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Illumina Body Map 2 (GSE30611)

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Results for IRF2_STAT2_IRF8_IRF1

Z-value: 4.47

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Transcription factors associated with IRF2_STAT2_IRF8_IRF1

Gene Symbol Gene ID Gene Info
ENSG00000168310.11 interferon regulatory factor 2
ENSG00000170581.14 signal transducer and activator of transcription 2
ENSG00000140968.11 interferon regulatory factor 8
ENSG00000125347.15 interferon regulatory factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF8hg38_v1_chr16_+_85902689_859028380.834.9e-09Click!
IRF1hg38_v1_chr5_-_132490750_1324908400.812.5e-08Click!
IRF2hg38_v1_chr4_-_184474518_1844745560.781.1e-07Click!
STAT2hg38_v1_chr12_-_56360084_563601460.551.2e-03Click!

Activity profile of IRF2_STAT2_IRF8_IRF1 motif

Sorted Z-values of IRF2_STAT2_IRF8_IRF1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_74773962 28.51 ENST00000289473.10
neutrophil cytosolic factor 1
chr12_+_112978504 22.73 ENST00000392583.7
2'-5'-oligoadenylate synthetase 2
chr12_+_112978424 22.00 ENST00000680685.1
ENST00000620097.2
2'-5'-oligoadenylate synthetase 2
chr12_+_112978562 21.88 ENST00000680122.1
2'-5'-oligoadenylate synthetase 2
chr16_+_56989479 21.20 ENST00000262510.10
NLR family CARD domain containing 5
chr12_+_112978386 20.82 ENST00000342315.8
2'-5'-oligoadenylate synthetase 2
chrX_+_37780049 20.72 ENST00000378588.5
cytochrome b-245 beta chain
chr22_+_39077264 18.96 ENST00000407997.4
apolipoprotein B mRNA editing enzyme catalytic subunit 3G
chr21_+_41361999 18.43 ENST00000436410.5
ENST00000435611.6
ENST00000330714.8
MX dynamin like GTPase 2
chr7_+_150685693 17.93 ENST00000223293.10
ENST00000474605.1
GTPase, IMAP family member 2
chr16_-_67936808 17.65 ENST00000358514.9
proteasome 20S subunit beta 10
chr15_+_44711487 17.35 ENST00000544417.5
ENST00000559916.1
ENST00000648006.3
beta-2-microglobulin
chr12_+_112978460 17.31 ENST00000449768.2
2'-5'-oligoadenylate synthetase 2
chr6_+_32854179 17.16 ENST00000374859.3
proteasome 20S subunit beta 9
chr12_+_112978535 17.00 ENST00000552756.6
2'-5'-oligoadenylate synthetase 2
chr16_+_11965193 16.65 ENST00000053243.6
ENST00000396495.3
TNF receptor superfamily member 17
chr1_+_1013485 16.64 ENST00000649529.1
ISG15 ubiquitin like modifier
chr1_+_12166978 16.51 ENST00000376259.7
ENST00000536782.2
TNF receptor superfamily member 1B
chr1_+_158831323 16.33 ENST00000368141.5
myeloid cell nuclear differentiation antigen
chr17_-_4739866 16.32 ENST00000574412.6
ENST00000293778.12
C-X-C motif chemokine ligand 16
chr11_-_105035113 16.10 ENST00000526568.5
ENST00000531166.5
ENST00000534497.5
ENST00000527979.5
ENST00000533400.6
ENST00000528974.1
ENST00000525825.5
ENST00000353247.9
ENST00000446369.5
ENST00000436863.7
caspase 1
chr13_-_42992165 15.33 ENST00000398762.7
ENST00000313640.11
ENST00000313624.12
epithelial stromal interaction 1
chr4_-_76023489 15.23 ENST00000306602.3
C-X-C motif chemokine ligand 10
chr6_+_26365215 14.86 ENST00000527422.5
ENST00000356386.6
ENST00000396948.5
butyrophilin subfamily 3 member A2
chr17_+_27631148 14.82 ENST00000313648.10
ENST00000395473.7
ENST00000577392.5
ENST00000584661.5
galectin 9
chr6_+_116461364 14.60 ENST00000368606.7
ENST00000368605.3
calcium homeostasis modulator family member 6
chr7_-_93148345 14.22 ENST00000437805.5
ENST00000446959.5
ENST00000439952.5
ENST00000414791.5
ENST00000446033.1
ENST00000411955.5
ENST00000318238.9
sterile alpha motif domain containing 9 like
chr3_-_49813880 14.09 ENST00000333486.4
ubiquitin like modifier activating enzyme 7
chr6_+_26365159 14.09 ENST00000532865.5
ENST00000396934.7
ENST00000508906.6
ENST00000530653.5
ENST00000527417.5
butyrophilin subfamily 3 member A2
chr2_-_151289613 14.06 ENST00000243346.10
N-myc and STAT interactor
chr6_+_26365176 14.00 ENST00000377708.7
butyrophilin subfamily 3 member A2
chr3_+_187368367 13.92 ENST00000259030.3
receptor transporter protein 4
chr9_-_98119184 13.52 ENST00000342043.3
ENST00000375098.7
ENST00000341469.7
tripartite motif containing 14
chr6_+_6588708 13.42 ENST00000230568.5
lymphocyte antigen 86
chr3_-_172523460 13.23 ENST00000420541.6
TNF superfamily member 10
chr3_-_172523423 13.18 ENST00000241261.7
TNF superfamily member 10
chr15_+_88639009 13.16 ENST00000306072.10
interferon stimulated exonuclease gene 20
chr6_+_32844108 13.13 ENST00000458296.2
ENST00000413039.6
ENST00000412095.1
ENST00000395330.5
PSMB8 antisense RNA 1 (head to head)
proteasome 20S subunit beta 9
chr1_-_89022827 13.12 ENST00000370481.9
ENST00000564665.1
guanylate binding protein 3
chr12_+_94148553 12.94 ENST00000258526.9
plexin C1
chr12_+_112938422 12.93 ENST00000680044.1
ENST00000680966.1
ENST00000548514.2
ENST00000681497.1
ENST00000551007.1
ENST00000228928.12
ENST00000680438.1
ENST00000681147.1
ENST00000679354.1
ENST00000681085.1
ENST00000680161.1
2'-5'-oligoadenylate synthetase 3
chr19_+_18173804 12.62 ENST00000407280.4
IFI30 lysosomal thiol reductase
chr6_+_26440472 12.49 ENST00000494393.5
ENST00000482451.5
ENST00000471353.5
ENST00000361232.7
ENST00000487627.5
ENST00000496719.1
ENST00000244519.7
ENST00000490254.5
ENST00000487272.1
butyrophilin subfamily 3 member A3
chr6_-_32853618 12.49 ENST00000354258.5
transporter 1, ATP binding cassette subfamily B member
chr3_-_27722699 12.28 ENST00000461503.2
eomesodermin
chr6_-_32853813 12.22 ENST00000643049.2
transporter 1, ATP binding cassette subfamily B member
chr11_+_5689780 12.15 ENST00000379965.8
ENST00000454828.5
tripartite motif containing 22
chr19_+_1077394 12.11 ENST00000590577.2
Rho GTPase activating protein 45
chr1_+_158931539 12.02 ENST00000368140.6
ENST00000368138.7
ENST00000392254.6
ENST00000392252.7
ENST00000368135.4
pyrin and HIN domain family member 1
chr10_+_89327989 11.95 ENST00000679923.1
ENST00000680085.1
ENST00000371818.9
ENST00000680779.1
interferon induced protein with tetratricopeptide repeats 3
chr3_-_36908503 11.87 ENST00000463764.2
tetratricopeptide repeat and ankyrin repeat containing 1
chr10_-_89414458 11.62 ENST00000371837.5
lipase A, lysosomal acid type
chr4_-_168480477 11.25 ENST00000514748.5
ENST00000512371.1
ENST00000505890.5
ENST00000682922.1
ENST00000511577.5
DExD/H-box 60 like
chr17_-_39864304 11.24 ENST00000346872.8
IKAROS family zinc finger 3
chr1_+_159010002 11.01 ENST00000359709.7
interferon gamma inducible protein 16
chr12_+_40224956 10.80 ENST00000298910.12
ENST00000343742.6
leucine rich repeat kinase 2
chr10_+_89327977 10.76 ENST00000681277.1
interferon induced protein with tetratricopeptide repeats 3
chr12_+_112938523 10.57 ENST00000679483.1
ENST00000679493.1
2'-5'-oligoadenylate synthetase 3
chr6_-_32843994 10.42 ENST00000395339.7
ENST00000374882.8
proteasome 20S subunit beta 8
chr1_-_161069962 10.40 ENST00000368015.1
Rho GTPase activating protein 30
chr4_+_99816797 10.35 ENST00000512369.2
ENST00000296414.11
dual adaptor of phosphotyrosine and 3-phosphoinositides 1
chr16_+_85902689 10.32 ENST00000563180.1
ENST00000564617.5
ENST00000564803.5
interferon regulatory factor 8
chr9_-_34710069 10.25 ENST00000378792.1
ENST00000259607.7
C-C motif chemokine ligand 21
chr1_-_150765785 10.23 ENST00000680311.1
ENST00000681728.1
ENST00000680288.1
cathepsin S
chr17_+_43211835 10.17 ENST00000588693.5
ENST00000588659.5
ENST00000541594.5
ENST00000536052.5
ENST00000612339.4
transmembrane protein 106A
chr5_+_96876480 10.17 ENST00000437043.8
ENST00000379904.8
endoplasmic reticulum aminopeptidase 2
chr4_+_146175702 10.05 ENST00000296581.11
ENST00000649747.1
ENST00000502781.5
LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
chr2_-_230219944 10.01 ENST00000455674.2
ENST00000392048.7
ENST00000258381.11
ENST00000358662.9
ENST00000258382.10
SP110 nuclear body protein
chr16_-_31202733 9.97 ENST00000350605.4
ENST00000247470.10
PYD and CARD domain containing
chr1_+_78620722 9.94 ENST00000679848.1
interferon induced protein 44 like
chr12_-_9869345 9.87 ENST00000228438.3
C-type lectin domain family 2 member B
chr9_+_5450503 9.75 ENST00000381573.8
ENST00000381577.4
CD274 molecule
chr1_+_2556361 9.71 ENST00000355716.5
TNF receptor superfamily member 14
chr1_+_159009886 9.65 ENST00000340979.10
ENST00000368131.8
ENST00000295809.12
ENST00000368132.7
interferon gamma inducible protein 16
chr22_+_39040857 9.56 ENST00000381565.2
ENST00000308521.10
apolipoprotein B mRNA editing enzyme catalytic subunit 3F
chr22_-_17219424 9.46 ENST00000649540.1
ENST00000399837.8
ENST00000543038.1
adenosine deaminase 2
chr1_-_89065200 9.41 ENST00000370473.5
guanylate binding protein 1
chr2_+_6877768 9.37 ENST00000382040.4
radical S-adenosyl methionine domain containing 2
chr16_-_88785210 9.36 ENST00000301015.14
piezo type mechanosensitive ion channel component 1
chr11_-_4393650 9.30 ENST00000254436.8
tripartite motif containing 21
chr11_-_60952559 9.27 ENST00000538739.2
solute carrier family 15 member 3
chr22_-_17219571 9.25 ENST00000610390.4
adenosine deaminase 2
chr4_+_101790717 9.21 ENST00000508653.5
ENST00000322953.9
B cell scaffold protein with ankyrin repeats 1
chr11_-_118225002 9.19 ENST00000356289.10
ENST00000526620.5
junction adhesion molecule like
chr1_-_89065357 9.15 ENST00000681280.1
guanylate binding protein 1
chr11_+_60455839 9.10 ENST00000532491.5
ENST00000532073.5
ENST00000345732.9
ENST00000534668.6
ENST00000528313.1
ENST00000533306.6
ENST00000674194.1
membrane spanning 4-domains A1
chr6_-_33314202 9.10 ENST00000426633.6
ENST00000467025.1
TAP binding protein
chr1_-_111204343 9.09 ENST00000369752.5
DENN domain containing 2D
chr7_-_93117956 9.03 ENST00000446617.1
ENST00000379958.3
ENST00000620985.4
sterile alpha motif domain containing 9
chr11_-_60952134 9.01 ENST00000679573.1
ENST00000681882.1
ENST00000681951.1
ENST00000227880.8
solute carrier family 15 member 3
chr15_+_88638947 9.01 ENST00000559876.2
interferon stimulated exonuclease gene 20
chr8_+_27326803 9.01 ENST00000522517.5
protein tyrosine kinase 2 beta
chr12_-_48925483 8.92 ENST00000550765.6
ENST00000552878.5
ENST00000453172.2
FKBP prolyl isomerase 11
chr11_+_1853049 8.90 ENST00000311604.8
lymphocyte specific protein 1
chr20_-_57620467 8.77 ENST00000395822.7
Z-DNA binding protein 1
chr16_+_3046552 8.74 ENST00000336577.9
matrix metallopeptidase 25
chr20_-_57620415 8.69 ENST00000371173.8
Z-DNA binding protein 1
chr6_+_26402237 8.67 ENST00000476549.6
ENST00000450085.6
ENST00000425234.6
ENST00000427334.5
ENST00000506698.1
ENST00000289361.11
butyrophilin subfamily 3 member A1
chr1_-_161069857 8.64 ENST00000368013.8
Rho GTPase activating protein 30
chr1_+_78649818 8.58 ENST00000370747.9
ENST00000438486.1
interferon induced protein 44
chr7_-_140062841 8.48 ENST00000263549.8
poly(ADP-ribose) polymerase family member 12
chr12_-_10390023 8.44 ENST00000240618.11
killer cell lectin like receptor K1
chr3_+_46407558 8.40 ENST00000357392.4
ENST00000400880.3
ENST00000433848.1
C-C motif chemokine receptor like 2
chr1_+_78620432 8.30 ENST00000370751.10
ENST00000459784.6
ENST00000680110.1
ENST00000680295.1
interferon induced protein 44 like
chr1_-_27672178 8.18 ENST00000339145.8
ENST00000361157.11
ENST00000362020.4
ENST00000679644.1
interferon alpha inducible protein 6
chr11_-_615921 8.12 ENST00000348655.11
ENST00000525445.6
ENST00000330243.9
interferon regulatory factor 7
chr12_+_25052512 8.12 ENST00000557489.5
ENST00000354454.7
ENST00000536173.5
inositol 1,4,5-triphosphate receptor associated 2
chr11_+_5689691 8.12 ENST00000425490.5
tripartite motif containing 22
chr1_+_220879434 8.11 ENST00000366903.8
H2.0 like homeobox
chr2_+_162318884 8.11 ENST00000446271.5
ENST00000429691.6
grancalcin
chr2_-_89143133 8.09 ENST00000492167.1
immunoglobulin kappa variable 3-20
chr22_+_35648438 8.08 ENST00000409652.5
apolipoprotein L6
chr6_-_33314055 8.08 ENST00000434618.7
TAP binding protein
chr15_-_44711306 7.99 ENST00000682850.1
PAT1 homolog 2
chr4_+_88457110 7.94 ENST00000264350.8
HECT and RLD domain containing E3 ubiquitin protein ligase 5
chr17_-_82333751 7.89 ENST00000580437.5
ENST00000583093.5
ENST00000269389.8
ENST00000582290.5
ENST00000582563.5
secreted and transmembrane 1
chr4_+_101790607 7.79 ENST00000428908.5
B cell scaffold protein with ankyrin repeats 1
chr5_+_96875978 7.77 ENST00000510373.5
endoplasmic reticulum aminopeptidase 2
chr16_-_11256192 7.74 ENST00000644787.1
ENST00000332029.4
suppressor of cytokine signaling 1
chr12_+_94262521 7.70 ENST00000545312.1
plexin C1
chr15_-_79971164 7.67 ENST00000335661.6
ENST00000267953.4
ENST00000677151.1
BCL2 related protein A1
chr6_-_33314247 7.66 ENST00000475304.5
ENST00000489157.5
TAP binding protein
chr6_+_26402289 7.64 ENST00000414912.2
butyrophilin subfamily 3 member A1
chr10_+_89332484 7.59 ENST00000371811.4
ENST00000680037.1
ENST00000679583.1
ENST00000679897.1
interferon induced protein with tetratricopeptide repeats 3
chr19_-_46714269 7.59 ENST00000600194.5
protein kinase D2
chr15_+_75198866 7.58 ENST00000562637.1
ENST00000360639.6
chromosome 15 open reading frame 39
chr10_-_5977589 7.51 ENST00000620345.4
ENST00000397251.7
ENST00000397248.6
ENST00000622442.4
ENST00000620865.4
interleukin 15 receptor subunit alpha
chr1_+_2556222 7.49 ENST00000409119.5
TNF receptor superfamily member 14
chr19_+_49474208 7.45 ENST00000597551.6
ENST00000596435.5
ENST00000204637.6
ENST00000600429.5
fms related receptor tyrosine kinase 3 ligand
chr13_+_108269629 7.43 ENST00000430559.5
ENST00000375887.9
TNF superfamily member 13b
chr2_-_191847068 7.19 ENST00000304141.5
caveolae associated protein 2
chr11_-_128522189 7.18 ENST00000526145.6
ETS proto-oncogene 1, transcription factor
chr17_+_80260826 7.12 ENST00000508628.6
ENST00000582970.5
ENST00000319921.4
ring finger protein 213
chr11_+_5624987 7.10 ENST00000429814.3
tripartite motif containing 34
chr12_+_53461015 7.09 ENST00000553064.6
ENST00000547859.2
poly(rC) binding protein 2
chrX_-_30577759 7.09 ENST00000378962.4
TLR adaptor interacting with endolysosomal SLC15A4
chr14_-_100375457 6.96 ENST00000556295.5
ENST00000554820.5
tryptophanyl-tRNA synthetase 1
chr11_-_68004043 6.94 ENST00000227471.7
unc-93 homolog B1, TLR signaling regulator
chr11_+_71998892 6.93 ENST00000393705.8
ENST00000393703.9
ENST00000337131.9
ENST00000620017.4
ENST00000531053.5
ENST00000404792.5
interleukin 18 binding protein
chr11_-_59212869 6.92 ENST00000361050.4
macrophage expressed 1
chr6_-_32838727 6.87 ENST00000652259.1
ENST00000374897.4
ENST00000620123.4
ENST00000452392.2
transporter 2, ATP binding cassette subfamily B member
novel protein, TAP2-HLA-DOB readthrough
chr8_+_143558329 6.84 ENST00000262580.9
ENST00000525721.1
ENST00000534018.5
gasdermin D
chr20_-_57620393 6.79 ENST00000541799.1
Z-DNA binding protein 1
chr1_-_161631032 6.76 ENST00000534776.1
ENST00000613418.4
ENST00000614870.4
Fc fragment of IgG receptor IIIb
chr10_+_89301932 6.69 ENST00000371826.4
ENST00000679755.1
interferon induced protein with tetratricopeptide repeats 2
chr13_+_49495941 6.67 ENST00000378319.8
ENST00000496623.5
ENST00000426879.5
PHD finger protein 11
chr19_+_49474561 6.67 ENST00000594009.5
ENST00000595510.1
ENST00000595815.1
fms related receptor tyrosine kinase 3 ligand
novel transcript
chr19_+_49335396 6.60 ENST00000598095.5
ENST00000426897.6
ENST00000323906.9
ENST00000535669.6
ENST00000597602.1
ENST00000595660.1
CD37 molecule
chr1_+_27342014 6.59 ENST00000618673.4
ENST00000318074.9
ENST00000616558.5
synaptotagmin like 1
chr22_-_36160773 6.57 ENST00000531095.1
ENST00000349314.6
ENST00000397293.6
apolipoprotein L3
chr13_+_49496355 6.50 ENST00000496612.5
ENST00000357596.7
ENST00000485919.5
ENST00000442195.5
PHD finger protein 11
chr2_+_201116396 6.49 ENST00000395148.6
CASP8 and FADD like apoptosis regulator
chr17_+_6755834 6.49 ENST00000346752.8
XIAP associated factor 1
chr1_-_161631152 6.46 ENST00000421702.3
ENST00000650385.1
Fc fragment of IgG receptor IIIb
chr17_-_35880350 6.45 ENST00000605140.6
ENST00000651122.1
ENST00000603197.6
C-C motif chemokine ligand 5
chr12_-_48924919 6.40 ENST00000444214.6
FKBP prolyl isomerase 11
chr5_-_39202991 6.39 ENST00000515010.5
FYN binding protein 1
chr1_-_182589239 6.36 ENST00000367559.7
ENST00000539397.1
ribonuclease L
chr10_+_89414555 6.33 ENST00000371795.5
ENST00000681422.1
interferon induced protein with tetratricopeptide repeats 5
chr10_-_5977535 6.23 ENST00000379977.8
interleukin 15 receptor subunit alpha
chr2_+_201257980 6.20 ENST00000447616.5
ENST00000358485.8
ENST00000392266.7
caspase 8
chr17_-_42112674 6.17 ENST00000251642.8
ENST00000591220.5
DExH-box helicase 58
chr14_-_100375333 6.16 ENST00000557297.5
ENST00000555813.5
ENST00000392882.7
ENST00000557135.5
ENST00000556698.5
ENST00000554509.5
ENST00000555410.5
tryptophanyl-tRNA synthetase 1
chr11_-_615570 6.15 ENST00000649187.1
ENST00000647801.1
ENST00000397566.5
ENST00000397570.5
interferon regulatory factor 7
chr11_-_118225086 6.11 ENST00000640745.1
junction adhesion molecule like
chr11_+_71999603 6.11 ENST00000260049.9
interleukin 18 binding protein
chr2_-_162318129 6.09 ENST00000679938.1
interferon induced with helicase C domain 1
chr3_+_122680802 6.06 ENST00000474629.7
poly(ADP-ribose) polymerase family member 14
chr4_-_129093454 6.05 ENST00000281142.10
ENST00000511426.5
sodium channel and clathrin linker 1
chr10_+_89414729 6.04 ENST00000681163.1
ENST00000681348.1
interferon induced protein with tetratricopeptide repeats 5
chr2_-_156342348 6.00 ENST00000409572.5
nuclear receptor subfamily 4 group A member 2
chr10_-_5978022 5.98 ENST00000525219.6
interleukin 15 receptor subunit alpha
chr6_+_25962792 5.96 ENST00000357085.5
tripartite motif containing 38
chr4_-_184474518 5.93 ENST00000393593.8
interferon regulatory factor 2
chr12_+_112906949 5.92 ENST00000679971.1
ENST00000675868.2
ENST00000550883.2
ENST00000553152.2
ENST00000202917.10
ENST00000679467.1
ENST00000680659.1
ENST00000540589.3
ENST00000552526.2
ENST00000681228.1
ENST00000680934.1
ENST00000681700.1
ENST00000679987.1
2'-5'-oligoadenylate synthetase 1
chr14_-_100375602 5.89 ENST00000553395.5
ENST00000553545.5
ENST00000344102.9
ENST00000556338.5
ENST00000553934.1
tryptophanyl-tRNA synthetase 1
chr12_-_53200443 5.88 ENST00000550743.6
integrin subunit beta 7
chr11_-_104898670 5.86 ENST00000422698.6
caspase 12 (gene/pseudogene)
chr10_+_132397168 5.84 ENST00000631148.2
ENST00000305233.6
PWWP domain containing 2B
chr7_-_77416300 5.76 ENST00000257626.12
gamma-secretase activating protein
chr15_-_50119215 5.76 ENST00000284509.11
ENST00000674213.1
ATPase phospholipid transporting 8B4 (putative)
chr22_+_39021113 5.74 ENST00000427494.6
ENST00000216099.13
apolipoprotein B mRNA editing enzyme catalytic subunit 3D
chr19_-_18086904 5.73 ENST00000322153.11
ENST00000593993.7
interleukin 12 receptor subunit beta 1
chr11_-_128522264 5.60 ENST00000531611.5
ETS proto-oncogene 1, transcription factor
chr11_-_57567617 5.57 ENST00000287156.9
ubiquitin conjugating enzyme E2 L6
chr11_+_71999927 5.56 ENST00000393707.4
interleukin 18 binding protein
chr2_+_90038848 5.56 ENST00000390270.2
immunoglobulin kappa variable 3D-20
chr16_+_10877181 5.56 ENST00000618207.4
ENST00000618327.4
ENST00000324288.14
ENST00000381835.9
class II major histocompatibility complex transactivator
chr17_-_82333942 5.52 ENST00000581691.5
secreted and transmembrane 1
chr7_+_80646305 5.51 ENST00000426978.5
ENST00000432207.5
CD36 molecule
chr1_+_112674416 5.51 ENST00000413052.6
ENST00000369645.5
Mov10 RISC complex RNA helicase
chr11_+_63536801 5.51 ENST00000255688.8
ENST00000439013.6
phospholipase A and acyltransferase 4
chr1_-_24964984 5.51 ENST00000338888.3
ENST00000399916.5
RUNX family transcription factor 3
chr8_-_78805515 5.47 ENST00000379113.6
ENST00000541183.2
interleukin 7
chr2_-_230219902 5.45 ENST00000409815.6
SP110 nuclear body protein
chr2_-_6865901 5.42 ENST00000256722.10
cytidine/uridine monophosphate kinase 2
chr17_+_6756035 5.42 ENST00000361842.8
ENST00000574907.5
XIAP associated factor 1
chr19_+_13151975 5.41 ENST00000588173.1
immediate early response 2
chr1_+_211326787 5.41 ENST00000261464.10
TNF receptor associated factor 5
chr20_-_49278034 5.39 ENST00000371744.5
ENST00000396105.6
ENST00000371752.5
zinc finger NFX1-type containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF2_STAT2_IRF8_IRF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
10.5 31.6 GO:0046967 cytosol to ER transport(GO:0046967)
8.7 17.4 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428)
8.1 121.7 GO:0018377 protein myristoylation(GO:0018377)
7.3 29.3 GO:0050822 peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823)
6.9 20.7 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
5.5 22.2 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
5.1 40.7 GO:0070383 DNA cytosine deamination(GO:0070383)
5.0 15.1 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
4.9 14.8 GO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
4.6 18.4 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)
4.5 13.4 GO:0034769 basement membrane disassembly(GO:0034769)
4.1 12.4 GO:1904887 regulation of thioredoxin peroxidase activity(GO:1903123) negative regulation of thioredoxin peroxidase activity(GO:1903124) negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation(GO:1903125) Wnt signalosome assembly(GO:1904887) negative regulation of peroxidase activity(GO:2000469)
4.1 12.3 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
4.0 24.2 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
4.0 15.8 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
3.9 19.4 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
3.8 49.4 GO:0032020 ISG15-protein conjugation(GO:0032020)
3.7 15.0 GO:0002636 positive regulation of germinal center formation(GO:0002636)
3.7 11.2 GO:0045062 extrathymic T cell selection(GO:0045062)
3.6 3.6 GO:0002590 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
3.4 17.2 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
3.4 10.2 GO:2000547 mesangial cell-matrix adhesion(GO:0035759) regulation of dendritic cell dendrite assembly(GO:2000547)
3.3 10.0 GO:0002582 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) positive regulation of antigen processing and presentation of peptide antigen(GO:0002585) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588)
3.1 18.7 GO:0006154 adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103)
3.0 21.2 GO:0060335 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
2.8 14.2 GO:0052056 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
2.8 14.1 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
2.8 8.4 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
2.7 21.5 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
2.7 37.4 GO:1901740 negative regulation of myoblast fusion(GO:1901740)
2.4 14.3 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
2.4 9.4 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
2.4 11.8 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
2.3 11.6 GO:2000538 regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
2.3 13.8 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
2.3 6.8 GO:0035915 pore formation in membrane of other organism(GO:0035915)
2.2 2.2 GO:0002859 negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) negative regulation of natural killer cell mediated immune response to tumor cell(GO:0002856) negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002859)
2.2 28.5 GO:0060700 regulation of ribonuclease activity(GO:0060700)
2.2 17.2 GO:1900165 negative regulation of interleukin-6 secretion(GO:1900165)
2.1 10.6 GO:1901545 cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
2.1 10.5 GO:0019805 quinolinate biosynthetic process(GO:0019805)
2.1 6.2 GO:1904604 regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904596) negative regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904597) regulation of advanced glycation end-product receptor activity(GO:1904603) negative regulation of advanced glycation end-product receptor activity(GO:1904604) negative regulation of connective tissue replacement(GO:1905204)
2.0 8.0 GO:0010607 negative regulation of cytoplasmic mRNA processing body assembly(GO:0010607)
1.9 16.9 GO:2000321 positive regulation of T-helper 17 cell differentiation(GO:2000321)
1.8 16.6 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
1.8 21.8 GO:0030578 PML body organization(GO:0030578)
1.7 59.3 GO:0072643 interferon-gamma secretion(GO:0072643)
1.7 78.9 GO:0035455 response to interferon-alpha(GO:0035455)
1.7 15.3 GO:0035696 monocyte extravasation(GO:0035696)
1.6 17.5 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
1.6 15.8 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
1.6 4.7 GO:0072308 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
1.5 6.0 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
1.5 22.4 GO:0034058 endosomal vesicle fusion(GO:0034058)
1.5 1.5 GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
1.4 7.1 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
1.4 6.8 GO:2001184 positive regulation of interleukin-12 secretion(GO:2001184)
1.3 12.1 GO:0061737 leukotriene signaling pathway(GO:0061737)
1.3 4.0 GO:0002901 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906) macrophage migration inhibitory factor signaling pathway(GO:0035691)
1.3 31.9 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
1.3 14.5 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
1.3 7.7 GO:0010533 regulation of activation of Janus kinase activity(GO:0010533)
1.2 28.0 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
1.2 10.9 GO:0045345 positive regulation of MHC class I biosynthetic process(GO:0045345)
1.2 8.3 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
1.2 5.9 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
1.2 8.1 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
1.2 4.6 GO:0046087 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
1.1 4.5 GO:0051097 negative regulation of helicase activity(GO:0051097)
1.1 12.4 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
1.1 3.3 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
1.1 3.3 GO:0033625 positive regulation of integrin activation(GO:0033625)
1.1 5.4 GO:0009197 dUDP biosynthetic process(GO:0006227) dTDP biosynthetic process(GO:0006233) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dTDP metabolic process(GO:0046072) dUDP metabolic process(GO:0046077)
1.1 22.5 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.9 7.6 GO:0089700 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033) protein kinase D signaling(GO:0089700)
0.9 2.8 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.9 5.6 GO:1902164 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) platelet alpha granule organization(GO:0070889) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.9 2.8 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.9 9.8 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.9 2.7 GO:0046968 peptide antigen transport(GO:0046968)
0.8 2.5 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.8 1.7 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.8 9.1 GO:0042100 B cell proliferation(GO:0042100)
0.8 6.6 GO:0035655 interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351)
0.8 54.8 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.8 4.1 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.8 7.3 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.8 17.8 GO:0010818 T cell chemotaxis(GO:0010818)
0.8 3.2 GO:1990108 protein linear deubiquitination(GO:1990108)
0.8 3.1 GO:0036496 regulation of translational initiation by eIF2 alpha dephosphorylation(GO:0036496)
0.8 3.0 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.7 6.0 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.7 4.4 GO:0033632 regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.7 2.2 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.7 5.8 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.7 4.3 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
0.7 85.2 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.7 10.3 GO:0044130 negative regulation of growth of symbiont in host(GO:0044130)
0.7 4.8 GO:0000432 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.7 4.7 GO:0048014 Tie signaling pathway(GO:0048014)
0.6 3.9 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.6 13.5 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.6 18.0 GO:1900115 extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.6 14.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.6 17.0 GO:0030889 negative regulation of B cell proliferation(GO:0030889)
0.6 3.1 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.6 3.1 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.6 1.2 GO:0031296 B cell costimulation(GO:0031296)
0.6 16.5 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.6 3.0 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474) thymocyte migration(GO:0072679)
0.6 12.5 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.6 2.8 GO:0070269 pyroptosis(GO:0070269)
0.6 1.7 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.6 9.4 GO:0046449 creatinine metabolic process(GO:0046449)
0.6 5.0 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
0.5 1.6 GO:0002372 myeloid dendritic cell cytokine production(GO:0002372)
0.5 4.2 GO:0006741 NADP biosynthetic process(GO:0006741)
0.5 2.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.5 1.4 GO:1902263 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139) apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.5 1.9 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.5 3.3 GO:0030421 defecation(GO:0030421)
0.5 2.4 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.5 1.9 GO:0033037 polysaccharide localization(GO:0033037)
0.5 2.3 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.5 3.2 GO:0050689 negative regulation of defense response to virus by host(GO:0050689)
0.5 3.6 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.4 1.8 GO:0046292 formaldehyde metabolic process(GO:0046292)
0.4 1.8 GO:2000753 regulation of phospholipid scramblase activity(GO:1900161) positive regulation of phospholipid scramblase activity(GO:1900163) regulation of glucosylceramide catabolic process(GO:2000752) positive regulation of glucosylceramide catabolic process(GO:2000753) regulation of sphingomyelin catabolic process(GO:2000754) positive regulation of sphingomyelin catabolic process(GO:2000755)
0.4 8.4 GO:0060022 hard palate development(GO:0060022)
0.4 1.3 GO:0097272 ammonia homeostasis(GO:0097272)
0.4 5.7 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.4 2.6 GO:0019075 virus maturation(GO:0019075)
0.4 1.7 GO:1990523 bone regeneration(GO:1990523)
0.4 2.5 GO:0008582 acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581) regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.4 23.1 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.4 1.2 GO:0097198 histone H3-K36 trimethylation(GO:0097198)
0.4 6.4 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.4 4.8 GO:0010528 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.4 2.8 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.4 1.2 GO:0098583 mastication(GO:0071626) learned vocalization behavior(GO:0098583)
0.4 1.2 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.4 25.8 GO:0030888 regulation of B cell proliferation(GO:0030888)
0.4 0.7 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.4 30.7 GO:0070206 protein trimerization(GO:0070206)
0.4 1.1 GO:0036451 cap mRNA methylation(GO:0036451)
0.4 1.4 GO:0045208 MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209)
0.4 0.4 GO:1903753 negative regulation of p38MAPK cascade(GO:1903753)
0.3 2.0 GO:0038112 interleukin-8-mediated signaling pathway(GO:0038112)
0.3 7.1 GO:0035456 response to interferon-beta(GO:0035456)
0.3 22.7 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.3 4.2 GO:0033227 dsRNA transport(GO:0033227)
0.3 7.1 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.3 1.0 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.3 1.9 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.3 3.2 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.3 1.0 GO:0007518 myoblast fate determination(GO:0007518)
0.3 1.5 GO:0034141 positive regulation of toll-like receptor 3 signaling pathway(GO:0034141)
0.3 0.3 GO:0034759 regulation of iron ion transport(GO:0034756) regulation of iron ion transmembrane transport(GO:0034759)
0.3 5.0 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.3 1.2 GO:0009443 pyridoxal 5'-phosphate salvage(GO:0009443)
0.3 5.8 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.3 2.0 GO:1905049 negative regulation of metallopeptidase activity(GO:1905049)
0.3 6.4 GO:0031953 negative regulation of protein autophosphorylation(GO:0031953)
0.3 9.6 GO:0045332 phospholipid translocation(GO:0045332)
0.3 4.7 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.3 7.4 GO:0097320 membrane tubulation(GO:0097320)
0.3 8.4 GO:0051639 actin filament network formation(GO:0051639)
0.3 1.6 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.3 1.3 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.3 2.4 GO:2000402 negative regulation of lymphocyte migration(GO:2000402)
0.3 0.8 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.3 1.3 GO:1903413 cellular response to bile acid(GO:1903413)
0.3 3.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.3 3.4 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.3 1.5 GO:0007296 vitellogenesis(GO:0007296)
0.2 0.5 GO:0021943 formation of radial glial scaffolds(GO:0021943)
0.2 1.7 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.2 2.2 GO:0002353 kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.2 2.4 GO:0016554 cytidine to uridine editing(GO:0016554)
0.2 4.1 GO:0015939 pantothenate metabolic process(GO:0015939)
0.2 2.4 GO:0070842 aggresome assembly(GO:0070842)
0.2 5.9 GO:0097264 self proteolysis(GO:0097264)
0.2 0.7 GO:0015734 taurine transport(GO:0015734)
0.2 4.4 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.2 1.4 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
0.2 2.2 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.2 1.5 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.2 0.7 GO:0060981 cell migration involved in coronary angiogenesis(GO:0060981)
0.2 1.1 GO:0050917 sensory perception of umami taste(GO:0050917)
0.2 0.9 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.2 0.7 GO:0031247 actin rod assembly(GO:0031247)
0.2 1.5 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.2 0.9 GO:1904017 cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.2 1.3 GO:1904799 regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.2 6.8 GO:0016578 histone deubiquitination(GO:0016578)
0.2 4.7 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.2 2.0 GO:2000172 regulation of branching morphogenesis of a nerve(GO:2000172)
0.2 8.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 2.0 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.2 7.4 GO:0032479 regulation of type I interferon production(GO:0032479)
0.2 0.2 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.2 1.6 GO:0010166 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.2 1.2 GO:0090234 regulation of kinetochore assembly(GO:0090234)
0.2 0.8 GO:0071348 cellular response to interleukin-11(GO:0071348)
0.2 10.0 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.2 1.7 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.2 1.0 GO:0061741 vacuolar transmembrane transport(GO:0034486) chaperone-mediated protein transport involved in chaperone-mediated autophagy(GO:0061741) negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
0.2 0.8 GO:2000152 regulation of ubiquitin-specific protease activity(GO:2000152) positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.2 3.4 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.2 2.4 GO:0033015 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.2 6.8 GO:0008053 mitochondrial fusion(GO:0008053)
0.2 1.5 GO:0035990 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.2 0.7 GO:1904977 lymphatic endothelial cell migration(GO:1904977)
0.2 2.7 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.2 0.2 GO:1902954 regulation of early endosome to recycling endosome transport(GO:1902954)
0.2 1.2 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.2 20.6 GO:0032481 positive regulation of type I interferon production(GO:0032481)
0.2 1.6 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.2 0.7 GO:0042335 cuticle development(GO:0042335)
0.2 1.7 GO:0097338 response to clozapine(GO:0097338)
0.2 1.2 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.2 10.7 GO:0034383 low-density lipoprotein particle clearance(GO:0034383)
0.2 3.0 GO:0061470 interleukin-21 production(GO:0032625) macrophage colony-stimulating factor production(GO:0036301) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619) regulation of macrophage colony-stimulating factor production(GO:1901256)
0.2 0.7 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.2 2.0 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.2 5.5 GO:0003094 glomerular filtration(GO:0003094)
0.2 3.3 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.2 0.9 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.2 6.7 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.2 5.2 GO:0045109 intermediate filament organization(GO:0045109)
0.2 3.5 GO:0032717 negative regulation of interleukin-8 production(GO:0032717)
0.2 3.0 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.2 0.8 GO:1904075 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.2 0.5 GO:0009720 detection of hormone stimulus(GO:0009720)
0.1 0.9 GO:0032916 positive regulation of transforming growth factor beta3 production(GO:0032916) chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.1 2.0 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1 13.0 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.1 1.1 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.1 9.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 4.1 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 2.1 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.1 0.5 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.1 0.3 GO:0070340 toll-like receptor 1 signaling pathway(GO:0034130) regulation of toll-like receptor 2 signaling pathway(GO:0034135) positive regulation of toll-like receptor 2 signaling pathway(GO:0034137) toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) detection of bacterial lipoprotein(GO:0042494) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
0.1 5.9 GO:0010390 histone monoubiquitination(GO:0010390)
0.1 0.7 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.1 0.3 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.1 0.8 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 25.0 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.1 0.4 GO:0042222 interleukin-1 biosynthetic process(GO:0042222) interleukin-1 beta biosynthetic process(GO:0050720)
0.1 2.1 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.1 1.8 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.1 1.8 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.1 0.5 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.1 1.3 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407) positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.1 0.3 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 2.9 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1 8.8 GO:0002456 T cell mediated immunity(GO:0002456)
0.1 0.7 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.1 0.3 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.1 1.8 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
0.1 7.3 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 0.3 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.1 4.8 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 0.7 GO:0061743 motor learning(GO:0061743)
0.1 0.3 GO:0006059 hexitol metabolic process(GO:0006059)
0.1 4.8 GO:0019835 cytolysis(GO:0019835)
0.1 0.4 GO:0030576 Cajal body organization(GO:0030576)
0.1 1.1 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.1 3.0 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.1 0.8 GO:0016264 gap junction assembly(GO:0016264)
0.1 2.9 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.1 5.9 GO:0006968 cellular defense response(GO:0006968)
0.1 0.8 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.1 1.4 GO:0043536 positive regulation of blood vessel endothelial cell migration(GO:0043536)
0.1 1.8 GO:0015671 oxygen transport(GO:0015671)
0.1 0.6 GO:0021764 amygdala development(GO:0021764)
0.1 2.9 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.1 3.2 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.1 8.2 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.1 0.5 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.1 1.1 GO:0048664 neuron fate determination(GO:0048664)
0.1 1.7 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.1 1.4 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.1 0.4 GO:0002349 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.1 0.7 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 2.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 0.3 GO:0002384 hepatic immune response(GO:0002384)
0.1 17.0 GO:0015992 proton transport(GO:0015992)
0.1 0.6 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.1 1.2 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 1.0 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.1 0.3 GO:0061763 multivesicular body-lysosome fusion(GO:0061763)
0.1 0.9 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.1 0.9 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.1 0.9 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 2.3 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.1 5.8 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.1 4.2 GO:0045576 mast cell activation(GO:0045576)
0.1 1.8 GO:0048147 negative regulation of fibroblast proliferation(GO:0048147)
0.1 0.8 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 0.7 GO:0090204 protein localization to nuclear pore(GO:0090204)
0.1 1.8 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.1 15.9 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.1 3.6 GO:0031529 ruffle organization(GO:0031529)
0.1 1.4 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 2.0 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.1 0.5 GO:1903826 arginine transmembrane transport(GO:1903826)
0.1 44.2 GO:0043312 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.1 0.3 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.1 0.6 GO:0006828 manganese ion transport(GO:0006828)
0.1 0.6 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.1 0.7 GO:0010578 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.1 0.9 GO:0015867 ADP transport(GO:0015866) ATP transport(GO:0015867)
0.1 3.2 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.1 0.7 GO:0010225 response to UV-C(GO:0010225)
0.1 0.3 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.1 0.3 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.1 0.5 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.1 1.5 GO:0042993 positive regulation of transcription factor import into nucleus(GO:0042993)
0.1 0.2 GO:0010909 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.1 0.3 GO:1900110 negative regulation of histone H3-K9 dimethylation(GO:1900110)
0.1 8.5 GO:0090630 activation of GTPase activity(GO:0090630)
0.1 0.7 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 0.3 GO:0033490 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.1 0.3 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 2.6 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.1 4.4 GO:0030574 collagen catabolic process(GO:0030574)
0.1 0.5 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 2.2 GO:0071539 protein localization to centrosome(GO:0071539)
0.1 0.4 GO:0019418 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.1 1.8 GO:0051923 sulfation(GO:0051923)
0.1 0.5 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.1 0.4 GO:0010663 positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
0.1 1.5 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 0.4 GO:0072711 response to hydroxyurea(GO:0072710) cellular response to hydroxyurea(GO:0072711)
0.1 1.2 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.1 0.6 GO:0022417 protein maturation by protein folding(GO:0022417)
0.0 0.2 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 1.4 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.4 GO:0090168 Golgi reassembly(GO:0090168)
0.0 1.3 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.0 0.5 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.0 0.6 GO:0072520 seminiferous tubule development(GO:0072520)
0.0 0.1 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.0 0.7 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.9 GO:0016180 snRNA processing(GO:0016180)
0.0 2.7 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.5 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.2 GO:0072047 proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081) specification of loop of Henle identity(GO:0072086)
0.0 0.5 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.1 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.0 5.7 GO:0002377 immunoglobulin production(GO:0002377)
0.0 0.3 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0 0.7 GO:0038129 ERBB3 signaling pathway(GO:0038129)
0.0 0.5 GO:0051661 maintenance of centrosome location(GO:0051661)
0.0 3.1 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.5 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 1.6 GO:0051972 regulation of telomerase activity(GO:0051972)
0.0 0.9 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 6.9 GO:0009615 response to virus(GO:0009615)
0.0 0.1 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.2 GO:0016584 nucleosome positioning(GO:0016584)
0.0 1.0 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.6 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 1.6 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.3 GO:0032119 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.0 0.1 GO:0035634 response to stilbenoid(GO:0035634)
0.0 1.1 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.8 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.1 GO:0010877 lipid transport involved in lipid storage(GO:0010877)
0.0 0.4 GO:0050427 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0 1.2 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.5 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.8 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.3 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.0 0.4 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.1 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016)
0.0 0.7 GO:0042102 positive regulation of T cell proliferation(GO:0042102)
0.0 0.1 GO:0072602 interleukin-4 secretion(GO:0072602)
0.0 0.7 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627)
0.0 0.4 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.0 0.5 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
0.0 0.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.3 GO:0009651 response to salt stress(GO:0009651)
0.0 0.1 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.2 GO:2000425 regulation of apoptotic cell clearance(GO:2000425) positive regulation of apoptotic cell clearance(GO:2000427)
0.0 2.8 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.5 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 0.1 GO:0098967 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.0 1.4 GO:0001895 retina homeostasis(GO:0001895)
0.0 1.3 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.7 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.3 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 0.5 GO:0030641 regulation of cellular pH(GO:0030641)
0.0 0.8 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 0.0 GO:1902173 negative regulation of keratinocyte apoptotic process(GO:1902173)
0.0 0.0 GO:0042976 activation of Janus kinase activity(GO:0042976)
0.0 0.6 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.8 GO:0006402 mRNA catabolic process(GO:0006402)
0.0 2.3 GO:0006310 DNA recombination(GO:0006310)
0.0 1.5 GO:0070268 cornification(GO:0070268)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
8.7 60.8 GO:0042825 TAP complex(GO:0042825)
7.3 58.3 GO:1990111 spermatoproteasome complex(GO:1990111)
7.1 28.5 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
6.5 38.9 GO:0097169 AIM2 inflammasome complex(GO:0097169)
4.1 12.4 GO:0032473 cytoplasmic side of mitochondrial outer membrane(GO:0032473) caveola neck(GO:0099400)
3.5 17.4 GO:0031905 early endosome lumen(GO:0031905)
2.8 16.7 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
2.6 28.5 GO:0032010 phagolysosome(GO:0032010)
2.3 7.0 GO:0042022 interleukin-12 receptor complex(GO:0042022)
2.3 18.0 GO:0043196 varicosity(GO:0043196)
1.7 20.5 GO:0043020 NADPH oxidase complex(GO:0043020)
1.6 8.1 GO:0071754 IgM immunoglobulin complex(GO:0071753) IgM immunoglobulin complex, circulating(GO:0071754) pentameric IgM immunoglobulin complex(GO:0071756)
1.6 6.4 GO:0008537 proteasome activator complex(GO:0008537)
1.5 38.3 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
1.2 8.6 GO:0036021 endolysosome lumen(GO:0036021)
1.2 5.9 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
1.0 5.8 GO:0036398 TCR signalosome(GO:0036398)
0.9 7.2 GO:0005901 caveola(GO:0005901)
0.8 5.7 GO:0020016 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.8 10.0 GO:0005688 U6 snRNP(GO:0005688)
0.7 5.4 GO:0044530 supraspliceosomal complex(GO:0044530)
0.7 12.1 GO:0008385 IkappaB kinase complex(GO:0008385)
0.7 2.0 GO:0030936 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.6 11.0 GO:0035631 CD40 receptor complex(GO:0035631)
0.6 5.8 GO:0030896 checkpoint clamp complex(GO:0030896)
0.6 6.3 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.6 0.6 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.6 13.1 GO:0071439 clathrin complex(GO:0071439)
0.6 7.2 GO:0032009 early phagosome(GO:0032009)
0.5 2.1 GO:0005588 collagen type V trimer(GO:0005588)
0.5 4.0 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.5 1.5 GO:0016590 ACF complex(GO:0016590)
0.5 42.1 GO:0015030 Cajal body(GO:0015030)
0.4 10.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.4 4.9 GO:0016589 NURF complex(GO:0016589)
0.4 2.0 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.4 3.2 GO:0071797 LUBAC complex(GO:0071797)
0.4 3.6 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.4 64.7 GO:0035578 azurophil granule lumen(GO:0035578)
0.4 3.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.4 7.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.3 12.5 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.3 36.0 GO:0005811 lipid particle(GO:0005811)
0.3 2.9 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.3 53.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.3 4.4 GO:0071438 invadopodium membrane(GO:0071438)
0.2 3.0 GO:0097524 sperm plasma membrane(GO:0097524)
0.2 7.8 GO:0031143 pseudopodium(GO:0031143)
0.2 4.0 GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.2 8.8 GO:0031528 microvillus membrane(GO:0031528)
0.2 1.8 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.2 2.4 GO:0016235 aggresome(GO:0016235)
0.2 9.4 GO:0031258 lamellipodium membrane(GO:0031258)
0.2 3.5 GO:0030870 Mre11 complex(GO:0030870)
0.2 88.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 1.2 GO:0097165 nuclear stress granule(GO:0097165)
0.2 2.2 GO:0042382 paraspeckles(GO:0042382)
0.2 0.6 GO:0071547 piP-body(GO:0071547)
0.2 1.0 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
0.2 2.7 GO:0005614 interstitial matrix(GO:0005614)
0.2 1.6 GO:0005577 fibrinogen complex(GO:0005577)
0.2 2.4 GO:0042587 glycogen granule(GO:0042587)
0.2 25.1 GO:0005643 nuclear pore(GO:0005643)
0.2 0.6 GO:0033167 ARC complex(GO:0033167)
0.2 1.6 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 12.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 2.6 GO:0000813 ESCRT I complex(GO:0000813)
0.1 2.0 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.1 0.9 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.1 2.5 GO:0043083 synaptic cleft(GO:0043083)
0.1 0.5 GO:0034455 t-UTP complex(GO:0034455)
0.1 4.4 GO:0018995 host(GO:0018995) host cell(GO:0043657)
0.1 0.1 GO:0097427 microtubule bundle(GO:0097427)
0.1 2.0 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 0.5 GO:0044307 dendritic branch(GO:0044307)
0.1 0.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 6.6 GO:0001772 immunological synapse(GO:0001772)
0.1 0.7 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 1.1 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 1.0 GO:0005767 secondary lysosome(GO:0005767)
0.1 1.3 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1 0.5 GO:0031264 death-inducing signaling complex(GO:0031264)
0.1 3.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 1.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.9 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 9.6 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 0.3 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 13.1 GO:0035579 specific granule membrane(GO:0035579)
0.1 0.2 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 123.9 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 6.8 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 1.2 GO:0005833 hemoglobin complex(GO:0005833)
0.1 4.0 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1 11.6 GO:0035097 histone methyltransferase complex(GO:0035097)
0.1 1.3 GO:0005587 collagen type IV trimer(GO:0005587)
0.1 8.2 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 0.8 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.1 2.2 GO:0000242 pericentriolar material(GO:0000242)
0.1 46.8 GO:0016607 nuclear speck(GO:0016607)
0.1 0.3 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 11.9 GO:0005903 brush border(GO:0005903)
0.1 0.6 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 0.5 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 0.9 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 2.3 GO:0030057 desmosome(GO:0030057)
0.1 6.5 GO:0035580 specific granule lumen(GO:0035580)
0.1 0.7 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.1 1.4 GO:0070938 contractile ring(GO:0070938)
0.1 1.0 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 1.7 GO:0042629 mast cell granule(GO:0042629)
0.1 5.0 GO:0005902 microvillus(GO:0005902)
0.1 1.8 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 2.6 GO:0071564 npBAF complex(GO:0071564)
0.1 8.0 GO:0016363 nuclear matrix(GO:0016363)
0.1 0.7 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 2.8 GO:0070821 tertiary granule membrane(GO:0070821)
0.1 1.4 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 25.2 GO:0005769 early endosome(GO:0005769)
0.1 3.9 GO:0005876 spindle microtubule(GO:0005876)
0.1 0.9 GO:0032039 integrator complex(GO:0032039)
0.1 0.3 GO:0070765 gamma-secretase complex(GO:0070765)
0.1 7.1 GO:0016605 PML body(GO:0016605)
0.1 12.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.6 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 8.3 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 1.0 GO:0031985 Golgi cisterna(GO:0031985)
0.0 0.7 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.6 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 12.8 GO:0001726 ruffle(GO:0001726)
0.0 0.5 GO:0070552 BRISC complex(GO:0070552)
0.0 0.6 GO:0031209 SCAR complex(GO:0031209)
0.0 2.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 4.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 84.1 GO:0005615 extracellular space(GO:0005615)
0.0 0.9 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.7 GO:0051233 spindle midzone(GO:0051233)
0.0 0.6 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 2.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 3.7 GO:0005802 trans-Golgi network(GO:0005802)
0.0 8.6 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 0.8 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 5.4 GO:0010008 endosome membrane(GO:0010008)
0.0 1.4 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.7 GO:0005795 Golgi stack(GO:0005795)
0.0 3.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.1 GO:0031010 ISWI-type complex(GO:0031010)
0.0 1.1 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.7 GO:0046930 pore complex(GO:0046930)
0.0 11.4 GO:0000790 nuclear chromatin(GO:0000790)
0.0 13.9 GO:0031410 cytoplasmic vesicle(GO:0031410)
0.0 14.5 GO:0005813 centrosome(GO:0005813)
0.0 3.1 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.3 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 17.7 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.8 GO:0005581 collagen trimer(GO:0005581)
0.0 0.1 GO:1990796 photoreceptor cell terminal bouton(GO:1990796)
0.0 12.9 GO:0000323 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 1.2 GO:1990391 DNA repair complex(GO:1990391)
0.0 7.2 GO:0016604 nuclear body(GO:0016604)
0.0 0.1 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.3 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 6.5 GO:0031012 extracellular matrix(GO:0031012)
0.0 2.3 GO:0005635 nuclear envelope(GO:0005635)
0.0 75.0 GO:0005654 nucleoplasm(GO:0005654)
0.0 0.9 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.1 GO:0097225 sperm midpiece(GO:0097225)
0.0 2.7 GO:0005794 Golgi apparatus(GO:0005794)
0.0 78.1 GO:0016021 integral component of membrane(GO:0016021)
0.0 1.1 GO:0005667 transcription factor complex(GO:0005667)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
10.7 171.2 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
8.1 24.2 GO:0003692 left-handed Z-DNA binding(GO:0003692)
7.4 22.2 GO:0008859 exoribonuclease II activity(GO:0008859)
7.2 36.1 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
6.2 18.6 GO:0042007 interleukin-18 binding(GO:0042007)
6.2 24.7 GO:0046979 TAP2 binding(GO:0046979)
5.2 26.0 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
4.2 12.7 GO:0005139 interleukin-7 receptor binding(GO:0005139)
4.1 12.4 GO:0034211 GTP-dependent protein kinase activity(GO:0034211) peroxidase inhibitor activity(GO:0036479)
3.2 22.3 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
3.0 15.2 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
3.0 14.8 GO:0048030 disaccharide binding(GO:0048030)
2.5 10.0 GO:0032090 Pyrin domain binding(GO:0032090)
2.3 7.0 GO:0016517 interleukin-12 receptor activity(GO:0016517)
2.3 11.6 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
2.3 16.1 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
2.2 6.6 GO:0042008 interleukin-18 receptor activity(GO:0042008)
2.1 8.2 GO:0005151 interleukin-1, Type II receptor binding(GO:0005151)
2.1 47.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
2.1 6.2 GO:1904599 advanced glycation end-product binding(GO:1904599)
1.9 18.6 GO:0042296 ISG15 transferase activity(GO:0042296)
1.8 5.4 GO:0033862 UMP kinase activity(GO:0033862)
1.7 11.9 GO:0004126 cytidine deaminase activity(GO:0004126)
1.7 18.7 GO:0031685 adenosine receptor binding(GO:0031685)
1.7 13.3 GO:0031849 olfactory receptor binding(GO:0031849)
1.6 50.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
1.6 49.9 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
1.5 12.1 GO:0004974 leukotriene receptor activity(GO:0004974)
1.5 14.7 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
1.5 11.6 GO:0004771 sterol esterase activity(GO:0004771)
1.4 2.8 GO:0019763 immunoglobulin receptor activity(GO:0019763)
1.4 10.8 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
1.3 6.5 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
1.3 10.3 GO:0031996 thioesterase binding(GO:0031996)
1.2 16.6 GO:0031386 protein tag(GO:0031386)
1.2 21.2 GO:0019864 IgG binding(GO:0019864)
1.2 10.5 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
1.0 8.3 GO:0019863 IgE binding(GO:0019863)
1.0 4.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
1.0 38.2 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
1.0 2.9 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.9 4.7 GO:0047280 nicotinamide phosphoribosyltransferase activity(GO:0047280)
0.9 20.6 GO:0017154 semaphorin receptor activity(GO:0017154)
0.9 45.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.9 46.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.9 5.4 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.8 3.4 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.8 3.0 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.7 30.9 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.7 3.7 GO:0004556 alpha-amylase activity(GO:0004556)
0.7 6.5 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.7 6.4 GO:0061133 endopeptidase activator activity(GO:0061133)
0.7 2.1 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.7 6.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.7 0.7 GO:1904713 beta-catenin destruction complex binding(GO:1904713)
0.6 2.4 GO:0004074 biliverdin reductase activity(GO:0004074)
0.6 3.6 GO:0015119 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.6 8.2 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.6 23.8 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.6 1.7 GO:0000247 C-8 sterol isomerase activity(GO:0000247) cholestenol delta-isomerase activity(GO:0047750)
0.6 1.7 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.5 4.2 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.5 13.6 GO:0042609 CD4 receptor binding(GO:0042609)
0.5 3.1 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.5 2.5 GO:0001069 regulatory region RNA binding(GO:0001069)
0.5 6.8 GO:0051525 NFAT protein binding(GO:0051525)
0.5 1.8 GO:0098770 FBXO family protein binding(GO:0098770)
0.5 6.8 GO:1901612 cardiolipin binding(GO:1901612)
0.4 9.9 GO:0042834 peptidoglycan binding(GO:0042834)
0.4 3.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.4 7.2 GO:0035325 Toll-like receptor binding(GO:0035325)
0.4 8.9 GO:0051400 BH domain binding(GO:0051400)
0.4 7.9 GO:0032183 SUMO binding(GO:0032183)
0.4 13.0 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.4 3.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.4 13.4 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.4 5.0 GO:0070087 chromo shadow domain binding(GO:0070087)
0.4 13.6 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.4 1.1 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.4 3.7 GO:0004064 arylesterase activity(GO:0004064)
0.4 1.1 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.4 12.5 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.4 1.8 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.4 10.6 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.4 3.9 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.3 15.5 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.3 2.0 GO:0004918 interleukin-8 receptor activity(GO:0004918)
0.3 11.9 GO:0000339 RNA cap binding(GO:0000339)
0.3 13.4 GO:0043394 proteoglycan binding(GO:0043394)
0.3 9.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.3 1.2 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.3 1.8 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.3 3.0 GO:0004000 adenosine deaminase activity(GO:0004000)
0.3 1.2 GO:0008478 pyridoxal kinase activity(GO:0008478)
0.3 18.1 GO:0051879 Hsp90 protein binding(GO:0051879)
0.3 1.2 GO:0034736 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.3 1.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.3 4.7 GO:0004568 chitinase activity(GO:0004568)
0.3 8.4 GO:0042288 MHC class I protein binding(GO:0042288)
0.3 1.9 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.3 0.8 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
0.3 1.6 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.3 34.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.3 1.8 GO:0030492 hemoglobin binding(GO:0030492)
0.3 38.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.2 2.2 GO:0070573 metallodipeptidase activity(GO:0070573)
0.2 3.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.2 9.5 GO:0004697 protein kinase C activity(GO:0004697)
0.2 6.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 0.7 GO:0005368 taurine transmembrane transporter activity(GO:0005368) taurine:sodium symporter activity(GO:0005369)
0.2 1.8 GO:0043208 glycosphingolipid binding(GO:0043208)
0.2 2.0 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.2 2.4 GO:0045159 myosin II binding(GO:0045159)
0.2 0.6 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.2 1.5 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.2 4.8 GO:0005522 profilin binding(GO:0005522)
0.2 0.8 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.2 3.0 GO:0046790 virion binding(GO:0046790)
0.2 4.7 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.2 5.9 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 0.8 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.2 2.3 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.2 4.5 GO:0032036 myosin heavy chain binding(GO:0032036)
0.2 3.0 GO:0019957 C-C chemokine binding(GO:0019957)
0.2 15.1 GO:0019843 rRNA binding(GO:0019843)
0.2 7.8 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.2 1.4 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.2 10.5 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.2 8.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 3.2 GO:1990380 Lys63-specific deubiquitinase activity(GO:0061578) Lys48-specific deubiquitinase activity(GO:1990380)
0.2 4.8 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.2 1.0 GO:0004977 melanocortin receptor activity(GO:0004977)
0.2 4.0 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.2 2.7 GO:0004985 opioid receptor activity(GO:0004985)
0.2 0.5 GO:0034437 glycoprotein transporter activity(GO:0034437)
0.1 86.3 GO:0005525 GTP binding(GO:0005525)
0.1 1.8 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 3.0 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.1 0.6 GO:0034584 piRNA binding(GO:0034584)
0.1 0.9 GO:0030375 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
0.1 0.7 GO:0000405 bubble DNA binding(GO:0000405)
0.1 14.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 0.9 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 2.9 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 1.3 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 4.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.4 GO:0008441 3'(2'),5'-bisphosphate nucleotidase activity(GO:0008441)
0.1 0.7 GO:0001093 TFIIB-class transcription factor binding(GO:0001093)
0.1 1.2 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1 0.7 GO:1990460 leptin receptor binding(GO:1990460)
0.1 0.7 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.1 2.3 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.1 5.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 3.0 GO:0050681 androgen receptor binding(GO:0050681)
0.1 5.4 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 1.7 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 1.0 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.1 3.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 2.7 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.1 0.7 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.1 2.8 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.1 3.0 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 1.0 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 18.0 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 1.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 20.3 GO:0001047 core promoter binding(GO:0001047)
0.1 10.1 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.1 22.7 GO:0004386 helicase activity(GO:0004386)
0.1 1.6 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 5.9 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 4.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 5.7 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 1.7 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.1 12.2 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.1 4.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 1.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 1.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.9 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 15.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.2 GO:0045499 chemorepellent activity(GO:0045499)
0.1 7.4 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 0.3 GO:0008665 2'-phosphotransferase activity(GO:0008665)
0.1 16.0 GO:0005178 integrin binding(GO:0005178)
0.1 0.3 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 1.3 GO:0042301 phosphate ion binding(GO:0042301)
0.1 0.3 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.1 0.6 GO:0004473 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.1 16.2 GO:0003823 antigen binding(GO:0003823)
0.1 0.6 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.1 0.8 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 0.8 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 2.4 GO:0070628 proteasome binding(GO:0070628)
0.1 3.3 GO:0003785 actin monomer binding(GO:0003785)
0.1 2.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 1.0 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 0.5 GO:0070513 death domain binding(GO:0070513)
0.1 3.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 1.5 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 2.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.9 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.1 5.1 GO:0043130 ubiquitin binding(GO:0043130)
0.1 3.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 3.9 GO:0042393 histone binding(GO:0042393)
0.1 0.3 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.1 0.7 GO:0016015 morphogen activity(GO:0016015)
0.1 21.4 GO:0030246 carbohydrate binding(GO:0030246)
0.1 0.3 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.1 0.5 GO:0004372 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1 1.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 16.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.8 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.2 GO:0031208 POZ domain binding(GO:0031208)
0.0 0.1 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.0 2.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.8 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.3 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.0 1.6 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.4 GO:0034452 dynactin binding(GO:0034452)
0.0 0.6 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 1.7 GO:0033558 histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)
0.0 23.9 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.4 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 2.8 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 3.2 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.9 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 1.1 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 3.5 GO:0002039 p53 binding(GO:0002039)
0.0 0.2 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
0.0 1.4 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 0.8 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 1.6 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.7 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.2 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.0 0.3 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 3.3 GO:0003682 chromatin binding(GO:0003682)
0.0 0.7 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 5.9 GO:0005319 lipid transporter activity(GO:0005319)
0.0 0.8 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 2.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 1.3 GO:0032452 histone demethylase activity(GO:0032452)
0.0 1.4 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.1 GO:0051500 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.0 1.9 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.0 0.7 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 1.6 GO:0061733 peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0 0.1 GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (uridine) methyltransferase activity(GO:0016436)
0.0 0.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.4 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.5 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.0 8.0 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 1.0 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.7 GO:0046961 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 3.4 GO:0019838 growth factor binding(GO:0019838)
0.0 0.0 GO:0009008 DNA-methyltransferase activity(GO:0009008)
0.0 1.6 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.1 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 11.5 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 2.6 GO:0005254 chloride channel activity(GO:0005254)
0.0 1.5 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 0.5 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.2 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 1.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.1 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0 0.7 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 1.7 GO:0003690 double-stranded DNA binding(GO:0003690)
0.0 0.3 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.4 GO:0008143 poly(A) binding(GO:0008143)
0.0 2.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 9.6 GO:0008270 zinc ion binding(GO:0008270)
0.0 0.5 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 22.4 GO:0003677 DNA binding(GO:0003677)
0.0 0.3 GO:0015026 coreceptor activity(GO:0015026)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 65.6 PID TRAIL PATHWAY TRAIL signaling pathway
0.7 16.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.6 74.2 PID IL12 2PATHWAY IL12-mediated signaling events
0.6 20.5 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.5 51.4 PID RAC1 PATHWAY RAC1 signaling pathway
0.4 24.1 PID IL2 1PATHWAY IL2-mediated signaling events
0.4 33.0 PID BCR 5PATHWAY BCR signaling pathway
0.3 8.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3 5.0 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.3 2.1 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.3 10.3 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.3 15.2 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.3 21.5 PID IL4 2PATHWAY IL4-mediated signaling events
0.3 2.8 PID S1P S1P4 PATHWAY S1P4 pathway
0.3 3.6 PID IL23 PATHWAY IL23-mediated signaling events
0.2 8.0 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.2 14.0 PID ENDOTHELIN PATHWAY Endothelins
0.2 8.6 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 5.9 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.2 60.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 5.9 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 16.4 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.2 42.8 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.2 1.2 ST JAK STAT PATHWAY Jak-STAT Pathway
0.2 11.4 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 4.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 0.7 ST ADRENERGIC Adrenergic Pathway
0.1 1.0 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 11.7 PID PLK1 PATHWAY PLK1 signaling events
0.1 1.4 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 14.2 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 11.6 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 6.8 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.1 13.8 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 1.3 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 10.0 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 1.6 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 1.8 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.1 6.2 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 2.3 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.1 5.7 PID SHP2 PATHWAY SHP2 signaling
0.1 4.2 PID PI3KCI PATHWAY Class I PI3K signaling events
0.1 1.7 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.1 8.0 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.8 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 8.8 PID CMYB PATHWAY C-MYB transcription factor network
0.1 0.8 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 1.8 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.1 2.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 2.5 PID ALK1 PATHWAY ALK1 signaling events
0.1 25.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 24.5 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 6.0 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 0.8 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.1 2.0 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 2.3 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 1.8 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.6 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.0 2.2 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.7 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 2.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 1.3 PID AURORA A PATHWAY Aurora A signaling
0.0 1.2 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.3 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.3 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 370.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
3.2 34.8 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
1.9 68.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
1.7 34.9 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
1.7 19.0 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
1.7 40.5 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
1.2 80.0 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.9 31.5 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.8 76.3 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.7 56.3 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.6 21.9 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.6 10.4 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.6 6.4 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.5 43.8 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.5 10.6 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.5 15.7 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.5 12.1 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.4 10.0 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.4 5.6 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.4 17.7 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.4 3.1 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.4 5.5 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.3 6.8 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.3 30.1 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.3 11.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.3 3.9 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.3 4.1 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.3 8.3 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.2 0.9 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2 8.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 4.3 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.2 2.8 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.2 10.0 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 3.4 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.2 1.5 REACTOME G ALPHA1213 SIGNALLING EVENTS Genes involved in G alpha (12/13) signalling events
0.2 14.4 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 12.4 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.2 0.7 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.2 10.3 REACTOME IL 2 SIGNALING Genes involved in Interleukin-2 signaling
0.1 2.8 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 1.8 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.1 1.7 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 11.5 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.1 4.9 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 13.8 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 9.8 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 3.9 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.1 2.1 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 5.0 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.1 1.7 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 1.7 REACTOME IL 3 5 AND GM CSF SIGNALING Genes involved in Interleukin-3, 5 and GM-CSF signaling
0.1 3.9 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 8.2 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 3.0 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 1.6 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.2 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 3.0 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras
0.1 2.6 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 1.5 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 1.3 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 3.2 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 4.5 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.1 5.3 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 14.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.5 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.6 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 1.2 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 5.0 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 4.0 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.9 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.3 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 2.9 REACTOME TRANS GOLGI NETWORK VESICLE BUDDING Genes involved in trans-Golgi Network Vesicle Budding
0.0 1.0 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.9 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 1.3 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 3.4 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 7.4 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.7 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 1.4 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 3.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.5 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.9 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.0 0.7 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.2 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 2.7 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 2.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.5 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.4 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.5 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.1 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.0 0.2 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.4 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery