ISMARA results: HSF1

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Illumina Body Map 2 (GSE30611)

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Results for HSF1

Z-value: 1.25

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Transcription factors associated with HSF1

Gene Symbol	Gene ID	Gene Info
HSF1 Ensembl NCBI GeneCards UniProt	ENSG00000185122.11	heat shock transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HSF1	hg38_v1_chr8_+_144291581_144291617	0.47	7.3e-03	Click!

Activity profile of HSF1 motif

Sorted Z-values of HSF1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_161524539 Show fit	4.74	ENST00000309758.6	HSPA6 Ensembl NCBI GeneCards UniProt Show fit	heat shock protein family A (Hsp70) member 6
chrX_+_147981324 Show fit	2.94	ENST00000370467.8	FMR1NB Ensembl NCBI GeneCards UniProt Show fit	FMR1 neighbor
chr3_-_46464868 Show fit	2.79	ENST00000417439.5 ENST00000231751.9 ENST00000431944.1	LTF Ensembl NCBI GeneCards UniProt Show fit	lactotransferrin
chr19_+_859654 Show fit	2.78	ENST00000592860.2 ENST00000327726.11	CFD Ensembl NCBI GeneCards UniProt Show fit	complement factor D
chr6_+_35297809 Show fit	2.77	ENST00000316637.7	DEF6 Ensembl NCBI GeneCards UniProt Show fit	DEF6 guanine nucleotide exchange factor
chr6_-_31815244 Show fit	2.71	ENST00000375654.5	HSPA1L Ensembl NCBI GeneCards UniProt Show fit	heat shock protein family A (Hsp70) member 1 like
chr7_+_80646436 Show fit	2.61	ENST00000419819.2	CD36 Ensembl NCBI GeneCards UniProt Show fit	CD36 molecule
chr15_+_75198866 Show fit	2.57	ENST00000562637.1 ENST00000360639.6	C15orf39 Ensembl NCBI GeneCards UniProt Show fit	chromosome 15 open reading frame 39
chr2_-_89213917 Show fit	2.53	ENST00000498435.1	IGKV1-27 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 1-27
chr1_-_183569186 Show fit	2.53	ENST00000420553.5 ENST00000419402.1	NCF2 Ensembl NCBI GeneCards UniProt Show fit	neutrophil cytosolic factor 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	8.4	GO:0010286	heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.5	7.0	GO:0072564	response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0	6.1	GO:0002377	immunoglobulin production(GO:0002377)
0.2	5.0	GO:0044146	negative regulation of growth of symbiont involved in interaction with host(GO:0044146)
0.1	4.5	GO:0006910	phagocytosis, recognition(GO:0006910)
0.0	4.3	GO:0006958	complement activation, classical pathway(GO:0006958)
0.0	4.3	GO:0002250	adaptive immune response(GO:0002250)
0.7	4.2	GO:1902283	negative regulation of primary amine oxidase activity(GO:1902283)
0.0	4.0	GO:0006968	cellular defense response(GO:0006968)
0.3	2.9	GO:0035995	detection of muscle stretch(GO:0035995)

Showing 1 to 10 of 270 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.8	GO:1904813	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0	8.7	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	7.4	GO:0035579	specific granule membrane(GO:0035579)
0.1	7.0	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.1	6.9	GO:0008180	COP9 signalosome(GO:0008180)
0.1	4.5	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.7	4.1	GO:0097013	phagocytic vesicle lumen(GO:0097013)
0.0	4.0	GO:0005902	microvillus(GO:0005902)
0.0	3.6	GO:0005741	mitochondrial outer membrane(GO:0005741)
0.0	3.4	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)

Showing 1 to 10 of 106 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	8.5	GO:0003823	antigen binding(GO:0003823)
0.6	7.0	GO:0070892	lipoteichoic acid receptor activity(GO:0070892)
0.1	5.7	GO:0001530	lipopolysaccharide binding(GO:0001530)
0.0	4.8	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.1	4.5	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.4	4.4	GO:0019863	IgE binding(GO:0019863)
0.8	4.2	GO:0052595	tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.4	4.2	GO:0055131	C3HC4-type RING finger domain binding(GO:0055131)
0.0	4.2	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	3.7	GO:0031072	heat shock protein binding(GO:0031072)

Showing 1 to 10 of 175 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.7	PID IL4 2PATHWAY	IL4-mediated signaling events
0.0	5.2	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	3.5	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	3.5	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	3.4	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	3.0	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.1	2.5	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	2.5	ST P38 MAPK PATHWAY	p38 MAPK Pathway
0.1	2.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.2	2.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway

Showing 1 to 10 of 42 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	11.6	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1	7.9	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1	3.7	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	3.5	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1	3.4	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	3.1	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	2.6	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	2.5	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.1	2.4	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.1	2.4	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix

Showing 1 to 10 of 65 entries

Results for HSF1

Z-value: 1.25

Motif logo

Transcription factors associated with HSF1

Activity-expression correlation:

Activity profile of HSF1 motif

Sorted Z-values of HSF1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: