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Illumina Body Map 2 (GSE30611)

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Results for IRX2

Z-value: 0.81

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Transcription factors associated with IRX2

Gene Symbol Gene ID Gene Info
ENSG00000170561.13 iroquois homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX2hg38_v1_chr5_-_2751670_2751694-0.086.5e-01Click!

Activity profile of IRX2 motif

Sorted Z-values of IRX2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_87975667 2.36 ENST00000237623.11
ENST00000682655.1
ENST00000508233.6
ENST00000360804.4
ENST00000395080.8
secreted phosphoprotein 1
chr11_+_33016106 2.10 ENST00000311388.7
DEP domain containing 7
chr5_-_39364484 2.07 ENST00000263408.5
complement C9
chr13_-_46105009 1.94 ENST00000439329.5
ENST00000674625.1
ENST00000181383.10
carboxypeptidase B2
chr5_-_35047935 1.88 ENST00000510428.1
ENST00000231420.11
alanine--glyoxylate aminotransferase 2
chr10_-_95069489 1.83 ENST00000371270.6
ENST00000535898.5
ENST00000623108.3
cytochrome P450 family 2 subfamily C member 8
chr3_-_194351290 1.81 ENST00000429275.1
ENST00000323830.4
carboxypeptidase N subunit 2
chr4_+_68815991 1.64 ENST00000265403.12
ENST00000458688.2
UDP glucuronosyltransferase family 2 member B10
chr14_-_64942783 1.43 ENST00000612794.1
glutathione peroxidase 2
chr1_+_166989254 1.39 ENST00000367872.9
ENST00000447624.1
maelstrom spermatogenic transposon silencer
chr16_+_82035245 1.36 ENST00000199936.9
hydroxysteroid 17-beta dehydrogenase 2
chr19_-_38229654 1.32 ENST00000412732.5
ENST00000456296.5
double PHD fingers 1
chr2_+_233729042 1.29 ENST00000482026.6
UDP glucuronosyltransferase family 1 member A3
chr2_-_233013228 1.27 ENST00000264051.8
neuronal guanine nucleotide exchange factor
chr15_+_37934626 1.16 ENST00000559502.5
ENST00000558148.5
ENST00000319669.5
ENST00000558158.5
transmembrane and coiled-coil domains 5A
chr14_+_24071552 1.16 ENST00000559207.1
copine 6
chr1_+_166989089 1.11 ENST00000367870.6
maelstrom spermatogenic transposon silencer
chr15_-_44194407 1.09 ENST00000484674.5
FERM domain containing 5
chr20_+_57561103 1.08 ENST00000319441.6
phosphoenolpyruvate carboxykinase 1
chr14_+_24071522 1.04 ENST00000558859.5
ENST00000559197.5
ENST00000560828.5
ENST00000560884.5
copine 6
chr4_+_186266183 1.04 ENST00000403665.7
ENST00000492972.6
ENST00000264692.8
coagulation factor XI
chr9_+_12695702 1.02 ENST00000381136.2
tyrosinase related protein 1
chr19_-_38229714 1.02 ENST00000416611.5
double PHD fingers 1
chr9_-_71121596 0.98 ENST00000377110.9
ENST00000377111.8
ENST00000677713.2
transient receptor potential cation channel subfamily M member 3
chr6_-_159044980 0.96 ENST00000367066.8
T cell activation RhoGTPase activating protein
chr3_-_151384741 0.95 ENST00000302632.4
purinergic receptor P2Y12
chr6_-_159045010 0.94 ENST00000338313.5
T cell activation RhoGTPase activating protein
chr16_+_58503833 0.88 ENST00000561738.5
NDRG family member 4
chr16_+_82035267 0.88 ENST00000566213.1
hydroxysteroid 17-beta dehydrogenase 2
chr16_+_82034978 0.88 ENST00000563491.5
hydroxysteroid 17-beta dehydrogenase 2
chr9_-_110337808 0.87 ENST00000374510.8
ENST00000374507.4
ENST00000423740.7
ENST00000374511.7
thioredoxin domain containing 8
chr5_-_138875290 0.84 ENST00000521094.2
ENST00000274711.7
leucine rich repeat transmembrane neuronal 2
chr16_+_56865202 0.84 ENST00000566786.5
ENST00000438926.6
ENST00000563236.6
ENST00000262502.5
solute carrier family 12 member 3
chr12_+_100503416 0.81 ENST00000551184.1
nuclear receptor subfamily 1 group H member 4
chr9_-_23779369 0.81 ENST00000440102.1
ELAV like RNA binding protein 2
chr10_-_14554141 0.81 ENST00000496330.5
family with sequence similarity 107 member B
chr4_-_167234266 0.80 ENST00000511269.5
ENST00000506697.5
ENST00000512042.1
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr4_+_157220691 0.80 ENST00000509417.5
ENST00000645636.1
ENST00000296526.12
ENST00000264426.14
glutamate ionotropic receptor AMPA type subunit 2
chr6_-_159045104 0.77 ENST00000326965.7
T cell activation RhoGTPase activating protein
chr10_+_99782628 0.75 ENST00000648689.1
ENST00000647814.1
ATP binding cassette subfamily C member 2
chr4_-_69214743 0.73 ENST00000446444.2
UDP glucuronosyltransferase family 2 member B11
chr4_+_157221598 0.73 ENST00000505888.1
glutamate ionotropic receptor AMPA type subunit 2
chr4_+_56505782 0.73 ENST00000640821.3
ADP ribosylation factor like GTPase 9
chr5_-_36301883 0.71 ENST00000502994.5
ENST00000515759.5
ENST00000296604.8
RAN binding protein 3 like
chr6_-_24489565 0.70 ENST00000230036.2
glycosylphosphatidylinositol specific phospholipase D1
chr2_-_165203870 0.69 ENST00000639244.1
ENST00000409101.7
ENST00000668657.1
sodium voltage-gated channel alpha subunit 3
chr19_-_35228699 0.69 ENST00000324675.3
family with sequence similarity 187 member B
chr14_+_22422371 0.67 ENST00000390469.2
T cell receptor delta variable 2
chr7_-_150323489 0.67 ENST00000683684.1
ENST00000478393.5
actin related protein 3C
chr2_-_165204042 0.66 ENST00000283254.12
ENST00000453007.1
sodium voltage-gated channel alpha subunit 3
chr5_+_161850597 0.65 ENST00000634335.1
ENST00000635880.1
gamma-aminobutyric acid type A receptor subunit alpha1
chr5_-_161546708 0.65 ENST00000393959.6
gamma-aminobutyric acid type A receptor subunit beta2
chr5_-_138875362 0.64 ENST00000518785.1
leucine rich repeat transmembrane neuronal 2
chr3_-_123980727 0.64 ENST00000620893.4
rhophilin associated tail protein 1
chr5_+_157269317 0.63 ENST00000618329.4
cytoplasmic FMR1 interacting protein 2
chr7_-_14841267 0.62 ENST00000406247.7
ENST00000399322.7
diacylglycerol kinase beta
chr18_+_52752032 0.61 ENST00000412726.5
ENST00000578080.1
ENST00000582875.1
DCC netrin 1 receptor
chr11_+_104036624 0.60 ENST00000302259.5
DNA damage inducible 1 homolog 1
chr6_+_46693835 0.59 ENST00000450697.1
tudor domain containing 6
chr20_-_31390483 0.58 ENST00000376315.2
defensin beta 119
chr3_+_97439603 0.58 ENST00000514100.5
EPH receptor A6
chr11_+_124919244 0.58 ENST00000408930.6
hepatocellular carcinoma, down-regulated 1
chr5_+_36608146 0.56 ENST00000381918.4
ENST00000513646.1
solute carrier family 1 member 3
chrX_-_132961390 0.55 ENST00000370836.6
ENST00000521489.5
heparan sulfate 6-O-sulfotransferase 2
chr6_+_143864458 0.54 ENST00000237275.9
zinc finger C2HC-type containing 1B
chr4_+_188139438 0.53 ENST00000332517.4
tripartite motif family like 1
chr7_-_105691637 0.52 ENST00000472195.1
ataxin 7 like 1
chr7_-_150323725 0.52 ENST00000477871.1
actin related protein 3C
chr4_-_167234552 0.51 ENST00000512648.5
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr1_-_8879170 0.50 ENST00000489867.2
enolase 1
chr2_-_163735989 0.50 ENST00000333129.4
ENST00000409634.5
fidgetin, microtubule severing factor
chr1_-_107688492 0.49 ENST00000415432.6
vav guanine nucleotide exchange factor 3
chr16_+_33459650 0.48 ENST00000617705.1
TP53 target 3 family member F
chr4_-_149815826 0.47 ENST00000636793.2
ENST00000636414.1
IQ motif containing M
chr6_-_49964160 0.45 ENST00000322066.4
defensin beta 114
chr8_-_81447428 0.45 ENST00000256103.3
ENST00000519260.1
peripheral myelin protein 2
chr4_-_167234579 0.45 ENST00000502330.5
ENST00000357154.7
ENST00000421836.6
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr4_-_38804783 0.45 ENST00000308979.7
ENST00000505940.1
ENST00000515861.5
toll like receptor 1
chr5_-_161546671 0.45 ENST00000517547.5
gamma-aminobutyric acid type A receptor subunit beta2
chr3_+_169821922 0.44 ENST00000340806.6
leucine rich repeats and IQ motif containing 4
chr16_+_7332744 0.44 ENST00000436368.6
ENST00000311745.9
ENST00000340209.8
ENST00000620507.4
RNA binding fox-1 homolog 1
chr7_+_69967464 0.44 ENST00000664521.1
activator of transcription and developmental regulator AUTS2
chr10_-_59362584 0.44 ENST00000618427.4
ENST00000611933.4
family with sequence similarity 13 member C
chr2_-_108989206 0.43 ENST00000258443.7
ENST00000409271.5
ENST00000376651.1
ectodysplasin A receptor
chr11_-_62709841 0.42 ENST00000464544.1
ENST00000530009.1
BSCL2 lipid droplet biogenesis associated, seipin
chr3_+_51975026 0.42 ENST00000458031.6
ENST00000273596.8
ENST00000463937.1
ENST00000635952.1
abhydrolase domain containing 14A
ABHD14A-ACY1 readthrough
chr10_-_59362824 0.42 ENST00000503444.1
family with sequence similarity 13 member C
chr4_+_113292838 0.41 ENST00000672411.1
ENST00000673231.1
ankyrin 2
chr14_+_75069577 0.41 ENST00000238686.8
zinc finger C2HC-type containing 1C
chr1_+_204870831 0.41 ENST00000404076.5
ENST00000539706.6
neurofascin
chr20_-_36700661 0.40 ENST00000422536.2
NDRG family member 3
chr16_+_33304344 0.40 ENST00000611321.1
TP53 target 3 family member E
chr4_-_152411734 0.39 ENST00000603841.1
F-box and WD repeat domain containing 7
chr5_-_150758683 0.39 ENST00000518015.5
dynactin subunit 4
chr4_-_167234426 0.39 ENST00000541354.5
ENST00000509854.5
ENST00000512681.5
ENST00000357545.9
ENST00000510741.5
ENST00000510403.5
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr7_-_602625 0.39 ENST00000400758.6
protein kinase cAMP-dependent type I regulatory subunit beta
chr8_+_7495892 0.39 ENST00000355602.3
defensin beta 107B
chr21_+_42403856 0.38 ENST00000291535.11
ubiquitin associated and SH3 domain containing A
chr1_+_162381703 0.38 ENST00000458626.4
chromosome 1 open reading frame 226
chr16_+_33194264 0.37 ENST00000360260.6
TP53 target 3C
chr16_+_33360879 0.37 ENST00000569741.1
TP53 target 3B
chr17_+_36486629 0.36 ENST00000619730.4
zinc finger HIT-type containing 3
chr6_+_13272709 0.35 ENST00000379335.8
phosphatase and actin regulator 1
chr7_+_73667824 0.35 ENST00000324941.5
ENST00000451519.1
VPS37D subunit of ESCRT-I
chr14_+_75069632 0.34 ENST00000439583.2
ENST00000554763.2
ENST00000524913.3
ENST00000525046.2
ENST00000674086.1
ENST00000526130.2
ENST00000674094.1
ENST00000532198.2
zinc finger C2HC-type containing 1C
chr19_+_110643 0.34 ENST00000318050.4
olfactory receptor family 4 subfamily F member 17
chr2_+_170783781 0.33 ENST00000409885.1
glutamate rich 2
chr3_-_114624921 0.33 ENST00000393785.6
zinc finger and BTB domain containing 20
chr1_+_31410164 0.32 ENST00000536859.5
serine incorporator 2
chr20_+_18507520 0.32 ENST00000336714.8
ENST00000646240.1
ENST00000450074.6
ENST00000262544.6
SEC23 homolog B, COPII coat complex component
chr4_-_69639642 0.31 ENST00000604629.6
ENST00000604021.1
UDP glucuronosyltransferase family 2 member A2
chr7_-_83649097 0.31 ENST00000643230.2
semaphorin 3E
chr10_+_100912955 0.31 ENST00000370271.7
ENST00000238961.9
ENST00000370269.3
ENST00000609386.1
SMC5-SMC6 complex localization factor 2
chr1_+_74235377 0.31 ENST00000326637.8
TNNI3 interacting kinase
chr3_-_58433810 0.31 ENST00000474765.1
ENST00000485460.5
ENST00000302746.11
ENST00000383714.8
pyruvate dehydrogenase E1 subunit beta
chrX_-_117985298 0.30 ENST00000469946.5
kelch like family member 13
chr2_+_48617798 0.30 ENST00000448460.5
ENST00000437125.5
ENST00000430487.6
general transcription factor IIA subunit 1 like
chr14_+_51860632 0.30 ENST00000555472.5
ENST00000556766.5
G protein subunit gamma 2
chr6_-_136525961 0.30 ENST00000438100.6
microtubule associated protein 7
chr1_-_173603041 0.30 ENST00000367714.4
solute carrier family 9 member C2 (putative)
chr5_-_83720813 0.28 ENST00000515590.1
ENST00000274341.9
hyaluronan and proteoglycan link protein 1
chr6_+_37929959 0.28 ENST00000373389.5
zinc finger AN1-type containing 3
chr7_+_116954391 0.27 ENST00000421345.5
ENST00000471110.5
novel protein, readthrough ST7-OT4 - ST7
ST7 overlapping transcript 4
chr2_+_63842102 0.27 ENST00000626380.2
ENST00000497883.5
UDP-glucose pyrophosphorylase 2
chr14_+_51860391 0.27 ENST00000335281.8
G protein subunit gamma 2
chr7_+_150368189 0.27 ENST00000519397.1
ENST00000479668.5
replication initiator 1
chr3_-_112846856 0.27 ENST00000488794.5
CD200 receptor 1 like
chr6_-_136526177 0.27 ENST00000617204.4
microtubule associated protein 7
chr4_+_157220795 0.27 ENST00000506284.5
glutamate ionotropic receptor AMPA type subunit 2
chr17_-_8757387 0.27 ENST00000580999.1
speedy/RINGO cell cycle regulator family member E4
chr6_-_53148822 0.26 ENST00000259803.8
glial cells missing transcription factor 1
chr2_+_63842325 0.26 ENST00000445915.6
ENST00000475462.5
UDP-glucose pyrophosphorylase 2
chr19_+_16197900 0.26 ENST00000429941.6
ENST00000291439.8
ENST00000444449.6
ENST00000589822.5
adaptor related protein complex 1 subunit mu 1
chr6_-_136526654 0.26 ENST00000611373.1
microtubule associated protein 7
chr3_-_114624979 0.26 ENST00000676079.1
zinc finger and BTB domain containing 20
chr12_-_123272234 0.25 ENST00000544658.5
cyclin dependent kinase 2 associated protein 1
chrX_-_24027186 0.25 ENST00000328046.8
kelch like family member 15
chr11_-_5059627 0.25 ENST00000321522.2
olfactory receptor family 52 subfamily E member 2
chr20_+_45221362 0.25 ENST00000372769.4
semenogelin 2
chr7_-_130687432 0.24 ENST00000456951.5
testis specific 13
chr2_+_46617180 0.24 ENST00000238892.4
CXXC repeat containing interactor of PDZ3 domain
chr21_+_42403874 0.24 ENST00000319294.11
ENST00000398367.1
ubiquitin associated and SH3 domain containing A
chr4_+_113292925 0.24 ENST00000673353.1
ENST00000505342.6
ENST00000672915.1
ENST00000509550.5
ankyrin 2
chr18_-_55403615 0.23 ENST00000568186.5
transcription factor 4
chr6_-_136526472 0.22 ENST00000454590.5
ENST00000432797.6
microtubule associated protein 7
chr17_+_36486668 0.22 ENST00000617429.5
ENST00000620324.4
ENST00000616269.1
zinc finger HIT-type containing 3
chr6_+_27957241 0.22 ENST00000244623.1
olfactory receptor family 2 subfamily B member 6
chr6_-_22302826 0.22 ENST00000651245.1
prolactin
chr13_+_102656933 0.22 ENST00000650757.1
tripeptidyl peptidase 2
chr2_+_170178136 0.21 ENST00000409044.7
ENST00000408978.9
myosin IIIB
chr8_+_12104389 0.21 ENST00000400085.7
zinc finger protein 705D
chr16_-_4351283 0.21 ENST00000318059.8
presequence translocase associated motor 16
chr9_-_21217311 0.21 ENST00000380216.1
interferon alpha 16
chr17_-_7857938 0.21 ENST00000575208.2
N-alpha-acetyltransferase 38, NatC auxiliary subunit
chr4_+_82900679 0.21 ENST00000302236.10
THAP domain containing 9
chr16_+_57646131 0.20 ENST00000569154.5
adhesion G protein-coupled receptor G1
chr2_+_112721486 0.20 ENST00000327581.4
5'-nucleotidase domain containing 4
chr20_+_45207025 0.20 ENST00000372781.4
semenogelin 1
chr17_-_40799939 0.20 ENST00000306658.8
keratin 28
chr7_-_108130349 0.19 ENST00000205386.8
ENST00000418464.1
ENST00000388781.8
laminin subunit beta 4
chr2_-_24047375 0.19 ENST00000295148.9
WD repeat and coiled coil containing
chr6_-_22302797 0.19 ENST00000651757.1
prolactin
chr15_-_90935130 0.19 ENST00000646620.1
HD domain containing 3
chr7_+_142787624 0.19 ENST00000633780.1
T cell receptor beta joining 1-3
chr1_-_156728388 0.18 ENST00000313146.10
interferon stimulated exonuclease gene 20 like 2
chr1_+_28812116 0.18 ENST00000621425.1
opioid receptor delta 1
chr1_+_67207614 0.18 ENST00000425614.3
interleukin 23 receptor
chr16_+_58392462 0.18 ENST00000318129.6
GINS complex subunit 3
chr2_-_88861920 0.18 ENST00000390242.2
immunoglobulin kappa joining 1
chr5_-_150758497 0.17 ENST00000521533.1
ENST00000424236.5
dynactin subunit 4
chr3_+_46574530 0.17 ENST00000542931.6
teratocarcinoma-derived growth factor 1
chr7_-_26995237 0.17 ENST00000432747.1
src kinase associated phosphoprotein 2
chr13_-_21459253 0.17 ENST00000400590.8
ENST00000382466.7
ENST00000415724.2
ENST00000542645.5
zinc finger DHHC-type palmitoyltransferase 20
chr7_-_151080787 0.17 ENST00000540185.5
ENST00000297532.11
Fas activated serine/threonine kinase
chr16_-_69339493 0.16 ENST00000562595.5
ENST00000615447.1
ENST00000306875.10
ENST00000562081.2
component of oligomeric golgi complex 8
chr2_+_137964279 0.16 ENST00000329366.8
histamine N-methyltransferase
chr6_-_27873525 0.16 ENST00000618305.2
H4 clustered histone 13
chr12_+_8992029 0.16 ENST00000543895.1
killer cell lectin like receptor G1
chr16_+_58392391 0.16 ENST00000426538.6
ENST00000328514.11
GINS complex subunit 3
chr1_+_28812160 0.16 ENST00000234961.7
opioid receptor delta 1
chr1_-_157841800 0.15 ENST00000368174.5
CD5 molecule like
chr12_+_77966204 0.15 ENST00000550503.1
neuron navigator 3
chr1_+_6244172 0.15 ENST00000377898.4
hes family bHLH transcription factor 3
chr21_-_30166782 0.15 ENST00000286808.5
claudin 17
chr12_-_23944301 0.15 ENST00000538083.1
SRY-box transcription factor 5
chr22_+_45318791 0.15 ENST00000424557.1
family with sequence similarity 118 member A
chr11_-_5783355 0.15 ENST00000641181.1
olfactory receptor family 52 subfamily N member 5
chr11_+_4594039 0.14 ENST00000530443.4
olfactory receptor family 52 subfamily I member 1
chrX_+_107777733 0.14 ENST00000509000.3
nuclear cap binding protein subunit 2 like
chr11_+_6845683 0.14 ENST00000299454.5
olfactory receptor family 10 subfamily A member 5
chr3_+_184097530 0.14 ENST00000425359.6
5-hydroxytryptamine receptor 3E
chr10_-_13761669 0.13 ENST00000650137.1
FERM domain containing 4A
chrX_+_136536099 0.13 ENST00000440515.5
ENST00000456412.1
vestigial like family member 1
chr7_-_151080833 0.13 ENST00000353841.6
ENST00000482571.2
Fas activated serine/threonine kinase
chr11_+_4586791 0.13 ENST00000641486.1
olfactory receptor family 52 subfamily I member 2
chr7_+_144003929 0.12 ENST00000408922.3
olfactory receptor family 6 subfamily B member 1
chr7_+_95485898 0.12 ENST00000428113.5
ankyrin repeat and SOCS box containing 4
chr6_+_24774925 0.12 ENST00000356509.7
ENST00000230056.8
geminin DNA replication inhibitor
chr10_-_59362867 0.12 ENST00000468840.6
family with sequence similarity 13 member C
chr5_+_159263282 0.11 ENST00000296786.8
ubiquitin like domain containing CTD phosphatase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0019836 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
0.5 1.9 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.5 2.4 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.5 1.9 GO:0009436 glyoxylate catabolic process(GO:0009436)
0.4 1.1 GO:0061402 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402)
0.3 1.0 GO:0043438 acetoacetic acid metabolic process(GO:0043438)
0.3 1.8 GO:0002933 lipid hydroxylation(GO:0002933)
0.3 1.0 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.2 0.7 GO:0050787 antibiotic metabolic process(GO:0016999) detoxification of mercury ion(GO:0050787)
0.2 0.7 GO:0010983 positive regulation of high-density lipoprotein particle clearance(GO:0010983)
0.2 3.1 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.2 0.6 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.1 0.4 GO:0034130 toll-like receptor 1 signaling pathway(GO:0034130)
0.1 0.9 GO:1904124 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 0.8 GO:0090294 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
0.1 2.5 GO:0034587 piRNA metabolic process(GO:0034587)
0.1 1.3 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1 0.4 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 1.3 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.1 0.5 GO:1902573 positive regulation of serine-type endopeptidase activity(GO:1900005) positive regulation of serine-type peptidase activity(GO:1902573)
0.1 0.7 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.1 0.5 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.3 GO:1990166 protein localization to site of double-strand break(GO:1990166)
0.1 0.5 GO:0061760 antifungal innate immune response(GO:0061760)
0.1 0.5 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.1 0.9 GO:0006662 glycerol ether metabolic process(GO:0006662)
0.1 0.3 GO:0060018 astrocyte fate commitment(GO:0060018)
0.1 1.8 GO:0071420 cellular response to histamine(GO:0071420)
0.1 0.6 GO:0036371 protein localization to T-tubule(GO:0036371)
0.1 0.3 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.1 0.5 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.0 0.6 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 1.5 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 0.3 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.0 0.6 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0 2.2 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.2 GO:0060164 trochlear nerve development(GO:0021558) regulation of timing of neuron differentiation(GO:0060164)
0.0 0.4 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.2 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.0 0.4 GO:0098582 innate vocalization behavior(GO:0098582)
0.0 0.9 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.0 0.7 GO:0008210 estrogen metabolic process(GO:0008210)
0.0 0.4 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 1.8 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.4 GO:0060605 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 1.0 GO:0016048 detection of temperature stimulus(GO:0016048)
0.0 0.2 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0 1.2 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.6 GO:0007097 nuclear migration(GO:0007097)
0.0 0.1 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
0.0 0.3 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 1.3 GO:0019228 neuronal action potential(GO:0019228)
0.0 0.1 GO:0001692 histamine metabolic process(GO:0001692)
0.0 0.3 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.6 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.3 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.0 0.5 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.0 0.4 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 0.4 GO:0034389 lipid particle organization(GO:0034389)
0.0 1.8 GO:0030449 regulation of complement activation(GO:0030449)
0.0 0.3 GO:0006271 DNA strand elongation involved in DNA replication(GO:0006271)
0.0 0.2 GO:0015074 DNA integration(GO:0015074)
0.0 0.6 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.1 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 0.2 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.0 0.4 GO:0039702 viral budding via host ESCRT complex(GO:0039702)
0.0 0.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.2 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0030849 autosome(GO:0030849)
0.3 2.1 GO:0044279 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.3 1.8 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.1 0.4 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.1 0.4 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 1.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 2.3 GO:0071565 nBAF complex(GO:0071565)
0.0 0.4 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.7 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 1.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.2 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.3 GO:0031417 NatC complex(GO:0031417)
0.0 1.0 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 1.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.6 GO:0033391 chromatoid body(GO:0033391)
0.0 0.2 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.0 0.6 GO:0005869 dynactin complex(GO:0005869)
0.0 0.4 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.3 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.3 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.4 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.1 GO:0005846 nuclear cap binding complex(GO:0005846)
0.0 0.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.8 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 2.5 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.9 GO:0009925 basal plasma membrane(GO:0009925)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.1 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.4 1.8 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.4 1.1 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.3 1.9 GO:0008453 alanine-glyoxylate transaminase activity(GO:0008453)
0.3 1.0 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.2 0.6 GO:0005042 netrin receptor activity(GO:0005042)
0.1 0.8 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
0.1 0.4 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.1 1.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 1.1 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.1 0.5 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1 0.7 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 0.4 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.1 0.4 GO:0005148 prolactin receptor binding(GO:0005148)
0.1 3.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.5 GO:0051748 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.1 2.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.9 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.1 0.9 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 3.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 0.2 GO:0008893 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity(GO:0008893) diphosphoric monoester hydrolase activity(GO:0016794)
0.1 0.4 GO:0004046 aminoacylase activity(GO:0004046)
0.1 0.7 GO:0004630 phospholipase D activity(GO:0004630)
0.0 1.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.4 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 1.0 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.0 0.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.2 GO:0004803 transposase activity(GO:0004803)
0.0 0.8 GO:0015377 cation:chloride symporter activity(GO:0015377)
0.0 1.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.2 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.0 0.2 GO:0042019 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.0 0.7 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 1.3 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.3 GO:0031013 troponin I binding(GO:0031013)
0.0 0.6 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 2.2 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.3 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.4 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.6 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.3 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.3 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.6 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.4 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.2 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 1.0 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.5 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.7 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.6 GO:0046966 thyroid hormone receptor binding(GO:0046966)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.3 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 2.2 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.6 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 1.6 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 1.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.8 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.7 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.2 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.8 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 1.9 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 1.1 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 1.9 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.6 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.9 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 1.8 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 2.1 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 1.8 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 1.0 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.4 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 6.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.4 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.6 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.3 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.6 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.7 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 2.4 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.6 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.5 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions