ISMARA results: HOXD4

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Illumina Body Map 2 (GSE30611)

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Results for HOXD4

Z-value: 1.25

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Transcription factors associated with HOXD4

Gene Symbol	Gene ID	Gene Info
HOXD4 Ensembl NCBI GeneCards UniProt	ENSG00000170166.6	homeobox D4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXD4	hg38_v1_chr2_+_176151543_176151559	0.01	9.5e-01	Click!

Activity profile of HOXD4 motif

Sorted Z-values of HOXD4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_-_10549612 Show fit	7.69	ENST00000532183.6 ENST00000397183.6 ENST00000420805.1	MYH2 Ensembl NCBI GeneCards UniProt Show fit	myosin heavy chain 2
chr17_-_10549652 Show fit	7.09	ENST00000245503.10	MYH2 Ensembl NCBI GeneCards UniProt Show fit	myosin heavy chain 2
chr17_-_10549694 Show fit	4.80	ENST00000622564.4	MYH2 Ensembl NCBI GeneCards UniProt Show fit	myosin heavy chain 2
chr10_+_68109433 Show fit	3.09	ENST00000613327.4 ENST00000358913.10 ENST00000373675.3	MYPN Ensembl NCBI GeneCards UniProt Show fit	myopalladin
chr10_-_49762335 Show fit	2.77	ENST00000419399.4 ENST00000432695.2	OGDHL Ensembl NCBI GeneCards UniProt Show fit	oxoglutarate dehydrogenase L
chr5_-_151347552 Show fit	2.36	ENST00000335244.9 ENST00000521967.1	SLC36A2 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 36 member 2
chr10_-_49762276 Show fit	2.24	ENST00000374103.9	OGDHL Ensembl NCBI GeneCards UniProt Show fit	oxoglutarate dehydrogenase L
chr2_+_167187364 Show fit	1.99	ENST00000672671.1	XIRP2 Ensembl NCBI GeneCards UniProt Show fit	xin actin binding repeat containing 2
chr3_+_142623386 Show fit	1.96	ENST00000337777.7 ENST00000497199.5	PLS1 Ensembl NCBI GeneCards UniProt Show fit	plastin 1
chr8_+_78591222 Show fit	1.95	ENST00000518467.1	PKIA Ensembl NCBI GeneCards UniProt Show fit	cAMP-dependent protein kinase inhibitor alpha

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	19.8	GO:0001778	plasma membrane repair(GO:0001778)
0.1	5.8	GO:0006099	tricarboxylic acid cycle(GO:0006099)
0.1	2.5	GO:0048739	cardiac muscle fiber development(GO:0048739)
0.8	2.4	GO:1904395	positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.2	2.4	GO:0015808	L-alanine transport(GO:0015808)
0.1	2.4	GO:0032782	bile acid secretion(GO:0032782)
0.0	2.2	GO:0006970	response to osmotic stress(GO:0006970)
0.4	2.0	GO:1902896	terminal web assembly(GO:1902896)
0.1	2.0	GO:2000480	negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1	1.9	GO:0043152	induction of bacterial agglutination(GO:0043152)

Showing 1 to 10 of 86 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	19.6	GO:0005826	actomyosin contractile ring(GO:0005826)
0.5	5.0	GO:0045252	oxoglutarate dehydrogenase complex(GO:0045252)
0.2	2.4	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	2.2	GO:0031594	neuromuscular junction(GO:0031594)
0.3	2.0	GO:1990357	terminal web(GO:1990357)
0.1	1.9	GO:0005577	fibrinogen complex(GO:0005577)
0.0	1.7	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	1.5	GO:0005871	kinesin complex(GO:0005871)
0.1	1.4	GO:0005827	polar microtubule(GO:0005827)
0.0	1.4	GO:0031941	filamentous actin(GO:0031941)

Showing 1 to 10 of 35 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	19.6	GO:0000146	microfilament motor activity(GO:0000146)
0.7	5.0	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1	3.4	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.6	2.4	GO:0035373	chondroitin sulfate proteoglycan binding(GO:0035373)
0.2	2.4	GO:0022858	hydrogen:amino acid symporter activity(GO:0005280) L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.1	2.4	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	2.0	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.1	2.0	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	2.0	GO:0051393	alpha-actinin binding(GO:0051393)
0.0	1.9	GO:0051087	chaperone binding(GO:0051087)

Showing 1 to 10 of 65 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	19.0	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	2.4	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	2.4	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.0	1.9	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	1.7	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling
0.0	1.4	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.0	0.4	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.4	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining

Showing 1 to 8 of 8 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.4	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.1	1.9	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.1	1.8	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.0	1.7	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0	1.2	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.0	1.2	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.1	1.0	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.0	0.9	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.0	0.9	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.0	0.8	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint

Showing 1 to 10 of 19 entries

Results for HOXD4

Z-value: 1.25

Motif logo

Transcription factors associated with HOXD4

Activity-expression correlation:

Activity profile of HOXD4 motif

Sorted Z-values of HOXD4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: