Project
Illumina Body Map 2 (GSE30611)
Navigation
Downloads
Results for IRF2_STAT2_IRF8_IRF1
Z-value: 4.47
Motif logo
Transcription factors associated with IRF2_STAT2_IRF8_IRF1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000168310.11 | interferon regulatory factor 2 | |
| ENSG00000170581.14 | signal transducer and activator of transcription 2 | |
| ENSG00000140968.11 | interferon regulatory factor 8 | |
| ENSG00000125347.15 | interferon regulatory factor 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF8 | hg38_v1_chr16_+_85902689_85902838 | 0.83 | 4.9e-09 | Click! |
| IRF1 | hg38_v1_chr5_-_132490750_132490840 | 0.81 | 2.5e-08 | Click! |
| IRF2 | hg38_v1_chr4_-_184474518_184474556 | 0.78 | 1.1e-07 | Click! |
| STAT2 | hg38_v1_chr12_-_56360084_56360146 | 0.55 | 1.2e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_74773962 Show fit | 28.51 |
ENST00000289473.10
|
neutrophil cytosolic factor 1 |
|
| chr12_+_112978504 Show fit | 22.73 |
ENST00000392583.7
|
2'-5'-oligoadenylate synthetase 2 |
|
| chr12_+_112978424 Show fit | 22.00 |
ENST00000680685.1
ENST00000620097.2 |
2'-5'-oligoadenylate synthetase 2 |
|
| chr12_+_112978562 Show fit | 21.88 |
ENST00000680122.1
|
2'-5'-oligoadenylate synthetase 2 |
|
| chr16_+_56989479 Show fit | 21.20 |
ENST00000262510.10
|
NLR family CARD domain containing 5 |
|
| chr12_+_112978386 Show fit | 20.82 |
ENST00000342315.8
|
2'-5'-oligoadenylate synthetase 2 |
|
| chrX_+_37780049 Show fit | 20.72 |
ENST00000378588.5
|
cytochrome b-245 beta chain |
|
| chr22_+_39077264 Show fit | 18.96 |
ENST00000407997.4
|
apolipoprotein B mRNA editing enzyme catalytic subunit 3G |
|
| chr21_+_41361999 Show fit | 18.43 |
ENST00000436410.5
ENST00000435611.6 ENST00000330714.8 |
MX dynamin like GTPase 2 |
|
| chr7_+_150685693 Show fit | 17.93 |
ENST00000223293.10
ENST00000474605.1 |
GTPase, IMAP family member 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF2_STAT2_IRF8_IRF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.1 | 121.7 | GO:0018377 | protein myristoylation(GO:0018377) |
| 0.7 | 85.2 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
| 1.7 | 78.9 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 1.7 | 59.3 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 0.8 | 54.8 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 3.8 | 49.4 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.1 | 44.2 | GO:0043312 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 5.1 | 40.7 | GO:0070383 | DNA cytosine deamination(GO:0070383) |
| 2.7 | 37.4 | GO:1901740 | negative regulation of myoblast fusion(GO:1901740) |
| 1.3 | 31.9 | GO:0097296 | activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 123.9 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.2 | 88.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 84.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 78.1 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.0 | 75.0 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.4 | 64.7 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 8.7 | 60.8 | GO:0042825 | TAP complex(GO:0042825) |
| 7.3 | 58.3 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.3 | 53.8 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.1 | 46.8 | GO:0016607 | nuclear speck(GO:0016607) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.7 | 171.2 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 86.3 | GO:0005525 | GTP binding(GO:0005525) |
| 1.6 | 50.5 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 1.6 | 49.9 | GO:0097153 | cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153) |
| 2.1 | 47.2 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.9 | 46.7 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.9 | 45.4 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.3 | 38.9 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 1.0 | 38.2 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 7.2 | 36.1 | GO:0015433 | peptide antigen-transporting ATPase activity(GO:0015433) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 74.2 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 1.0 | 65.6 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.2 | 60.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.5 | 51.4 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.2 | 42.8 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.4 | 33.0 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 25.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 24.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.4 | 24.1 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.3 | 21.5 | PID IL4 2PATHWAY | IL4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 370.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 1.2 | 80.0 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.8 | 76.3 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 1.9 | 68.1 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.7 | 56.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.5 | 43.8 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 1.7 | 40.5 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 1.7 | 34.9 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 3.2 | 34.8 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.9 | 31.5 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |