 Ensembl NCBI GeneCards UniProt Show fit	ankyrin 3
chr12_+_78864768 Show fit	4.07	ENST00000261205.9 ENST00000457153.6	SYT1 Ensembl NCBI GeneCards UniProt Show fit	synaptotagmin 1
chr3_+_156120572 Show fit	4.07	ENST00000389636.9 ENST00000490337.6	KCNAB1 Ensembl NCBI GeneCards UniProt Show fit	potassium voltage-gated channel subfamily A member regulatory beta subunit 1
chr5_-_150289941 Show fit	4.06	ENST00000682786.1	CAMK2A Ensembl NCBI GeneCards UniProt Show fit	calcium/calmodulin dependent protein kinase II alpha
chr18_-_43277482 Show fit	4.05	ENST00000255224.8 ENST00000590752.5 ENST00000596867.1	SYT4 Ensembl NCBI GeneCards UniProt Show fit	synaptotagmin 4
chr15_+_51377247 Show fit	4.04	ENST00000396399.6	GLDN Ensembl NCBI GeneCards UniProt Show fit	gliomedin
chr9_+_84669707 Show fit	4.02	ENST00000277120.8 ENST00000323115.10	NTRK2 Ensembl NCBI GeneCards UniProt Show fit	neurotrophic receptor tyrosine kinase 2
chr17_-_10549652 Show fit	3.97	ENST00000245503.10	MYH2 Ensembl NCBI GeneCards UniProt Show fit	myosin heavy chain 2

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB6_PRRX2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
7.2	79.6	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
5.0	55.2	GO:0003138	primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
3.6	10.9	GO:0021758	caudate nucleus development(GO:0021757) putamen development(GO:0021758)
3.6	54.6	GO:0097116	gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
3.6	21.3	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
2.8	19.9	GO:0021764	amygdala development(GO:0021764)
2.8	16.8	GO:0098923	retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543)
2.3	6.9	GO:0099540	synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
2.2	11.1	GO:0061034	olfactory bulb mitral cell layer development(GO:0061034)
2.2	10.8	GO:1901846	positive regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901846)
2.1	6.2	GO:0014873	response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
2.0	8.0	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
2.0	57.4	GO:0071420	cellular response to histamine(GO:0071420)
2.0	13.8	GO:0021778	oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
1.9	7.6	GO:0051795	embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795)
1.8	7.3	GO:1990926	short-term synaptic potentiation(GO:1990926)
1.8	1.8	GO:1990927	calcium ion regulated lysosome exocytosis(GO:1990927)
1.8	5.4	GO:0043438	acetoacetic acid metabolic process(GO:0043438)
1.6	25.6	GO:0014809	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
1.5	17.0	GO:0036371	protein localization to T-tubule(GO:0036371)
1.5	6.1	GO:1903045	neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
1.5	4.6	GO:0044007	negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage(GO:0010768) transmission of virus(GO:0019089) dissemination or transmission of symbiont from host(GO:0044007) dissemination or transmission of organism from other organism involved in symbiotic interaction(GO:0051821)
1.5	6.0	GO:1902261	positive regulation of delayed rectifier potassium channel activity(GO:1902261)
1.5	6.0	GO:2000638	regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
1.4	7.0	GO:0061026	cardiac muscle tissue regeneration(GO:0061026)
1.4	1.4	GO:0048686	regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
1.3	10.2	GO:1900383	regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
1.2	20.5	GO:1903764	regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760) regulation of potassium ion export across plasma membrane(GO:1903764)
1.2	18.7	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
1.1	3.4	GO:0021763	subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) superior vena cava morphogenesis(GO:0060578)
1.1	9.0	GO:0010650	positive regulation of cell communication by electrical coupling(GO:0010650)
1.1	8.9	GO:0030241	skeletal muscle myosin thick filament assembly(GO:0030241)
1.1	4.4	GO:0098957	anterograde axonal transport of mitochondrion(GO:0098957)
1.1	6.6	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
1.1	5.5	GO:2000866	positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
1.0	8.3	GO:0046952	ketone body catabolic process(GO:0046952)
1.0	10.0	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
1.0	10.9	GO:0051611	negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
1.0	14.5	GO:0071688	striated muscle myosin thick filament assembly(GO:0071688)
0.9	7.6	GO:0061709	reticulophagy(GO:0061709)
0.9	11.3	GO:0021902	commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.9	2.8	GO:0036323	vascular endothelial growth factor receptor-1 signaling pathway(GO:0036323)
0.9	9.2	GO:0097338	response to clozapine(GO:0097338)
0.9	6.3	GO:0099558	maintenance of synapse structure(GO:0099558)
0.9	15.1	GO:0003322	pancreatic A cell development(GO:0003322)
0.9	12.9	GO:1901843	positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.9	2.6	GO:1904638	cellular response to nitrite(GO:0071250) response to nitrite(GO:0080033) positive regulation of mitochondrial DNA metabolic process(GO:1901860) glomerular visceral epithelial cell apoptotic process(GO:1903210) regulation of glomerular visceral epithelial cell apoptotic process(GO:1904633) positive regulation of glomerular visceral epithelial cell apoptotic process(GO:1904635) response to resveratrol(GO:1904638) cellular response to resveratrol(GO:1904639) positive regulation of progesterone biosynthetic process(GO:2000184)
0.8	18.6	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.8	1.7	GO:0060024	rhythmic synaptic transmission(GO:0060024)
0.8	5.9	GO:2000821	regulation of grooming behavior(GO:2000821)
0.8	5.9	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.8	35.3	GO:0097120	receptor localization to synapse(GO:0097120)
0.8	6.4	GO:0033353	S-adenosylmethionine cycle(GO:0033353)
0.8	8.6	GO:0060385	axonogenesis involved in innervation(GO:0060385)
0.8	8.4	GO:0086024	adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.7	11.9	GO:0001778	plasma membrane repair(GO:0001778)
0.7	2.2	GO:0002121	inter-male aggressive behavior(GO:0002121)
0.7	3.7	GO:0046013	regulation of T cell homeostatic proliferation(GO:0046013)
0.7	5.0	GO:0018032	protein amidation(GO:0018032)
0.7	4.3	GO:0030240	skeletal muscle thin filament assembly(GO:0030240)
0.7	3.5	GO:0014886	transition between slow and fast fiber(GO:0014886)
0.7	9.7	GO:0016191	synaptic vesicle uncoating(GO:0016191)
0.7	7.8	GO:0048245	eosinophil chemotaxis(GO:0048245)
0.7	2.0	GO:0072579	molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579)
0.6	5.7	GO:0051589	negative regulation of neurotransmitter transport(GO:0051589)
0.6	57.8	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.6	52.6	GO:1901016	regulation of potassium ion transmembrane transporter activity(GO:1901016)
0.6	1.8	GO:0042245	RNA repair(GO:0042245)
0.6	6.1	GO:0051835	positive regulation of synapse structural plasticity(GO:0051835)
0.6	1.8	GO:1901877	regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.6	35.2	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.6	6.7	GO:0097105	presynaptic membrane assembly(GO:0097105)
0.6	10.3	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)
0.6	15.5	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.6	5.4	GO:0007197	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.6	4.7	GO:0007412	axon target recognition(GO:0007412)
0.6	14.7	GO:0046069	cGMP catabolic process(GO:0046069)
0.6	2.4	GO:0010645	regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.6	3.5	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.6	3.5	GO:1900042	positive regulation of interleukin-2 secretion(GO:1900042)
0.6	4.5	GO:2000670	positive regulation of dendritic cell apoptotic process(GO:2000670)
0.6	9.4	GO:0090091	positive regulation of extracellular matrix disassembly(GO:0090091)
0.6	2.8	GO:0048388	endosomal lumen acidification(GO:0048388)
0.5	4.1	GO:0001550	ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
0.5	3.1	GO:1902897	regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.5	6.7	GO:0061669	spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.5	34.9	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
0.5	7.1	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.5	2.9	GO:0098886	modification of dendritic spine(GO:0098886)
0.5	2.9	GO:0072092	ureteric bud invasion(GO:0072092)
0.5	5.7	GO:0071313	cellular response to caffeine(GO:0071313)
0.5	5.1	GO:0021740	trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740)
0.5	6.8	GO:0070327	thyroid hormone transport(GO:0070327)
0.5	2.7	GO:0033133	positive regulation of glucokinase activity(GO:0033133)
0.5	2.3	GO:0035022	positive regulation of Rac protein signal transduction(GO:0035022)
0.4	2.7	GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.4	1.8	GO:1902498	regulation of protein autoubiquitination(GO:1902498)
0.4	6.1	GO:0021860	pyramidal neuron development(GO:0021860)
0.4	23.1	GO:0048665	neuron fate specification(GO:0048665)
0.4	4.3	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.4	10.2	GO:0002091	negative regulation of receptor internalization(GO:0002091)
0.4	5.8	GO:2000291	regulation of myoblast proliferation(GO:2000291)
0.4	0.8	GO:0086004	regulation of cardiac muscle cell contraction(GO:0086004)
0.4	6.9	GO:0008627	intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.4	8.2	GO:0071578	zinc II ion transmembrane import(GO:0071578)
0.4	7.3	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.4	1.6	GO:0000921	septin ring assembly(GO:0000921) septin ring organization(GO:0031106)
0.4	2.8	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
0.4	2.4	GO:0008628	hormone-mediated apoptotic signaling pathway(GO:0008628)
0.4	16.8	GO:0060074	synapse maturation(GO:0060074)
0.4	3.6	GO:0007406	negative regulation of neuroblast proliferation(GO:0007406)
0.4	2.0	GO:0010513	positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.4	4.0	GO:0048743	positive regulation of skeletal muscle fiber development(GO:0048743)
0.4	2.0	GO:0007206	phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.4	3.5	GO:0035494	SNARE complex disassembly(GO:0035494)
0.4	2.7	GO:1903215	negative regulation of protein targeting to mitochondrion(GO:1903215)
0.4	8.0	GO:0048935	peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.4	3.3	GO:0014718	positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
0.4	1.5	GO:0072023	thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.4	1.5	GO:0060529	ectoderm and mesoderm interaction(GO:0007499) squamous basal epithelial stem cell differentiation involved in prostate gland acinus development(GO:0060529)
0.4	1.1	GO:0031550	positive regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031550)
0.4	2.9	GO:0060087	relaxation of vascular smooth muscle(GO:0060087)
0.4	8.2	GO:0008090	retrograde axonal transport(GO:0008090)
0.4	1.4	GO:2000393	negative regulation of lamellipodium morphogenesis(GO:2000393)
0.3	2.4	GO:0090324	negative regulation of oxidative phosphorylation(GO:0090324)
0.3	1.4	GO:0071963	establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.3	0.7	GO:0035054	embryonic heart tube anterior/posterior pattern specification(GO:0035054)
0.3	7.7	GO:0007021	tubulin complex assembly(GO:0007021)
0.3	6.3	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.3	6.8	GO:2000480	negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.3	27.4	GO:0048384	retinoic acid receptor signaling pathway(GO:0048384)
0.3	3.8	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
0.3	1.3	GO:0097156	fasciculation of motor neuron axon(GO:0097156)
0.3	6.3	GO:0097151	positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.3	2.2	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.3	4.3	GO:0038166	angiotensin-activated signaling pathway(GO:0038166)
0.3	2.8	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.3	0.6	GO:0021965	spinal cord ventral commissure morphogenesis(GO:0021965)
0.3	1.5	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.3	3.0	GO:0035881	amacrine cell differentiation(GO:0035881)
0.3	2.4	GO:0003025	regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025)
0.3	8.0	GO:0021542	dentate gyrus development(GO:0021542)
0.3	1.2	GO:1903770	regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208) negative regulation of single strand break repair(GO:1903517) negative regulation of beta-galactosidase activity(GO:1903770) telomere single strand break repair(GO:1903823) negative regulation of telomere single strand break repair(GO:1903824)
0.3	1.7	GO:1900454	positive regulation of long term synaptic depression(GO:1900454)
0.3	6.3	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.3	3.4	GO:0019227	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.3	1.1	GO:0036367	adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.3	1.1	GO:1904381	Golgi apparatus mannose trimming(GO:1904381)
0.3	2.0	GO:0048664	neuron fate determination(GO:0048664)
0.3	1.1	GO:0070092	regulation of glucagon secretion(GO:0070092)
0.3	2.8	GO:0061732	mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.3	1.7	GO:0006127	glycerophosphate shuttle(GO:0006127)
0.3	1.9	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.3	1.4	GO:0023016	signal transduction by trans-phosphorylation(GO:0023016)
0.3	0.8	GO:1903598	positive regulation of gap junction assembly(GO:1903598)
0.3	10.7	GO:0008038	neuron recognition(GO:0008038)
0.3	0.8	GO:1903015	regulation of exo-alpha-sialidase activity(GO:1903015)
0.3	21.3	GO:0051965	positive regulation of synapse assembly(GO:0051965)
0.3	2.2	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.3	1.1	GO:0072137	condensed mesenchymal cell proliferation(GO:0072137)
0.3	1.1	GO:0002314	germinal center B cell differentiation(GO:0002314)
0.3	1.6	GO:0040034	regulation of development, heterochronic(GO:0040034) regulation of timing of cell differentiation(GO:0048505)
0.3	12.2	GO:0070884	regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.3	0.8	GO:0048561	establishment of organ orientation(GO:0048561)
0.3	18.3	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.3	0.8	GO:0051389	inactivation of MAPKK activity(GO:0051389)
0.3	4.0	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.2	24.1	GO:0021954	central nervous system neuron development(GO:0021954)
0.2	2.2	GO:0051694	pointed-end actin filament capping(GO:0051694)
0.2	1.0	GO:1990168	protein K33-linked deubiquitination(GO:1990168)
0.2	0.2	GO:1990709	presynaptic active zone organization(GO:1990709)
0.2	4.1	GO:0030043	actin filament fragmentation(GO:0030043)
0.2	2.6	GO:0021984	adenohypophysis development(GO:0021984)
0.2	11.1	GO:0003301	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.2	1.7	GO:0051012	microtubule sliding(GO:0051012)
0.2	2.3	GO:0055048	regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.2	2.8	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.2	6.0	GO:0051531	NFAT protein import into nucleus(GO:0051531)
0.2	1.1	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.2	0.5	GO:0098712	L-glutamate import across plasma membrane(GO:0098712)
0.2	1.8	GO:0046604	positive regulation of mitotic centrosome separation(GO:0046604)
0.2	2.0	GO:0072221	distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221)
0.2	0.9	GO:0036269	swimming behavior(GO:0036269)
0.2	1.1	GO:1900039	positive regulation of cellular response to hypoxia(GO:1900039)
0.2	0.6	GO:0046108	uridine metabolic process(GO:0046108)
0.2	1.3	GO:0035948	positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.2	1.5	GO:0044245	polysaccharide digestion(GO:0044245)
0.2	11.4	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
0.2	3.3	GO:0089711	L-glutamate transmembrane transport(GO:0089711)
0.2	1.7	GO:0051684	maintenance of Golgi location(GO:0051684)
0.2	1.4	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.2	1.4	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.2	6.9	GO:0008045	motor neuron axon guidance(GO:0008045)
0.2	1.0	GO:0032764	negative regulation of mast cell cytokine production(GO:0032764)
0.2	0.4	GO:0031290	retinal ganglion cell axon guidance(GO:0031290)
0.2	1.8	GO:0021681	cerebellar granular layer development(GO:0021681)
0.2	2.6	GO:0045794	negative regulation of cell volume(GO:0045794)
0.2	0.4	GO:1902358	sulfate transmembrane transport(GO:1902358)
0.2	11.1	GO:1901379	regulation of potassium ion transmembrane transport(GO:1901379)
0.2	1.2	GO:0008354	germ cell migration(GO:0008354)
0.2	5.0	GO:0051901	positive regulation of mitochondrial depolarization(GO:0051901)
0.2	1.0	GO:1990523	bone regeneration(GO:1990523)
0.2	1.0	GO:0038026	reelin-mediated signaling pathway(GO:0038026)
0.2	1.5	GO:1902514	regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.2	1.5	GO:1901558	response to metformin(GO:1901558)
0.2	1.5	GO:0097475	motor neuron migration(GO:0097475)
0.2	2.4	GO:1902902	negative regulation of autophagosome assembly(GO:1902902)
0.2	1.7	GO:0070459	prolactin secretion(GO:0070459)
0.2	30.9	GO:0043149	contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.2	3.7	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.2	1.1	GO:0015692	lead ion transport(GO:0015692)
0.2	2.8	GO:0032596	protein transport into membrane raft(GO:0032596)
0.2	0.7	GO:0052651	monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.2	1.8	GO:0016264	gap junction assembly(GO:0016264)
0.2	1.8	GO:0035507	regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.2	3.6	GO:0042340	keratan sulfate catabolic process(GO:0042340)
0.2	13.6	GO:0055008	cardiac muscle tissue morphogenesis(GO:0055008)
0.2	2.5	GO:2001224	positive regulation of neuron migration(GO:2001224)
0.2	0.4	GO:1903774	positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.2	0.5	GO:0035990	tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.2	1.1	GO:2000329	negative regulation of T-helper 17 cell lineage commitment(GO:2000329)
0.2	2.0	GO:1901731	positive regulation of platelet aggregation(GO:1901731)
0.2	3.1	GO:0061339	establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
0.2	7.8	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.2	1.0	GO:1900126	negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.2	0.5	GO:2001045	negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.2	6.5	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.2	3.1	GO:0006527	arginine catabolic process(GO:0006527)
0.2	7.6	GO:1901385	regulation of voltage-gated calcium channel activity(GO:1901385)
0.2	3.7	GO:0030502	negative regulation of bone mineralization(GO:0030502)
0.2	3.0	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880)
0.2	0.3	GO:0061394	regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.2	1.8	GO:0048739	cardiac muscle fiber development(GO:0048739)
0.2	0.8	GO:0046116	queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.2	3.1	GO:0098719	sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.2	30.9	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2	2.9	GO:0055003	cardiac myofibril assembly(GO:0055003)
0.2	2.2	GO:0010667	negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.2	0.6	GO:0016119	carotene metabolic process(GO:0016119)
0.2	3.1	GO:1900745	positive regulation of p38MAPK cascade(GO:1900745)
0.2	0.8	GO:2000169	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) regulation of peptidyl-cysteine S-nitrosylation(GO:2000169)
0.2	1.1	GO:0036343	psychomotor behavior(GO:0036343) motor behavior(GO:0061744)
0.2	1.2	GO:1904885	beta-catenin destruction complex assembly(GO:1904885)
0.2	1.7	GO:0006216	cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.2	2.3	GO:0007258	JUN phosphorylation(GO:0007258)
0.2	0.9	GO:0001956	positive regulation of neurotransmitter secretion(GO:0001956)
0.2	0.6	GO:0038018	Wnt receptor catabolic process(GO:0038018)
0.1	1.2	GO:0038044	transforming growth factor-beta secretion(GO:0038044)
0.1	6.5	GO:0030318	melanocyte differentiation(GO:0030318)
0.1	0.3	GO:0097325	melanocyte proliferation(GO:0097325)
0.1	8.6	GO:0097352	autophagosome maturation(GO:0097352)
0.1	5.9	GO:0010107	potassium ion import(GO:0010107)
0.1	3.6	GO:0006688	glycosphingolipid biosynthetic process(GO:0006688)
0.1	0.4	GO:0032877	positive regulation of DNA endoreduplication(GO:0032877)
0.1	4.4	GO:0007628	adult walking behavior(GO:0007628)
0.1	1.0	GO:0031161	phosphatidylinositol catabolic process(GO:0031161)
0.1	0.7	GO:0070358	actin polymerization-dependent cell motility(GO:0070358)
0.1	1.3	GO:1904220	regulation of serine C-palmitoyltransferase activity(GO:1904220)
0.1	1.2	GO:0043314	negative regulation of neutrophil degranulation(GO:0043314)
0.1	1.8	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1	5.2	GO:0014047	glutamate secretion(GO:0014047)
0.1	0.5	GO:0042427	serotonin biosynthetic process(GO:0042427)
0.1	2.4	GO:0045793	positive regulation of cell size(GO:0045793)
0.1	0.9	GO:0010455	positive regulation of cell fate commitment(GO:0010455)
0.1	0.4	GO:0072675	osteoclast fusion(GO:0072675)
0.1	2.0	GO:2000300	regulation of synaptic vesicle exocytosis(GO:2000300)
0.1	3.8	GO:0002230	positive regulation of defense response to virus by host(GO:0002230)
0.1	0.5	GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.1	0.5	GO:1903593	regulation of histamine secretion by mast cell(GO:1903593)
0.1	4.3	GO:0007019	microtubule depolymerization(GO:0007019)
0.1	0.7	GO:0071386	cellular response to corticosterone stimulus(GO:0071386)
0.1	7.3	GO:0060997	dendritic spine morphogenesis(GO:0060997)
0.1	0.9	GO:0035610	protein side chain deglutamylation(GO:0035610)
0.1	1.4	GO:0010801	negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.1	7.4	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.1	1.3	GO:0010832	negative regulation of myotube differentiation(GO:0010832)
0.1	0.9	GO:0003148	outflow tract septum morphogenesis(GO:0003148)
0.1	1.3	GO:2001214	positive regulation of vasculogenesis(GO:2001214)
0.1	8.0	GO:0019933	cAMP-mediated signaling(GO:0019933)
0.1	0.5	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.1	0.9	GO:0014807	regulation of somitogenesis(GO:0014807)
0.1	0.7	GO:0002317	plasma cell differentiation(GO:0002317)
0.1	1.8	GO:0001542	ovulation from ovarian follicle(GO:0001542)
0.1	0.8	GO:0006196	AMP catabolic process(GO:0006196)
0.1	2.5	GO:0050951	sensory perception of temperature stimulus(GO:0050951)
0.1	0.5	GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.1	1.2	GO:0010748	regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.1	1.1	GO:0032233	positive regulation of actin filament bundle assembly(GO:0032233)
0.1	0.9	GO:0010166	wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.1	0.7	GO:2000507	positive regulation of energy homeostasis(GO:2000507)
0.1	0.6	GO:0060754	positive regulation of mast cell chemotaxis(GO:0060754)
0.1	2.3	GO:0007216	G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.1	11.1	GO:1902476	chloride transmembrane transport(GO:1902476)
0.1	0.3	GO:0061536	glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1	1.5	GO:0061635	regulation of protein complex stability(GO:0061635)
0.1	0.5	GO:1904428	negative regulation of tubulin deacetylation(GO:1904428)
0.1	0.5	GO:0090362	positive regulation of platelet-derived growth factor production(GO:0090362)
0.1	1.1	GO:0007617	mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.1	4.3	GO:0051693	actin filament capping(GO:0051693)
0.1	2.2	GO:0006020	inositol metabolic process(GO:0006020)
0.1	6.6	GO:1904893	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1	2.3	GO:0046710	GDP metabolic process(GO:0046710)
0.1	1.4	GO:0032228	regulation of synaptic transmission, GABAergic(GO:0032228)
0.1	1.5	GO:0015824	proline transport(GO:0015824)
0.1	0.5	GO:1900108	growth plate cartilage chondrocyte proliferation(GO:0003419) negative regulation of nodal signaling pathway(GO:1900108)
0.1	1.3	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.1	7.8	GO:0015701	bicarbonate transport(GO:0015701)
0.1	18.3	GO:0034605	cellular response to heat(GO:0034605)
0.1	0.6	GO:0015705	iodide transport(GO:0015705)
0.1	0.5	GO:0009099	branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.1	0.2	GO:1902896	terminal web assembly(GO:1902896)
0.1	0.6	GO:0048050	post-embryonic eye morphogenesis(GO:0048050)
0.1	0.5	GO:0035063	nuclear speck organization(GO:0035063)
0.1	0.9	GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.1	0.6	GO:0046223	mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.1	9.1	GO:0006501	C-terminal protein lipidation(GO:0006501)
0.1	1.4	GO:0051775	response to redox state(GO:0051775)
0.1	0.5	GO:1903566	positive regulation of protein localization to cilium(GO:1903566)
0.1	1.5	GO:0018298	protein-chromophore linkage(GO:0018298)
0.1	1.0	GO:0048339	paraxial mesoderm development(GO:0048339)
0.1	0.9	GO:0031339	negative regulation of vesicle fusion(GO:0031339)
0.1	1.3	GO:0042090	interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.1	1.1	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.1	1.2	GO:0015874	norepinephrine transport(GO:0015874)
0.1	8.4	GO:0031032	actomyosin structure organization(GO:0031032)
0.1	0.6	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1	1.0	GO:0007084	mitotic nuclear envelope reassembly(GO:0007084)
0.1	0.4	GO:0008218	bioluminescence(GO:0008218)
0.1	2.5	GO:0030325	adrenal gland development(GO:0030325)
0.1	0.4	GO:0044339	canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.1	0.5	GO:0032468	Golgi calcium ion homeostasis(GO:0032468)
0.1	2.0	GO:0009649	entrainment of circadian clock(GO:0009649)
0.1	0.6	GO:2000124	endocannabinoid signaling pathway(GO:0071926) regulation of endocannabinoid signaling pathway(GO:2000124)
0.1	0.5	GO:0051451	myoblast migration(GO:0051451)
0.1	0.4	GO:0042138	meiotic DNA double-strand break formation(GO:0042138)
0.1	2.1	GO:0044342	type B pancreatic cell proliferation(GO:0044342)
0.1	1.4	GO:0043508	negative regulation of JUN kinase activity(GO:0043508)
0.1	1.1	GO:0035873	lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.1	2.3	GO:0015695	organic cation transport(GO:0015695)
0.1	5.8	GO:0050806	positive regulation of synaptic transmission(GO:0050806)
0.1	1.1	GO:0006700	C21-steroid hormone biosynthetic process(GO:0006700)
0.1	0.4	GO:0010727	negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.1	2.2	GO:0050919	negative chemotaxis(GO:0050919)
0.1	0.4	GO:2000543	positive regulation of gastrulation(GO:2000543)
0.1	0.4	GO:0019474	L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.1	1.2	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1	0.3	GO:0046485	ether lipid metabolic process(GO:0046485)
0.1	1.6	GO:0051602	response to electrical stimulus(GO:0051602)
0.1	3.5	GO:0030032	lamellipodium assembly(GO:0030032)
0.1	19.2	GO:0065004	protein-DNA complex assembly(GO:0065004)
0.1	0.4	GO:0090527	actin filament reorganization(GO:0090527)
0.1	2.6	GO:0050771	negative regulation of axonogenesis(GO:0050771)
0.1	0.5	GO:0019236	response to pheromone(GO:0019236)
0.1	1.4	GO:0006004	fucose metabolic process(GO:0006004)
0.1	2.2	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.1	2.2	GO:0045773	positive regulation of axon extension(GO:0045773)
0.1	1.3	GO:0010991	regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.1	0.6	GO:0035020	regulation of Rac protein signal transduction(GO:0035020)
0.1	3.5	GO:0006699	bile acid biosynthetic process(GO:0006699)
0.1	1.3	GO:0014912	negative regulation of smooth muscle cell migration(GO:0014912)
0.1	2.5	GO:0046676	negative regulation of insulin secretion(GO:0046676)
0.1	0.8	GO:0031953	negative regulation of protein autophosphorylation(GO:0031953)
0.1	0.5	GO:0010968	regulation of microtubule nucleation(GO:0010968)
0.1	2.5	GO:0071300	cellular response to retinoic acid(GO:0071300)
0.1	0.5	GO:0061298	retina vasculature development in camera-type eye(GO:0061298)
0.1	0.8	GO:0000380	alternative mRNA splicing, via spliceosome(GO:0000380)
0.1	0.1	GO:0031947	negative regulation of glucocorticoid metabolic process(GO:0031944) regulation of glucocorticoid biosynthetic process(GO:0031946) negative regulation of glucocorticoid biosynthetic process(GO:0031947) negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of hormone metabolic process(GO:0032351) negative regulation of hormone biosynthetic process(GO:0032353) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of steroid hormone biosynthetic process(GO:0090032) regulation of cortisol biosynthetic process(GO:2000064) negative regulation of cortisol biosynthetic process(GO:2000065)
0.1	0.4	GO:0035865	cellular response to potassium ion(GO:0035865)
0.1	6.5	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.1	12.2	GO:0006936	muscle contraction(GO:0006936)
0.1	0.2	GO:0097210	response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.1	0.3	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1	1.6	GO:1903779	regulation of cardiac conduction(GO:1903779)
0.0	0.6	GO:0031116	positive regulation of microtubule polymerization(GO:0031116)
0.0	0.6	GO:0071285	cellular response to lithium ion(GO:0071285)
0.0	0.2	GO:0036438	maintenance of lens transparency(GO:0036438)
0.0	2.1	GO:0086010	membrane depolarization during action potential(GO:0086010)
0.0	0.6	GO:0007635	chemosensory behavior(GO:0007635)
0.0	3.1	GO:0000186	activation of MAPKK activity(GO:0000186)
0.0	1.3	GO:0006309	apoptotic DNA fragmentation(GO:0006309)
0.0	0.3	GO:0007168	receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0	1.3	GO:0015671	oxygen transport(GO:0015671)
0.0	1.6	GO:0007528	neuromuscular junction development(GO:0007528)
0.0	0.6	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0	0.3	GO:0042026	protein refolding(GO:0042026)
0.0	0.4	GO:1901314	negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.0	6.5	GO:0046718	viral entry into host cell(GO:0046718)
0.0	1.0	GO:0003334	keratinocyte development(GO:0003334)
0.0	1.5	GO:0009408	response to heat(GO:0009408)
0.0	0.1	GO:0097534	lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535) regulation of positive thymic T cell selection(GO:1902232)
0.0	8.8	GO:0035023	regulation of Rho protein signal transduction(GO:0035023)
0.0	1.1	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.0	0.1	GO:0021937	cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.0	0.1	GO:0002940	tRNA N2-guanine methylation(GO:0002940)
0.0	0.8	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	3.9	GO:0030832	regulation of actin polymerization or depolymerization(GO:0008064) regulation of actin filament length(GO:0030832)
0.0	0.1	GO:0033504	floor plate development(GO:0033504)
0.0	0.6	GO:0046135	pyrimidine nucleoside catabolic process(GO:0046135)
0.0	3.5	GO:0010923	negative regulation of phosphatase activity(GO:0010923)
0.0	0.5	GO:0042226	interleukin-6 biosynthetic process(GO:0042226)
0.0	0.4	GO:0006657	CDP-choline pathway(GO:0006657)
0.0	0.4	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902176)
0.0	0.1	GO:1902109	negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.0	1.4	GO:0032728	positive regulation of interferon-beta production(GO:0032728)
0.0	0.6	GO:1903861	positive regulation of dendrite extension(GO:1903861)
0.0	2.5	GO:0080171	lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0	0.8	GO:0042744	hydrogen peroxide catabolic process(GO:0042744)
0.0	4.8	GO:0008360	regulation of cell shape(GO:0008360)
0.0	0.2	GO:0070345	negative regulation of fat cell proliferation(GO:0070345)
0.0	1.1	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0	0.5	GO:2000828	post-embryonic body morphogenesis(GO:0040032) regulation of parathyroid hormone secretion(GO:2000828)
0.0	0.4	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0	0.2	GO:0007068	negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
0.0	0.4	GO:0030041	actin filament polymerization(GO:0030041)
0.0	0.0	GO:0021847	ventricular zone neuroblast division(GO:0021847)
0.0	0.9	GO:0008053	mitochondrial fusion(GO:0008053)
0.0	0.4	GO:0046325	negative regulation of glucose import(GO:0046325)
0.0	0.1	GO:0030263	apoptotic chromosome condensation(GO:0030263)
0.0	0.1	GO:0032815	negative regulation of natural killer cell activation(GO:0032815)
0.0	0.2	GO:0060005	vestibular reflex(GO:0060005)
0.0	1.3	GO:0015698	inorganic anion transport(GO:0015698)
0.0	0.2	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.9	GO:0006783	heme biosynthetic process(GO:0006783)
0.0	0.3	GO:0034214	protein hexamerization(GO:0034214)
0.0	0.6	GO:0045332	phospholipid translocation(GO:0045332)
0.0	0.6	GO:0060325	face morphogenesis(GO:0060325)
0.0	0.1	GO:0045229	cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.0	0.7	GO:0007520	myoblast fusion(GO:0007520)
0.0	0.7	GO:0032211	negative regulation of telomere maintenance via telomerase(GO:0032211)
0.0	0.6	GO:0002323	natural killer cell activation involved in immune response(GO:0002323)
0.0	0.1	GO:0001967	suckling behavior(GO:0001967)
0.0	6.8	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0	1.9	GO:1903955	positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0	0.2	GO:2000628	regulation of miRNA metabolic process(GO:2000628)
0.0	0.1	GO:0010714	positive regulation of collagen metabolic process(GO:0010714) positive regulation of collagen biosynthetic process(GO:0032967) positive regulation of multicellular organismal metabolic process(GO:0044253)
0.0	0.2	GO:2000269	regulation of fibroblast apoptotic process(GO:2000269)
0.0	1.0	GO:0045540	regulation of cholesterol biosynthetic process(GO:0045540)
0.0	0.1	GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0	0.1	GO:0032439	endosome localization(GO:0032439)
0.0	0.6	GO:0043392	negative regulation of DNA binding(GO:0043392)
0.0	0.3	GO:0050982	detection of mechanical stimulus(GO:0050982)
0.0	1.3	GO:0019722	calcium-mediated signaling(GO:0019722)
0.0	5.1	GO:0043413	protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.0	1.1	GO:0018210	peptidyl-threonine phosphorylation(GO:0018107) peptidyl-threonine modification(GO:0018210)
0.0	0.5	GO:0061512	protein localization to cilium(GO:0061512)
0.0	0.1	GO:0018095	protein polyglutamylation(GO:0018095)
0.0	0.2	GO:0006069	ethanol oxidation(GO:0006069)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.2	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.8	31.0	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)
2.4	21.3	GO:0060201	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
1.7	8.7	GO:1990425	ryanodine receptor complex(GO:1990425)
1.6	6.6	GO:0045259	mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
1.6	26.9	GO:0016013	syntrophin complex(GO:0016013)
1.4	5.7	GO:0032127	dense core granule membrane(GO:0032127)
1.4	62.1	GO:1902711	GABA-A receptor complex(GO:1902711)
1.4	4.1	GO:0014802	terminal cisterna(GO:0014802)
1.2	11.8	GO:0005826	actomyosin contractile ring(GO:0005826)
1.2	4.7	GO:0005863	striated muscle myosin thick filament(GO:0005863)
1.1	7.6	GO:0098843	postsynaptic endocytic zone(GO:0098843)
1.0	7.3	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
1.0	2.9	GO:0097444	spine apparatus(GO:0097444)
0.9	16.8	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.9	20.5	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.9	8.2	GO:0031673	H zone(GO:0031673)
0.9	20.2	GO:0032982	myosin filament(GO:0032982)
0.9	2.6	GO:1990844	subsarcolemmal mitochondrion(GO:1990843) interfibrillar mitochondrion(GO:1990844)
0.8	6.6	GO:0005916	fascia adherens(GO:0005916)
0.8	4.1	GO:0097454	Schwann cell microvillus(GO:0097454)
0.8	6.0	GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.7	8.7	GO:0033269	internode region of axon(GO:0033269)
0.7	15.5	GO:0045277	respiratory chain complex IV(GO:0045277)
0.7	2.6	GO:0034685	integrin alphav-beta6 complex(GO:0034685)
0.6	43.8	GO:0031430	M band(GO:0031430)
0.6	5.7	GO:1990578	perinuclear endoplasmic reticulum membrane(GO:1990578)
0.6	17.3	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.6	1.7	GO:0048237	rough endoplasmic reticulum lumen(GO:0048237)
0.6	15.4	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.5	34.7	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.5	22.7	GO:0044295	axonal growth cone(GO:0044295)
0.5	4.5	GO:0098839	postsynaptic density membrane(GO:0098839)
0.5	82.2	GO:0042734	presynaptic membrane(GO:0042734)
0.5	3.5	GO:0032279	asymmetric synapse(GO:0032279)
0.5	8.5	GO:0031045	dense core granule(GO:0031045)
0.5	8.8	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.4	7.6	GO:0098563	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.4	10.9	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.4	11.9	GO:0010369	chromocenter(GO:0010369)
0.4	1.3	GO:0035841	growing cell tip(GO:0035838) new growing cell tip(GO:0035841)
0.4	2.1	GO:0097232	lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.4	7.0	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.4	137.9	GO:0045211	postsynaptic membrane(GO:0045211)
0.4	2.7	GO:0032584	growth cone membrane(GO:0032584)
0.4	4.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.4	3.6	GO:0012510	trans-Golgi network transport vesicle membrane(GO:0012510)
0.3	9.2	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.3	4.3	GO:0005828	kinetochore microtubule(GO:0005828)
0.3	7.2	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.3	4.8	GO:0043194	axon initial segment(GO:0043194)
0.3	1.1	GO:0044305	calyx of Held(GO:0044305)
0.3	4.1	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.3	1.4	GO:0072534	perineuronal net(GO:0072534)
0.3	14.2	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.3	100.7	GO:0098794	postsynapse(GO:0098794)
0.3	56.0	GO:0042383	sarcolemma(GO:0042383)
0.3	5.2	GO:0048786	presynaptic active zone(GO:0048786)
0.3	2.8	GO:0070852	cell body fiber(GO:0070852)
0.2	83.8	GO:0005802	trans-Golgi network(GO:0005802)
0.2	16.0	GO:0005747	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2	1.7	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.2	2.3	GO:0055028	cortical microtubule(GO:0055028)
0.2	2.8	GO:0005750	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.2	8.2	GO:0030673	axolemma(GO:0030673)
0.2	38.1	GO:0030018	Z disc(GO:0030018)
0.2	2.8	GO:0031466	Cul5-RING ubiquitin ligase complex(GO:0031466)
0.2	1.4	GO:0043034	costamere(GO:0043034)
0.2	0.7	GO:0060342	photoreceptor inner segment membrane(GO:0060342)
0.2	2.8	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.2	1.0	GO:0071149	TEAD-1-YAP complex(GO:0071148) TEAD-2-YAP complex(GO:0071149)
0.2	0.6	GO:0005592	collagen type XI trimer(GO:0005592)
0.2	2.2	GO:0043198	dendritic shaft(GO:0043198)
0.2	1.4	GO:0000308	cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.2	1.1	GO:0070826	paraferritin complex(GO:0070826)
0.2	1.3	GO:0032144	4-aminobutyrate transaminase complex(GO:0032144)
0.2	2.0	GO:0071439	clathrin complex(GO:0071439)
0.2	1.8	GO:0035253	ciliary rootlet(GO:0035253)
0.2	4.4	GO:0005640	nuclear outer membrane(GO:0005640)
0.1	1.2	GO:1990909	Wnt signalosome(GO:1990909)
0.1	9.1	GO:1904115	axon cytoplasm(GO:1904115)
0.1	1.0	GO:0016600	flotillin complex(GO:0016600)
0.1	3.6	GO:0005922	connexon complex(GO:0005922)
0.1	5.1	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.1	2.3	GO:0097433	dense body(GO:0097433)
0.1	6.4	GO:0030669	clathrin-coated endocytic vesicle membrane(GO:0030669)
0.1	0.7	GO:0032591	dendritic spine membrane(GO:0032591)
0.1	7.3	GO:0005801	cis-Golgi network(GO:0005801)
0.1	0.9	GO:0070695	FHF complex(GO:0070695)
0.1	2.6	GO:0005861	troponin complex(GO:0005861)
0.1	28.1	GO:0031225	anchored component of membrane(GO:0031225)
0.1	1.5	GO:0031211	serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1	0.3	GO:1990622	CHOP-ATF3 complex(GO:1990622)
0.1	3.9	GO:0031594	neuromuscular junction(GO:0031594)
0.1	17.9	GO:0030427	site of polarized growth(GO:0030427)
0.1	2.4	GO:0070469	respiratory chain(GO:0070469)
0.1	5.8	GO:0034707	chloride channel complex(GO:0034707)
0.1	0.8	GO:0071144	SMAD2-SMAD3 protein complex(GO:0071144)
0.1	0.9	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	1.2	GO:0070187	telosome(GO:0070187)
0.1	1.3	GO:0060076	excitatory synapse(GO:0060076)
0.1	0.7	GO:0032444	activin responsive factor complex(GO:0032444)
0.1	0.8	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1	22.3	GO:0032993	protein-DNA complex(GO:0032993)
0.1	10.2	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.1	1.4	GO:0005859	muscle myosin complex(GO:0005859)
0.1	2.2	GO:0036379	striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.1	0.2	GO:1990357	terminal web(GO:1990357)
0.1	1.1	GO:0030118	clathrin coat(GO:0030118)
0.1	6.2	GO:0005771	multivesicular body(GO:0005771)
0.1	0.6	GO:0071942	XPC complex(GO:0071942)
0.1	1.9	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1	1.6	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
0.1	0.6	GO:0070545	PeBoW complex(GO:0070545)
0.1	0.9	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.1	2.7	GO:0035371	microtubule plus-end(GO:0035371)
0.1	0.8	GO:0031674	I band(GO:0031674)
0.1	29.6	GO:0043025	neuronal cell body(GO:0043025)
0.1	37.5	GO:0045202	synapse(GO:0045202)
0.1	4.7	GO:0032420	stereocilium(GO:0032420)
0.1	0.5	GO:0097422	tubular endosome(GO:0097422)
0.1	13.6	GO:0043209	myelin sheath(GO:0043209)
0.1	7.7	GO:0030424	axon(GO:0030424)
0.1	2.8	GO:0000421	autophagosome membrane(GO:0000421)
0.1	9.5	GO:0005581	collagen trimer(GO:0005581)
0.1	0.3	GO:0030897	HOPS complex(GO:0030897)
0.1	1.2	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.1	4.2	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.1	0.1	GO:0097629	extrinsic component of omegasome membrane(GO:0097629)
0.1	9.8	GO:0005875	microtubule associated complex(GO:0005875)
0.0	1.2	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	1.3	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.0	0.1	GO:0044207	eukaryotic 48S preinitiation complex(GO:0033290) translation initiation ternary complex(GO:0044207)
0.0	1.7	GO:0090545	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0	2.0	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	2.7	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.4	GO:0005921	gap junction(GO:0005921)
0.0	8.3	GO:0043005	neuron projection(GO:0043005)
0.0	0.3	GO:0031595	nuclear proteasome complex(GO:0031595)
0.0	0.3	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.2	GO:0097149	centralspindlin complex(GO:0097149)
0.0	2.2	GO:0031907	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0	11.5	GO:0000151	ubiquitin ligase complex(GO:0000151)
0.0	0.3	GO:0061574	ASAP complex(GO:0061574)
0.0	1.4	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	10.3	GO:0016324	apical plasma membrane(GO:0016324)
0.0	3.8	GO:0035578	azurophil granule lumen(GO:0035578)
0.0	0.4	GO:0000815	ESCRT III complex(GO:0000815) Flemming body(GO:0090543)
0.0	1.6	GO:0005637	nuclear inner membrane(GO:0005637)
0.0	0.4	GO:0000800	lateral element(GO:0000800)
0.0	2.7	GO:0016605	PML body(GO:0016605)
0.0	0.2	GO:0000808	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	0.6	GO:0034451	centriolar satellite(GO:0034451)
0.0	1.8	GO:0035579	specific granule membrane(GO:0035579)
0.0	10.2	GO:0005759	mitochondrial matrix(GO:0005759)
0.0	2.0	GO:0005923	bicellular tight junction(GO:0005923)
0.0	0.3	GO:0005665	DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0	1.4	GO:0005811	lipid particle(GO:0005811)
0.0	0.8	GO:0035580	specific granule lumen(GO:0035580)
0.0	0.1	GO:0045179	apical cortex(GO:0045179)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.7	27.1	GO:0030348	syntaxin-3 binding(GO:0030348)
2.5	14.7	GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
2.4	55.2	GO:0003680	AT DNA binding(GO:0003680)
2.3	6.9	GO:0060175	brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
2.1	8.3	GO:0008260	3-oxoacid CoA-transferase activity(GO:0008260)
2.1	20.6	GO:0050682	AF-2 domain binding(GO:0050682)
2.0	20.2	GO:0005237	inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
1.6	30.8	GO:0008503	benzodiazepine receptor activity(GO:0008503)
1.6	51.4	GO:0097109	neuroligin family protein binding(GO:0097109)
1.5	4.5	GO:0008511	sodium:potassium:chloride symporter activity(GO:0008511)
1.5	51.9	GO:0002162	dystroglycan binding(GO:0002162)
1.4	12.3	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
1.3	10.6	GO:0050816	phosphothreonine binding(GO:0050816)
1.3	6.4	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
1.3	11.5	GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
1.3	10.0	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
1.2	18.7	GO:0015501	glutamate:sodium symporter activity(GO:0015501)
1.2	3.6	GO:0086057	voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057)
1.2	4.6	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
1.1	8.7	GO:0004517	nitric-oxide synthase activity(GO:0004517)
1.1	5.4	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
1.1	20.5	GO:0097016	L27 domain binding(GO:0097016)
0.9	4.7	GO:1990430	extracellular matrix protein binding(GO:1990430)
0.9	2.8	GO:0036326	VEGF-A-activated receptor activity(GO:0036326) VEGF-B-activated receptor activity(GO:0036327) placental growth factor-activated receptor activity(GO:0036332)
0.9	6.4	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.9	22.9	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.8	10.6	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
0.8	25.0	GO:0001087	transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.8	4.0	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.8	4.7	GO:0031694	alpha-2A adrenergic receptor binding(GO:0031694)
0.8	33.1	GO:0004385	guanylate kinase activity(GO:0004385)
0.7	29.2	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.7	5.0	GO:0004598	peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.7	6.4	GO:0015319	sodium:inorganic phosphate symporter activity(GO:0015319)
0.7	2.8	GO:0072320	volume-sensitive chloride channel activity(GO:0072320)
0.7	2.0	GO:0099530	G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.7	2.0	GO:0008940	nitrate reductase activity(GO:0008940) molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599)
0.6	3.8	GO:0008281	sulfonylurea receptor activity(GO:0008281)
0.6	30.3	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.6	10.2	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.6	5.4	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.6	6.5	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.6	12.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.5	2.2	GO:0004923	leukemia inhibitory factor receptor activity(GO:0004923)
0.5	23.9	GO:0051393	alpha-actinin binding(GO:0051393)
0.5	2.9	GO:0004692	cGMP-dependent protein kinase activity(GO:0004692)
0.5	1.9	GO:0055100	adiponectin binding(GO:0055100)
0.5	1.8	GO:0035514	DNA demethylase activity(GO:0035514)
0.5	15.1	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.5	11.4	GO:0030215	semaphorin receptor binding(GO:0030215)
0.4	4.0	GO:0071253	connexin binding(GO:0071253)
0.4	1.3	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.4	15.5	GO:0016676	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.4	4.3	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.4	12.9	GO:0005248	voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.4	68.0	GO:0030165	PDZ domain binding(GO:0030165)
0.4	2.5	GO:0042030	ATPase inhibitor activity(GO:0042030)
0.4	3.7	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.4	13.9	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.4	7.7	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.4	3.1	GO:0016403	dimethylargininase activity(GO:0016403)
0.4	1.9	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.4	5.7	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.4	7.0	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.4	11.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.4	21.7	GO:0046875	ephrin receptor binding(GO:0046875)
0.4	99.8	GO:0044325	ion channel binding(GO:0044325)
0.4	1.1	GO:0005169	neurotrophin TRKB receptor binding(GO:0005169)
0.4	2.5	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.4	1.1	GO:0050692	DBD domain binding(GO:0050692)
0.4	1.1	GO:0015322	proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322)
0.4	1.1	GO:0004574	oligo-1,6-glucosidase activity(GO:0004574)
0.3	1.7	GO:0052591	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.3	10.0	GO:0005523	tropomyosin binding(GO:0005523)
0.3	12.5	GO:0051010	microtubule plus-end binding(GO:0051010)
0.3	1.0	GO:0034189	very-low-density lipoprotein particle binding(GO:0034189)
0.3	0.6	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.3	2.8	GO:0016681	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.3	2.8	GO:0004738	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.3	2.7	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.3	7.5	GO:0004691	cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.3	18.3	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3	4.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.3	10.2	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.3	1.4	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.3	5.1	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)
0.3	1.7	GO:0031708	endothelin B receptor binding(GO:0031708)
0.3	3.3	GO:0031432	titin binding(GO:0031432)
0.3	1.4	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.3	1.9	GO:0005499	vitamin D binding(GO:0005499)
0.3	0.8	GO:0061629	RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.3	8.0	GO:0030506	ankyrin binding(GO:0030506)
0.3	30.1	GO:0005262	calcium channel activity(GO:0005262)
0.3	1.0	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.3	2.6	GO:0060072	large conductance calcium-activated potassium channel activity(GO:0060072)
0.2	9.9	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.2	6.8	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.2	1.2	GO:0005334	norepinephrine:sodium symporter activity(GO:0005334)
0.2	9.6	GO:0017075	syntaxin-1 binding(GO:0017075)
0.2	3.6	GO:0042805	actinin binding(GO:0042805)
0.2	0.9	GO:1902379	receptor tyrosine kinase-like orphan receptor binding(GO:0005115) chemoattractant activity involved in axon guidance(GO:1902379)
0.2	9.3	GO:0017091	AU-rich element binding(GO:0017091)
0.2	7.3	GO:0050811	GABA receptor binding(GO:0050811)
0.2	0.6	GO:0016608	growth hormone-releasing hormone activity(GO:0016608)
0.2	2.1	GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.2	0.6	GO:0004850	uridine phosphorylase activity(GO:0004850)
0.2	1.9	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.2	3.1	GO:0022821	potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
0.2	3.1	GO:0045294	alpha-catenin binding(GO:0045294)
0.2	6.4	GO:0005212	structural constituent of eye lens(GO:0005212)
0.2	4.4	GO:0033038	bitter taste receptor activity(GO:0033038)
0.2	59.9	GO:0005516	calmodulin binding(GO:0005516)
0.2	0.8	GO:0030379	neurotensin receptor activity, non-G-protein coupled(GO:0030379)
0.2	0.4	GO:0008271	secondary active sulfate transmembrane transporter activity(GO:0008271)
0.2	0.8	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.2	1.2	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.2	1.7	GO:0004126	cytidine deaminase activity(GO:0004126)
0.2	2.6	GO:0005004	GPI-linked ephrin receptor activity(GO:0005004)
0.2	1.5	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.2	1.1	GO:0015087	cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.2	1.3	GO:0047298	4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.2	3.6	GO:0008432	JUN kinase binding(GO:0008432)
0.2	62.9	GO:0044822	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.2	1.8	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.2	2.3	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.2	5.9	GO:0030552	cAMP binding(GO:0030552)
0.2	1.4	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.2	8.2	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.2	0.9	GO:0017018	myosin phosphatase activity(GO:0017018) myosin-light-chain-phosphatase activity(GO:0050115)
0.2	11.3	GO:0070888	E-box binding(GO:0070888)
0.2	0.3	GO:0055077	gap junction hemi-channel activity(GO:0055077)
0.2	42.9	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2	2.0	GO:0043176	amine binding(GO:0043176) serotonin binding(GO:0051378)
0.2	4.1	GO:0004000	adenosine deaminase activity(GO:0004000)
0.2	2.9	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.2	0.9	GO:0005298	proline:sodium symporter activity(GO:0005298)
0.2	7.8	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2	1.6	GO:0016167	glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.2	1.1	GO:0004594	pantothenate kinase activity(GO:0004594)
0.2	0.6	GO:0005042	netrin receptor activity(GO:0005042)
0.2	0.6	GO:0008665	2'-phosphotransferase activity(GO:0008665)
0.1	2.6	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.1	0.9	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.1	1.4	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1	2.8	GO:0005452	inorganic anion exchanger activity(GO:0005452)
0.1	18.3	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1	0.8	GO:0008241	peptidyl-dipeptidase activity(GO:0008241)
0.1	0.8	GO:0008479	queuine tRNA-ribosyltransferase activity(GO:0008479)
0.1	1.5	GO:0019534	toxin transporter activity(GO:0019534)
0.1	0.8	GO:0003998	acylphosphatase activity(GO:0003998)
0.1	0.4	GO:0004105	choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1	1.8	GO:0005243	gap junction channel activity(GO:0005243)
0.1	0.4	GO:0017098	sulfonylurea receptor binding(GO:0017098)
0.1	35.0	GO:0051015	actin filament binding(GO:0051015)
0.1	28.3	GO:0005057	receptor signaling protein activity(GO:0005057)
0.1	1.1	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1	1.3	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)
0.1	15.4	GO:0004860	protein kinase inhibitor activity(GO:0004860)
0.1	1.5	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.1	5.3	GO:0015248	sterol transporter activity(GO:0015248)
0.1	2.1	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.1	6.6	GO:0015078	hydrogen ion transmembrane transporter activity(GO:0015078)
0.1	7.8	GO:0015459	potassium channel regulator activity(GO:0015459)
0.1	1.0	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)
0.1	0.5	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.1	1.2	GO:0035198	miRNA binding(GO:0035198)
0.1	0.5	GO:0004556	alpha-amylase activity(GO:0004556)
0.1	0.3	GO:0001596	angiotensin type I receptor activity(GO:0001596) bradykinin receptor binding(GO:0031711)
0.1	0.5	GO:0052656	branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1	0.9	GO:0033857	diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.1	1.2	GO:0003720	telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.1	8.9	GO:0002039	p53 binding(GO:0002039)
0.1	0.3	GO:0004967	glucagon receptor activity(GO:0004967)
0.1	0.8	GO:0048018	receptor agonist activity(GO:0048018)
0.1	1.3	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.1	0.6	GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.1	0.8	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.1	2.6	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.1	0.8	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1	1.2	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)
0.1	1.1	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.1	0.5	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.1	1.0	GO:0008934	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.1	2.0	GO:0048487	beta-tubulin binding(GO:0048487)
0.1	0.4	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1	2.1	GO:0004745	retinol dehydrogenase activity(GO:0004745)
0.1	1.1	GO:0015129	lactate transmembrane transporter activity(GO:0015129)
0.1	1.0	GO:0032051	clathrin light chain binding(GO:0032051)
0.1	3.1	GO:0043014	alpha-tubulin binding(GO:0043014)
0.1	1.1	GO:0048156	tau protein binding(GO:0048156)
0.1	2.8	GO:0005109	frizzled binding(GO:0005109)
0.1	31.4	GO:0015631	tubulin binding(GO:0015631)
0.1	1.3	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.1	0.5	GO:0047522	13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.1	1.3	GO:0008199	ferric iron binding(GO:0008199)
0.1	0.2	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.1	7.9	GO:0001618	virus receptor activity(GO:0001618)
0.1	0.8	GO:0008200	ion channel inhibitor activity(GO:0008200)
0.1	1.3	GO:0005344	oxygen transporter activity(GO:0005344)
0.1	0.6	GO:0015172	L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.1	0.6	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.1	0.5	GO:0034452	dynactin binding(GO:0034452)
0.1	0.5	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.1	1.2	GO:1990380	Lys48-specific deubiquitinase activity(GO:1990380)
0.1	1.2	GO:0043548	phosphatidylinositol 3-kinase binding(GO:0043548)
0.1	0.4	GO:0016402	pristanoyl-CoA oxidase activity(GO:0016402)
0.1	2.0	GO:0035255	ionotropic glutamate receptor binding(GO:0035255)
0.1	0.3	GO:0004679	AMP-activated protein kinase activity(GO:0004679)
0.0	1.1	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.8	GO:0005542	folic acid binding(GO:0005542)
0.0	0.3	GO:0031433	telethonin binding(GO:0031433)
0.0	0.7	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.0	0.4	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.9	GO:0051428	peptide hormone receptor binding(GO:0051428)
0.0	0.5	GO:0050694	galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0	0.7	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0	1.1	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
0.0	0.6	GO:0005132	type I interferon receptor binding(GO:0005132)
0.0	0.4	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0046848	hydroxyapatite binding(GO:0046848)
0.0	0.6	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	1.4	GO:0008307	structural constituent of muscle(GO:0008307)
0.0	0.3	GO:0036402	proteasome-activating ATPase activity(GO:0036402)
0.0	1.1	GO:0001223	transcription coactivator binding(GO:0001223)
0.0	4.1	GO:0005254	chloride channel activity(GO:0005254)
0.0	13.3	GO:0003779	actin binding(GO:0003779)
0.0	1.1	GO:0008066	glutamate receptor activity(GO:0008066)
0.0	0.9	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	7.0	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	23.4	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.0	0.9	GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.0	0.2	GO:0017095	heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.0	0.9	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.0	1.1	GO:0070628	proteasome binding(GO:0070628)
0.0	2.0	GO:0005549	odorant binding(GO:0005549)
0.0	0.5	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.6	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.3	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.0	0.3	GO:0031386	protein tag(GO:0031386)
0.0	0.2	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	1.1	GO:0001671	ATPase activator activity(GO:0001671)
0.0	3.4	GO:0047485	protein N-terminus binding(GO:0047485)
0.0	3.7	GO:0016779	nucleotidyltransferase activity(GO:0016779)
0.0	0.4	GO:0005227	calcium activated cation channel activity(GO:0005227)
0.0	0.2	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.9	GO:0004712	protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0	2.3	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.0	1.3	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	0.2	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0	0.3	GO:0022850	serotonin-gated cation channel activity(GO:0022850)
0.0	0.9	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	0.1	GO:0004809	tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.0	15.4	GO:0004930	G-protein coupled receptor activity(GO:0004930)
0.0	0.3	GO:0004383	guanylate cyclase activity(GO:0004383)
0.0	0.6	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.1	GO:0030305	heparanase activity(GO:0030305)
0.0	2.2	GO:0051082	unfolded protein binding(GO:0051082)
0.0	0.6	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0	4.1	GO:0035091	phosphatidylinositol binding(GO:0035091)
0.0	0.2	GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0	0.4	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.1	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.8	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0	0.4	GO:0004550	nucleoside diphosphate kinase activity(GO:0004550)
0.0	0.2	GO:0003688	DNA replication origin binding(GO:0003688)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.7	71.8	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.5	9.7	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.4	29.3	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.3	15.3	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.3	27.8	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.3	26.7	PID LKB1 PATHWAY	LKB1 signaling events
0.2	22.2	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.2	7.3	ST P38 MAPK PATHWAY	p38 MAPK Pathway
0.2	27.7	PID CDC42 PATHWAY	CDC42 signaling events
0.2	2.9	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.2	6.5	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.2	19.6	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.2	5.7	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.1	2.4	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1	7.5	PID RAS PATHWAY	Regulation of Ras family activation
0.1	4.8	PID EPHA FWDPATHWAY	EPHA forward signaling
0.1	0.4	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1	1.3	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.1	7.6	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway
0.1	9.7	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.1	1.3	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	10.4	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.1	2.9	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.1	4.9	PID MYC PATHWAY	C-MYC pathway
0.1	7.4	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.1	5.5	SIG CHEMOTAXIS	Genes related to chemotaxis
0.1	2.6	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	13.9	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.1	2.3	PID RHOA PATHWAY	RhoA signaling pathway
0.1	7.1	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.1	2.7	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.1	7.4	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	1.8	PID FGF PATHWAY	FGF signaling pathway
0.1	4.1	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	3.8	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.1	1.8	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.1	1.2	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.1	4.6	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	3.4	PID ILK PATHWAY	Integrin-linked kinase signaling
0.1	0.7	PID ERBB1 RECEPTOR PROXIMAL PATHWAY	EGF receptor (ErbB1) signaling pathway
0.1	1.9	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.1	1.2	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.1	1.0	ST G ALPHA I PATHWAY	G alpha i Pathway
0.1	1.0	PID REELIN PATHWAY	Reelin signaling pathway
0.0	1.4	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.0	1.4	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	0.7	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.0	3.6	NABA COLLAGENS	Genes encoding collagen proteins
0.0	1.1	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	0.3	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0	3.0	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	2.5	PID P73PATHWAY	p73 transcription factor network
0.0	0.8	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.5	ST GA12 PATHWAY	G alpha 12 Pathway
0.0	0.6	PID IFNG PATHWAY	IFN-gamma pathway
0.0	0.9	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0	7.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	0.6	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	0.5	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	0.2	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	0.4	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	0.8	PID ENDOTHELIN PATHWAY	Endothelins
0.0	0.4	PID ARF 3PATHWAY	Arf1 pathway
0.0	1.0	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.4	63.0	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
1.1	33.6	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.8	87.9	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.7	25.0	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.6	1.2	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.6	33.0	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.5	13.7	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.4	18.2	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.4	31.6	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.4	25.2	REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	Genes involved in Nitric oxide stimulates guanylate cyclase
0.4	16.1	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1	Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.3	16.3	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.3	21.3	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.3	7.4	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.3	9.1	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.2	3.6	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.2	22.1	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.2	7.2	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.2	10.7	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.2	6.0	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.2	44.4	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2	8.7	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
0.2	25.7	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.2	5.9	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.1	5.8	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.1	2.9	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.1	2.8	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1	2.0	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.1	5.1	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.1	6.3	REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	Genes involved in GRB2 events in ERBB2 signaling
0.1	2.0	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.1	2.1	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.1	2.3	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.1	1.5	REACTOME OPSINS	Genes involved in Opsins
0.1	2.3	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1	2.8	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1	5.8	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1	3.1	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.1	5.9	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.1	1.7	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1	1.3	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1	1.2	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.1	2.0	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation
0.1	2.9	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1	2.1	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.1	26.1	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1	1.3	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.1	1.8	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.1	1.5	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.1	0.6	REACTOME PI3K EVENTS IN ERBB2 SIGNALING	Genes involved in PI3K events in ERBB2 signaling
0.1	1.6	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.1	2.2	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.1	0.8	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.1	1.8	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.1	1.1	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.1	2.9	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.1	3.8	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.1	3.3	REACTOME GLUCAGON TYPE LIGAND RECEPTORS	Genes involved in Glucagon-type ligand receptors
0.1	3.3	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.0	1.1	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	1.0	REACTOME G ALPHA1213 SIGNALLING EVENTS	Genes involved in G alpha (12/13) signalling events
0.0	2.7	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	6.9	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
0.0	1.5	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.0	1.0	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0	0.6	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.0	1.2	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.0	1.6	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
0.0	0.8	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.9	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.0	0.6	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.0	0.3	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.0	0.9	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.7	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.0	5.3	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.0	0.3	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.0	0.6	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER
0.0	0.5	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.0	5.6	REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM	Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.0	0.5	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	1.2	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.0	0.4	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.0	1.3	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0	0.2	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.0	0.3	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.0	1.2	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.0	0.4	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0	0.5	REACTOME PERK REGULATED GENE EXPRESSION	Genes involved in PERK regulated gene expression

Results for HOXB6_PRRX2

Z-value: 3.14

Motif logo

Transcription factors associated with HOXB6_PRRX2

Activity-expression correlation:

Activity profile of HOXB6_PRRX2 motif

Sorted Z-values of HOXB6_PRRX2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB6_PRRX2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: