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Illumina Body Map 2 (GSE30611)

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Results for IRF9

Z-value: 1.04

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Transcription factors associated with IRF9

Gene Symbol Gene ID Gene Info
ENSG00000213928.9 interferon regulatory factor 9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF9hg38_v1_chr14_+_24161257_241613220.431.3e-02Click!

Activity profile of IRF9 motif

Sorted Z-values of IRF9 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_22462932 6.43 ENST00000390477.2
T cell receptor delta constant
chr21_+_41361999 5.80 ENST00000436410.5
ENST00000435611.6
ENST00000330714.8
MX dynamin like GTPase 2
chr1_-_161631152 5.06 ENST00000421702.3
ENST00000650385.1
Fc fragment of IgG receptor IIIb
chr1_-_161631032 5.01 ENST00000534776.1
ENST00000613418.4
ENST00000614870.4
Fc fragment of IgG receptor IIIb
chr6_+_6588708 4.58 ENST00000230568.5
lymphocyte antigen 86
chr1_-_150765735 4.49 ENST00000679898.1
ENST00000448301.7
ENST00000680664.1
ENST00000679512.1
ENST00000368985.8
ENST00000679582.1
cathepsin S
chr1_-_150765785 4.39 ENST00000680311.1
ENST00000681728.1
ENST00000680288.1
cathepsin S
chr19_+_16143678 4.15 ENST00000613986.4
ENST00000593031.1
hematopoietic SH2 domain containing
chr22_+_39901075 3.90 ENST00000344138.9
GRB2 related adaptor protein 2
chr6_-_24935942 3.50 ENST00000645100.1
ENST00000643898.2
ENST00000613507.4
RHO family interacting cell polarization regulator 2
chr3_-_27722699 3.16 ENST00000461503.2
eomesodermin
chr17_+_6755834 3.00 ENST00000346752.8
XIAP associated factor 1
chr12_+_112906949 2.96 ENST00000679971.1
ENST00000675868.2
ENST00000550883.2
ENST00000553152.2
ENST00000202917.10
ENST00000679467.1
ENST00000680659.1
ENST00000540589.3
ENST00000552526.2
ENST00000681228.1
ENST00000680934.1
ENST00000681700.1
ENST00000679987.1
2'-5'-oligoadenylate synthetase 1
chrX_+_37780049 2.79 ENST00000378588.5
cytochrome b-245 beta chain
chr18_-_69956924 2.53 ENST00000581982.5
ENST00000280200.8
CD226 molecule
chr12_+_112907006 2.51 ENST00000680455.1
ENST00000551241.6
ENST00000550689.2
ENST00000679841.1
ENST00000679494.1
ENST00000553185.2
2'-5'-oligoadenylate synthetase 1
chr21_+_41426590 2.49 ENST00000679543.1
ENST00000680364.1
MX dynamin like GTPase 1
chr6_+_106098933 2.43 ENST00000369089.3
PR/SET domain 1
chr12_-_121039236 2.26 ENST00000257570.9
2'-5'-oligoadenylate synthetase like
chr12_-_121039204 2.17 ENST00000620239.5
2'-5'-oligoadenylate synthetase like
chr13_-_40982880 2.17 ENST00000635415.1
E74 like ETS transcription factor 1
chr1_+_241532121 2.16 ENST00000366558.7
kynurenine 3-monooxygenase
chr4_-_76023489 2.16 ENST00000306602.3
C-X-C motif chemokine ligand 10
chr4_-_168480477 2.14 ENST00000514748.5
ENST00000512371.1
ENST00000505890.5
ENST00000682922.1
ENST00000511577.5
DExD/H-box 60 like
chr2_-_151289613 2.12 ENST00000243346.10
N-myc and STAT interactor
chrX_-_30577759 2.06 ENST00000378962.4
TLR adaptor interacting with endolysosomal SLC15A4
chr21_+_41426168 2.03 ENST00000681266.1
ENST00000417963.6
MX dynamin like GTPase 1
chr17_+_80260826 2.01 ENST00000508628.6
ENST00000582970.5
ENST00000319921.4
ring finger protein 213
chr21_+_41426031 1.98 ENST00000455164.6
ENST00000681849.1
ENST00000679705.1
ENST00000424365.6
MX dynamin like GTPase 1
chr12_-_121039156 1.97 ENST00000339275.10
2'-5'-oligoadenylate synthetase like
chr2_-_151289871 1.97 ENST00000414946.1
N-myc and STAT interactor
chr12_+_112906777 1.89 ENST00000452357.7
ENST00000445409.7
2'-5'-oligoadenylate synthetase 1
chr2_+_162318884 1.89 ENST00000446271.5
ENST00000429691.6
grancalcin
chr15_+_44711487 1.87 ENST00000544417.5
ENST00000559916.1
ENST00000648006.3
beta-2-microglobulin
chr3_-_121660892 1.87 ENST00000428394.6
ENST00000314583.8
hematopoietic cell-specific Lyn substrate 1
chr6_-_33314202 1.86 ENST00000426633.6
ENST00000467025.1
TAP binding protein
chr17_+_27631148 1.85 ENST00000313648.10
ENST00000395473.7
ENST00000577392.5
ENST00000584661.5
galectin 9
chr21_+_41426232 1.79 ENST00000398598.8
ENST00000681896.1
ENST00000680629.1
ENST00000680760.1
ENST00000680176.1
ENST00000680776.1
ENST00000681607.1
ENST00000680536.1
MX dynamin like GTPase 1
chr12_+_112938422 1.76 ENST00000680044.1
ENST00000680966.1
ENST00000548514.2
ENST00000681497.1
ENST00000551007.1
ENST00000228928.12
ENST00000680438.1
ENST00000681147.1
ENST00000679354.1
ENST00000681085.1
ENST00000680161.1
2'-5'-oligoadenylate synthetase 3
chr20_-_57620415 1.73 ENST00000371173.8
Z-DNA binding protein 1
chr21_+_41426197 1.73 ENST00000680942.1
ENST00000288383.11
ENST00000679386.1
MX dynamin like GTPase 1
chr21_+_41426289 1.71 ENST00000679408.1
ENST00000681039.1
ENST00000681671.1
MX dynamin like GTPase 1
chr20_-_57620467 1.68 ENST00000395822.7
Z-DNA binding protein 1
chr6_-_33314247 1.67 ENST00000475304.5
ENST00000489157.5
TAP binding protein
chr1_+_241532370 1.67 ENST00000366559.9
ENST00000366557.8
kynurenine 3-monooxygenase
chr1_+_66354375 1.66 ENST00000480109.2
phosphodiesterase 4B
chr12_-_121038967 1.63 ENST00000680620.1
ENST00000679655.1
ENST00000543677.2
2'-5'-oligoadenylate synthetase like
chr17_+_43211835 1.61 ENST00000588693.5
ENST00000588659.5
ENST00000541594.5
ENST00000536052.5
ENST00000612339.4
transmembrane protein 106A
chr8_+_27380629 1.58 ENST00000412793.5
protein tyrosine kinase 2 beta
chr6_-_33314055 1.56 ENST00000434618.7
TAP binding protein
chr13_-_46387447 1.56 ENST00000676051.1
ENST00000378787.7
ENST00000378781.7
ENST00000378797.6
rubicon like autophagy enhancer
chr12_+_112938523 1.56 ENST00000679483.1
ENST00000679493.1
2'-5'-oligoadenylate synthetase 3
chr18_-_69956670 1.54 ENST00000583955.5
CD226 molecule
chr13_-_42992165 1.48 ENST00000398762.7
ENST00000313640.11
ENST00000313624.12
epithelial stromal interaction 1
chr10_-_89414458 1.43 ENST00000371837.5
lipase A, lysosomal acid type
chr1_+_78649818 1.41 ENST00000370747.9
ENST00000438486.1
interferon induced protein 44
chr2_+_6877768 1.38 ENST00000382040.4
radical S-adenosyl methionine domain containing 2
chr14_-_67515153 1.35 ENST00000555994.6
transmembrane protein 229B
chr6_-_32838727 1.35 ENST00000652259.1
ENST00000374897.4
ENST00000620123.4
ENST00000452392.2
transporter 2, ATP binding cassette subfamily B member
novel protein, TAP2-HLA-DOB readthrough
chr3_-_71360753 1.32 ENST00000648783.1
forkhead box P1
chr11_-_4393650 1.26 ENST00000254436.8
tripartite motif containing 21
chr12_-_56360084 1.26 ENST00000314128.9
ENST00000557235.5
ENST00000651915.1
signal transducer and activator of transcription 2
chr11_-_615570 1.25 ENST00000649187.1
ENST00000647801.1
ENST00000397566.5
ENST00000397570.5
interferon regulatory factor 7
chr17_+_6756035 1.24 ENST00000361842.8
ENST00000574907.5
XIAP associated factor 1
chr16_-_74700786 1.20 ENST00000306247.11
ENST00000575686.1
mixed lineage kinase domain like pseudokinase
chr2_-_6865901 1.19 ENST00000256722.10
cytidine/uridine monophosphate kinase 2
chr11_-_57567260 1.15 ENST00000526659.1
ENST00000527022.1
ubiquitin conjugating enzyme E2 L6
chr6_-_33314386 1.15 ENST00000456592.3
TAP binding protein
chr18_-_69957176 1.13 ENST00000580335.1
CD226 molecule
chr9_-_32526185 1.10 ENST00000379883.3
ENST00000379868.6
ENST00000679859.1
DExD/H-box helicase 58
chr3_+_122564327 1.10 ENST00000296161.9
ENST00000383661.3
deltex E3 ubiquitin ligase 3L
chr13_-_46387724 1.10 ENST00000675585.1
rubicon like autophagy enhancer
chr15_-_44711306 1.10 ENST00000682850.1
PAT1 homolog 2
chr1_-_154608140 1.08 ENST00000529168.2
ENST00000368474.9
ENST00000680305.1
ENST00000648231.2
adenosine deaminase RNA specific
chr17_-_56914032 1.06 ENST00000537230.3
ENST00000316881.9
tripartite motif containing 25
chr3_-_122564232 1.04 ENST00000471785.5
ENST00000466126.1
poly(ADP-ribose) polymerase family member 9
chr3_+_187368367 1.03 ENST00000259030.3
receptor transporter protein 4
chr11_+_5624987 1.03 ENST00000429814.3
tripartite motif containing 34
chr9_-_83978429 1.02 ENST00000351839.7
heterogeneous nuclear ribonucleoprotein K
chr12_+_6772512 1.00 ENST00000441671.6
ENST00000203629.3
lymphocyte activating 3
chr1_+_159010002 0.99 ENST00000359709.7
interferon gamma inducible protein 16
chr1_+_154405193 0.97 ENST00000622330.4
ENST00000344086.8
interleukin 6 receptor
chr10_+_89414729 0.97 ENST00000681163.1
ENST00000681348.1
interferon induced protein with tetratricopeptide repeats 5
chr17_-_76493133 0.96 ENST00000585701.5
ENST00000591192.1
ENST00000589526.5
rhomboid 5 homolog 2
chr7_+_18496269 0.94 ENST00000432645.6
histone deacetylase 9
chr3_-_142448028 0.94 ENST00000392981.7
5'-3' exoribonuclease 1
chr14_+_24161257 0.94 ENST00000396864.8
ENST00000557894.5
ENST00000559284.5
ENST00000560275.5
interferon regulatory factor 9
chr10_+_89301932 0.93 ENST00000371826.4
ENST00000679755.1
interferon induced protein with tetratricopeptide repeats 2
chr3_-_71581540 0.91 ENST00000650068.1
forkhead box P1
chr1_+_220879434 0.87 ENST00000366903.8
H2.0 like homeobox
chr3_-_122564253 0.86 ENST00000492382.5
ENST00000682323.1
ENST00000462315.5
poly(ADP-ribose) polymerase family member 9
chr14_+_100065400 0.86 ENST00000555706.5
ENST00000392920.8
ENST00000555048.5
Enah/Vasp-like
chr1_+_1013485 0.86 ENST00000649529.1
ISG15 ubiquitin like modifier
chr3_+_63911929 0.85 ENST00000487717.5
ataxin 7
chr20_-_57620393 0.85 ENST00000541799.1
Z-DNA binding protein 1
chr1_+_112674416 0.84 ENST00000413052.6
ENST00000369645.5
Mov10 RISC complex RNA helicase
chr7_-_140062841 0.84 ENST00000263549.8
poly(ADP-ribose) polymerase family member 12
chr11_-_615921 0.79 ENST00000348655.11
ENST00000525445.6
ENST00000330243.9
interferon regulatory factor 7
chr17_+_6755559 0.79 ENST00000574394.5
XIAP associated factor 1
chr6_+_20401864 0.77 ENST00000346618.8
ENST00000613242.4
E2F transcription factor 3
chr1_+_159009886 0.76 ENST00000340979.10
ENST00000368131.8
ENST00000295809.12
ENST00000368132.7
interferon gamma inducible protein 16
chr11_-_57567617 0.76 ENST00000287156.9
ubiquitin conjugating enzyme E2 L6
chr3_-_142448060 0.75 ENST00000264951.8
5'-3' exoribonuclease 1
chr7_+_135148041 0.73 ENST00000275767.3
transmembrane protein 140
chr4_-_146521666 0.71 ENST00000507030.5
solute carrier family 10 member 7
chr6_-_81752671 0.70 ENST00000320172.11
ENST00000369754.7
ENST00000369756.3
terminal nucleotidyltransferase 5A
chr15_-_25863304 0.70 ENST00000555815.6
ENST00000673716.1
ATPase phospholipid transporting 10A (putative)
chr12_+_112938284 0.69 ENST00000681346.1
2'-5'-oligoadenylate synthetase 3
chr20_-_49278034 0.67 ENST00000371744.5
ENST00000396105.6
ENST00000371752.5
zinc finger NFX1-type containing 1
chr14_-_56810448 0.66 ENST00000339475.10
ENST00000555006.5
ENST00000672264.2
ENST00000554559.5
ENST00000555804.1
orthodenticle homeobox 2
chr5_+_134526100 0.63 ENST00000395003.5
jade family PHD finger 2
chr3_+_122680802 0.61 ENST00000474629.7
poly(ADP-ribose) polymerase family member 14
chr14_-_56810380 0.61 ENST00000672125.1
ENST00000673481.1
orthodenticle homeobox 2
chr10_+_89414555 0.59 ENST00000371795.5
ENST00000681422.1
interferon induced protein with tetratricopeptide repeats 5
chr3_-_146544538 0.55 ENST00000462666.5
phospholipid scramblase 1
chrX_-_40097403 0.54 ENST00000397354.7
BCL6 corepressor
chr8_-_143986425 0.53 ENST00000313059.9
ENST00000524918.5
ENST00000313028.12
ENST00000525773.5
poly(ADP-ribose) polymerase family member 10
chr3_-_122564577 0.51 ENST00000477522.6
ENST00000360356.6
poly(ADP-ribose) polymerase family member 9
chr10_-_93482287 0.51 ENST00000371489.5
myoferlin
chr2_+_6865557 0.49 ENST00000680607.1
ENST00000680320.1
ENST00000442639.6
radical S-adenosyl methionine domain containing 2
chr3_+_122680850 0.49 ENST00000494811.2
poly(ADP-ribose) polymerase family member 14
chr2_-_37156942 0.48 ENST00000680273.1
ENST00000233057.9
ENST00000679979.1
ENST00000679507.1
ENST00000681463.1
ENST00000395127.6
eukaryotic translation initiation factor 2 alpha kinase 2
chr3_+_63912588 0.47 ENST00000522345.2
ataxin 7
chr2_+_33476640 0.46 ENST00000425210.5
ENST00000444784.5
ENST00000423159.5
ENST00000403687.8
RAS guanyl releasing protein 3
chr16_-_15643024 0.45 ENST00000540441.6
meiosis regulator and mRNA stability factor 1
chr1_+_112674649 0.45 ENST00000369644.5
Mov10 RISC complex RNA helicase
chr13_+_49495941 0.45 ENST00000378319.8
ENST00000496623.5
ENST00000426879.5
PHD finger protein 11
chr20_-_49278416 0.42 ENST00000371754.8
zinc finger NFX1-type containing 1
chr20_+_62804794 0.42 ENST00000290291.10
opioid growth factor receptor
chr19_+_10111689 0.39 ENST00000321826.5
purinergic receptor P2Y11
chr13_+_49496355 0.39 ENST00000496612.5
ENST00000357596.7
ENST00000485919.5
ENST00000442195.5
PHD finger protein 11
chr3_-_146544701 0.37 ENST00000487389.5
phospholipid scramblase 1
chr1_+_112674722 0.37 ENST00000357443.2
Mov10 RISC complex RNA helicase
chr4_-_146521830 0.35 ENST00000511374.5
solute carrier family 10 member 7
chr3_-_179451387 0.34 ENST00000675901.1
ENST00000232564.8
ENST00000674862.1
ENST00000497513.1
G protein subunit beta 4
chr1_-_182589239 0.34 ENST00000367559.7
ENST00000539397.1
ribonuclease L
chr11_-_60952559 0.34 ENST00000538739.2
solute carrier family 15 member 3
chr15_+_58410543 0.34 ENST00000356113.10
ENST00000414170.7
lipase C, hepatic type
chr2_-_37157093 0.34 ENST00000681507.1
eukaryotic translation initiation factor 2 alpha kinase 2
chr18_+_3262956 0.33 ENST00000584539.1
myosin light chain 12B
chr10_-_5978022 0.31 ENST00000525219.6
interleukin 15 receptor subunit alpha
chr3_-_146544850 0.31 ENST00000472349.1
phospholipid scramblase 1
chr3_-_142448004 0.31 ENST00000463916.5
5'-3' exoribonuclease 1
chr16_+_28950807 0.29 ENST00000564978.5
ENST00000320805.8
nuclear factor of activated T cells 2 interacting protein
chr11_-_60952134 0.29 ENST00000679573.1
ENST00000681882.1
ENST00000681951.1
ENST00000227880.8
solute carrier family 15 member 3
chr10_-_93482194 0.28 ENST00000358334.9
ENST00000371488.3
myoferlin
chr3_-_146544578 0.28 ENST00000342435.9
ENST00000448787.6
phospholipid scramblase 1
chr19_+_17405685 0.28 ENST00000646744.1
ENST00000635536.2
ENST00000635060.2
ENST00000634291.2
ENST00000645298.1
ENST00000528911.5
BST2 interferon stimulated positive regulator
multivesicular body subunit 12A
chr3_-_146544636 0.25 ENST00000486631.5
phospholipid scramblase 1
chr10_-_93482326 0.25 ENST00000359263.9
myoferlin
chr2_-_6865655 0.24 ENST00000404168.1
cytidine/uridine monophosphate kinase 2
chr8_-_28083850 0.23 ENST00000418860.1
nuclear GTPase, germinal center associated
chr9_+_99906646 0.23 ENST00000259400.11
ENST00000531035.5
ENST00000525640.5
ENST00000534052.1
ENST00000526607.1
syntaxin 17
chr17_-_4263847 0.19 ENST00000570535.5
ENST00000574367.5
ENST00000341657.9
ankyrin repeat and FYVE domain containing 1
chr2_+_33476616 0.18 ENST00000442390.5
RAS guanyl releasing protein 3
chr7_-_84492718 0.18 ENST00000424555.5
semaphorin 3A
chr2_-_6865799 0.18 ENST00000458098.5
cytidine/uridine monophosphate kinase 2
chr17_+_56153458 0.17 ENST00000318698.6
ENST00000682825.1
ENST00000566473.6
ankyrin repeat and fibronectin type III domain containing 1
chr10_+_89332484 0.15 ENST00000371811.4
ENST00000680037.1
ENST00000679583.1
ENST00000679897.1
interferon induced protein with tetratricopeptide repeats 3
chr2_+_6933043 0.15 ENST00000416587.5
ring finger protein 144A
chr3_-_28348436 0.13 ENST00000415852.1
5-azacytidine induced 2
chr6_-_117573571 0.12 ENST00000467125.1
novel protein, GOPC-ROS1 readthrough
chr19_+_17405734 0.09 ENST00000635572.1
ENST00000634675.1
ENST00000634813.1
ENST00000647283.1
ENST00000635435.2
ENST00000634731.2
ENST00000635339.1
ENST00000528604.5
BST2 interferon stimulated positive regulator
multivesicular body subunit 12A
chr11_+_67022719 0.06 ENST00000525457.5
synaptotagmin 12
chr6_+_37433197 0.06 ENST00000455891.5
ENST00000373451.9
cap methyltransferase 1
chr7_-_105691637 0.05 ENST00000472195.1
ataxin 7 like 1
chr11_-_86672328 0.04 ENST00000526834.1
ENST00000323418.10
malic enzyme 3
chr16_-_11256192 0.03 ENST00000644787.1
ENST00000332029.4
suppressor of cytokine signaling 1
chr3_-_167734510 0.03 ENST00000475915.6
ENST00000462725.6
ENST00000461494.5
programmed cell death 10
chr16_-_28506826 0.01 ENST00000356897.1
interleukin 27

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 8.9 GO:0034769 basement membrane disassembly(GO:0034769)
1.6 6.2 GO:0050823 peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823)
1.1 3.2 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428)
1.1 3.2 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.0 4.1 GO:1902524 negative regulation of interferon-alpha biosynthetic process(GO:0045355) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.9 2.8 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.9 5.2 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
0.8 2.4 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.8 3.8 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.7 17.5 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.6 1.9 GO:2000562 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.6 3.5 GO:2001107 negative regulation of establishment of T cell polarity(GO:1903904) negative regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001107)
0.5 4.6 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.4 2.0 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.4 2.0 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.4 4.1 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
0.3 1.6 GO:0006233 dUDP biosynthetic process(GO:0006227) dTDP biosynthetic process(GO:0006233) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dTDP metabolic process(GO:0046072) dUDP metabolic process(GO:0046077)
0.3 1.6 GO:2000538 regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.3 1.3 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.3 1.9 GO:0034165 positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
0.3 4.0 GO:0060700 regulation of ribonuclease activity(GO:0060700)
0.3 2.0 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
0.3 1.1 GO:0010607 negative regulation of cytoplasmic mRNA processing body assembly(GO:0010607)
0.3 0.8 GO:0051805 evasion or tolerance of host immune response(GO:0020012) evasion or tolerance of host defense response(GO:0030682) evasion or tolerance by virus of host immune response(GO:0030683) evasion or tolerance of immune response of other organism involved in symbiotic interaction(GO:0051805) evasion or tolerance of defense response of other organism involved in symbiotic interaction(GO:0051807)
0.3 2.9 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.2 1.0 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.2 22.6 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.2 1.0 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
0.2 1.0 GO:0002384 hepatic immune response(GO:0002384)
0.2 2.2 GO:0010819 regulation of T cell chemotaxis(GO:0010819)
0.2 1.7 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.1 1.5 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 0.9 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.1 2.2 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 1.3 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 0.5 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.1 1.9 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 1.7 GO:1901898 neutrophil homeostasis(GO:0001780) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 3.1 GO:0035456 response to interferon-beta(GO:0035456)
0.1 10.1 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.1 0.8 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.1 6.4 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 1.3 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.1 1.1 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.1 2.2 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 1.0 GO:0001778 plasma membrane repair(GO:0001778)
0.1 0.9 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.1 1.1 GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production(GO:0032725)
0.0 0.2 GO:0016240 autophagosome docking(GO:0016240)
0.0 1.1 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 0.9 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.2 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.0 0.6 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 3.9 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 1.4 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.0 1.2 GO:0070207 protein homotrimerization(GO:0070207)
0.0 1.0 GO:0070206 protein trimerization(GO:0070206)
0.0 0.4 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.3 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 1.3 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 1.1 GO:0010390 histone monoubiquitination(GO:0010390)
0.0 2.9 GO:0032481 positive regulation of type I interferon production(GO:0032481)
0.0 0.1 GO:0036451 cap mRNA methylation(GO:0036451)
0.0 0.4 GO:0023041 neuronal signal transduction(GO:0023041)
0.0 0.7 GO:0045332 phospholipid translocation(GO:0045332)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 8.9 GO:0036021 endolysosome lumen(GO:0036021)
1.1 7.6 GO:0042825 TAP complex(GO:0042825)
0.4 1.9 GO:0031905 early endosome lumen(GO:0031905)
0.3 3.5 GO:0060171 stereocilium membrane(GO:0060171)
0.2 1.0 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 2.8 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 1.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 6.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 1.6 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 1.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 1.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 5.8 GO:0005643 nuclear pore(GO:0005643)
0.0 9.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.2 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 6.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.6 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 8.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 5.7 GO:0005741 mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968)
0.0 10.6 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.2 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 3.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.0 GO:0002102 podosome(GO:0002102)
0.0 1.9 GO:0035578 azurophil granule lumen(GO:0035578)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 7.6 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
1.4 4.3 GO:0003692 left-handed Z-DNA binding(GO:0003692)
1.2 19.4 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.6 10.1 GO:0019864 IgG binding(GO:0019864)
0.5 1.6 GO:0033862 UMP kinase activity(GO:0033862)
0.4 2.2 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.4 1.9 GO:0048030 disaccharide binding(GO:0048030)
0.3 2.0 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.3 1.6 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.3 3.8 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.2 1.0 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
0.2 8.9 GO:0001968 fibronectin binding(GO:0001968)
0.2 1.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.2 1.4 GO:0004771 sterol esterase activity(GO:0004771)
0.2 1.5 GO:0042296 ISG15 transferase activity(GO:0042296)
0.1 2.8 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.1 1.0 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 1.0 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 0.8 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.1 4.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 6.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 1.1 GO:0031386 protein tag(GO:0031386)
0.1 1.8 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 1.1 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 8.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 1.3 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 3.5 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.3 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 1.6 GO:0000339 RNA cap binding(GO:0000339)
0.0 2.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.9 GO:0005522 profilin binding(GO:0005522)
0.0 17.5 GO:0003924 GTPase activity(GO:0003924)
0.0 3.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 4.1 GO:0043621 protein self-association(GO:0043621)
0.0 0.9 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.4 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 1.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.4 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.1 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.0 0.3 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.4 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 1.9 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 2.6 GO:0004386 helicase activity(GO:0004386)
0.0 3.6 GO:0001047 core promoter binding(GO:0001047)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 3.9 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 1.0 ST STAT3 PATHWAY STAT3 Pathway
0.1 5.0 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 2.2 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 1.6 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 2.2 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 2.8 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 8.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.9 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.8 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 1.5 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 1.1 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.8 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 1.0 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 2.0 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 10.7 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.4 48.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 2.1 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 1.1 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.1 1.0 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 4.8 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 2.0 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 2.6 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 1.3 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 0.8 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 2.8 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 5.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 1.6 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.6 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 2.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 4.6 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.0 1.7 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 1.5 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases