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Illumina Body Map 2 (GSE30611)
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Results for HOXC13
Z-value: 0.76
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Transcription factors associated with HOXC13
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXC13 | hg38_v1_chr12_+_53938824_53938852 | 0.21 | 2.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXC13
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 8.9 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 0.0 | 4.8 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 3.0 | GO:1901685 | glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687) |
| 0.3 | 2.9 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.3 | 2.8 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.0 | 2.7 | GO:0003341 | cilium movement(GO:0003341) |
| 0.3 | 2.6 | GO:0070171 | negative regulation of tooth mineralization(GO:0070171) |
| 0.1 | 2.6 | GO:0097296 | activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296) |
| 0.1 | 2.5 | GO:0090331 | negative regulation of platelet aggregation(GO:0090331) |
| 0.1 | 2.4 | GO:0034755 | iron ion transmembrane transport(GO:0034755) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 8.9 | GO:0071757 | hexameric IgM immunoglobulin complex(GO:0071757) |
| 0.0 | 5.8 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 2.9 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 2.7 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.8 | 2.4 | GO:0001534 | radial spoke(GO:0001534) |
| 0.2 | 2.2 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.2 | 2.0 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 1.9 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.5 | 1.6 | GO:0043512 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
| 0.0 | 1.5 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 8.9 | GO:0019862 | IgA binding(GO:0019862) |
| 0.0 | 5.6 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 5.0 | GO:0003823 | antigen binding(GO:0003823) |
| 0.5 | 2.9 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.1 | 2.9 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.3 | 2.6 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.0 | 2.6 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 2.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 2.4 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.2 | 2.3 | GO:0004064 | arylesterase activity(GO:0004064) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.9 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 4.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 3.1 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 2.8 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 2.3 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.0 | 2.2 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 2.1 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 1.8 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.0 | 1.6 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 1.4 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.2 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 3.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 2.9 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 2.6 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 2.3 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.0 | 2.1 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 2.0 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 1.8 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 1.4 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 1.3 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |