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Illumina Body Map 2 (GSE30611)
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Results for IRF6_IRF4_IRF5
Z-value: 1.25
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Transcription factors associated with IRF6_IRF4_IRF5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF5 | hg38_v1_chr7_+_128937917_128937994 | 0.60 | 2.9e-04 | Click! |
| IRF4 | hg38_v1_chr6_+_391743_391759 | 0.40 | 2.2e-02 | Click! |
| IRF6 | hg38_v1_chr1_-_209802149_209802166 | -0.06 | 7.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF6_IRF4_IRF5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 13.1 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 0.3 | 7.7 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 1.5 | 6.1 | GO:0033606 | B cell receptor transport within lipid bilayer(GO:0032595) B cell receptor transport into membrane raft(GO:0032597) protein transport out of membrane raft(GO:0032599) chemokine receptor transport out of membrane raft(GO:0032600) negative regulation of transforming growth factor beta3 production(GO:0032913) chemokine receptor transport within lipid bilayer(GO:0033606) |
| 0.1 | 6.0 | GO:0033198 | response to ATP(GO:0033198) |
| 0.1 | 5.8 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.5 | 5.5 | GO:0051902 | negative regulation of mitochondrial depolarization(GO:0051902) |
| 0.1 | 5.5 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.5 | 5.1 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 0.1 | 4.7 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.1 | 4.6 | GO:0032897 | negative regulation of viral transcription(GO:0032897) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.8 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.0 | 8.1 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 7.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.2 | 6.1 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.0 | 5.0 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 4.6 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.2 | 3.5 | GO:0097433 | dense body(GO:0097433) |
| 0.1 | 2.9 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 2.3 | GO:0090544 | BAF-type complex(GO:0090544) |
| 0.0 | 2.1 | GO:0005903 | brush border(GO:0005903) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 13.1 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.0 | 9.2 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.1 | 6.1 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.8 | 6.0 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.1 | 6.0 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.8 | 5.8 | GO:0050659 | N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659) |
| 0.1 | 4.5 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.0 | 4.3 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 4.1 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.4 | 3.9 | GO:0015057 | thrombin receptor activity(GO:0015057) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.0 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 4.4 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 4.1 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 3.7 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 3.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 2.6 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 2.1 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.0 | 1.7 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 1.6 | PID NECTIN PATHWAY | Nectin adhesion pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 6.9 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 5.8 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 5.2 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.0 | 4.9 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.3 | 3.8 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.1 | 3.6 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 3.6 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 3.1 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.1 | 2.8 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |