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Illumina Body Map 2 (GSE30611)

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Results for IRX2

Z-value: 0.81

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Transcription factors associated with IRX2

Gene Symbol Gene ID Gene Info
IRX2
ENSG00000170561.13 iroquois homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX2hg38_v1_chr5_-_2751670_2751694-0.086.5e-01Click!

Activity profile of IRX2 motif

Sorted Z-values of IRX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_87975667 2.36 ENST00000237623.11
ENST00000682655.1
ENST00000508233.6
ENST00000360804.4
ENST00000395080.8
SPP1
secreted phosphoprotein 1
chr11_+_33016106 2.10 ENST00000311388.7
DEPDC7
DEP domain containing 7
chr5_-_39364484 2.07 ENST00000263408.5
C9
complement C9
chr13_-_46105009 1.94 ENST00000439329.5
ENST00000674625.1
ENST00000181383.10
CPB2
carboxypeptidase B2
chr5_-_35047935 1.88 ENST00000510428.1
ENST00000231420.11
AGXT2
alanine--glyoxylate aminotransferase 2
chr10_-_95069489 1.83 ENST00000371270.6
ENST00000535898.5
ENST00000623108.3
CYP2C8
cytochrome P450 family 2 subfamily C member 8
chr3_-_194351290 1.81 ENST00000429275.1
ENST00000323830.4
CPN2
carboxypeptidase N subunit 2
chr4_+_68815991 1.64 ENST00000265403.12
ENST00000458688.2
UGT2B10
UDP glucuronosyltransferase family 2 member B10
chr14_-_64942783 1.43 ENST00000612794.1
GPX2
glutathione peroxidase 2
chr1_+_166989254 1.39 ENST00000367872.9
ENST00000447624.1
MAEL
maelstrom spermatogenic transposon silencer
chr16_+_82035245 1.36 ENST00000199936.9
HSD17B2
hydroxysteroid 17-beta dehydrogenase 2
chr19_-_38229654 1.32 ENST00000412732.5
ENST00000456296.5
DPF1
double PHD fingers 1
chr2_+_233729042 1.29 ENST00000482026.6
UGT1A3
UDP glucuronosyltransferase family 1 member A3
chr2_-_233013228 1.27 ENST00000264051.8
NGEF
neuronal guanine nucleotide exchange factor
chr15_+_37934626 1.16 ENST00000559502.5
ENST00000558148.5
ENST00000319669.5
ENST00000558158.5
TMCO5A
transmembrane and coiled-coil domains 5A
chr14_+_24071552 1.16 ENST00000559207.1
CPNE6
copine 6
chr1_+_166989089 1.11 ENST00000367870.6
MAEL
maelstrom spermatogenic transposon silencer
chr15_-_44194407 1.09 ENST00000484674.5
FRMD5
FERM domain containing 5
chr20_+_57561103 1.08 ENST00000319441.6
PCK1
phosphoenolpyruvate carboxykinase 1
chr14_+_24071522 1.04 ENST00000558859.5
ENST00000559197.5
ENST00000560828.5
ENST00000560884.5
CPNE6
copine 6
chr4_+_186266183 1.04 ENST00000403665.7
ENST00000492972.6
ENST00000264692.8
F11
coagulation factor XI
chr9_+_12695702 1.02 ENST00000381136.2
TYRP1
tyrosinase related protein 1
chr19_-_38229714 1.02 ENST00000416611.5
DPF1
double PHD fingers 1
chr9_-_71121596 0.98 ENST00000377110.9
ENST00000377111.8
ENST00000677713.2
TRPM3
transient receptor potential cation channel subfamily M member 3
chr6_-_159044980 0.96 ENST00000367066.8
TAGAP
T cell activation RhoGTPase activating protein
chr3_-_151384741 0.95 ENST00000302632.4
P2RY12
purinergic receptor P2Y12
chr6_-_159045010 0.94 ENST00000338313.5
TAGAP
T cell activation RhoGTPase activating protein
chr16_+_58503833 0.88 ENST00000561738.5
NDRG4
NDRG family member 4
chr16_+_82035267 0.88 ENST00000566213.1
HSD17B2
hydroxysteroid 17-beta dehydrogenase 2
chr16_+_82034978 0.88 ENST00000563491.5
HSD17B2
hydroxysteroid 17-beta dehydrogenase 2
chr9_-_110337808 0.87 ENST00000374510.8
ENST00000374507.4
ENST00000423740.7
ENST00000374511.7
TXNDC8
thioredoxin domain containing 8
chr5_-_138875290 0.84 ENST00000521094.2
ENST00000274711.7
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr16_+_56865202 0.84 ENST00000566786.5
ENST00000438926.6
ENST00000563236.6
ENST00000262502.5
SLC12A3
solute carrier family 12 member 3
chr12_+_100503416 0.81 ENST00000551184.1
NR1H4
nuclear receptor subfamily 1 group H member 4
chr9_-_23779369 0.81 ENST00000440102.1
ELAVL2
ELAV like RNA binding protein 2
chr10_-_14554141 0.81 ENST00000496330.5
FAM107B
family with sequence similarity 107 member B
chr4_-_167234266 0.80 ENST00000511269.5
ENST00000506697.5
ENST00000512042.1
SPOCK3
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr4_+_157220691 0.80 ENST00000509417.5
ENST00000645636.1
ENST00000296526.12
ENST00000264426.14
GRIA2
glutamate ionotropic receptor AMPA type subunit 2
chr6_-_159045104 0.77 ENST00000326965.7
TAGAP
T cell activation RhoGTPase activating protein
chr10_+_99782628 0.75 ENST00000648689.1
ENST00000647814.1
ABCC2
ATP binding cassette subfamily C member 2
chr4_-_69214743 0.73 ENST00000446444.2
UGT2B11
UDP glucuronosyltransferase family 2 member B11
chr4_+_157221598 0.73 ENST00000505888.1
GRIA2
glutamate ionotropic receptor AMPA type subunit 2
chr4_+_56505782 0.73 ENST00000640821.3
ARL9
ADP ribosylation factor like GTPase 9
chr5_-_36301883 0.71 ENST00000502994.5
ENST00000515759.5
ENST00000296604.8
RANBP3L
RAN binding protein 3 like
chr6_-_24489565 0.70 ENST00000230036.2
GPLD1
glycosylphosphatidylinositol specific phospholipase D1
chr2_-_165203870 0.69 ENST00000639244.1
ENST00000409101.7
ENST00000668657.1
SCN3A
sodium voltage-gated channel alpha subunit 3
chr19_-_35228699 0.69 ENST00000324675.3
FAM187B
family with sequence similarity 187 member B
chr14_+_22422371 0.67 ENST00000390469.2
TRDV2
T cell receptor delta variable 2
chr7_-_150323489 0.67 ENST00000683684.1
ENST00000478393.5
ACTR3C
actin related protein 3C
chr2_-_165204042 0.66 ENST00000283254.12
ENST00000453007.1
SCN3A
sodium voltage-gated channel alpha subunit 3
chr5_+_161850597 0.65 ENST00000634335.1
ENST00000635880.1
GABRA1
gamma-aminobutyric acid type A receptor subunit alpha1
chr5_-_161546708 0.65 ENST00000393959.6
GABRB2
gamma-aminobutyric acid type A receptor subunit beta2
chr5_-_138875362 0.64 ENST00000518785.1
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr3_-_123980727 0.64 ENST00000620893.4
ROPN1
rhophilin associated tail protein 1
chr5_+_157269317 0.63 ENST00000618329.4
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr7_-_14841267 0.62 ENST00000406247.7
ENST00000399322.7
DGKB
diacylglycerol kinase beta
chr18_+_52752032 0.61 ENST00000412726.5
ENST00000578080.1
ENST00000582875.1
DCC
DCC netrin 1 receptor
chr11_+_104036624 0.60 ENST00000302259.5
DDI1
DNA damage inducible 1 homolog 1
chr6_+_46693835 0.59 ENST00000450697.1
TDRD6
tudor domain containing 6
chr20_-_31390483 0.58 ENST00000376315.2
DEFB119
defensin beta 119
chr3_+_97439603 0.58 ENST00000514100.5
EPHA6
EPH receptor A6
chr11_+_124919244 0.58 ENST00000408930.6
HEPN1
hepatocellular carcinoma, down-regulated 1
chr5_+_36608146 0.56 ENST00000381918.4
ENST00000513646.1
SLC1A3
solute carrier family 1 member 3
chrX_-_132961390 0.55 ENST00000370836.6
ENST00000521489.5
HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr6_+_143864458 0.54 ENST00000237275.9
ZC2HC1B
zinc finger C2HC-type containing 1B
chr4_+_188139438 0.53 ENST00000332517.4
TRIML1
tripartite motif family like 1
chr7_-_105691637 0.52 ENST00000472195.1
ATXN7L1
ataxin 7 like 1
chr7_-_150323725 0.52 ENST00000477871.1
ACTR3C
actin related protein 3C
chr4_-_167234552 0.51 ENST00000512648.5
SPOCK3
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr1_-_8879170 0.50 ENST00000489867.2
ENO1
enolase 1
chr2_-_163735989 0.50 ENST00000333129.4
ENST00000409634.5
FIGN
fidgetin, microtubule severing factor
chr1_-_107688492 0.49 ENST00000415432.6
VAV3
vav guanine nucleotide exchange factor 3
chr16_+_33459650 0.48 ENST00000617705.1
TP53TG3F
TP53 target 3 family member F
chr4_-_149815826 0.47 ENST00000636793.2
ENST00000636414.1
IQCM
IQ motif containing M
chr6_-_49964160 0.45 ENST00000322066.4
DEFB114
defensin beta 114
chr8_-_81447428 0.45 ENST00000256103.3
ENST00000519260.1
PMP2
peripheral myelin protein 2
chr4_-_167234579 0.45 ENST00000502330.5
ENST00000357154.7
ENST00000421836.6
SPOCK3
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr4_-_38804783 0.45 ENST00000308979.7
ENST00000505940.1
ENST00000515861.5
TLR1
toll like receptor 1
chr5_-_161546671 0.45 ENST00000517547.5
GABRB2
gamma-aminobutyric acid type A receptor subunit beta2
chr3_+_169821922 0.44 ENST00000340806.6
LRRIQ4
leucine rich repeats and IQ motif containing 4
chr16_+_7332744 0.44 ENST00000436368.6
ENST00000311745.9
ENST00000340209.8
ENST00000620507.4
RBFOX1
RNA binding fox-1 homolog 1
chr7_+_69967464 0.44 ENST00000664521.1
AUTS2
activator of transcription and developmental regulator AUTS2
chr10_-_59362584 0.44 ENST00000618427.4
ENST00000611933.4
FAM13C
family with sequence similarity 13 member C
chr2_-_108989206 0.43 ENST00000258443.7
ENST00000409271.5
ENST00000376651.1
EDAR
ectodysplasin A receptor
chr11_-_62709841 0.42 ENST00000464544.1
ENST00000530009.1
BSCL2
BSCL2 lipid droplet biogenesis associated, seipin
chr3_+_51975026 0.42 ENST00000458031.6
ENST00000273596.8
ENST00000463937.1
ENST00000635952.1
ABHD14A
ABHD14A-ACY1
abhydrolase domain containing 14A
ABHD14A-ACY1 readthrough
chr10_-_59362824 0.42 ENST00000503444.1
FAM13C
family with sequence similarity 13 member C
chr4_+_113292838 0.41 ENST00000672411.1
ENST00000673231.1
ANK2
ankyrin 2
chr14_+_75069577 0.41 ENST00000238686.8
ZC2HC1C
zinc finger C2HC-type containing 1C
chr1_+_204870831 0.41 ENST00000404076.5
ENST00000539706.6
NFASC
neurofascin
chr20_-_36700661 0.40 ENST00000422536.2
NDRG3
NDRG family member 3
chr16_+_33304344 0.40 ENST00000611321.1
TP53TG3E
TP53 target 3 family member E
chr4_-_152411734 0.39 ENST00000603841.1
FBXW7
F-box and WD repeat domain containing 7
chr5_-_150758683 0.39 ENST00000518015.5
DCTN4
dynactin subunit 4
chr4_-_167234426 0.39 ENST00000541354.5
ENST00000509854.5
ENST00000512681.5
ENST00000357545.9
ENST00000510741.5
ENST00000510403.5
SPOCK3
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr7_-_602625 0.39 ENST00000400758.6
PRKAR1B
protein kinase cAMP-dependent type I regulatory subunit beta
chr8_+_7495892 0.39 ENST00000355602.3
DEFB107B
defensin beta 107B
chr21_+_42403856 0.38 ENST00000291535.11
UBASH3A
ubiquitin associated and SH3 domain containing A
chr1_+_162381703 0.38 ENST00000458626.4
C1orf226
chromosome 1 open reading frame 226
chr16_+_33194264 0.37 ENST00000360260.6
TP53TG3C
TP53 target 3C
chr16_+_33360879 0.37 ENST00000569741.1
TP53TG3B
TP53 target 3B
chr17_+_36486629 0.36 ENST00000619730.4
ZNHIT3
zinc finger HIT-type containing 3
chr6_+_13272709 0.35 ENST00000379335.8
PHACTR1
phosphatase and actin regulator 1
chr7_+_73667824 0.35 ENST00000324941.5
ENST00000451519.1
VPS37D
VPS37D subunit of ESCRT-I
chr14_+_75069632 0.34 ENST00000439583.2
ENST00000554763.2
ENST00000524913.3
ENST00000525046.2
ENST00000674086.1
ENST00000526130.2
ENST00000674094.1
ENST00000532198.2
ZC2HC1C
zinc finger C2HC-type containing 1C
chr19_+_110643 0.34 ENST00000318050.4
OR4F17
olfactory receptor family 4 subfamily F member 17
chr2_+_170783781 0.33 ENST00000409885.1
ERICH2
glutamate rich 2
chr3_-_114624921 0.33 ENST00000393785.6
ZBTB20
zinc finger and BTB domain containing 20
chr1_+_31410164 0.32 ENST00000536859.5
SERINC2
serine incorporator 2
chr20_+_18507520 0.32 ENST00000336714.8
ENST00000646240.1
ENST00000450074.6
ENST00000262544.6
SEC23B
SEC23 homolog B, COPII coat complex component
chr4_-_69639642 0.31 ENST00000604629.6
ENST00000604021.1
UGT2A2
UDP glucuronosyltransferase family 2 member A2
chr7_-_83649097 0.31 ENST00000643230.2
SEMA3E
semaphorin 3E
chr10_+_100912955 0.31 ENST00000370271.7
ENST00000238961.9
ENST00000370269.3
ENST00000609386.1
SLF2
SMC5-SMC6 complex localization factor 2
chr1_+_74235377 0.31 ENST00000326637.8
TNNI3K
TNNI3 interacting kinase
chr3_-_58433810 0.31 ENST00000474765.1
ENST00000485460.5
ENST00000302746.11
ENST00000383714.8
PDHB
pyruvate dehydrogenase E1 subunit beta
chrX_-_117985298 0.30 ENST00000469946.5
KLHL13
kelch like family member 13
chr2_+_48617798 0.30 ENST00000448460.5
ENST00000437125.5
ENST00000430487.6
GTF2A1L
general transcription factor IIA subunit 1 like
chr14_+_51860632 0.30 ENST00000555472.5
ENST00000556766.5
GNG2
G protein subunit gamma 2
chr6_-_136525961 0.30 ENST00000438100.6
MAP7
microtubule associated protein 7
chr1_-_173603041 0.30 ENST00000367714.4
SLC9C2
solute carrier family 9 member C2 (putative)
chr5_-_83720813 0.28 ENST00000515590.1
ENST00000274341.9
HAPLN1
hyaluronan and proteoglycan link protein 1
chr6_+_37929959 0.28 ENST00000373389.5
ZFAND3
zinc finger AN1-type containing 3
chr7_+_116954391 0.27 ENST00000421345.5
ENST00000471110.5
ENSG00000288635.1
ST7-OT4
novel protein, readthrough ST7-OT4 - ST7
ST7 overlapping transcript 4
chr2_+_63842102 0.27 ENST00000626380.2
ENST00000497883.5
UGP2
UDP-glucose pyrophosphorylase 2
chr14_+_51860391 0.27 ENST00000335281.8
GNG2
G protein subunit gamma 2
chr7_+_150368189 0.27 ENST00000519397.1
ENST00000479668.5
REPIN1
replication initiator 1
chr3_-_112846856 0.27 ENST00000488794.5
CD200R1L
CD200 receptor 1 like
chr6_-_136526177 0.27 ENST00000617204.4
MAP7
microtubule associated protein 7
chr4_+_157220795 0.27 ENST00000506284.5
GRIA2
glutamate ionotropic receptor AMPA type subunit 2
chr17_-_8757387 0.27 ENST00000580999.1
SPDYE4
speedy/RINGO cell cycle regulator family member E4
chr6_-_53148822 0.26 ENST00000259803.8
GCM1
glial cells missing transcription factor 1
chr2_+_63842325 0.26 ENST00000445915.6
ENST00000475462.5
UGP2
UDP-glucose pyrophosphorylase 2
chr19_+_16197900 0.26 ENST00000429941.6
ENST00000291439.8
ENST00000444449.6
ENST00000589822.5
AP1M1
adaptor related protein complex 1 subunit mu 1
chr6_-_136526654 0.26 ENST00000611373.1
MAP7
microtubule associated protein 7
chr3_-_114624979 0.26 ENST00000676079.1
ZBTB20
zinc finger and BTB domain containing 20
chr12_-_123272234 0.25 ENST00000544658.5
CDK2AP1
cyclin dependent kinase 2 associated protein 1
chrX_-_24027186 0.25 ENST00000328046.8
KLHL15
kelch like family member 15
chr11_-_5059627 0.25 ENST00000321522.2
OR52E2
olfactory receptor family 52 subfamily E member 2
chr20_+_45221362 0.25 ENST00000372769.4
SEMG2
semenogelin 2
chr7_-_130687432 0.24 ENST00000456951.5
TSGA13
testis specific 13
chr2_+_46617180 0.24 ENST00000238892.4
CRIPT
CXXC repeat containing interactor of PDZ3 domain
chr21_+_42403874 0.24 ENST00000319294.11
ENST00000398367.1
UBASH3A
ubiquitin associated and SH3 domain containing A
chr4_+_113292925 0.24 ENST00000673353.1
ENST00000505342.6
ENST00000672915.1
ENST00000509550.5
ANK2
ankyrin 2
chr18_-_55403615 0.23 ENST00000568186.5
TCF4
transcription factor 4
chr6_-_136526472 0.22 ENST00000454590.5
ENST00000432797.6
MAP7
microtubule associated protein 7
chr17_+_36486668 0.22 ENST00000617429.5
ENST00000620324.4
ENST00000616269.1
ZNHIT3
zinc finger HIT-type containing 3
chr6_+_27957241 0.22 ENST00000244623.1
OR2B6
olfactory receptor family 2 subfamily B member 6
chr6_-_22302826 0.22 ENST00000651245.1
PRL
prolactin
chr13_+_102656933 0.22 ENST00000650757.1
TPP2
tripeptidyl peptidase 2
chr2_+_170178136 0.21 ENST00000409044.7
ENST00000408978.9
MYO3B
myosin IIIB
chr8_+_12104389 0.21 ENST00000400085.7
ZNF705D
zinc finger protein 705D
chr16_-_4351283 0.21 ENST00000318059.8
PAM16
presequence translocase associated motor 16
chr9_-_21217311 0.21 ENST00000380216.1
IFNA16
interferon alpha 16
chr17_-_7857938 0.21 ENST00000575208.2
NAA38
N-alpha-acetyltransferase 38, NatC auxiliary subunit
chr4_+_82900679 0.21 ENST00000302236.10
THAP9
THAP domain containing 9
chr16_+_57646131 0.20 ENST00000569154.5
ADGRG1
adhesion G protein-coupled receptor G1
chr2_+_112721486 0.20 ENST00000327581.4
NT5DC4
5'-nucleotidase domain containing 4
chr20_+_45207025 0.20 ENST00000372781.4
SEMG1
semenogelin 1
chr17_-_40799939 0.20 ENST00000306658.8
KRT28
keratin 28
chr7_-_108130349 0.19 ENST00000205386.8
ENST00000418464.1
ENST00000388781.8
LAMB4
laminin subunit beta 4
chr2_-_24047375 0.19 ENST00000295148.9
WDCP
WD repeat and coiled coil containing
chr6_-_22302797 0.19 ENST00000651757.1
PRL
prolactin
chr15_-_90935130 0.19 ENST00000646620.1
HDDC3
HD domain containing 3
chr7_+_142787624 0.19 ENST00000633780.1
TRBJ1-3
T cell receptor beta joining 1-3
chr1_-_156728388 0.18 ENST00000313146.10
ISG20L2
interferon stimulated exonuclease gene 20 like 2
chr1_+_28812116 0.18 ENST00000621425.1
OPRD1
opioid receptor delta 1
chr1_+_67207614 0.18 ENST00000425614.3
IL23R
interleukin 23 receptor
chr16_+_58392462 0.18 ENST00000318129.6
GINS3
GINS complex subunit 3
chr2_-_88861920 0.18 ENST00000390242.2
IGKJ1
immunoglobulin kappa joining 1
chr5_-_150758497 0.17 ENST00000521533.1
ENST00000424236.5
DCTN4
dynactin subunit 4
chr3_+_46574530 0.17 ENST00000542931.6
TDGF1
teratocarcinoma-derived growth factor 1
chr7_-_26995237 0.17 ENST00000432747.1
SKAP2
src kinase associated phosphoprotein 2
chr13_-_21459253 0.17 ENST00000400590.8
ENST00000382466.7
ENST00000415724.2
ENST00000542645.5
ZDHHC20
zinc finger DHHC-type palmitoyltransferase 20
chr7_-_151080787 0.17 ENST00000540185.5
ENST00000297532.11
FASTK
Fas activated serine/threonine kinase
chr16_-_69339493 0.16 ENST00000562595.5
ENST00000615447.1
ENST00000306875.10
ENST00000562081.2
COG8
component of oligomeric golgi complex 8
chr2_+_137964279 0.16 ENST00000329366.8
HNMT
histamine N-methyltransferase
chr6_-_27873525 0.16 ENST00000618305.2
H4C13
H4 clustered histone 13
chr12_+_8992029 0.16 ENST00000543895.1
KLRG1
killer cell lectin like receptor G1
chr16_+_58392391 0.16 ENST00000426538.6
ENST00000328514.11
GINS3
GINS complex subunit 3
chr1_+_28812160 0.16 ENST00000234961.7
OPRD1
opioid receptor delta 1
chr1_-_157841800 0.15 ENST00000368174.5
CD5L
CD5 molecule like
chr12_+_77966204 0.15 ENST00000550503.1
NAV3
neuron navigator 3
chr1_+_6244172 0.15 ENST00000377898.4
HES3
hes family bHLH transcription factor 3
chr21_-_30166782 0.15 ENST00000286808.5
CLDN17
claudin 17
chr12_-_23944301 0.15 ENST00000538083.1
SOX5
SRY-box transcription factor 5
chr22_+_45318791 0.15 ENST00000424557.1
FAM118A
family with sequence similarity 118 member A
chr11_-_5783355 0.15 ENST00000641181.1
OR52N5
olfactory receptor family 52 subfamily N member 5
chr11_+_4594039 0.14 ENST00000530443.4
OR52I1
olfactory receptor family 52 subfamily I member 1
chrX_+_107777733 0.14 ENST00000509000.3
NCBP2L
nuclear cap binding protein subunit 2 like
chr11_+_6845683 0.14 ENST00000299454.5
OR10A5
olfactory receptor family 10 subfamily A member 5
chr3_+_184097530 0.14 ENST00000425359.6
HTR3E
5-hydroxytryptamine receptor 3E
chr10_-_13761669 0.13 ENST00000650137.1
FRMD4A
FERM domain containing 4A
chrX_+_136536099 0.13 ENST00000440515.5
ENST00000456412.1
VGLL1
vestigial like family member 1
chr7_-_151080833 0.13 ENST00000353841.6
ENST00000482571.2
FASTK
Fas activated serine/threonine kinase
chr11_+_4586791 0.13 ENST00000641486.1
OR52I2
olfactory receptor family 52 subfamily I member 2
chr7_+_144003929 0.12 ENST00000408922.3
OR6B1
olfactory receptor family 6 subfamily B member 1
chr7_+_95485898 0.12 ENST00000428113.5
ASB4
ankyrin repeat and SOCS box containing 4
chr6_+_24774925 0.12 ENST00000356509.7
ENST00000230056.8
GMNN
geminin DNA replication inhibitor
chr10_-_59362867 0.12 ENST00000468840.6
FAM13C
family with sequence similarity 13 member C
chr5_+_159263282 0.11 ENST00000296786.8
UBLCP1
ubiquitin like domain containing CTD phosphatase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0019836 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
0.5 1.9 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.5 2.4 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.5 1.9 GO:0009436 glyoxylate catabolic process(GO:0009436)
0.4 1.1 GO:0061402 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402)
0.3 1.0 GO:0043438 acetoacetic acid metabolic process(GO:0043438)
0.3 1.8 GO:0002933 lipid hydroxylation(GO:0002933)
0.3 1.0 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.2 0.7 GO:0050787 antibiotic metabolic process(GO:0016999) detoxification of mercury ion(GO:0050787)
0.2 0.7 GO:0010983 positive regulation of high-density lipoprotein particle clearance(GO:0010983)
0.2 3.1 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.2 0.6 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.1 0.4 GO:0034130 toll-like receptor 1 signaling pathway(GO:0034130)
0.1 0.9 GO:1904124 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 0.8 GO:0090294 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
0.1 2.5 GO:0034587 piRNA metabolic process(GO:0034587)
0.1 1.3 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1 0.4 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 1.3 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.1 0.5 GO:1902573 positive regulation of serine-type endopeptidase activity(GO:1900005) positive regulation of serine-type peptidase activity(GO:1902573)
0.1 0.7 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.1 0.5 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.3 GO:1990166 protein localization to site of double-strand break(GO:1990166)
0.1 0.5 GO:0061760 antifungal innate immune response(GO:0061760)
0.1 0.5 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.1 0.9 GO:0006662 glycerol ether metabolic process(GO:0006662)
0.1 0.3 GO:0060018 astrocyte fate commitment(GO:0060018)
0.1 1.8 GO:0071420 cellular response to histamine(GO:0071420)
0.1 0.6 GO:0036371 protein localization to T-tubule(GO:0036371)
0.1 0.3 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.1 0.5 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.0 0.6 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 1.5 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 0.3 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.0 0.6 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0 2.2 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.2 GO:0060164 trochlear nerve development(GO:0021558) regulation of timing of neuron differentiation(GO:0060164)
0.0 0.4 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.2 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.0 0.4 GO:0098582 innate vocalization behavior(GO:0098582)
0.0 0.9 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.0 0.7 GO:0008210 estrogen metabolic process(GO:0008210)
0.0 0.4 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 1.8 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.4 GO:0060605 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 1.0 GO:0016048 detection of temperature stimulus(GO:0016048)
0.0 0.2 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0 1.2 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.6 GO:0007097 nuclear migration(GO:0007097)
0.0 0.1 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
0.0 0.3 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 1.3 GO:0019228 neuronal action potential(GO:0019228)
0.0 0.1 GO:0001692 histamine metabolic process(GO:0001692)
0.0 0.3 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.6 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.3 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.0 0.5 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.0 0.4 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 0.4 GO:0034389 lipid particle organization(GO:0034389)
0.0 1.8 GO:0030449 regulation of complement activation(GO:0030449)
0.0 0.3 GO:0006271 DNA strand elongation involved in DNA replication(GO:0006271)
0.0 0.2 GO:0015074 DNA integration(GO:0015074)
0.0 0.6 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.1 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 0.2 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.0 0.4 GO:0039702 viral budding via host ESCRT complex(GO:0039702)
0.0 0.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.2 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0030849 autosome(GO:0030849)
0.3 2.1 GO:0044279 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.3 1.8 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.1 0.4 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.1 0.4 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 1.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 2.3 GO:0071565 nBAF complex(GO:0071565)
0.0 0.4 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.7 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 1.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.2 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.3 GO:0031417 NatC complex(GO:0031417)
0.0 1.0 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 1.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.6 GO:0033391 chromatoid body(GO:0033391)
0.0 0.2 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.0 0.6 GO:0005869 dynactin complex(GO:0005869)
0.0 0.4 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.3 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.3 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.4 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.1 GO:0005846 nuclear cap binding complex(GO:0005846)
0.0 0.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.8 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 2.5 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.9 GO:0009925 basal plasma membrane(GO:0009925)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.1 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.4 1.8 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.4 1.1 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.3 1.9 GO:0008453 alanine-glyoxylate transaminase activity(GO:0008453)
0.3 1.0 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.2 0.6 GO:0005042 netrin receptor activity(GO:0005042)
0.1 0.8 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
0.1 0.4 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.1 1.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 1.1 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.1 0.5 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1 0.7 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 0.4 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.1 0.4 GO:0005148 prolactin receptor binding(GO:0005148)
0.1 3.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.5 GO:0051748 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.1 2.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.9 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.1 0.9 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 3.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 0.2 GO:0008893 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity(GO:0008893) diphosphoric monoester hydrolase activity(GO:0016794)
0.1 0.4 GO:0004046 aminoacylase activity(GO:0004046)
0.1 0.7 GO:0004630 phospholipase D activity(GO:0004630)
0.0 1.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.4 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 1.0 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.0 0.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.2 GO:0004803 transposase activity(GO:0004803)
0.0 0.8 GO:0015377 cation:chloride symporter activity(GO:0015377)
0.0 1.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.2 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.0 0.2 GO:0042019 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.0 0.7 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 1.3 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.3 GO:0031013 troponin I binding(GO:0031013)
0.0 0.6 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 2.2 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.3 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.4 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.6 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.3 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.3 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.6 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.4 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.2 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 1.0 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.5 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.7 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.6 GO:0046966 thyroid hormone receptor binding(GO:0046966)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.3 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 2.2 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.6 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 1.6 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 1.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.8 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.7 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.2 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.8 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 1.9 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 1.1 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 1.9 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.6 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.9 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 1.8 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 2.1 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 1.8 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 1.0 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.4 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 6.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.4 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.6 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.3 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.6 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.7 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 2.4 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.6 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.5 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions