ISMARA results: IRF3

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Illumina Body Map 2 (GSE30611)

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Results for IRF3

Z-value: 1.71

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Transcription factors associated with IRF3

Gene Symbol	Gene ID	Gene Info
IRF3 Ensembl NCBI GeneCards UniProt	ENSG00000126456.16	interferon regulatory factor 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
IRF3	hg38_v1_chr19_-_49665603_49665617	0.39	2.7e-02	Click!

Activity profile of IRF3 motif

Sorted Z-values of IRF3 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_-_73982019 Show fit	10.88	ENST00000296029.4	PF4 Ensembl NCBI GeneCards UniProt Show fit	platelet factor 4
chr19_+_18173804 Show fit	8.49	ENST00000407280.4	IFI30 Ensembl NCBI GeneCards UniProt Show fit	IFI30 lysosomal thiol reductase
chr17_-_35880350 Show fit	8.48	ENST00000605140.6 ENST00000651122.1 ENST00000603197.6	CCL5 Ensembl NCBI GeneCards UniProt Show fit	C-C motif chemokine ligand 5
chr2_+_162318884 Show fit	7.73	ENST00000446271.5 ENST00000429691.6	GCA Ensembl NCBI GeneCards UniProt Show fit	grancalcin
chr12_+_112978562 Show fit	7.18	ENST00000680122.1	OAS2 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 2
chr2_+_218260991 Show fit	6.74	ENST00000522678.5 ENST00000519574.2 ENST00000521462.1	GPBAR1 Ensembl NCBI GeneCards UniProt Show fit	G protein-coupled bile acid receptor 1
chr3_-_36908503 Show fit	6.49	ENST00000463764.2	TRANK1 Ensembl NCBI GeneCards UniProt Show fit	tetratricopeptide repeat and ankyrin repeat containing 1
chr6_-_132763424 Show fit	6.45	ENST00000532012.1 ENST00000525270.5 ENST00000530536.5 ENST00000524919.5	VNN2 Ensembl NCBI GeneCards UniProt Show fit	vanin 2
chr5_-_43040311 Show fit	5.80	ENST00000616064.2	ANXA2R Ensembl NCBI GeneCards UniProt Show fit	annexin A2 receptor
chr12_+_112978424 Show fit	5.43	ENST00000680685.1 ENST00000620097.2	OAS2 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 2
chr12_+_112978535 Show fit	5.39	ENST00000552756.6	OAS2 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 2
chr3_-_27722316 Show fit	5.36	ENST00000449599.4	EOMES Ensembl NCBI GeneCards UniProt Show fit	eomesodermin
chr7_-_93117956 Show fit	5.34	ENST00000446617.1 ENST00000379958.3 ENST00000620985.4	SAMD9 Ensembl NCBI GeneCards UniProt Show fit	sterile alpha motif domain containing 9
chr12_+_112978504 Show fit	5.28	ENST00000392583.7	OAS2 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 2
chr12_+_112978386 Show fit	5.00	ENST00000342315.8	OAS2 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 2
chr7_+_142587857 Show fit	4.86	ENST00000617639.1	TRBV14 Ensembl NCBI GeneCards UniProt Show fit	T cell receptor beta variable 14
chr1_+_151156627 Show fit	4.81	ENST00000368910.4	TNFAIP8L2 Ensembl NCBI GeneCards UniProt Show fit	TNF alpha induced protein 8 like 2
chr1_-_161069962 Show fit	4.78	ENST00000368015.1	ARHGAP30 Ensembl NCBI GeneCards UniProt Show fit	Rho GTPase activating protein 30
chr1_-_161069857 Show fit	4.30	ENST00000368013.8	ARHGAP30 Ensembl NCBI GeneCards UniProt Show fit	Rho GTPase activating protein 30
chr3_-_27722699 Show fit	4.28	ENST00000461503.2	EOMES Ensembl NCBI GeneCards UniProt Show fit	eomesodermin
chr15_+_88639009 Show fit	4.02	ENST00000306072.10	ISG20 Ensembl NCBI GeneCards UniProt Show fit	interferon stimulated exonuclease gene 20
chr6_+_31572279 Show fit	3.98	ENST00000418386.3	LTA Ensembl NCBI GeneCards UniProt Show fit	lymphotoxin alpha
chr12_+_112978460 Show fit	3.97	ENST00000449768.2	OAS2 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 2
chr1_-_159076742 Show fit	3.97	ENST00000368130.9	AIM2 Ensembl NCBI GeneCards UniProt Show fit	absent in melanoma 2
chr6_-_32853618 Show fit	3.94	ENST00000354258.5	TAP1 Ensembl NCBI GeneCards UniProt Show fit	transporter 1, ATP binding cassette subfamily B member
chr4_-_168480477 Show fit	3.93	ENST00000514748.5 ENST00000512371.1 ENST00000505890.5 ENST00000682922.1 ENST00000511577.5	DDX60L Ensembl NCBI GeneCards UniProt Show fit	DExD/H-box 60 like
chr3_+_186931344 Show fit	3.87	ENST00000417392.5	ST6GAL1 Ensembl NCBI GeneCards UniProt Show fit	ST6 beta-galactoside alpha-2,6-sialyltransferase 1
chr7_-_93148345 Show fit	3.85	ENST00000437805.5 ENST00000446959.5 ENST00000439952.5 ENST00000414791.5 ENST00000446033.1 ENST00000411955.5 ENST00000318238.9	SAMD9L Ensembl NCBI GeneCards UniProt Show fit	sterile alpha motif domain containing 9 like
chr6_-_32853813 Show fit	3.82	ENST00000643049.2	TAP1 Ensembl NCBI GeneCards UniProt Show fit	transporter 1, ATP binding cassette subfamily B member
chr8_-_66613208 Show fit	3.72	ENST00000522677.8	MYBL1 Ensembl NCBI GeneCards UniProt Show fit	MYB proto-oncogene like 1
chr10_+_89327989 Show fit	3.59	ENST00000679923.1 ENST00000680085.1 ENST00000371818.9 ENST00000680779.1	IFIT3 Ensembl NCBI GeneCards UniProt Show fit	interferon induced protein with tetratricopeptide repeats 3
chr5_-_95822711 Show fit	3.56	ENST00000512469.2 ENST00000379979.8 ENST00000505427.1 ENST00000508780.5 ENST00000237858.11	GLRX Ensembl NCBI GeneCards UniProt Show fit	glutaredoxin
chr6_+_26365215 Show fit	3.48	ENST00000527422.5 ENST00000356386.6 ENST00000396948.5	BTN3A2 Ensembl NCBI GeneCards UniProt Show fit	butyrophilin subfamily 3 member A2
chr12_+_112938422 Show fit	3.45	ENST00000680044.1 ENST00000680966.1 ENST00000548514.2 ENST00000681497.1 ENST00000551007.1 ENST00000228928.12 ENST00000680438.1 ENST00000681147.1 ENST00000679354.1 ENST00000681085.1 ENST00000680161.1	OAS3 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 3
chr20_-_57620415 Show fit	3.39	ENST00000371173.8	ZBP1 Ensembl NCBI GeneCards UniProt Show fit	Z-DNA binding protein 1
chr15_+_44711487 Show fit	3.36	ENST00000544417.5 ENST00000559916.1 ENST00000648006.3	B2M Ensembl NCBI GeneCards UniProt Show fit	beta-2-microglobulin
chr10_+_89327977 Show fit	3.31	ENST00000681277.1	IFIT3 Ensembl NCBI GeneCards UniProt Show fit	interferon induced protein with tetratricopeptide repeats 3
chr20_-_57620467 Show fit	3.30	ENST00000395822.7	ZBP1 Ensembl NCBI GeneCards UniProt Show fit	Z-DNA binding protein 1
chr6_+_32854179 Show fit	3.19	ENST00000374859.3	PSMB9 Ensembl NCBI GeneCards UniProt Show fit	proteasome 20S subunit beta 9
chr6_+_26365176 Show fit	3.18	ENST00000377708.7	BTN3A2 Ensembl NCBI GeneCards UniProt Show fit	butyrophilin subfamily 3 member A2
chr11_-_4393650 Show fit	3.10	ENST00000254436.8	TRIM21 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 21
chr6_+_26402237 Show fit	3.05	ENST00000476549.6 ENST00000450085.6 ENST00000425234.6 ENST00000427334.5 ENST00000506698.1 ENST00000289361.11	BTN3A1 Ensembl NCBI GeneCards UniProt Show fit	butyrophilin subfamily 3 member A1
chr11_+_63536801 Show fit	3.04	ENST00000255688.8 ENST00000439013.6	PLAAT4 Ensembl NCBI GeneCards UniProt Show fit	phospholipase A and acyltransferase 4
chr12_+_112938523 Show fit	3.00	ENST00000679483.1 ENST00000679493.1	OAS3 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 3
chr6_+_26440472 Show fit	2.98	ENST00000494393.5 ENST00000482451.5 ENST00000471353.5 ENST00000361232.7 ENST00000487627.5 ENST00000496719.1 ENST00000244519.7 ENST00000490254.5 ENST00000487272.1	BTN3A3 Ensembl NCBI GeneCards UniProt Show fit	butyrophilin subfamily 3 member A3
chr22_+_39077264 Show fit	2.98	ENST00000407997.4	APOBEC3G Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein B mRNA editing enzyme catalytic subunit 3G
chr19_+_49474208 Show fit	2.92	ENST00000597551.6 ENST00000596435.5 ENST00000204637.6 ENST00000600429.5	FLT3LG Ensembl NCBI GeneCards UniProt Show fit	fms related receptor tyrosine kinase 3 ligand
chr6_+_26365159 Show fit	2.90	ENST00000532865.5 ENST00000396934.7 ENST00000508906.6 ENST00000530653.5 ENST00000527417.5	BTN3A2 Ensembl NCBI GeneCards UniProt Show fit	butyrophilin subfamily 3 member A2
chr15_+_75201873 Show fit	2.86	ENST00000394987.5	C15orf39 Ensembl NCBI GeneCards UniProt Show fit	chromosome 15 open reading frame 39
chr6_+_26402289 Show fit	2.83	ENST00000414912.2	BTN3A1 Ensembl NCBI GeneCards UniProt Show fit	butyrophilin subfamily 3 member A1
chr1_+_78649818 Show fit	2.76	ENST00000370747.9 ENST00000438486.1	IFI44 Ensembl NCBI GeneCards UniProt Show fit	interferon induced protein 44
chr11_-_57567260 Show fit	2.74	ENST00000526659.1 ENST00000527022.1	UBE2L6 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin conjugating enzyme E2 L6
chr19_+_49474561 Show fit	2.73	ENST00000594009.5 ENST00000595510.1 ENST00000595815.1	FLT3LG Ensembl NCBI GeneCards UniProt Show fit ENSG00000273189.1 Ensembl NCBI GeneCards UniProt Show fit	fms related receptor tyrosine kinase 3 ligand novel transcript
chr8_-_66613229 Show fit	2.71	ENST00000517885.5	MYBL1 Ensembl NCBI GeneCards UniProt Show fit	MYB proto-oncogene like 1
chr19_-_47232649 Show fit	2.69	ENST00000449228.5 ENST00000300880.11 ENST00000341983.8	BBC3 Ensembl NCBI GeneCards UniProt Show fit	BCL2 binding component 3
chr2_-_162318129 Show fit	2.67	ENST00000679938.1	IFIH1 Ensembl NCBI GeneCards UniProt Show fit	interferon induced with helicase C domain 1
chr1_-_89198868 Show fit	2.60	ENST00000355754.7	GBP4 Ensembl NCBI GeneCards UniProt Show fit	guanylate binding protein 4
chr2_-_230219944 Show fit	2.58	ENST00000455674.2 ENST00000392048.7 ENST00000258381.11 ENST00000358662.9 ENST00000258382.10	SP110 Ensembl NCBI GeneCards UniProt Show fit	SP110 nuclear body protein
chr6_+_31571957 Show fit	2.56	ENST00000454783.5	LTA Ensembl NCBI GeneCards UniProt Show fit	lymphotoxin alpha
chr22_+_35648438 Show fit	2.55	ENST00000409652.5	APOL6 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein L6
chr7_-_139109337 Show fit	2.47	ENST00000464606.5	ZC3HAV1 Ensembl NCBI GeneCards UniProt Show fit	zinc finger CCCH-type containing, antiviral 1
chr14_-_20413420 Show fit	2.46	ENST00000556935.5 ENST00000556549.1 ENST00000262715.10	TEP1 Ensembl NCBI GeneCards UniProt Show fit	telomerase associated protein 1
chr2_+_112095189 Show fit	2.39	ENST00000649734.1	TMEM87B Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 87B
chr1_+_1013485 Show fit	2.34	ENST00000649529.1	ISG15 Ensembl NCBI GeneCards UniProt Show fit	ISG15 ubiquitin like modifier
chr9_+_5450503 Show fit	2.33	ENST00000381573.8 ENST00000381577.4	CD274 Ensembl NCBI GeneCards UniProt Show fit	CD274 molecule
chr21_+_41420515 Show fit	2.31	ENST00000398600.6 ENST00000679626.1	MX1 Ensembl NCBI GeneCards UniProt Show fit	MX dynamin like GTPase 1
chr8_+_27380629 Show fit	2.28	ENST00000412793.5	PTK2B Ensembl NCBI GeneCards UniProt Show fit	protein tyrosine kinase 2 beta
chr2_-_230219902 Show fit	2.27	ENST00000409815.6	SP110 Ensembl NCBI GeneCards UniProt Show fit	SP110 nuclear body protein
chr7_-_106284524 Show fit	2.27	ENST00000681936.1 ENST00000680786.1 ENST00000681550.1	NAMPT Ensembl NCBI GeneCards UniProt Show fit	nicotinamide phosphoribosyltransferase
chr1_+_112674416 Show fit	2.24	ENST00000413052.6 ENST00000369645.5	MOV10 Ensembl NCBI GeneCards UniProt Show fit	Mov10 RISC complex RNA helicase
chr12_+_50504970 Show fit	2.23	ENST00000301180.10	DIP2B Ensembl NCBI GeneCards UniProt Show fit	disco interacting protein 2 homolog B
chr15_-_44711306 Show fit	2.18	ENST00000682850.1	PATL2 Ensembl NCBI GeneCards UniProt Show fit	PAT1 homolog 2
chr10_+_89301932 Show fit	2.17	ENST00000371826.4 ENST00000679755.1	IFIT2 Ensembl NCBI GeneCards UniProt Show fit	interferon induced protein with tetratricopeptide repeats 2
chr1_+_149475045 Show fit	2.17	ENST00000651566.2	NBPF19 Ensembl NCBI GeneCards UniProt Show fit	NBPF member 19
chr11_-_615570 Show fit	2.17	ENST00000649187.1 ENST00000647801.1 ENST00000397566.5 ENST00000397570.5	IRF7 Ensembl NCBI GeneCards UniProt Show fit	interferon regulatory factor 7
chr7_-_139109702 Show fit	2.11	ENST00000471652.1 ENST00000242351.10	ZC3HAV1 Ensembl NCBI GeneCards UniProt Show fit	zinc finger CCCH-type containing, antiviral 1
chr14_+_24136152 Show fit	2.11	ENST00000559123.5 ENST00000206451.11 ENST00000382708.7 ENST00000561435.5	PSME1 Ensembl NCBI GeneCards UniProt Show fit	proteasome activator subunit 1
chr9_-_94640130 Show fit	2.10	ENST00000414122.1	FBP1 Ensembl NCBI GeneCards UniProt Show fit	fructose-bisphosphatase 1
chr7_-_106285898 Show fit	2.07	ENST00000424768.2 ENST00000681255.1	NAMPT Ensembl NCBI GeneCards UniProt Show fit	nicotinamide phosphoribosyltransferase
chr6_-_32838727 Show fit	1.98	ENST00000652259.1 ENST00000374897.4 ENST00000620123.4 ENST00000452392.2	TAP2 Ensembl NCBI GeneCards UniProt Show fit ENSG00000250264.1 Ensembl NCBI GeneCards UniProt Show fit	transporter 2, ATP binding cassette subfamily B member novel protein, TAP2-HLA-DOB readthrough
chr4_+_118034480 Show fit	1.94	ENST00000296499.6	NDST3 Ensembl NCBI GeneCards UniProt Show fit	N-deacetylase and N-sulfotransferase 3
chr20_-_57620393 Show fit	1.91	ENST00000541799.1	ZBP1 Ensembl NCBI GeneCards UniProt Show fit	Z-DNA binding protein 1
chr3_+_63911929 Show fit	1.88	ENST00000487717.5	ATXN7 Ensembl NCBI GeneCards UniProt Show fit	ataxin 7
chr3_+_187368367 Show fit	1.88	ENST00000259030.3	RTP4 Ensembl NCBI GeneCards UniProt Show fit	receptor transporter protein 4
chrX_-_110318062 Show fit	1.84	ENST00000372059.6 ENST00000262844.10	AMMECR1 Ensembl NCBI GeneCards UniProt Show fit	AMMECR nuclear protein 1
chr12_-_8066331 Show fit	1.79	ENST00000546241.1 ENST00000307637.5	C3AR1 Ensembl NCBI GeneCards UniProt Show fit	complement C3a receptor 1
chr7_-_140062841 Show fit	1.78	ENST00000263549.8	PARP12 Ensembl NCBI GeneCards UniProt Show fit	poly(ADP-ribose) polymerase family member 12
chr11_-_615921 Show fit	1.76	ENST00000348655.11 ENST00000525445.6 ENST00000330243.9	IRF7 Ensembl NCBI GeneCards UniProt Show fit	interferon regulatory factor 7
chr8_-_23069012 Show fit	1.75	ENST00000347739.3 ENST00000276431.9	TNFRSF10B Ensembl NCBI GeneCards UniProt Show fit	TNF receptor superfamily member 10b
chr3_-_122564232 Show fit	1.75	ENST00000471785.5 ENST00000466126.1	PARP9 Ensembl NCBI GeneCards UniProt Show fit	poly(ADP-ribose) polymerase family member 9
chr11_-_57567617 Show fit	1.72	ENST00000287156.9	UBE2L6 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin conjugating enzyme E2 L6
chr17_-_65056659 Show fit	1.71	ENST00000439174.7	GNA13 Ensembl NCBI GeneCards UniProt Show fit	G protein subunit alpha 13
chr18_+_24014733 Show fit	1.66	ENST00000317571.8	TTC39C Ensembl NCBI GeneCards UniProt Show fit	tetratricopeptide repeat domain 39C
chr16_-_28211908 Show fit	1.64	ENST00000566073.1 ENST00000304658.10	XPO6 Ensembl NCBI GeneCards UniProt Show fit	exportin 6
chr1_-_161044941 Show fit	1.64	ENST00000368020.5	USF1 Ensembl NCBI GeneCards UniProt Show fit	upstream transcription factor 1
chr12_-_98894830 Show fit	1.63	ENST00000549797.5 ENST00000333732.11 ENST00000341752.11	ANKS1B Ensembl NCBI GeneCards UniProt Show fit	ankyrin repeat and sterile alpha motif domain containing 1B
chrX_+_57286680 Show fit	1.62	ENST00000374900.5	FAAH2 Ensembl NCBI GeneCards UniProt Show fit	fatty acid amide hydrolase 2
chr5_-_96807899 Show fit	1.61	ENST00000503921.5 ENST00000508227.5 ENST00000507154.1 ENST00000443439.7	ERAP1 Ensembl NCBI GeneCards UniProt Show fit	endoplasmic reticulum aminopeptidase 1
chr1_-_154608140 Show fit	1.60	ENST00000529168.2 ENST00000368474.9 ENST00000680305.1 ENST00000648231.2	ADAR Ensembl NCBI GeneCards UniProt Show fit	adenosine deaminase RNA specific
chr9_-_32526185 Show fit	1.58	ENST00000379883.3 ENST00000379868.6 ENST00000679859.1	DDX58 Ensembl NCBI GeneCards UniProt Show fit	DExD/H-box helicase 58
chr14_+_73058591 Show fit	1.57	ENST00000525161.5	RBM25 Ensembl NCBI GeneCards UniProt Show fit	RNA binding motif protein 25
chr5_-_60843521 Show fit	1.55	ENST00000511799.5	ELOVL7 Ensembl NCBI GeneCards UniProt Show fit	ELOVL fatty acid elongase 7
chr20_-_49278034 Show fit	1.50	ENST00000371744.5 ENST00000396105.6 ENST00000371752.5	ZNFX1 Ensembl NCBI GeneCards UniProt Show fit	zinc finger NFX1-type containing 1
chr17_+_6755834 Show fit	1.49	ENST00000346752.8	XAF1 Ensembl NCBI GeneCards UniProt Show fit	XIAP associated factor 1
chr3_+_122564327 Show fit	1.45	ENST00000296161.9 ENST00000383661.3	DTX3L Ensembl NCBI GeneCards UniProt Show fit	deltex E3 ubiquitin ligase 3L
chr2_+_201116396 Show fit	1.44	ENST00000395148.6	CFLAR Ensembl NCBI GeneCards UniProt Show fit	CASP8 and FADD like apoptosis regulator
chr8_-_143986425 Show fit	1.42	ENST00000313059.9 ENST00000524918.5 ENST00000313028.12 ENST00000525773.5	PARP10 Ensembl NCBI GeneCards UniProt Show fit	poly(ADP-ribose) polymerase family member 10
chr20_-_25058115 Show fit	1.42	ENST00000323482.9	ACSS1 Ensembl NCBI GeneCards UniProt Show fit	acyl-CoA synthetase short chain family member 1
chr12_-_213656 Show fit	1.41	ENST00000359674.8	SLC6A12 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 6 member 12
chr22_+_39040857 Show fit	1.41	ENST00000381565.2 ENST00000308521.10	APOBEC3F Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein B mRNA editing enzyme catalytic subunit 3F
chr3_-_122564253 Show fit	1.41	ENST00000492382.5 ENST00000682323.1 ENST00000462315.5	PARP9 Ensembl NCBI GeneCards UniProt Show fit	poly(ADP-ribose) polymerase family member 9
chr3_+_122680802 Show fit	1.40	ENST00000474629.7	PARP14 Ensembl NCBI GeneCards UniProt Show fit	poly(ADP-ribose) polymerase family member 14
chr1_+_112674649 Show fit	1.40	ENST00000369644.5	MOV10 Ensembl NCBI GeneCards UniProt Show fit	Mov10 RISC complex RNA helicase
chr2_-_73642413 Show fit	1.39	ENST00000272425.4	NAT8 Ensembl NCBI GeneCards UniProt Show fit	N-acetyltransferase 8 (putative)
chr7_-_904994 Show fit	1.38	ENST00000453175.6	ADAP1 Ensembl NCBI GeneCards UniProt Show fit	ArfGAP with dual PH domains 1
chr12_+_6452024 Show fit	1.38	ENST00000266556.8 ENST00000544021.5	TAPBPL Ensembl NCBI GeneCards UniProt Show fit	TAP binding protein like
chr17_-_42112674 Show fit	1.37	ENST00000251642.8 ENST00000591220.5	DHX58 Ensembl NCBI GeneCards UniProt Show fit	DExH-box helicase 58
chr14_-_24146314 Show fit	1.35	ENST00000559056.5	PSME2 Ensembl NCBI GeneCards UniProt Show fit	proteasome activator subunit 2
chr11_+_5624987 Show fit	1.34	ENST00000429814.3	TRIM34 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 34
chr22_+_31496275 Show fit	1.33	ENST00000432498.5	SFI1 Ensembl NCBI GeneCards UniProt Show fit	SFI1 centrin binding protein
chr1_+_112674722 Show fit	1.28	ENST00000357443.2	MOV10 Ensembl NCBI GeneCards UniProt Show fit	Mov10 RISC complex RNA helicase
chr9_-_98192614 Show fit	1.27	ENST00000375077.5	CORO2A Ensembl NCBI GeneCards UniProt Show fit	coronin 2A
chr12_-_214146 Show fit	1.26	ENST00000684302.1	SLC6A12 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 6 member 12
chr12_+_112938284 Show fit	1.25	ENST00000681346.1	OAS3 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 3
chr6_-_36387736 Show fit	1.24	ENST00000373737.8 ENST00000373738.4 ENST00000538992.3 ENST00000615781.4 ENST00000620358.4	ETV7 Ensembl NCBI GeneCards UniProt Show fit	ETS variant transcription factor 7
chrX_+_120250752 Show fit	1.24	ENST00000326624.2 ENST00000557385.2	ZBTB33 Ensembl NCBI GeneCards UniProt Show fit	zinc finger and BTB domain containing 33
chr14_-_24146596 Show fit	1.23	ENST00000560410.5 ENST00000216802.10 ENST00000615264.4 ENST00000630027.1	PSME2 Ensembl NCBI GeneCards UniProt Show fit	proteasome activator subunit 2
chr11_+_66241227 Show fit	1.20	ENST00000531597.1	PACS1 Ensembl NCBI GeneCards UniProt Show fit	phosphofurin acidic cluster sorting protein 1
chr1_-_161045961 Show fit	1.20	ENST00000368021.7	USF1 Ensembl NCBI GeneCards UniProt Show fit	upstream transcription factor 1
chr3_+_63912588 Show fit	1.16	ENST00000522345.2	ATXN7 Ensembl NCBI GeneCards UniProt Show fit	ataxin 7
chr2_-_213152427 Show fit	1.16	ENST00000452786.2	IKZF2 Ensembl NCBI GeneCards UniProt Show fit	IKAROS family zinc finger 2
chr9_-_92325577 Show fit	1.15	ENST00000358855.8 ENST00000421075.6 ENST00000536624.5	NOL8 Ensembl NCBI GeneCards UniProt Show fit	nucleolar protein 8
chr1_-_161045873 Show fit	1.11	ENST00000534633.5	USF1 Ensembl NCBI GeneCards UniProt Show fit	upstream transcription factor 1
chr10_-_100286341 Show fit	1.11	ENST00000441611.5 ENST00000614731.4	BLOC1S2 Ensembl NCBI GeneCards UniProt Show fit	biogenesis of lysosomal organelles complex 1 subunit 2
chr2_-_165794642 Show fit	1.11	ENST00000431484.1 ENST00000412248.5	GALNT3 Ensembl NCBI GeneCards UniProt Show fit	polypeptide N-acetylgalactosaminyltransferase 3
chr22_+_31496387 Show fit	1.10	ENST00000443011.5 ENST00000400288.7 ENST00000400289.5 ENST00000444859.5	SFI1 Ensembl NCBI GeneCards UniProt Show fit	SFI1 centrin binding protein
chr1_-_182589239 Show fit	1.10	ENST00000367559.7 ENST00000539397.1	RNASEL Ensembl NCBI GeneCards UniProt Show fit	ribonuclease L
chr15_-_55319107 Show fit	1.10	ENST00000565225.1 ENST00000436697.3 ENST00000567948.1 ENST00000563262.5	PIGBOS1 Ensembl NCBI GeneCards UniProt Show fit RAB27A Ensembl NCBI GeneCards UniProt Show fit	PIGB opposite strand 1 RAB27A, member RAS oncogene family
chr1_-_7940825 Show fit	1.08	ENST00000377507.8	TNFRSF9 Ensembl NCBI GeneCards UniProt Show fit	TNF receptor superfamily member 9
chr20_+_62804794 Show fit	1.08	ENST00000290291.10	OGFR Ensembl NCBI GeneCards UniProt Show fit	opioid growth factor receptor
chr20_-_25058168 Show fit	1.08	ENST00000432802.6	ACSS1 Ensembl NCBI GeneCards UniProt Show fit	acyl-CoA synthetase short chain family member 1
chr1_-_211188507 Show fit	1.05	ENST00000450040.2 ENST00000638880.1	ENSG00000284376.1 Ensembl NCBI GeneCards UniProt Show fit ENSG00000283952.1 Ensembl NCBI GeneCards UniProt Show fit	novel transcript novel protein
chr13_+_108629605 Show fit	1.05	ENST00000457511.7	MYO16 Ensembl NCBI GeneCards UniProt Show fit	myosin XVI
chr22_+_31496139 Show fit	1.03	ENST00000540643.5	SFI1 Ensembl NCBI GeneCards UniProt Show fit	SFI1 centrin binding protein
chr1_+_25272527 Show fit	1.02	ENST00000342055.9 ENST00000357542.8 ENST00000417538.6 ENST00000423810.6 ENST00000568195.5	RHD Ensembl NCBI GeneCards UniProt Show fit	Rh blood group D antigen
chr14_-_91510530 Show fit	1.02	ENST00000557018.5	PPP4R3A Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase 4 regulatory subunit 3A
chr3_-_122564577 Show fit	1.01	ENST00000477522.6 ENST00000360356.6	PARP9 Ensembl NCBI GeneCards UniProt Show fit	poly(ADP-ribose) polymerase family member 9
chr9_-_92325322 Show fit	0.98	ENST00000542613.5 ENST00000542053.5 ENST00000442668.7 ENST00000545558.5 ENST00000432670.6 ENST00000433029.6 ENST00000411621.6	NOL8 Ensembl NCBI GeneCards UniProt Show fit	nucleolar protein 8
chr2_-_144517663 Show fit	0.98	ENST00000427902.5 ENST00000462355.2 ENST00000470879.5 ENST00000409487.7 ENST00000435831.5 ENST00000630572.2	ZEB2 Ensembl NCBI GeneCards UniProt Show fit	zinc finger E-box binding homeobox 2
chr19_+_10086305 Show fit	0.97	ENST00000253110.16 ENST00000591813.5	SHFL Ensembl NCBI GeneCards UniProt Show fit	shiftless antiviral inhibitor of ribosomal frameshifting
chr7_-_127392060 Show fit	0.97	ENST00000436992.5	ZNF800 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 800
chr14_-_100375602 Show fit	0.97	ENST00000553395.5 ENST00000553545.5 ENST00000344102.9 ENST00000556338.5 ENST00000553934.1	WARS1 Ensembl NCBI GeneCards UniProt Show fit	tryptophanyl-tRNA synthetase 1
chr5_-_136365476 Show fit	0.96	ENST00000378459.7 ENST00000502753.4 ENST00000513104.6 ENST00000352189.8	TRPC7 Ensembl NCBI GeneCards UniProt Show fit	transient receptor potential cation channel subfamily C member 7
chr16_-_11256192 Show fit	0.96	ENST00000644787.1 ENST00000332029.4	SOCS1 Ensembl NCBI GeneCards UniProt Show fit	suppressor of cytokine signaling 1
chr10_+_89332484 Show fit	0.95	ENST00000371811.4 ENST00000680037.1 ENST00000679583.1 ENST00000679897.1	IFIT3 Ensembl NCBI GeneCards UniProt Show fit	interferon induced protein with tetratricopeptide repeats 3
chr20_-_35284715 Show fit	0.94	ENST00000374436.7 ENST00000675032.1	EIF6 Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 6
chr4_+_129096113 Show fit	0.94	ENST00000508673.5	C4orf33 Ensembl NCBI GeneCards UniProt Show fit	chromosome 4 open reading frame 33
chr11_+_125591712 Show fit	0.94	ENST00000527606.5	STT3A Ensembl NCBI GeneCards UniProt Show fit	STT3 oligosaccharyltransferase complex catalytic subunit A
chr15_+_55319202 Show fit	0.91	ENST00000164305.10 ENST00000566999.5 ENST00000539642.5	PIGB Ensembl NCBI GeneCards UniProt Show fit	phosphatidylinositol glycan anchor biosynthesis class B
chr20_-_49278416 Show fit	0.91	ENST00000371754.8	ZNFX1 Ensembl NCBI GeneCards UniProt Show fit	zinc finger NFX1-type containing 1
chr20_-_35284745 Show fit	0.89	ENST00000374443.7 ENST00000374450.8	EIF6 Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 6
chr10_-_100286660 Show fit	0.88	ENST00000370372.7	BLOC1S2 Ensembl NCBI GeneCards UniProt Show fit	biogenesis of lysosomal organelles complex 1 subunit 2
chr8_-_108443409 Show fit	0.86	ENST00000678023.1 ENST00000679198.1 ENST00000678881.1 ENST00000677084.1 ENST00000676663.1 ENST00000677614.1 ENST00000677040.1 ENST00000676487.1 ENST00000677409.1 ENST00000678797.1 ENST00000678334.1	EIF3E Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 3 subunit E
chr3_+_122680850 Show fit	0.84	ENST00000494811.2	PARP14 Ensembl NCBI GeneCards UniProt Show fit	poly(ADP-ribose) polymerase family member 14
chr4_+_129096144 Show fit	0.83	ENST00000425929.6 ENST00000508622.1	C4orf33 Ensembl NCBI GeneCards UniProt Show fit	chromosome 4 open reading frame 33
chr20_+_408030 Show fit	0.82	ENST00000640614.1 ENST00000475269.5	RBCK1 Ensembl NCBI GeneCards UniProt Show fit	RANBP2-type and C3HC4-type zinc finger containing 1
chr12_-_214082 Show fit	0.82	ENST00000535347.5 ENST00000536824.5	SLC6A12 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 6 member 12
chr16_-_29862890 Show fit	0.82	ENST00000563415.1	CDIPT Ensembl NCBI GeneCards UniProt Show fit	CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr5_-_96808093 Show fit	0.81	ENST00000296754.7	ERAP1 Ensembl NCBI GeneCards UniProt Show fit	endoplasmic reticulum aminopeptidase 1
chr10_-_14954018 Show fit	0.79	ENST00000378241.5 ENST00000456122.1 ENST00000418843.5 ENST00000378249.5 ENST00000396817.6 ENST00000378255.5 ENST00000378254.5 ENST00000357717.6 ENST00000378258.5 ENST00000378246.6 ENST00000378278.7	DCLRE1C Ensembl NCBI GeneCards UniProt Show fit	DNA cross-link repair 1C
chr14_-_91510450 Show fit	0.76	ENST00000555462.5	PPP4R3A Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase 4 regulatory subunit 3A
chr11_-_67650682 Show fit	0.76	ENST00000255082.8	ACY3 Ensembl NCBI GeneCards UniProt Show fit	aminoacylase 3
chr10_-_22003678 Show fit	0.74	ENST00000376980.8	DNAJC1 Ensembl NCBI GeneCards UniProt Show fit	DnaJ heat shock protein family (Hsp40) member C1
chr16_-_29863117 Show fit	0.74	ENST00000566113.5 ENST00000569956.5 ENST00000570016.5 ENST00000219789.11	CDIPT Ensembl NCBI GeneCards UniProt Show fit	CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr20_+_45881218 Show fit	0.73	ENST00000372523.1	ZSWIM1 Ensembl NCBI GeneCards UniProt Show fit	zinc finger SWIM-type containing 1
chr19_-_39846329 Show fit	0.73	ENST00000599134.1 ENST00000597634.5 ENST00000598417.5 ENST00000601274.5 ENST00000594309.5 ENST00000221801.8	FBL Ensembl NCBI GeneCards UniProt Show fit	fibrillarin
chr2_+_201116143 Show fit	0.72	ENST00000443227.5 ENST00000309955.8 ENST00000341222.10 ENST00000341582.10	CFLAR Ensembl NCBI GeneCards UniProt Show fit	CASP8 and FADD like apoptosis regulator
chr18_+_24014390 Show fit	0.70	ENST00000584250.1	TTC39C Ensembl NCBI GeneCards UniProt Show fit	tetratricopeptide repeat domain 39C
chr8_+_22589240 Show fit	0.69	ENST00000450780.6 ENST00000430850.6 ENST00000447849.2 ENST00000614502.4 ENST00000443561.3	ENSG00000248235.6 Ensembl NCBI GeneCards UniProt Show fit PDLIM2 Ensembl NCBI GeneCards UniProt Show fit	novel protein PDZ and LIM domain 2
chr11_+_118359572 Show fit	0.65	ENST00000252108.8 ENST00000431736.6	UBE4A Ensembl NCBI GeneCards UniProt Show fit	ubiquitination factor E4A
chr22_-_36239552 Show fit	0.64	ENST00000454728.5	APOL2 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein L2
chr6_+_42050876 Show fit	0.64	ENST00000465926.5 ENST00000482432.1	TAF8 Ensembl NCBI GeneCards UniProt Show fit	TATA-box binding protein associated factor 8
chr3_+_155870623 Show fit	0.63	ENST00000295920.7 ENST00000496455.7	GMPS Ensembl NCBI GeneCards UniProt Show fit	guanine monophosphate synthase
chr14_-_100375457 Show fit	0.62	ENST00000556295.5 ENST00000554820.5	WARS1 Ensembl NCBI GeneCards UniProt Show fit	tryptophanyl-tRNA synthetase 1
chr14_-_75051426 Show fit	0.62	ENST00000556257.5 ENST00000355774.7 ENST00000557648.1 ENST00000553263.1 ENST00000380968.6	MLH3 Ensembl NCBI GeneCards UniProt Show fit	mutL homolog 3
chr6_-_41071825 Show fit	0.58	ENST00000468811.5	OARD1 Ensembl NCBI GeneCards UniProt Show fit	O-acyl-ADP-ribose deacylase 1
chr15_+_56918763 Show fit	0.57	ENST00000557843.5	TCF12 Ensembl NCBI GeneCards UniProt Show fit	transcription factor 12
chr19_+_17405685 Show fit	0.55	ENST00000646744.1 ENST00000635536.2 ENST00000635060.2 ENST00000634291.2 ENST00000645298.1 ENST00000528911.5	BISPR Ensembl NCBI GeneCards UniProt Show fit MVB12A Ensembl NCBI GeneCards UniProt Show fit	BST2 interferon stimulated positive regulator multivesicular body subunit 12A
chr20_+_408278 Show fit	0.55	ENST00000356286.10 ENST00000382181.2 ENST00000400247.3	RBCK1 Ensembl NCBI GeneCards UniProt Show fit	RANBP2-type and C3HC4-type zinc finger containing 1
chr20_+_408147 Show fit	0.52	ENST00000441733.5 ENST00000353660.7	RBCK1 Ensembl NCBI GeneCards UniProt Show fit	RANBP2-type and C3HC4-type zinc finger containing 1
chr19_+_50384323 Show fit	0.52	ENST00000599857.7 ENST00000613923.6 ENST00000601098.6 ENST00000440232.7 ENST00000595904.6 ENST00000593887.1	POLD1 Ensembl NCBI GeneCards UniProt Show fit	DNA polymerase delta 1, catalytic subunit
chr6_-_36387654 Show fit	0.52	ENST00000340181.9	ETV7 Ensembl NCBI GeneCards UniProt Show fit	ETS variant transcription factor 7
chr16_-_28506826 Show fit	0.48	ENST00000356897.1	IL27 Ensembl NCBI GeneCards UniProt Show fit	interleukin 27
chr20_-_21514046 Show fit	0.44	ENST00000377142.5	NKX2-2 Ensembl NCBI GeneCards UniProt Show fit	NK2 homeobox 2
chr3_+_130443484 Show fit	0.44	ENST00000512482.1	COL6A5 Ensembl NCBI GeneCards UniProt Show fit	collagen type VI alpha 5 chain
chr2_+_201116238 Show fit	0.42	ENST00000342795.9	CFLAR Ensembl NCBI GeneCards UniProt Show fit	CASP8 and FADD like apoptosis regulator
chr7_+_135148041 Show fit	0.40	ENST00000275767.3	TMEM140 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 140
chr2_+_218069248 Show fit	0.39	ENST00000374155.7	RUFY4 Ensembl NCBI GeneCards UniProt Show fit	RUN and FYVE domain containing 4
chr6_+_42050513 Show fit	0.39	ENST00000372978.7 ENST00000494547.5 ENST00000456846.6 ENST00000372982.8 ENST00000472818.5 ENST00000372977.8	TAF8 Ensembl NCBI GeneCards UniProt Show fit	TATA-box binding protein associated factor 8
chr9_+_92325910 Show fit	0.37	ENST00000375587.8 ENST00000618653.1	CENPP Ensembl NCBI GeneCards UniProt Show fit	centromere protein P

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF3

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
3.2	9.7	GO:0046967	cytosol to ER transport(GO:0046967)
3.2	9.6	GO:0002302	CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
2.2	6.5	GO:0002876	positive regulation of chronic inflammatory response to antigenic stimulus(GO:0002876)
2.1	32.2	GO:0018377	protein myristoylation(GO:0018377)
2.1	8.5	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
1.7	3.4	GO:0002428	antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428)
1.6	10.9	GO:0045653	negative regulation of megakaryocyte differentiation(GO:0045653)
1.4	1.4	GO:0002590	regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
1.1	5.7	GO:0090290	positive regulation of osteoclast proliferation(GO:0090290)
1.0	4.0	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
0.9	10.2	GO:0070212	protein poly-ADP-ribosylation(GO:0070212)
0.8	3.1	GO:0090086	negative regulation of protein deubiquitination(GO:0090086)
0.8	3.9	GO:0034344	type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.7	6.7	GO:0038183	bile acid signaling pathway(GO:0038183)
0.7	3.9	GO:2000110	negative regulation of macrophage apoptotic process(GO:2000110)
0.6	9.2	GO:0034058	endosomal vesicle fusion(GO:0034058)
0.6	7.7	GO:0060700	regulation of ribonuclease activity(GO:0060700)
0.6	4.0	GO:0070269	pyroptosis(GO:0070269)
0.6	4.0	GO:0000432	regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.5	4.4	GO:0070383	DNA cytosine deamination(GO:0070383)
0.5	2.2	GO:0010607	negative regulation of cytoplasmic mRNA processing body assembly(GO:0010607)
0.5	1.1	GO:2001180	negative regulation of interleukin-10 secretion(GO:2001180)
0.5	2.1	GO:0005986	sucrose biosynthetic process(GO:0005986)
0.5	6.7	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.5	7.1	GO:0035457	cellular response to interferon-alpha(GO:0035457)
0.5	2.5	GO:0019542	acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate biosynthetic process(GO:0019542)
0.5	15.4	GO:0072643	interferon-gamma secretion(GO:0072643)
0.4	4.9	GO:0098795	mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.4	2.3	GO:0010752	regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.4	6.5	GO:0015939	pantothenate metabolic process(GO:0015939)
0.4	1.8	GO:1902626	assembly of large subunit precursor of preribosome(GO:1902626)
0.3	1.7	GO:0031584	activation of phospholipase D activity(GO:0031584)
0.3	1.4	GO:0039534	negative regulation of MDA-5 signaling pathway(GO:0039534)
0.3	1.6	GO:1900369	negative regulation of RNA interference(GO:1900369)
0.3	3.0	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.2	0.7	GO:0033967	box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
0.2	2.9	GO:1903944	regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.2	1.1	GO:0018242	protein O-linked glycosylation via serine(GO:0018242)
0.2	4.3	GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.2	1.6	GO:1900383	regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.2	2.3	GO:2001179	interleukin-10 secretion(GO:0072608) regulation of interleukin-10 secretion(GO:2001179) positive regulation of interleukin-10 secretion(GO:2001181)
0.2	0.6	GO:0051805	evasion or tolerance of host immune response(GO:0020012) evasion or tolerance of host defense response(GO:0030682) evasion or tolerance by virus of host immune response(GO:0030683) evasion or tolerance of immune response of other organism involved in symbiotic interaction(GO:0051805) evasion or tolerance of defense response of other organism involved in symbiotic interaction(GO:0051807)
0.2	0.9	GO:0043686	co-translational protein modification(GO:0043686)
0.2	1.1	GO:0002483	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.2	1.9	GO:0097039	protein linear polyubiquitination(GO:0097039)
0.2	1.1	GO:1903435	positive regulation of constitutive secretory pathway(GO:1903435)
0.1	0.4	GO:0021530	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1	3.9	GO:0006054	N-acetylneuraminate metabolic process(GO:0006054)
0.1	2.1	GO:1902570	protein localization to nucleolus(GO:1902570)
0.1	1.9	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1	16.4	GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.1	2.5	GO:0000722	telomere maintenance via recombination(GO:0000722)
0.1	3.5	GO:0015812	gamma-aminobutyric acid transport(GO:0015812)
0.1	0.6	GO:0009139	dUDP biosynthetic process(GO:0006227) dTDP biosynthetic process(GO:0006233) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dTDP metabolic process(GO:0046072) dUDP metabolic process(GO:0046077)
0.1	2.0	GO:0060155	platelet dense granule organization(GO:0060155)
0.1	1.6	GO:0019368	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1	1.8	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.1	0.6	GO:0006177	GMP biosynthetic process(GO:0006177)
0.1	3.6	GO:0045838	positive regulation of membrane potential(GO:0045838)
0.1	2.3	GO:0003374	dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.1	1.0	GO:0010533	regulation of activation of Janus kinase activity(GO:0010533)
0.1	0.5	GO:0006287	base-excision repair, gap-filling(GO:0006287)
0.1	1.0	GO:1902748	positive regulation of lens fiber cell differentiation(GO:1902748)
0.1	1.7	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1	8.6	GO:0032481	positive regulation of type I interferon production(GO:0032481)
0.1	1.0	GO:0001833	inner cell mass cell proliferation(GO:0001833)
0.1	1.1	GO:0038003	opioid receptor signaling pathway(GO:0038003)
0.1	1.0	GO:0006828	manganese ion transport(GO:0006828)
0.1	1.6	GO:0046341	CDP-diacylglycerol metabolic process(GO:0046341)
0.0	0.0	GO:0050717	positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.0	0.5	GO:0045078	positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0	0.3	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0	1.5	GO:0015695	organic cation transport(GO:0015695)
0.0	0.9	GO:0016254	preassembly of GPI anchor in ER membrane(GO:0016254)
0.0	0.6	GO:0007144	female meiosis I(GO:0007144)
0.0	1.2	GO:0000042	protein targeting to Golgi(GO:0000042)
0.0	1.1	GO:2001275	positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.0	0.4	GO:0009249	protein lipoylation(GO:0009249)
0.0	1.5	GO:0010390	histone monoubiquitination(GO:0010390)
0.0	0.8	GO:0033151	V(D)J recombination(GO:0033151)
0.0	1.2	GO:0090200	positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0	4.8	GO:0050728	negative regulation of inflammatory response(GO:0050728)
0.0	3.5	GO:0010923	negative regulation of phosphatase activity(GO:0010923)
0.0	1.9	GO:0051205	protein insertion into membrane(GO:0051205)
0.0	1.4	GO:0050435	beta-amyloid metabolic process(GO:0050435)
0.0	1.6	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	7.1	GO:0061025	membrane fusion(GO:0061025)
0.0	0.0	GO:0032696	negative regulation of interleukin-13 production(GO:0032696)
0.0	1.3	GO:0070206	protein trimerization(GO:0070206)
0.0	0.7	GO:0035456	response to interferon-beta(GO:0035456)
0.0	1.6	GO:0006611	protein export from nucleus(GO:0006611)
0.0	0.1	GO:0030242	pexophagy(GO:0030242)
0.0	1.4	GO:0002456	T cell mediated immunity(GO:0002456)
0.0	0.1	GO:0035385	Roundabout signaling pathway(GO:0035385)
0.0	3.1	GO:0042157	lipoprotein metabolic process(GO:0042157)
0.0	8.2	GO:0051056	regulation of small GTPase mediated signal transduction(GO:0051056)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
3.6	10.9	GO:0020005	symbiont-containing vacuole membrane(GO:0020005) other organism cytoplasm(GO:0097679)
1.4	9.7	GO:0042825	TAP complex(GO:0042825)
1.2	4.7	GO:0008537	proteasome activator complex(GO:0008537)
1.1	4.4	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.7	3.4	GO:0031905	early endosome lumen(GO:0031905)
0.7	4.0	GO:0097169	AIM2 inflammasome complex(GO:0097169)
0.4	3.2	GO:1990111	spermatoproteasome complex(GO:1990111)
0.3	3.9	GO:0016589	NURF complex(GO:0016589)
0.2	1.9	GO:0071797	LUBAC complex(GO:0071797)
0.2	1.6	GO:0044530	supraspliceosomal complex(GO:0044530)
0.1	0.7	GO:0001651	dense fibrillar component(GO:0001651)
0.1	5.7	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.1	0.6	GO:0005712	chiasma(GO:0005712)
0.1	2.9	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.1	2.3	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.1	0.5	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.1	2.5	GO:0005682	U5 snRNP(GO:0005682)
0.1	2.0	GO:0000930	gamma-tubulin complex(GO:0000930)
0.1	1.1	GO:0033093	Weibel-Palade body(GO:0033093)
0.1	0.8	GO:0070419	nonhomologous end joining complex(GO:0070419)
0.1	11.1	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.0	0.9	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	7.7	GO:0035578	azurophil granule lumen(GO:0035578)
0.0	1.6	GO:0030687	preribosome, large subunit precursor(GO:0030687)
0.0	3.1	GO:0015030	Cajal body(GO:0015030)
0.0	1.2	GO:0030137	COPI-coated vesicle(GO:0030137)
0.0	4.0	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	0.9	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0	37.8	GO:0048471	perinuclear region of cytoplasm(GO:0048471)
0.0	5.3	GO:0031225	anchored component of membrane(GO:0031225)
0.0	1.7	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	1.8	GO:0035577	azurophil granule membrane(GO:0035577)
0.0	0.3	GO:0000177	cytoplasmic exosome (RNase complex)(GO:0000177)
0.0	4.1	GO:0016363	nuclear matrix(GO:0016363)
0.0	1.4	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0	1.4	GO:0005811	lipid particle(GO:0005811)
0.0	8.8	GO:0005769	early endosome(GO:0005769)
0.0	2.2	GO:0005814	centriole(GO:0005814)
0.0	0.4	GO:0034361	very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0	0.0	GO:0032002	interleukin-28 receptor complex(GO:0032002)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.9	8.6	GO:0003692	left-handed Z-DNA binding(GO:0003692)
2.5	39.9	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
2.2	10.9	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
1.7	8.5	GO:0031726	CCR1 chemokine receptor binding(GO:0031726)
1.6	6.5	GO:0017159	pantetheine hydrolase activity(GO:0017159)
1.3	4.0	GO:0008859	exoribonuclease II activity(GO:0008859)
1.2	9.7	GO:0023029	MHC class Ib protein binding(GO:0023029)
0.9	4.3	GO:0047280	nicotinamide phosphoribosyltransferase activity(GO:0047280)
0.7	6.7	GO:0038181	bile acid receptor activity(GO:0038181)
0.6	2.4	GO:0005151	interleukin-1, Type II receptor binding(GO:0005151)
0.6	3.0	GO:0047844	deoxycytidine deaminase activity(GO:0047844)
0.5	2.1	GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.5	4.7	GO:0061133	endopeptidase activator activity(GO:0061133)
0.5	2.3	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.4	1.7	GO:0045569	TRAIL binding(GO:0045569)
0.4	4.4	GO:0042296	ISG15 transferase activity(GO:0042296)
0.4	6.4	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.4	3.9	GO:0003835	beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.4	3.6	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.4	2.5	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.4	3.5	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.3	1.6	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.3	8.7	GO:0070403	NAD+ binding(GO:0070403)
0.2	1.7	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.2	0.7	GO:1990259	protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
0.2	1.9	GO:0031849	olfactory receptor binding(GO:0031849)
0.2	1.9	GO:0042328	heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.2	1.4	GO:0004126	cytidine deaminase activity(GO:0004126)
0.2	0.6	GO:0033862	UMP kinase activity(GO:0033862)
0.2	2.5	GO:0003720	telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.2	1.4	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.2	2.3	GO:0031386	protein tag(GO:0031386)
0.2	7.7	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2	1.6	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.2	0.9	GO:0004376	glycolipid mannosyltransferase activity(GO:0004376)
0.1	1.8	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.1	4.3	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1	6.5	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.1	1.4	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.1	1.8	GO:0004875	complement receptor activity(GO:0004875)
0.1	1.6	GO:0102336	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1	9.6	GO:0001102	RNA polymerase II activating transcription factor binding(GO:0001102)
0.1	3.2	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1	8.5	GO:0016667	oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.1	0.8	GO:0004046	aminoacylase activity(GO:0004046)
0.1	0.4	GO:0016979	lipoate-protein ligase activity(GO:0016979)
0.1	0.6	GO:0003696	satellite DNA binding(GO:0003696)
0.1	1.0	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.1	0.6	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.1	4.5	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.1	0.8	GO:0035312	5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1	1.1	GO:0004985	opioid receptor activity(GO:0004985)
0.1	0.9	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1	2.9	GO:0005123	death receptor binding(GO:0005123)
0.0	12.4	GO:0004386	helicase activity(GO:0004386)
0.0	5.7	GO:0030971	receptor tyrosine kinase binding(GO:0030971)
0.0	0.5	GO:0008296	3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0	1.1	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0	2.0	GO:0043015	gamma-tubulin binding(GO:0043015)
0.0	1.1	GO:0031489	myosin V binding(GO:0031489)
0.0	0.6	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0	1.5	GO:0008519	ammonium transmembrane transporter activity(GO:0008519)
0.0	0.8	GO:0008035	high-density lipoprotein particle binding(GO:0008035)
0.0	1.1	GO:0005035	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0	1.6	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	1.2	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	3.5	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0	1.6	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	1.0	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.0	0.5	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0	2.7	GO:0051117	ATPase binding(GO:0051117)
0.0	1.0	GO:0070412	R-SMAD binding(GO:0070412)
0.0	0.2	GO:1990247	N6-methyladenosine-containing RNA binding(GO:1990247)
0.0	0.7	GO:0001671	ATPase activator activity(GO:0001671)
0.0	1.1	GO:0019843	rRNA binding(GO:0019843)
0.0	0.2	GO:0019213	deacetylase activity(GO:0019213)
0.0	7.9	GO:0005096	GTPase activator activity(GO:0005096)
0.0	1.6	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0	0.9	GO:0003743	translation initiation factor activity(GO:0003743)
0.0	1.9	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity(GO:0036459)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.7	PID S1P S1P4 PATHWAY	S1P4 pathway
0.1	14.1	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.1	15.4	PID IL4 2PATHWAY	IL4-mediated signaling events
0.1	10.9	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.1	8.5	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.1	4.6	PID TRAIL PATHWAY	TRAIL signaling pathway
0.1	2.3	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	2.5	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	4.0	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	0.8	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	0.5	PID IL27 PATHWAY	IL27-mediated signaling events
0.0	2.7	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	3.9	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.0	1.6	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.0	1.4	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.9	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	1.0	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	0.6	PID TCPTP PATHWAY	Signaling events mediated by TCPTP

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.7	3.4	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.6	10.9	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.5	64.0	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.5	12.1	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.3	3.0	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.2	3.9	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.2	8.5	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.1	2.5	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.1	4.7	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	3.9	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.1	2.7	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.1	4.0	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.1	7.9	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1	4.9	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.1	8.5	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.1	5.7	REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.1	3.6	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1	2.3	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.1	1.2	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1	1.0	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.1	2.4	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1	2.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	1.7	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.0	1.9	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	2.6	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	1.6	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0	0.6	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	1.1	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	6.7	REACTOME G ALPHA S SIGNALLING EVENTS	Genes involved in G alpha (s) signalling events
0.0	0.9	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0	0.5	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.0	7.1	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0	2.1	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.0	8.2	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	0.6	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.0	1.0	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.0	0.9	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0	0.3	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0	1.8	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events

Results for IRF3

Z-value: 1.71

Motif logo

Transcription factors associated with IRF3

Activity-expression correlation:

Activity profile of IRF3 motif

Sorted Z-values of IRF3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: